研究発表

目次
  1)論文リスト
  2)成果報告

1) 論文リスト
Morita Y, Ohno M, Nishi K, Hiraoka Y, Saijo S, Matsuda S, Kita T, Kimura T and *Nishi E
Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression
Sci Rep. 7: 14801, 2017
doi: 10.1038/s41598-017-14942-4.

Fujii T, *Nishi E, *Ito H, Yoshitomi H, Furu M, Okabe N, Ohno M, Nishi K, Morita Yus, Morita Yug, Azukizawa M, Okahata A, Tomizawa T, Kimura T, and Matsuda S
Nardilysin is involved in autoimmune arthritis via the regulation of TNF- secretion
RMD Open 3: e000436, 2017
doi: 10.1136/rmdopen-2017-000436

Chen PM, Ohno M, Hiwasa T, Nishi K, Saijo S, Sakamoto J, Morita Y, Matsuda S, Watanabe S, Kuwabara Y, Ono K, Imai M, Inoue K, Murai T, Inada T, Tanaka M, Kita T, Kimura T and *Nishi E
Nardilysin is a promising biomarker for the early diagnosis of Acute Coronary Syndrome
Int J Cardiol. 243: 1-8, 2017
doi: 10.1016/j.ijcard.2017.04.047.

Kasai Y, Toriguchi K, *Hatano E, Nishi K, Ohno M, Yoh T, Fukuyaman K, Nishio T, Okuno M, Iwaisako K, Seo S, Taura K, Kurokawa M, Kunichika M, Uemoto S, *Nishi E
Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3
Cancer Sci. 108: 910-917, 2017
doi: 10.1111/cas.13204.

Kimura Y, Ikuta K, Kimura T, Chiba T, Oshima H, Oshima M, *Nishi E, *Seno H
Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach
Sci Rep. 7: 43052, 2017
doi: 10.1038/srep43052.

Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Michael F. Wangler MF, Karaca E, Lupski JR, and Bellen HJ
Loss of Nardilysin, a mitochondrial co-chaperone for -Ketoglutarate Dehydrogenase, promotes mTORC1 activation and neurodegeneration
Neuron 93: 115-131, 2017

Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T and *Nishi E
Nardilysin is Required for maintaining Pancreatic -Cell Function
Diabetes 65: 3015-27, 2016
DOI: 10.2337/db16-0178

Hiwasa T, Zhang XM, Kimura R, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Kamitsukasa I, Wada T, Aotsuka A, Mine S, Takizawa H, Kashiwado K, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H.
Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosisrelated Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
J Circ Biomark, 5:8, 2016
doi: 10.5772/63218

Hiwasa T, Machida T, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Mine S, Ohno M, Chen PM, Nishi E, Kitamura K, Yamazoe R, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Matsutani T, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Nakayama T, Harada JY, Kobayashi Y, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai KI, Fujimoto M, Yokote K, Goto K, Matsumura R, Sugiyama T, Hayashi H, Hasegawa R, Shimada H, Ito M, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H.
Elevated Levels of Autoantibodies against ATP2B4 and BMP-1 in Sera of Patients with Atherosclerosis-related Diseases.
Immunome Res 11: 097, 2015.
doi:10.4172/17457580.1000097

Hiwasa T, Zhang XM, Kimura R, Machida T, Kitamura K, Yamazoe R, Kunimatsu M, Mine S, Kobayashi E, Iwadate Y, Saeki N, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai KI, Fujimoto M, Yokote K, Iwata Y, Nakayama T, Harada JY, Kobayashi Y, Ohno M, Chen PM, Nishi E, Yokota M, Kamitsukasa I, Wada T, Aotsuka A, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Goto K, Matsumura R, Takizawa H, Shimada H, Ito M, Wang H, Taira A, Arita E, Iwase K, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H
Association of Serum Antibody Levels against TUBB2C with Diabetes and Cerebral Infarction
Gratis J Biomed Sci, 1(2): 49-63. 2015.
doi: 10.18314/gjbs.v1i2.27

Goto K, Sugiyama T, Matsumura R, Zhang XM, Kimura R, Taira A, Arita E, Iwase K, Kobayashi E, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chin H, Nishi E, Machida T, Iwata Y, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Katayama K, Kikkawa Y, Sunami K, Takizawa H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H and Hiwasa T
Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus.
J Mol Biomark Diagn 6: 219. 2015.
doi: 10.4172/2155-9929.1000219

Tien DN, Kishihata M, Yoshikawa A, Hashimoto A, Sabe H, Nishi E, Kamei K, Arai H, Kita T, Kimura T, Yokode M, Ashida N.
AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.
Sci Rep. 4:5094. 2014.
doi: 10.1038/srep05094.

Ishizu-Higashi S, *Seno H, *Nishi E, Matsumoto Y, Ikuta K, Tsuda M, Kimura Y, Takada Y, Kimura Y, Nakanishi Y, Kanda K, Komekado H, Chiba T (*Co-corresponding author)
Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes
PLOS ONE 9(5): e98017, 2014
doi:10.1371/journal.pone.0098017

Hiraoka Y, Matsuoka T, Ohno M, Nakamura K, Saijo S, Matsumura S, Nishi K, Sakamoto J, Chen Po-Min, Inoue K, Fushiki T, Kita T, Kimura T and *Nishi E
Critical roles of nardilysin in the maintenance of body temperature homeostasis
Nat. Commun. 5: 3224, 2014.
doi: 10.1038/ncomms4224

Ohno M, Hiraoka Y, Lichtenthaler S, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T and *Nishi E
Nardilysin prevents amyloid plaque formation by enhancing -secretase activity in an Alzheimer’s disease mouse model
Neurobiol Aging 35: 213-22, 2014.
doi: 10.1016/j.neurobiolaging.2013.07.014.

Li J, Chu M, Wang S, Chan D, Qi S, Wu M, Zhou Z, Li Z, Nishi E, Qin J and Wong J
Identification and Characterization of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation
J Biol Chem, 287:10089-98, 2012.
doi: 10.1074/jbc.M111.313965

Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi Y, Nakatsuji M, Akitake-Kawano R, Ohno M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika M, Kimura T, *Seno H, *Nishi E, and ChibaT (*Co-corresponding author)
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-a
EMBO Mol Med, 4:396-411, 2012.
doi: 10.1002/emmm.201200216

Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa, S Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, and Uemoto S
Continuous cell supply from the Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Nat. Genet. 43: 34-41, 2011.

16.Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E, and Furuse M.
Angulin/LSR defines cell corners for tricellular tight junction formation in epithelial cells
J. Cell. Sci. 15: 548-55, 2011.

Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway
Cardiovasc Res. 2010; 87: 656-64.

Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H, Kimura T, Kita T, and *Nishi E.
Nardilysin Regulates Axonal Maturation and Myelination in the Central and Peripheral Nervous System
Nat. Neurosci. 2009; 12: 1506-1513

Hoshino K, Horiuchi H, Tada T, Tazaki J, Nishi E, Kawato M, Ikeda T, Yamamoto H, Akao M, Furukawa Y, Shizuta S, Toma M, Tamura T, Saito N, Doi T, Ozasa N, Jinnai T, Takahashi K, Watanabe H, Yoshikawa Y, Nishimoto N, Ouchi C, Morimoto T, Kita T, Kimura T.
Clopidogrel Resistance in Japanese Patients Scheduled for Percutaneous Coronary Intervention
Circ J. 2009; 73: 336-42

Mitsuoka H, Kume N, Hayashida K, Inui-Hayashiada A, Aramaki Y, Toyohara M, Jinnai T, Nishi E, Kita T.
Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1).
Atherosclerosis. 2009; 202: 176-82

Hiraoka Y, Yoshida K, Ohno M, Matsuoka T, Kita T, Nishi E*.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.
Biochem. Biophs. Res. Commun. 2008; 370: 154-8

Matsuda M, Kobayashi Y, Masuda S, Adachi M, Watanabe T, Yamashita JK, Nishi E, Tsukita S, Furuse M.
Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.
Exp Cell Res. 2008; 314: 939-49

Furukawa, K., Fujiwara, H., Sato, Y., Zeng, BX., Fujii, H., Yoshioka, S., Nishi, E. and Nishio, T. ; Platelets Are Novel Regulators of Neovascularization and Luteinization during Human Corpus Luteum Formation.
Endocrinology 2007; 148: 3056-64

Hiraoka, Y., Ohno, M., Yoshida, K., Okawa, K., Tomimoto, H., Kita, T. and Nishi E.
Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin.
J Neurochem. 2007; 102: 1595-1605

Nishi, E., Hiraoka, Y., Yoshida, K., Okawa, K. and Kita, T.
Nardilysin enhances ectodomain shedding of heparin-binding EGF-like growth factor through activation of TNF-alpha converting enzyme.
J. Biol. Chem. 281, 31164-72 (2006)

Ohtsuka, T., Imayoshi, I., Shimojo, H, Nishi, E., Kageyama, R. and McConnell, SK.
Visualization of embryonic neural stem cells using Hes promoters in transgenic mice.
Mol Cell Neurosci. 31, 109-22 (2006)

Nishi, E., and Klagsbrun, M.
Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) is a Mediator of Multiple Physiological and Pathological Pathways.
Growth Factors. 22, 253-260 (2004)

Park, P.W, Foster, T.J., Nishi, E., Duncan,.S.J., Klagsbrun, M., and Chen, Y.
Activation of syndecan-1 ectodomain shedding by Staphylococcus aureus and toxins.
J. Biol. Chem. 279, 251-258 (2004)

Goishi K, Lee P, Davidson AJ, Nishi E, Zon LI and Klagsbrun M.
Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.
Mech Dev. 2003; 120: 811-822.

Hospital V, Nishi E, Klagsbrun M, Cohen P, Seidah NG, Prat A.
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding EGF-like growth factor (HB-EGF).
Biochem J. 2002; 367: 229-238

Jin K, Mao XO, Sun Y, Xie L, Jin L, Nishi E, Klagsbrun M, Greenberg DA.
Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo.
J Neurosci. 2002; 22: 5365-73.

Nishi,E., Prat,A., Veronique,H., Elenius,K. and Klagsbrun,M.
N-arginine dibasic convertase is a specific receptor for heparin-bnding EGF-like growth factor that mediates cell migration
EMBO J. 2001; 20: 3342-50.

Ueno, Y., Kume N, Miyamoto S, Morimoto M, Kataoka H, Ochi H, Nishi E, Moriwaki H, Minami M, Hashimoto N, Kita T.
Lysophosphatidylcholine phosphorylates CREB and activates the jun2TRE site of c-jun promoter in vascular endothelial cells.
FEBS Lett. 1999; 457: 241-5.

Elenius, K., C J CHoi, S.Paul, E.Santiestevan, E.Nishi, and M.Klagsbrun.
Characterization of a naturally occuring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase
Oncogene. 1999; 18: 2607-15.

Moriwaki, H., N.Kume, T.Sawamura, H.Ochi, E.Nishi, T.Masaki, and T.Kita. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha.
FEBS Lett. 1998; 440: 29-32.

Moriwaki, H., N.Kume, T.Sawamura, T.Aoyama, H.Hoshikawa, H.Ochi, E.Nishi, T.Masaki, and T.Kita.
Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein
Arterioscler Thromb Vasc Biol. 1998; 18: 1541-7.

Sakata-Kaneko, S., Y.Wakatsuki, T.Usui, Y.Matsunaga, T.Ito, E.Nishi,
N.Kume, T.Kita
Lysophosphatidylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells.
FEBS Lett. 1998; 433: 161-5.

Nishi, E., N.Kume, Y.Ueno, H.Ochi, H.Moriwaki and T.Kita.
Lysophosphatidylcholine upregulates cytokine-induced interferon- expression in human T-lymphocytes
Circ Res. 1998; 83: 508-15.

Ochi, H., N.Kume, E.Nishi, H.Moriwaki, M.Masuda, K.Fujiwara and T.Kita.
Tyrosine phosphorylation of platlet endothelial cell adhesion molecule-1 induced by lysophosphatidylcholine in cultured endothelial cells
Biochem. Biophs. Res. Commun. 1998; 243: 862-868

Nishi, E., N.Kume, H.Ochi, H.Moriwaki, Y.Wakatsuki, S.Higashiyama, N.Taniguchi and T.Kita.
Lysophosphatidylcholine increases expression of heparin-binding epidermal growth factor-like growth factor in human T-lymphocytes
Circ Res. 1997; 80: 638-644

Kita, T., N.Kume, H.Ochi, E.Nishi, A.Sakai, K.Ishii, Y.Nagano, and M.Yokode.
Induction of endothelial platelet-derived growth factor-B-chain and intercellular adhesion molecule-1 by lysophosphatidylcholine
Ann N Y Acad Sci. 1997; 811: 70-5

Nishi, E., N.Kume, H.Ochi, H.Moriwaki, S.Higashiyama, N.Taniguchi and T.Kita.
Lysophosphatidylcholine induces heparin-binding epidermal growth factor-like growth factor and interferon- in human T-lymphocytes
Ann. N. Y. Acad. Sci. 1997; 811: 519-524

Sakai, A., N.Kume, E.Nishi, K.Tanoue, M.Miyasaka and T.Kita.
P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits prior to intimal accumulation of macrophage and T-lymphocytes
Arterioscler Thromb Vasc Biol. 1997; 17: 310-316

Kume, N., H.Ochi, E.Nishi, M.A.Gimbrone, Jr., and T.Kita.
Involvement of protein kinase C-independent mechanisms in endothelial ICAM-1 up-regulation by lysophosphatidylcholine
Ann. N. Y. Acad. Sci. 1997; 748:541-2

Ochi, H., N.Kume, E.Nishi, and T.Kita.
Elevated levels of cAMP inhibit protein kinase C-independent mechanisms of endothelial platelet-derived growth factor-B chain and intercellular adhesion molecule-1 gene induction by lysophosphatidylcholine.
Circ Res. 1995; 77:530-5

Nishi,E., J.Akiyama, M.Sato, T.Yamada, Y.Takashima, T.Shimada, H.Hayakawa and A.Sato.
Serial bronchoalveolar lavage studies in a patient with pulmonary fibrosis following Legionnaires' disease
Internal Medicine, 32; 659-662, 1993.

2)成果報告