滋賀医科大学 動物生命科学研究センター 幹細胞・ヒト疾患モデル研究分野（依馬研究室）のホームページです

学術論文


2024年

  • ● Tsuruta H, Yasuda-Yamahara M, Yoshibayashi M, Kuwagata S, Yamahara K, Tanaka-Sasaki Y, Chin-Kanasaki M, Matsumoto S, Ema M, Kume S. Fructose overconsumption accelerates renal dysfunction with aberrant glomerular endothelial-mesangial cell interactions in db/db mice. Biochem Biophy Acta Mol Basis Dis. (2024)
    > PubMed

  • ● Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, Nishi E, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Mizutani K, Ema M*. Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Exp Anim. (2024)
    > PubMed

  • ● Mikami N, Nguyen CLK, Osawa Y, Kato K, Ishida M, Tanimoto Y, Morimoto K, Murata K, Kang W, Sugiyama F, Ema M, Takahasi S, Mizuno S. Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Exp Anim. (2024)
    > PubMed


    • 2023年

  • ● Okamura E#, Mizuno S#, Matsumoto S#, Murata K, Tanimoto Y, Dinh T, Suzuki H, Kang W, Ema T, Morimoto K, Kato K, Matsumoto T, Masuyama N, Kijima Y, Morimura F, Sugiyama S, Takahashi S, Mizutani E, Woltjen K, Yachie N, Ema M*. Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation. bioRxiv. (2023) #The authors contributed equally to this work.
    > bioRxiv

  • ● Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, Takubo K, Kubota Y. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis. Nat Cell Biol. (2023)
    > PubMed

  • ● Sato A, Tsukiyama T, Komeno M, Iwatani C, Tsuchiya H, Kawamoto I, Murase M, Nakagawa T, Itagaki I, Seita Y, Matsumoto S, Nakaya M, Shimizu A, Yamada A, Ema M, Ogita H. Generation of a fimilial hypercholesterolemia model in non-human primate. Sci Rep. (2023)
    > PubMed

  • ● Akiyama T, Sadahiro T, Yamada Y, Fujita R, Abe Y, Nakano K, Honda S, Ema M, Kubota Y, Sakai S, Hizawa N, Ieda M. Flk1 Deficiency and Hypoxia Synergistically Promote Endothelial Dysfunction, Vascular Remodeling, and Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. (2023)
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  • ● Matsumoto S*, Okamura E, Muto M, Ema M*. Similarities and differences in placental development between humans and cynomolgus monkeys. Reprod Med Biol. (2023)
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  • ● Utagawa K, Shin T, Yamada H, Ochi H, Sunamura S, Unno A, Akazawa C, Ema M, Takeda S, Okawa A, Sato S. Three-dimensional visualization of neural networks inside bone by Osteo-DISCO protocol and alteration of bone remodeling by surgical nerve ablation. Sci Rep. (2023)
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  • ● Wada H, Hikiami R, Kusui M, Minamiyama S, Asada-Utsugi M, Shodai A, Muramatsu SI, Morimura T, Urushitani M, In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD. Neurosci Res. (2023)
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  • ● Miyazaki T, Kanatsu-Shinohara M, Ema M, Shinohara T. Signal regulatory protein alpha is a conserved marker for mouse and rat spermatogonial stem cells. Biol Reprod. (2023)
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  • ● Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, Moreno-Irusta A, Kozai K, Varberg KM, Okae H, Arima T, Sucov HM, Soares MJ. CITED2 is a conserved regulator of the uterine-placental interface. Proc Natl Acad Sci U S A. (2023)
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  • ● Kozai K, Moreno-Irusta A, Iqbal K, Winchester ML, Scott RL, Simon ME, Muto M, Parrish MR, Soares MJ. The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation. Development. (2023)
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    • 2022年

  • ● Takigawa-Imamura H, Hirano S, Watanabe C, Ohtaka-Maruyama C, Ema M, Mizutani KI. Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels. Life (Basel). (2022)
    > PubMed

  • ● Tabata H, Sasaki M, Agetsuma M, Sano H, Hirota Y, Miyajima M, Hayashi K, Honda T, Nishikawa M, Inaguma Y, Ito H, Takebayashi H, Ema M, Ikenaka K, Nabekura J, Nagata KI, Nakajima K. Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex. Nat Commun. (2022)
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  • ● Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, Matsumoto S, Matsushita J, Azami T, Kubota Y, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Tamura M, Mizutani K, Ema M. Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice. Life. (2022)
    > PubMed

  • ● Ueda Y, Suzuki K, Kajimoto M, Fujimoto K, Mahendroo M, Ema M, Yamada G, Hara I. Possible testosterone redundancy for 5α-dihydrotestosterone in the masculinization of mouse external genitalia. Exp Anim. (2022)
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  • ● Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M, Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induced mitochondrial dysfunction and cytosolic aggregates. Sci Rep. (2022)
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  • ● Asada-Utsugi M, Uemura K, Ayaki T, T Uemura M, Minamiyama S, Hikiami R, Morimura T, Shodai A, Ueki T, Takahashi R, Kinoshita A, Urushitani M, Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro. Commun Biol. (2022)
    > PubMed

  • ● Matsubara T, Iga T, Sugiura Y Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, Kubota Y. Coupling of angiogenesis and odontogenesiis orchestrates tooth mineralization in mice. J Exp Med. (2022)
    > PubMed

  • ● Abe S, Murashima A, Kimura E, Ema M, Hitomi J. Early development of pulmonary vascular system: An anatomical and histochemical reinvestigation of the pulmonary venous return development in mice. Acta Histochem. (2022)
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  • ● Kido Y, Ando T, Iga T, Ema M, Kubota Y, Tai-Nagara I. Genetic Deletion of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells Leads to Immediate Disruption of Tumor Vessels and Aggravation of Hypoxia. Am J Pathol. (2022)
    > PubMed


    • 2021年

  • ● Muto M, Chakraborty D, Varberg KM, Moreno-Irusta A, Iqbal K, Scott RL, McNally RP, Choudhury RH, Aplin JD, Okae H, Arima T, Matsumoto S, Ema M, Mast AE, Grundberg E, Soares MJ. Intersection of regulatory pathways controlling hemostasis and hemochorial placentation. Proc Natl Acad Sci U S A. (2021)
    > PubMed

  • ● Kido Y, Ando T, Iga T, Ema M, Kubota Y, Tai-Nagara I. Genetic Deletion of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells Leads to Immediate Disruption of Tumor Vessels and Aggravation of Hypoxia. Am J Pathol. (2021)
    > PubMed

  • ● Okamoto I, Nakamura T, Sasaki K, Yabuta Y, Iwatani C, Tsuchiya H, Nakamura SI, Ema M, Yamamoto T, Saitou M. The X chromosome dosage compensation program during the development of cynomolgus monkeys. Science. (2021)
    > PubMed

  • ● Kumegawa S, Yamada G, Hashimoto D, Hirashima T, Kajimoto M, Isono K, Fujimoto K, Suzuki K, Uemura K, Ema M, Asamura S. Development of Surgical and Visualization Procedures to Analyze Vasculatures by Mouse Tail Edema Model. Biol Proced. (2021)
    > PubMed

  • ● Abdelhakim M, Dohi T, Yamato M, Takada H, Sakai A, Suzuki H, Ema M, Fukuhara S, Ogawa R. A New Model for Specific Visualization of Skin Graft Neoangiogenesis Using Flt1-tdsRed BAC Transgenic Mice. Plast Reconstr Surg. (2021)
    > PubMed

  • ● Jayakumar V, Nishimura O, Kadota M, Hirose N, Sano H, Murakawa Y, Yamamoto Y, Nakaya M, Tsukiyama T, Seita Y, Nakamura S, Kawai J, Sasaki E, Ema M, Kuraku S, Kawaji H, Sakakibara Y. Chromosomal-scale de novo genome assemblies of Cynomolgus Macaque and Common Marmoset. Sci Data. (2021)
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  • ● Osawa Y, Murata K, Usui M, Kuba Y, Le HT, Mikami N, Nakagawa T, Daitoku Y, Kato K, Shawki HH, Ikeda Y, Kuno A, Morimoto K, Tanimoto Y, Dinh TTH, Yagami KI, Ema M, Yoshida S, Takahashi S, Mizuno S, Sugiyama F. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice. Elife. (2021)
    > PubMed

  • ● Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell RM, Sugiyama F. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.Elife. (2021)
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  • ● Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ. ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proc Natl Acad Sci U S A. (2021)
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  • ● Otsu K, Ida-Yonemochi H, Ikezaki S, Ema M, Hitomi J, Ohshima H, Harada H. Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor. Development. (2021)
    > PubMed


    • 2020年

  • ● Wang S, Yamakawa BA, Santosa SM, Neeraj Chawla BS, Guo K, Montana M, Hallak JA, Han KY, Ema M, Rosenblatt MI, Chang JH, Azar DT. Quantification of angiogenesis and lymphangiogenesis in the dual ex vivo aortic and thoracic duct assay. Protein Pept Lett. (2020)
    > PubMed

  • ● Kisu I, Kato Y, Masugi Y, Ishigaki H, Yamada Y, Matsubara K, Obara H, Emoto K, Matoba Y, Adachi M, Banno K, Saiki Y, Sasamura T, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T. First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques. J Clin Med. (2020)
    > PubMed

  • ● Kisu I, Emoto K, Masugi Y, Yamada Y, Matsubara K, Obara H, Matoba Y, Banno K, Kato Y, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Murase M, Nakagawa T, Tsuchiya H, Ishigaki H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T. Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques. Sci Rep. (2020)
    > PubMed

  • ● Takahashi M, Misaki M, Shibata S, Iga T, Shindo T, Tai-Nagara I, Hirata A, Ogawa M, Miyamoto T, Nakagawa T, Ema M, Ichiyama Y, Shima DT, Hozumi K, Nishimura S, Kubota Y. Macrophages fine-tune pupil shape during development. Dev Biol. (2020)
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  • ● Santosa SM, Guo K, Yamakawa M, Ivakhnitskaia E, Chawla N, Nguyen T, Han KY, Ema M, Rosenblatt MI, Chang JH, Azar DT. Simultaneous fluorescence imaging of distinct nerve and blood vessel patterns in dual Thy1-YFP and Flt1-DsRed transgenic mice. Angiogenesis. (2020)
    > PubMed

  • ● Wu Y, Seong YJ, Li K, Choi D, Park E, Daghlian GH, Jung E, Bui K, Zhao L, Madhavan S, Daghlian S, Daghlian P, Chin D, Cho IT, Wong AK, Heur M, Zhang-Nunes S, Tan JC, Ema M, Wong TT, Huang AS, Hong YK. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye. JCI Insight. (2020)
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  • ● Buyandelger U, Walker DG, Yanagisawa D, Morimura T, Tooyama I. Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis. Int J Mol Sci. (2020)
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  • ● Matsumoto S, Porter CJ, Ogasawara N, Iwatani C, Tsuchiya H, Seita Y, Chang YW, Okamoto I, Saitou M, Ema M, Perkins TJ, Stanford WL, Tanaka S. Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts. Sci Rep. (2020)
    > PubMed

  • ● Okabe K, Fukada H, Tai-Nagara I, Ando T, Honda T, Nakajima K, Takeda N, Fong G, Ema M, Kubota Y. Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism. Dev Biol. (2020)
    > PubMed

  • ● Watanabe C, Imaizumi T, Kawai H, Suda K, Honma Y, Ichihashi M, Ema M, Mizutani K. Aging of the Vascular System and Neural Diseases. Front Aging Neurosci. (2020)
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  • ● Seita Y, Morimura T, Watanabe N, Iwatani C., Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I. Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. J Alzheimers Dis. (2020)
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  • ● Sakai Y., Nakamura T., Okamoto I., Gyobu-Motani S., Ohta H., Yabuta Y., Tsukiyama T., Iwatani C., Tsuchiya H., Ema M., Morizane A., Takahashi J., Yamamoto T., Saitou M. Induction of the Germ-Cell Fate from Pluripotent Stem Cells in Cynomolgus Monkeys. Biol Reprod. (2020)
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    • 2019年

  • ● Tsukiyama T., Kobayashi K., Nakaya M., Iwatani C., Seita Y., Tsuchiya H., Matsushita J., Kitajima K., Kawamoto I., Nakagawa T., Fukuda K., Iwakiri T., Izumi H., Itagaki I., Kume S., Maegawa H., Nishinakamura R., Nishio S., Nakamura S., Kawauchi A., Ema M. Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease. Nat Commun. (2019)
    > PubMed

  • ● Kobayashi K., Tsukiyama T., Nakaya M., Kageyama S., Tomita K., Murai R., Yoshida T., Narita M., Kawauchi A., and Ema M. Generation of an OCT3/4 reporter Cynomolgus monkey ES cell line using CRISPR/Cas9. Stem Cell Res. (2019)
    > PubMed

  • ● Seita Y., Tsukiyama T., Azami T., Kobayashi K., Iwatani C., Tsuchiya H., Nakaya M., Tanabe H., Hitoshi S., Miyoshi H., Nakamura S., Kawauchi A., and Ema M. Comprehensive evaluation of ubiquitous promoters suitable for the generation of transgenic cynomolgus monkeys. Biol Reprod. (2019)
    > PubMed

  • ● Seita Y., Iwatani C., Tsuchiya H., Nakamura S., Kimura F., Murakami T., and Ema M. Poor second ovarian stimulation in cynomolgus monkeys (Macaca fascicularis) is associated with the production of antibodies against human follicle-stimulating hormone. J Reprod Dev. (2019)
    > PubMed

  • ● Watanabe C, Matsushita J, Azami T, Tsukiyama-Fujii S, Tsukiyama T, Mizuno S, Takahashi S, Ema M. Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells. PLoS One. (2019)
    > PubMed

  • ● Kitadate Y, Jörg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C, Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto Y, Takahashi S, Simons BD, Yoshida S. Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche. Cell Stem Cell. (2019)
    > PubMed

  • ● Shimauchi-Ohtaki H, Kurachi M, Naruse M, Shibasaki K, Sugio S, Matsumoto K, Ema M, Yoshimoto Y, Ishizaki Y. The dynamics of revascularization after white matter infarction monitored in Flt1-tdsRed and Flk1-GFP mice. Neurosci Lett. (2019)
    > PubMed

  • ● Suzuki-Komabayashi M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, Ajioka I, Matsushita J, Kidoya H, Takakura N, Okamoto T, Kinoshita K, Ichihashi M, Nagata K, Ema M, and Mizutani K. Spatiotemporally dependent vascularization is differently utilized among neural progenitor subtypes during neocortical development. Cell Rep. (2019)
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    • 2018年

  • ● Azami T, Matsumoto K, Jeon H, Waku T, Muratani M, Niwa H, Takahashi S, Ema M. Klf5 suppresses ERK signaling in mouse pluripotent stem cells. PLoS One. (2018)
    > PubMed

  • ● Doh SJ, Yamakawa M, Santosa SM, Montana M, Guo K, Sauer JR, Curran N, Han KY, Yu C, Ema M, Rosenblatt MI, Chang JH, Azar DT. Fluorescent reporter transgenic mice for in vivo live imaging of angiogenesis and lymphangiogenesis. Angiogenesis. (2018)
    > PubMed

  • ● Goto S, Onishi A, Misaki K, Yonemura S, Sugita S, Ito H, Ohigashi Y, Ema M, Sakaguchi H, Nishida K, Takahashi M. Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells. Elife. (2018)
    > PubMed

  • ● Okada H, Yamada M, Kamimoto K, Kok CY, Kaneko K, Ema M, Miyajima A, Itoh T. The transcription factor Klf5 is essential for intrahepatic biliary epithelial tissue remodeling after cholestatic liver injury. Biol Chem. (2018)
    > PubMed

  • ● Herz K, Becker A, Shi C, Ema M, Takahashi S, Potente M, Hesse M, Fleischmann BK, Wenzel D. Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system. Angiogenesis. (2018)
    > PubMed

  • ● Kurotsu S, Osakabe R, Isomi M, Tamura F, Sadahiro T, Muraoka N, Kojima H, Haginiwa S, Tani H, Nara K, Kubota Y, Ema M, Fukuda K, Suzuki T, Ieda M. Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction. Biochem Biophys Res Commun. (2018)
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    • 2017年

  • ● Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M. Klf5 maintains the balance of primitive endoderm to epiblast specification during mouse embryonic development by suppression of Fgf4. Development. (2017)
    > PubMed

  • ● Zhong W, Gao X, Wang S, Han K, Ema M, Adams S, Adams RH, Rosenblatt MI, Chang JH, Azar DT. Prox1-GFP/Flt1-DsRed transgenic mice: an animal model for simultaneous live imaging of angiogenesis and lymphangiogenesis. Angiogenesis. (2017)
    > PubMed

  • ● Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M. Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice. Sci Rep. (2017)
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  • ● Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, MukouyamaYS. Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature. Cell Rep. (2017)
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  • ● Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. (2017)
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    • 2016年

  • ● Kawaguchi T., Cho D., Hayashi M., Tsukiyama T., Kimura K., Matsuyama S., Minami N., Yamada M. and Imai H. Derivation of Induced Trophoblast Cell Lines in Cattle by Doxycycline-Inducible piggyBac Vectors. PLoS One. (2016)
    > PubMed

  • ● Sasaki K, Nakamura T, Okamoto I, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Shiraki N, Takakuwa T, Yamamoto T, Saitou M. The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion. Dev Cell. (2016)
    > PubMed

  • ● Hara H, Ono F, Nakamura S, Matsumoto SE, Jin H, Hattori N, Tabira T. An Oral Aβ Vaccine Using a Recombinant Adeno-Associated Virus Vector in Aged Monkeys: Reduction in Plaque Amyloid and Increase in Aβ Oligomers. J Alzheimers Dis. (2016)
    > PubMed

  • ● Nakamura T, Okamoto I, Sasaki K, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Yamamoto T, Saitou M. A developmental coordinate of pluripotency among mice, monkeys and humans. Nature. (2016)
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  • ● Khoa le TP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M. Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. PLoS One. (2016)
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  • ● Yoshikawa Y, Yamada T, Tai-Nagara I, Okabe K, Kitagawa Y, Ema M, Kubota Y. Developmental regression of hyaloid vasculature is triggered by neurons. J Exp Med. (2016)
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  • ● Adachi M, Kisu I, Nagai T, Emoto K, Banno K, Umene K, Nogami Y, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ogasawara K, Aoki D. Evaluation of allowable time and histopathological changes in warm ischemia of the uterus in cynomolgus monkey as a model for uterus transplantation. Acta Obstet Gynecol Scand. (2016)
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  • ● Koyama S, Fukuda K, Watanabe S, Kohara S, Tsuchiya H, Fukuzaki K, Nagano M, Uno Y, Hosoi Y. Development of a new device for artificial insemination in cynomolgus macaques. J Reprod Dev. (2016)
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  • ● Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M. Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body. Sci Rep. (2016)
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  • ● Jeon H, Waku T, Azami T, Khoa le TP, Yanagisawa J, Takahashi S, Ema M. Comprehensive Identification of Krüppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming. PLoS One. (2016)
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  • ● Okumura N, Sakamoto Y, Fujii K, Kitano J, Nakano S, Tsujimoto Y, Nakamura S, Ueno M, Hagiya M, Hamuro J, Matsuyama A, Suzuki S, Shiina T, Kinoshita S, Koizumi N. Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction. Sci Rep. (2016)
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    • 2015年

  • ● Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W, Momose A. Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus. Development. (2015)
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  • ● Kawaguchi T., Tsukiyama T., Kimura K., Matsuyama S., Minami N., Yamada M. and Imai H. Generation of naive bovine induced pluripotent stem cells using piggyBac transposition of doxycycline-inducible transcription factors. PLoS One. (2015)
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  • ● Hongu T., Funakoshi Y., Fukuhara S., Suzuki T., Sakimoto S., Takakura N., Ema M., Takahashi S., Itoh S., Kato M., Hasegawa H, Mochizuki N., Kanaho Y. Arf6 regulates tumor angiogenesis and growth through HGF-induced endothelial β1 integrin recycling. Nat Commun. (2015)
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  • ● Shiina T, Yamada Y, Aarnink A, Suzuki S, Masuya A, Ito S, Ido D, Yamanaka H, Iwatani C, Tsuchiya H, Ishigaki H, Itoh Y, Ogasawara K, Kulski JK, Blancher A. Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing: Mafa-class I polymorphism. Immunogenetics. (2015)
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  • ● Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. (2015)
    > PubMed

  • ● Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A, Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates. Antimicrob Agents Chemother. (2015)
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  • ● Iizuka S, Sakurai F, Shimizu K, Ohashi K, Nakamura S, Tachibana M, Mizuguchi H. Evaluation of transduction properties of an adenovirus vector in neonatal mice. Biomed Res Int. (2015)
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  • ● Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A. Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression. Stem Cells. (2015)
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  • ● Suzuki S., Tsukiyama T., Kaneko T., Imai H., Minami N. A hyperactive piggyBac transposon system is an easy-to-implement method for introducing foreign genes into mouse preimplantation embryos. J Reprod Dev. (2015)
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  • ● Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC, Okuda A. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells. Stem Cells. (2015)
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  • ● Masuda T, Otsu K, Kumakami-Sakano M, Fujiwara N, Ema M, Hitomi J, Sugiyama Y, and Harada H. Combined administration of BMP-2 and HGF facilitate bone regeneration through angiogenic mechanisms. J Hard Tissue Biol. (2015)
    > J-STAGE



    • 2014年

  • ● Okabe K, Kobayashi S, Yamada T, Kurihara T, Tai-Nagara T, Miyamoto T, Mukouyama Y, Sato TN, Suda T, Ema M, Kubota Y. Neurons limit angiogenesis by titrating VEGF in retina. Cell. (2014)
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  • ● Kowata S, Isogai S, Murai K, Ito S, Tohyama K, Ema M, Hitomi J, Ishida Y. Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow. Thromb Haemost. (2014)
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  • ● Matsumoto K, Ema M. Roles of VEGF-A signalling in development, regeneration, and tumours. J Biochem. (2014)
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  • ● Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K. Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination. Exp Anim. (2014)
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  • ● Moi ML, Takasaki T, Omatsu T, Nakamura S, Katakai Y, Ami Y, Suzaki Y, Saijo M, Akari H, Kurane I. Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humans. J Gen Virol. (2014)
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  • ● Shimizu K, Sakurai F, Tomita K, Nagamoto Y, Nakamura S, Katayama K, Tachibana M, Kawabata K, Mizuguchi H. Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome. Mol Ther Methods Clin Dev. (2014)
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  • ● Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K, Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Quynh Mai L, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A. Protective efficacy of passive immunization with monoclonal antibodies in animal models of H5N1 highly pathogenic avian influenza virus infection. PLoS Pathog. (2014)
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  • ● Kitano M, Itoh Y, Ishigaki H, Nakayama M, Ishida H, Pham VL, Arikata M, Shichinohe S, Tsuchiya H, Kitagawa N, Kobayashi M, Yoshida R, Sato A, Le QM, Kawaoka Y, Ogasawara K. Efficacy of repeated intravenous administration of peramivir against highly pathogenic avian influenza A (H5N1) virus in cynomolgus macaques. Antimicrob Agents Chemother. (2014)
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  • ● Kisu I, Kato Y, Tsuchiya H, Kawamoto I, Nakagawa T, Ogasawara K, Hayakawa T, Yamayoshi Y, Iketan O, Mihara M, Banno K, Sato S, Shiina T, Aoki D. Pharmacokinetic Properties of Cyclosporine A after Subcutaneous Injection in Cynomolgus Monkey. Study of International Journal of Pharmacology (2014)



    • 2013年

  • ● Hasegawa Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K. Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination. Exp Anim. (2013)
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  • ● Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamaguchi T, Ikehara Y, Hamada M, Matsumoto K, Ema M, Murata S, Ohkohchi N, Narimatsu H, Takahashi S. C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes. Blood. (2013)
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  • ● Nishimoto M, Katano M, Yamagishi T, Hishida T, Kamon M, Suzuki A, Hirasaki M, Nabeshima Y, Nabeshima Y, Katsura Y, Satta Y, Deakin JE, Graves JA, Kuroki Y, Ono R, Ishino F, Ema M, Takahashi S, Kato H, Okuda A. In vivo function and evolution of the eutherian-specific pluripotency marker UTF1. PLoS One. (2013)
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  • ● Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H. Dynamics of cellular immune responses in the acute phase of dengue virus infection. Arch Virol. (2013)
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  • ● Lebrun C., Avci HX., Wehrlé R., Doulazmi M., Jaudon F., Morel MP., Rivals I.,Ema M., Schmidt S., Sotelo C., Vodjdani G., Dusart I. Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture. Mol Cell Neurosci. (2013)
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  • ● Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N, Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Ito M, Kawaoka Y, Kida H, Ogasawara K. Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine. PLoS One. (2013)
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  • ● Pham VL, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, Ishida H, Kitagawa N, Shichinohe S, Okamatsu M, Sakoda Y, Tsuchiya H, Nakamura S, Kida H, Ogasawara K. Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. PLoS One. (2013)
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  • ● Moi ML, Omatsu T, Hirayama T, Nakamura S, Katakai Y, Yoshida T, Saito A, Tajima S, Ito M, Takasaki T, Akari H, Kurane I. Presence of viral genome in urine and development of hematuria and pathological changes in kidneys in common marmoset (Callithrix jacchus) after inoculation with dengue virus. Pathogen. (2013)
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  • ● Okumura N, Koizumi N, Kay EP, Ueno M, Sakamoto Y, Nakamura S, Hamuro J, Kinoshita S. The ROCK inhibitor eye drop accelerates corneal endothelium wound healing. Invest Ophthalmol Vis Sci. (2013)
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  • ● Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Tai PH, Ema M, Kudo T, Takahashi S. Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions. PLoS One. (2013)
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  • ● Fujishiro SH., Nakano K., Mizukami Y., Azami T., Arai Y., Matsunari H., Ishino R., Nishimura T., Watanabe M., Abe T., Furukawa Y., Umeyama K., Yamanaka S., Ema M., Nagashima H., Hanazono Y. Generation of Naive-like Porcine Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development. Stem Cells Dev. (2013)
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