Staff and specialities
Professor: Akira ANDOH
Associate Professor: Keiko HODOHARA
Assistant Professor: Takafumi OKUNO
Assistant Professor: Shigeki BAMBA
Assistant Professor: Osamu INATOMI
Assistant Professor: Yusuke KOIZUMI
Assistant Professor: Makoto SHIOYA
Assistant Professor: Atsushi NISHIDA
Assistant Professor: Takashi NISHIMURA
Professor: Tomoyuki TSUJIKAWA (Department of Comprehensive Internal Medicine)
Outline of the department
The clinical specialties of our department relate to the medical care of patients with digestive and hematological diseases. These include latest diagnostic and therapeutic approaches for inflammatory bowel diseases (IBD), gastrointestinal and hepato-biliary-pancreatic diseases, and hematopoietic stem cell transplantations (allo-BMT, auto-BMT and PBSCT) for hematological diseases.
Research in the Department of Gastroenterology covers the clinical, investigative and educational fields of Gastroenterology, and we conduct both clinical and basic research based on cutting-edge medical science, currently focusing on the following projects.
1) Latest therapeutics of IBD using biologics, cytapheresis, immunomodulatory
agents, and nutritional assessment.
2) Diagnostic and interventional approach for gastrointestinal malignancy include
endoscopic submucosal dissection (ESD), endoscopic ultrasonography (EUS),
endoscopic retrograde cholangiopancreatography (ERCP), and radiofrequency
1) Identifying regulatory mechanisms of intestinal absorption and intestinal
epithelial cell growth induced by dietary components as intraluminal substrates.
2) Establishing animal models of IBD to analyze the possible roles played by
cytokines and chemical mediators in the pathogenesis of IBD, and proposing
development of novel therapeutic agents.
3) Elucidating the pathogenic role of periacinal myofibroblasts in the
progression of pancreatic fibrosis.
Department of Hematology provides expert primary and consultative care for patients with benign and malignant blood-related disorders. Clinical disorders of particular interest include: acute leukemias, malignant lymphomas, multiple myelomas, bone marrow failure disorders (aplastic anemia, myelodysplastic syndromes), myeloproliferative neoplasms (polycythemia vera, essential thrombocytosis, chronic myeloid leukemia, myelofibrosis), and a variety of other benign and malignant disorders. More than 200 adult stem cell transplant procedures are performed at our program, autologous peripheral stem cell transplants for lymphomas and myelomas, and allogeneic transplantations for acute leukemias. Our program is accredited by Japan Marrow Donor Program.
Research in this department is principally concerned with gastroenterology and hematology, and currently focuses on
1) Elucidating regulatory functions of bone marrow derived stroma cells on
megakaryopotesis and clonal growth of leukemic cells.
2) Isolation and characterization of hematopoietic stem cells in order to develop
an in vitro expansion system for these cells.
3) Development of tumor specific molecular target drugs.
4) Promotion of BCR-ABL-mediated myeloid cell proliferation, differentiation and
exhaustion of CML stem cells by C/EBPÎ² transcription factor.