2024
1. Hirohito Ishigaki, Sayaka Ito, Takako Sasamura, Hideaki Ishida, Misako Nakayama, Cong Thanh Nguyen, Takaaki Kinoshita,
Shingo Suzuki, Chizuru Iwatani, Hideaki Tsuchiya, Hisashi Yamanaka, Jerzy K. Kulski, Yasushi Itoh, Takashi Shiina.
MHC-DRB alleles with amino acids Val11, Phe13 and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques.
HLA: Immune Response Genetics 103, e15316, 2024. https://doi.org/10.1111/tan.15316
2. Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki,
Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, Ichiro Tojima, Hideaki Kouzaki, Takeshi Shimizu.
SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in nonhuman primates.
Journal of Neuroimmunology 387, 578228, 2024.https://doi.org/10.1016/j.jneuroim.2024.578288
2023
1. Misako Nakayama, Hannah Marchi, Anna M. Dmitrieva,Ashesh Chakraborty, Juliane Merl-Pham,Elisabeth Hennen, Ronan Le Gleut, Clemens Ruppert,Andreas Guenther, Kathrin Kahnert, Jurgen Behr,Anne Hilgendorff, Stefanie M. Hauck, Heiko Adler and Claudia A. Staab-Weijnitz
Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection.
Frontiers in Microbiology 13:957830, 2023. DOI 10.3389/fmicb.2022.957
2. Ohno M, Sagata M, Sekiya T, Nomura N, Shingai M, Endo M, Kimachi K, Suzuki S, Nguyen CT, Nakayama M, Ishigaki H, Ogasawara K, Itoh Y, Kino Y, Kida H. Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques.
Vaccine. 2023 Jan 16;41(3):787-794. doi:
10.1016/j.vaccine.2022.12.020.
3. Takashi Matsuyama, Shu Saeki, Satoru Kosaka, Yoriko Matsuoka, Yoshifumi Aoki, Yasushi Itoh, Takao Imaeda. Inactivation of SARS-CoV-2 variants by nitrogen-doped titanium dioxide loaded with metals as visible-light photocatalysts.
Biotechnology Letters 45, 551-561, 2023. doi
10.1007/s10529-023-03361-3
4. Eri Kawakami, Norikazu Saiki, Yosuke Yoneyama, Chiharu Moriya, Mari Maezawa, Shuntaro Kawamura, Akiko Kinebuchi, Tamaki Kono, Masaaki Funata, Ayaka Sakoda1 Shigeru Kondo, Takeshi Ebihara, Hisatake Matsumoto, Yuki Togami, Hiroshi Ogura, Fuminori Sugihara, Daisuke Okuzaki, Takashi Kojima, Sayaka Deguchi, Sebastien Vallee, Susan McQuade, Rizwana Islam, Madhusudan Natarajan, Hirohito Ishigaki, Misako Nakayama, Cong Thanh Nguyen, Yoshinori Kitagawa, Yunheng Wu, Kensaku Mori, Takayuki Hishiki, Tomohiko Takasaki, Yasushi Itoh,Kazuo Takayama, Yasunori Nio, Takanori Takebe.
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
Cell Stem Cell Vol. 30, 1315-1330, 2023. https://doi.org/10.1016/j.stem.2023.09.001
2022
1. Terada K, Kondo K, Ishigaki H, Nagashima A, Satooka H, Nagano S, Masuda K, Kawamura T, Hirata T, Ogasawara K, Itoh Y, Kawamoto H, Agata Y.
Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.
Molecular Therapy: Oncolytics 2022; 24, 77-86. doi: https://doi.org/10.1016/j.omto.2021.12.003 .
2. Fumihiko Yasui, Yusuke Matsumoto, Naoki Yamamoto, Takahiro Sanada, Tomoko Honda, Tsubasa Munakata, Yasushi Itoh, Michinori Kohara.
Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB/c mice.
Sci Rep. 2022 Mar 9;12(1):4150. doi:10.1038/s41598-022-08104-4.
3. Masanori Shiohara, Saori Suzuki, Shintaro Shichinohe, Hirohito Ishigaki, Misako Nakayama, Naoki Nomura, Masashi Shingai, Toshiki Sekiya, Marumi Ohno, Sayaka Iida, Naoko Kawai, Mamiko Kawahara, Junya Yamagishi, Kimihito Ito, Ryotarou Mitsumata, Tomio Ikeda, Kenji Motokawa, Tomoyoshi Sobue, Hiroshi Kida, Kazumasa Ogasawara, Yasushi Itoh.
Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques.
Vaccine 40 (30), 4026-4037, 2022. https://doi.org/10.1016/j.vaccine.2022.05.045
4. Shin-ichi Tsukumo, Poorani Ganesh Subramani, Noe Seija, Mizuho Tabata, Yoichi Maekawa, Yuya Mori, Chieko Ishifune, Yasushi Itoh, Mineto Ota, Keishi Fujio, Javier M. Di Noia, Koji Yasutomo.
AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination.
Science Advances 8, eabq0008, 2022. (https://www.science.org/doi/10.1126/sciadv.abq0008)
5. Hirohito Ishigaki, Yasushi Itoh.
Detection of sialic acids on the cell surface using flow cytometry.
Glycovirology, Methods and Protocols, 1st ed. 2022. Methods in Molecular Biology, Vol. 2556, pp. 31-35.
Editor: Suzuki Yasuo. Humana New York, NY, Springer Nature, eBook ISBN 978-1-0716-2635-1, Series ISSN 1064-3745, E-ISSN 1940-6029.
6. Misako Nakayama, Yasushi Itoh.
Lectin Staining to Detect Human and Avian influenza Virus Receptors in the Airway of Nonhuman Primates.
Glycovirology, Methods and Protocols, 1st ed. 2022. Methods in Molecular Biology, Vol. 2556, pp. 37-43.
Editor: Suzuki Yasuo. Humana New York, NY, Springer Nature, eBook ISBN 978-1-0716-2635-1, Series ISSN 1064-3745, E-ISSN 1940-6029.
7. Brendon Y. Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C. Rowntree, Thi H. O. Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R. Habel, Kevin Selva, Adam K. Wheatley, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, David C. Jackson, Lorena E. Brown, Masashi Shingai, Katherine Kedzierska, Hiroshi Kida.
Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques.
PLOS Pathogens 18(10): e1010891. doi.org/10.1371/journal.ppat.1010891
8. Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda, Tsubasa Munakata, Masahiko Higa, Sakiko Toyama, Risa Kono, Asako Takagi, Yusuke Matsumoto, Kaori Hayashi, Masanori Shiohara, Koji Ishii, Yasushi Saeki, Yasushi Itoh, Michinori Kohara.
An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants.
Frontiers in Microbiology 13:967019, 2022. doi: 10.3389/fmicb.2022.967019
9. Masaru Takeshita, Hidehiro Fukuyama, Katsuhiko Kamada, Takehisa Matsumoto, Chieko Makino-Okamura, Tomomi Uchikubo-Kamo, Yuri Tomabechi, Kazuharu Hanada, Saya Moriyama, Yoshimasa Takahashi,
Hirohito, Ishigaki, Misako Nakayama, Cong Thanh Nguyen, Yoshinori Kitagawa, Yasushi Itoh , Masaki Imai, Tadashi Maemura, Yuri Furusawa, Hiroshi Ueki, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Yoshihiro Kawaoka, Mikako Shirouzu, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi, the Keio Donner Project. Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models. iScience 25, 105596, 2022. https://doi.org/10.1016/j.isci.2022.105596
(http://www.shiga-med.ac.jp/~hqpatho2/lecture/covid19/covid19_06.html)
2021
1. Ishigaki H, Pham VL,Terai J, Sasamura T, Nguyen CT, Ishida H, Okahara J, Kaneko S, Shiina T, Nakayama M, Itoh Y, Ogasawara K.
No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques.
Cell Transplant. 2021; 30:963689721992066. doi: 10.1177/0963689721992066.
2. Ishigaki H, Nakayama M, Kitagawa Y,Nguyen CT, Hayashi K, Shiohara M, Gotoh B, Itoh Y.
Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.
Virology . 2021; 554: 97-105.
3. Saori Suzuki, Cong Thanh Nguyen,Ayako Ogata-Nakahara, Akihiro Shibata, Hiroyuki Osaka, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara, Yasushi Itoh.
Efficacy of a cap-dependent endonuclease inhibitor and neuraminidase inhibitors against H7N9 highly pathogenic avian influenza virus causing severe viral pneumonia in cynomolgus macaques.
Antimicrobial Agents and Chemotherapy , 2021; 65 (3): e01825-20.
4. Koutsakos M, Sekiya T, Chua BY, Nguyen THO, Wheatley AK, Juno JA, Ohno M, Nomura N, Ohara Y, Nishimura T, Endo M, Suzuki S,Ishigaki H, Nakayama M,Nguyen CT, Itoh Y, Shingai M, Ogasawara K, Kino Y, Kent SJ, Jackson DC, Brown LE, Kida H, Kedzierska K.
Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays.
Immunol Cell Biol . 2021;99: 97-106.
5. Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh,Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Le Thi Quynh Mai, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara.
Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenza.
Nat Commun. 12:2654, 2021.
https://doi.org/10.1038/s41467-021-22964-w
6. Honda T, Gomi S, Yamane D, Yasui F, Yamamoto T, Munakata T, Itoh Y, Ogasawara K, Sanada T, Yamaji K, Yasutomi Y, Tsukiyama-Kohara K, Kohara M.
Development and characterization of a highly sensitive NanoLuciferase-based immunoprecipitation system for the detection of anti-influenza virus HA antibodies. mSphere. 2021;6(3):e01342-20. doi: 10.1128/mSphere.01342-20.
7. Shingai M, Nomura N, Sekiya T, Ohno M, Fujikura D, Handabile C, Omori R, Ohara Y, Nishimura T, Endo M, Kimachi K, Mitsumata R, Ikeda T, Kitayama H, Hatanaka H, Sobue T, Muro F,Suzuki S, Thanh Nguyen C, Ishigaki H, Nakayama M, Mori Y, Itoh Y, Koutsakos M, Chua BY, Kedzierska K, Brown LE, Jackson DC, Ogasawara K, Kino Y, Kida H.
Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells.
Vaccine 2021;39:3940-3951. doi: 10.1016/j.vaccine.2021.05.065.
8. Yasushi Itoh.
Establishment of a nonhuman primate model for development of vaccines and anti-viral drugs against COVID-19.
Translational and Regulatory Sciences, 3;109-101, 2021.
2020
1. Kisu I, Banno K, Obara H, Kato Y, Yamada Y, Matsubara K, Matoba Y, Adachi M, Emoto K, Masugi Y, Saiki Y, Ishigaki H, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Nakagawa K, Shiina T, Aoki D.
Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques.
J Obstet Gynaecol Res. 2020, 46:2251-2260. doi: 10.1111/jog.14477.
2. Ishigaki H, Itoh Y.
Embryonal Carcinoma and Glioblastoma Cell Lines Derived from Monkey Induced Pluripotent Stem Cells.
Methods in Molecular Biology. Springer, New York, NY. 2020 Aug 25. doi: 10.1007/7651_2020_303.
3. Kisu I, Emoto K, Masugi Y, Yamada Y, Matsubara K, Obara H, Matoba Y, Banno K, Kato Y, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Murase M, Nakagawa T, Tsuchiya H, Ishigaki H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T.
Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques.
Sci Rep. 2020;10(1):13910. doi: 10.1038/s41598-020-70914-1.
4. Hayashi K, Nakayama M, Iwatani C, Tsuchiya H, Nakamura S, Nonoguchi K, Itoh Y, Tsuji S,Ishigaki H, Mori T, Murakami T, Ogasawara K.
The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years.
Tohoku J Exp Med. 2020 Aug;251(4):241-253. doi: 10.1620/tjem.251.241.
5. Saori Suzuki, Shintaro Shichinohe, Yasushi Itoh, Misako Nakayama, Hirohito Ishigaki, Yuya Mori, Ayako Ogata-Nakahara, Cong Thanh Nguyen , Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara.
Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza A virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
Antiviral Research , 178: 104790, 2020. doi.org/10.1016/j.antiviral.2020.104790
6. Cong Thanh Nguyen, Saori Suzuki, Yasushi Itoh, Hirohito Ishigaki, Misako Nakayama, Kaori Hayashi, Keita Matsuno, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara.
Efficacy of neuraminidase inhibitors against H5N6 highly pathogenic avian influenza virus in a non-human primate model.
Antimicrobial Agents and Chemotherapy, 64 (7): e02561-19, 2020. Doi:10.1128/AAC.02561-19
7. Satooka H, Ishigaki H, Todo K, Terada K, Agata Y, Itoh Y, Ogasawara K, Hirata T.
Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.
Sci Rep. 2020;10(1):8414. doi: 10.1038/s41598-020-65488-x.
2019
1. Fukuda M, Ishigaki H, Sugimoto M, Mukaisho KI, Matsubara A, Ishida H, Moritani S, Itoh Y, Sugihara H, Andoh A, Ogasawara K, Murakami K, Kushima R.
Histological analysis of fundic gland polyps secondary to PPI therapy.
Histopathology 75:537-545, 2019. doi: 10.1111/his.13902.
2. Arikata M, Itoh Y, Shichinohe S, Nakayama M, Ishigaki H, Kinoshita T, Le MQ, Kawaoka Y, Ogasawara K, Shimizu T.
Efficacy of clarithromycin against H5N1 and H7N9 avian influenza a virus infection in cynomolgus monkeys.
Antiviral Res. 2019;171:104591. doi: 10.1016/j.antiviral.2019.104591.
3. Sekiya T, Mifsud EJ, Ohno M, Nomura N, Sasada M, Fujikura D, Daito T, Shingai M, Ohara Y, Nishimura T, Endo M, Mitsumata R, Ikeda T, Hatanaka H, Kitayama H, Motokawa K, Sobue T, Suzuki S, Itoh Y, Brown LE, Ogasawara K, Kino Y, Kida H.
Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 induction is ideal for influenza.
Vaccine. 2019;37(15):2158-2166. doi: 10.1016/j.vaccine.2019.02.057.
4. Iori Kisu, Hirohito Ishigaki, Katsura Emoto, Yojiro Kato, Yohei Yamada, Kentaro Matsubara, Hideaki Obara, Yohei Masugi, Yusuke Matoba, Masataka Adachi, Kouji Banno, Yoko Saiki, Iori Itagaki, Ikuo Kawamoto, Chizuru Iwatani, Takahiro Nakagawa, Hideaki Tsuchiya,Takako Sasamura, Hiroyuki Urano, Masatsugu Ema, Kazumasa Ogasawara, Daisuke Aoki, Kenshi Nakagawa, Takashi Shiina
Long-term outcome and rejection after allogeneic uterus transplantation in cynomolgus macaques
J Clin Med. 2019;8(10). pii: E1572. doi: 10.3390/jcm8101572.
5. Siddique SM, Kubouchi K, Shinmichi Y, Sawada N, Sugiura R, Itoh Y, Uehara S, Nishimura K, Okamura S, Ohsaki H, Kamoshida S, Yamashita Y, Tamura S, Sonoki T, Matsuoka H, Itoh T, Mukai H.
PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.
Sci Rep. 9(1):13977, 2019. doi: 10.1038/s41598-019-50419-2.
2018
1. Fukuda M, Ishigaki H, Ban H, Sugimoto M, Tanaka E, Yonemaru J, Kuroe S, Namura T, Matsubara A, Moritani S, Murakami K, Andoh A, Kushima R.
No transformation of a fundic gland polyp with dysplasia into invasive carcinoma after 14 years of follow-up in a proton pump inhibitor-treated patient: A case report.
Pathol Int. 68:706-71, 2018. doi: 10.1111/pin.12739.
2. Ishigaki H, Shiina T, Ogasawara K.
MHC-identical and transgenic cynomolgus macaques for preclinical studies.
Inflamm Regen. 38:30. doi: 10.1186/s41232-018-0088-3.
3. Hanada T, Tsuji S, Nakayama M, Wakinoue S, Kasahara K, Kimura F, Mori T, Ogasawara K, Murakami T.
Suppressive regulatory T cells and latent transforming growth factor-β-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis.
Reprod Biol Endocrinol. 16:9, 2018.
4. Murai R, Itoh Y, Kageyama S, Nakayama M, Ishigaki H, Teramoto K, Narita M, Yoshida T, Tomita K, Kobayashi KI, Wada A, Nagasawa M, Kubota S, Ogasawara K, Kawauchi A.
Prediction of intravesical recurrence of non-muscle-invasive bladder cancer by evaluation of intratumoral Foxp3+ T cells in the primary transurethral resection of bladder tumor specimens.
PLoS One. 13(9):e0204745, 2018. doi: 10.1371/journal.pone.0204745.
2017
1. Misako Nakayama, Yasushi Itoh, Shintaro Shichinohe, Rumi Nakabayashi, Hirohito Ishigaki, Yoshihiro Sakoda, Quynh Mai Le, Yoshihiro Kawaoka, Hiroshi Kida, Kazumasa Ogasawara.
Potential Risk of Repeated Nasal Vaccination that Induces Allergic Reaction with Mucosal IgE and Airway Eosinophilic Infiltration in Cynomolgus Macaques infected with H5N1 Highly Pathogenic Avian Influenza Virus.
Vaccine 35: 1008-1017, 2017.
2. Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J.
MHC matching improves engraftment of iPSC-derived neurons in non-human primates.
Nat Commun. 30;8:385. doi: 10.1038/s41467-017-00926-5, 2017.
3. Ishigaki H, Maeda T, Inoue H, Akagi T,Sasamura T, Ishida H, Inubushi T, Okahara J, Shiina T, Nakayama M, Itoh Y, Ogasawara K.
Transplantation of iPS-derived tumor cells with a homozygous MHC haplotype induces GRP94 antibody production in MHC-matched macaques.
Cancer Res. 77(21); 6001-10, 2017. doi: 10.1158/0008-5472.CAN-17-0775.
4. Kiso M, Iwatsuki-Horimoto K, Yamayoshi S, Uraki R, Ito M, Nakajima N, Yamada S, Imai M, Kawakami E, Tomita Y, Fukuyama S, Itoh Y, Ogasawara K, Lopes TJS, Watanabe T, Moncla LH, Hasegawa H, Friedrich TC, Neumann G, Kawaoka Y.
Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques.
J Infect Dis . 216:582-593, 2017.
5. Teramoto K.
Fundamental knowledge of hemoperfusion and Plasmaperfusion.
Regenerative medicine, artificial cells and Nanomedicine 4: 141-171, 2017.
2016
1. Itoh Y.
Translational research on influenza virus infection using a nonhuman primate model.
Pathol Int 66: 132-141, 2016.
2. Shichinohe S, Itoh Y, Nakayama M, Ozaki H, Soda K,Ishigaki H,Okamatsu M, Sakoda Y, Kida H, Ogasawara K.
Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques.
Virology 493: 31-38, 2016.
3. Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M.
Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body.
Sci Rep. 6: 24868, 2016.
4. Maeda K, Kawai H, Sanada M, Terashima T, Ogawa N, Idehara R, Makiishi T, Yasuda H, Sato S, Hoshi K, Yahikozawa H, Nishi K, Itoh Y, Ogasawara K, Tomita K, Indo HP, Majima HJ.
Clinical phenotype and segregation of mitochondrial 3243A>G mutation in 2 pairs of monozygotic twins.
JAMA Neurol. 73: 990-993, 2016.
5. Misako Nakayama, Hiroichi Ozaki,Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho Park, Hideaki Tsuchiya, Hiroshi Kida, Kazumasa Ogasawara.
Vaccination against H9N2 avian influenza virus reduces bronchus-associated lymphoid tissue formation in cynomolgus macaques after intranasal virus challenge infection.
Pathol Int 66: 678-686, 2016.
6. Hideaki Obara, Iori Kisu, Yojiro Kato, Yohei Yamada, Kentaro Matsubara, Katsura Emoto, Masataka Adachi, Yuusuke Matoba, Kiyoko Umene, Yuya Nogami, Kouji Banno, Hideaki Tsuchiya, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Hirohito Ishigaki, Yasushi Itoh, Kazumasa Ogasawara, Yoko Saiki, Shin-ichi Sato, Kenshi Nakagawa, Takashi Shiina, Daisuke Aoki, Yuko Kitagawa.
Surgical technique for allogeneic uterus transplantation in macaques.
Sci Rep. 6:35989, 2016.
7. Fumihiko Yasui, Yasushi Itoh, Ai Ikejiri, Masahiro Kitabatake, Nobuo Sakaguchi, Keisuke Munekata, Shintaro Shichinohe, Yukiko Hayashi, Hirohito Ishigaki, Misako Nakayama, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara, Michinori Kohara.
Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus.
Sci Rep. 6:37915, 2016.
2015
1. Ohshio Y, Teramoto K, Hanaoka J, Tezuka N, Itoh Y, Asai T, Daigo Y, Ogasawara K.
Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in the dendritic cell-based vaccine.
Cancer Science 106: 134-142, 2015. (DOI: 10.1111/cas.12584)
2. Mohamed RH, Sutoh Y, Itoh Y, Otsuka N, Miyatake Y, Ogasawara K, Kasahara M.
The SKINT1-Like Gene Is Inactivated in Hominoids But Not in All Primate Species: Implications for the Origin of Dendritic Epidermal T Cells.
PLoS ONE 10(4): e0123258, 2015. (doi:10.1371/journal.pone.0123258)
3. Ishigaki H, Nakae A, Nakai M, Ogasawara K.
Mesenteric cavernous hemangioma with urological symptoms.
Intern Med . 2015;54(4):437-8. doi: 10.2169/internalmedicine.54.3654.
4. Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A,Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K.
Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates.
Antimicrobial Agents and Chemotherapy 59: 4962-4973, 2015. doi:10.1128/AAC.00793-15
5. Shiina T, Yamada Y, Aarnink A, Suzuki S, Masuya A, Ito S, Ido D, Yamanaka H, Iwatani C, Tsuchiya H, Ishigaki H, Itoh Y, Ogasawara K, Kulski JK, Blancher A.
Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing.
Immunogenetics 67:563-578, 2015.
6. Araki S, Imai S, Ishigaki H, Mimura T, Nishizawa K, Ueba H, Kumagai K, Kubo M, Mori K, Ogasawara K, Matsusue Y.
Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model.
Acta Orthopaedica 86(1): 119-126, 2015.
2014
1. Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K , Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Le Q M, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A.
Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection.
PLoS Pathogens 10 (6): e1004192, 2014. (doi:10.1371/journal.ppat.1004192)
2. Kitano M, Itoh Y, Ishigaki H, Nakayama M, Ishida H, Pham VL, Arikata M, Shichinohe S, Tsuchiya H, Kitagawa N, Kobayashi M, Yoshida R, Sato A, Le QM, Kawaoka Y, Ogasawara K.
Efficacy of repeated intravenous administration of peramivir against highly pathogenic avian influenza A (H5N1) virus in cynomolgus macaques.
Antimicrobial Agents and Chemotherapy 58 (8): 4795-4803, 2014 (doi:10.1128/AAC.02817-14)
3. Muramoto Y, Shoemaker J, Le M, Itoh Y, Tamura D, Sakai-Tagawa Y, Imai H, Uraki R, Takano R, Kawakami E, Ito M, Okamoto K, Ishigaki H, Mimuro H, Sasakawa C, Matsuoka Y, Noda T, Fukuyama S, Ogasawara K, Kitano H, Kawaoka Y.
Disease severity is associated with differential gene expression at the early and late phases of infection in non-human primates infected with different H5N1 highly pathogenic avian influenza viruses.
Journal of Virology 88: 8981-8997, 2014 (doi: 10.1128/JVI.00907-14)
2013
1. Kitano M, Kodama M, Itoh Y, Kanazu T, Kobayashi M, Yoshida R, Sato A.
Efficacy of repeated intravenous injection of peramivir against influenza A (H1N1) 2009 virus infection in immunosuppressed mice.
Antimicrobial Agents and Chemotherapy. 57, 2286-2294, 2013.
2. Pham VL, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, Ishida H, Kitagawa N, Shichinohe S , Okamatsu M, Sakoda Y, Tsuchiya H, Nakamura S, Kida H, Ogasawara K.
Pathogenicity of Pandemic H1N1 Influenza A Virus in Immunocompromised Cynomolgus Macaques.
PLoS ONE 8. e75910, 2013.
3. Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N , Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Itoh M, Kawaoka Y, Kida H, Ogasawara K.
Protection against H5N1 Highly Pathogenic Avian and Pandemic (H1N1) 2009 Influenza Virus Infection in Cynomolgus Monkeys by an Inactivated H5N1 Whole Particle Vaccine.
PLoS ONE 8. e82740, 2013.
2012
1. Arikata M, Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y,Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K.
Memory immune responses against pandemic (H1N1) 2009 influenza virus induced by a whole particle vaccine in cynomolgus monkeys carrying Mafa-A*052:02.
PLoS ONE 7, e37220, 2012.
2011
1. Ishigaki, H, Miyauchi J, Yokoe A,Nakayama M, Yanagi T, Taga T, Ohta S, Itoh Y, Ogasawara K.
Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case.
Human Pathol. 42, 141-145, 2011.
2. Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Ishida H,Baba K, Noda T, Sato K, Nihashi Y, Kanazu T, Yoshida R, Torii R, Sato A, Ogasawara K.
Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomolgus macaques.
Antimicrobial Agents and Chemotherapy. 55, 4961-4970, 2011.
2010
1. Miyake T, Soda K, Itoh Y, Sakoda Y, Ishigaki H, Nagata T, Ishida H, Nakayama M, Ozaki H, Tsuchiya H, Torii R, Kida H, Ogasawara K.
Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model.
J Med Primatol. 39, 58-70, 2010.
2. Itoh Y, Ozaki H, Ishigaki H, Sakoda Y,Nagata T, Soda K, Isoda N, Miyake T, Ishida H, Okamoto K, Nakayama M, Tsuchiya H, Torii R, Kida H, Ogasawara K.
Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques.
Vaccine 28, 780-789, 2010.
3. Miyake T, Sawada O, Kakinoki M, Sawada T, Kawamura H, Ogasawara K, Ohji M.
Pharomacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes.
Invest Opthalmol Vis Sci. 51, 1606-1608, 2010.
4. Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Nagata T, Ishida H, Tsuchiya H, Torii R, Baba K, Yoshida R, Sato A, Ogasawara K.
Establishment of a cynomolgus macaque model of influenza B virus infection.
Virology 407,178-84, 2010.
2009
1. Itoh Y, Segawa H, Kito K, Hodohara K,Ishigaki H, Sugihara H, Fujiyama Y, Ogasawara K.
Lipoid pneumonia with chronic myelomonocytic leukemia.
Pathol. Res. Pract. 205, 143-147, 2009.
2. Fujita T, Teramoto K, Ozaki Y, Hanaoka J, Tezuka N,Itoh Y, Asai T, Fujino S, Kontani K, Ogasawara K.
Inhibition of transforming growth factor-beta-mediated immunosuppression in tumor-draining lymph nodes augments antitumor responses by various immunologic cell types.
Cancer Res . 69, 5142-5150, 2009.
3. Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T.
MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque.
Immunogenetics 61, 635-648, 2009.
4. Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D. Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y.
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses.
Nature 460, 1021-1025, 2009.
5. Kashima Y, Ikeda M, Itoh Y, Nagata T, Miyake T, Sakoda Y, Sodae K, Ozaki H, Ishigaki H, Nakayama M, Ishida H, Kawaoka Y, Kida H, Ogasawara K.
Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration routes of vaccines.
Vaccine 27, 7402-7408, 2009.
6. Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, Saito T.
CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.
J Immunol . 183, 4220-4228, 2009.
2008
1. Itoh Y, Ozaki H, Tsuchiya H, Okamoto K , Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H.
A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques.
Vaccine 26, 562-572, 2008.
2. Yamamoto Y, Ishigaki H, Ishida H, Itoh Y, Noda Y, Ogasawara K.
Analysis of splenic Gr-1int immature myeloid cells in tumor-bearing mice.
Microbiol Immunol 52, 47-53, 2008.
3. Sawai T, Itoh Y, Ozaki H, Isoda N,Okamoto K, Kashima Y, Kawaoka Y, Takeuchi Y, Kida H, Ogasawara K.
Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin.
Immunology 124, 155-65, 2008.
2007
1. Teramoto K, Kontani K, Fujita T, Ozaki Y, Sawai S, Tezuka N, Fujino S, Itoh Y, Taguchi O, Kannagi R, Ogasawara K .
Successful tumor eradication was achieved by collaboration of augmented cytotoxic activity and anti-angiogenic effects following therapeutic vaccines containing helper-activating analog-loaded dendritic cells and tumor antigen DNA.
Cancer Immunol Immunother 56, 331-342, 2007.
2. Kontani K, Teramoto K, Ozaki Y, Sawai S, Tezuka N, Ishida H, Kajino K, Fujino S, Yamauchi A, Taguchi O, Kannagi R, Yokomise H, Ogasawara K.
Cytotoxic T Lymphocytes in Patients with Metastatic Cancer Using Penicillin-killed Streptococcus Pyogenes (OK432) and Anti-CD40 Antibody.
Oncol Rep 17, 895-902, 2007.
3. Nagata T, Toyota T, Ishigaki H, Ichihashi T, Kajino K, Kashima Y, Itoh Y, Mori M, Nishida M, Yamamura H, Taneichi M, Uchida T, Ogasawara K.
Peptides coupled to the surface of a kind of liposome protect infection of influenza viruses.
Vaccine 25, 4914-4921, 2007.
2006
1. Taneichi M, Ishida H, Kajino K, Ogasawara K, Tanaka Y, Kasai M, Mori M, Nishida M, Yamamura H, Mizuguchi J, Uchida T.
Antigens chemically coupled to the surface of liposomes are cross-presented to CD8+T cells and induce potent antitumor immunity.
J Immunol . 177, 2324-2330, 2006.
2. Ishigaki H, Yamamoto Y, Ishida H, Kajino K, Itoh Y, Fujiyama Y, Ogasawara K.
Preparation and Functional Analysis of Tumor-Infiltrating Stoma Cells Using Bone Marrow Chimera Mice.
Microbiol Immunol. 50:655-662, 2006.
2005
1. Bamba H, Ishigaki H, Ishida H, Kajino K, Fujiyama Y, Ogasawara K.
B1-B cells are the main antigen presenting cells in CpG-ODN-stimulated peritoneal exudates cells.
Microbiol Immunol. 49, 89-95, 2005.
2. Itoh Y, Wang Z, Ishida H, Eichelber K, Fujimoto N, Makino J, Ogasawara K, Germain RN.
Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduce Ca2+ signaling.
Eur J Immunol . 35, 3187-3195, 2005.
2003
1. Fujimoto N, Ishida H, Nakamura I, Ogasawara K, Itoh Y.
Quantities of interleukin-12p40 in mature CD8 alpha negative dendritic cells correlate with strength of TCR signal and determine Th cell development.
Microbiol Immunol. 47, 1017-1024, 2003.
2. Teramoto K, Kontani K, Okazaki Y, Sawai S, Tezuka M, Nagata T, Koide Y, Fujino S, Itoh Y, Ogasawara K.
DNA encoding a pan-MHC class II peptide analogue augmented antigen-specific cellular immunity and suppressive effects on tumor growth elicited by DNA vaccine immunology.
Cancer Res 63, 7920-7925, 2003.
2002
1. Kontani K, Taguchi O, Ozaki Y, Hanaoka J, Tezuka N, Sawai S, Inoue S, Fujino S, Maeda T, Itoh Y, Ogasawara K, Sato H, Ohkubo I, Kudo T.
Novel vaccination protocol consisting of injecting MUC1 DNA and nonprimed dendritic cells at the same region greatly enhanced MUC1-specific antitumor immunity in a murine model.
Cancer Gene Therapy. 9:330-337, 2002.
2. Itoh Y, Germain RN.
Variant ligands, Altered T-cell receptor signaling, hierarchical response thresholds, and CD4+ effector responses.
CYTOKINES AND AUTOIMMUNE DISEASES Kuchroo VK, Sarvetnick N, Hafler DA, Nicholson LB (eds): pp49-78, Humana Press Inc, 2002.
2001
1. Li-Yun Huang, Caetano Reis e Sousa, Yasushi Itoh, John Inman, Dorothy E. Scott.
IL-12 Induction by a Th1-Inducing Adjuvant In Vivo: Dendritic Cell Subsets and Regulation by IL-10.
J Immunol . 167:1423-1430, 2001.
2. Ken J. Ishii, Koichi Suzuki, Cevayir Coban, Fumihiko Takeshita, Yasushi Itoh, Hana Matoba, Leonard D. Kohn, Dennis M. Klinman.
Genomic DNA Released by Dying Cells Induces the Maturation of APCs.
J Immunol . 167:2602-2607, 2001.