Division of Molecular Physiological Chemistry

Corresponding:horiike@belle.shiga-med.ac.jp
Link to the detailed department page:

Staff and specialities

Professor:  Kihachiro HORIIKE
   1. Molecular physiological chemistry of dioxygen
   2. Biochemistry of D-amino acids
   3. Enzymology of oxidases and oxygenases
Associate Professor:  Tetsuo ISHIDA
   Molecular enzymology, Biophysical chemistry of proteins
Senior Assistant Professor:  Hiroyuki TANAKA
   1. Physiological chemistry of D-amino acids
   2. Enzymology of flavo-oxidases and PLP(B6)-dependent dehydratase
Assistant Professor:  Atsushi YAMAMOTO
   1. Physiological chemistry of D-amino acids
   2. Enzymology of flavo-oxidases

Outline of the department

Research activities in this department are centered on the mechanism of 
cellular dioxygen metabolism, with particular emphasis on the control of the 
oxidative reactions mediated by oxidases and oxygenases.  The chemical nature, 
structure, function and regulation of nonheme iron-containing dioxygenases and 
flavin-containing oxidases are being studied.  Present main research projects 
focus on:
 1) The physiological and pathological significance of D-amino acids in
    central nervous systems of mammals.
    Research on D-amino-acid oxidase, D-aspartate oxidase and D-serine
    dehydratase. 
 2) The structure, function and regulation of nonheme iron-containing
    catechol dioxygenases.
 3) Research on protein-ligand and protein-protein interactions by frontal
    gel chromatography and Hummel-Dreyer method. 

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