大学院での研究紹介

マイクロ波手術機器の開発,次世代MR画像誘導下手術システムの開発

主な担当研究者
谷 徹
仲 成幸
塩見 尚礼
山田 篤史
村上 耕一郎
東口 貴之(大学院生)
谷 総一郎(大学院生)
Nguen Quoc Vinh(大学院生)

Utility of a microwave surgical instrument in sealing lymphatic vessels.
Takebayashi K, Shiomi H, Naka S, Murayama H, Murakami K, Akabori H, Yamaguchi T, Shimizu T, Murata S, Yamamoto H, Kurumi Y, Tani T.
Am J Surg. 2013 May 28. doi:pii: S0002-9610(13)00219-5. 10.1016/j.amjsurg.2012.07.048.

Correlation between high field MR images and histopathological findings of rat transplanted cancer immediately after partial microwave coagulation.
Murakami K, Morikawa S, Naka S, Demura K, Sato K, Shiomi H, Kurumi Y, Inubushi T, Tani T.  Magn Reson Med Sci. 2008;7(3):105-12

腹膜播種の機序とその制御に関する研究

術中癌細胞の腹膜転移能、癌細胞に対する温熱作用などを中心に胃癌腹膜転移の病態解明とその制御に関する研究を行っています。

主な担当研究者
村田 聡
竹林 克士(大学院生)
児玉 泰一(大学院生)

Surgery-Induced Peritoneal Cancer Cells in Patients Who Have Undergone Curative Gastrectomy for Gastric Cancer.
Takebayashi K, Murata S, Yamamoto H, Ishida M, Yamaguchi T, Kojima M, Shimizu T, Shiomi H, Sonoda H, Naka S, Mekata E, Okabe H, Tani T.
Ann Surg Oncol. 2014 Feb 6. [Epub ahead of print]

腫瘍免疫に関する研究

マウス腫瘍モデルを用いて,costimulatory signalやサイトカインを用いた効果的ながんワクチン療法および免疫細胞療法の研究を行っています.また,病理学講座と共同し,癌治療カラムの研究開発を行っています.

主な担当研究者
村田 聡
小島 正継(大学院生)
Ngoc Bao Binh

Fusion Protein of Mutant B7-DC and Fc Enhances the Antitumor Immune Effect of GM-CSF-secreting Whole-cell Vaccine.
Kojima M, Murata S, Mekata E, Takebayashi K, Jaffee EM, Tani T.
J Immunother. 2014 Mar 4. [Epub ahead of print]

OX40 costimulation can abrogate Foxp3+ regulatory T cell-mediated suppression of antitumor immunity.
Kitamura N, Murata S, Ueki T, Mekata E, Reilly RT, Jaffee EM, Tani T.
Int J Cancer. 2009 1;125(3):630-8

Pre-treatment with cyclophosphamide or OX40 (CD134) costimulation targeting regulatory T cell function enhances the anti-tumor immune effect of adoptively transferred CD8+ T cells from wild-type mice.
Ueki T, Murata S, Kitamura N, Mekata E, Tani T.
Mol Med Rep. 2009;2(4):615-20

OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen.
Murata S, Ladle BH, Kim PS, Lutz ER, Wolpoe ME, Ivie SE, Smith HM, Armstrong TD, Emens LA, Jaffee EM, Reilly RT.
J Immunol. 2006 Jan 15;176(2):974-83.

肥満手術に関する基礎研究

主な担当研究者
山本 寛
Vo Nguyen Trung(大学院生)

Intact neural system of the portal vein is important for maintaining normal glucose metabolism by regulating glucagon-like peptide-1 and insulin sensitivity.
Trung VN, Yamamoto H, Yamaguchi T, Murata S, Aimi Y, Kuwahara A, Tani T.
Peptides. 2013 Dec 11;52C:38-43. doi: 10.1016/j.peptides.2013.12.003.

Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging.
Trung VN, Yamamoto H, Furukawa A, Yamaguchi T, Murata S, Yoshimura M, Murakami Y, Sato S, Otani H, Ugi S, Morino K, Maegawa H, Tani T.
PLoS One. 2013 Jun 18;8(6):e65739. Print 2013.

Effect of sleeve gastrectomy on body weight, food intake, glucose tolerance, and metabolic hormone level in two different rat models: Goto-Kakizaki and diet-induced obese rat.
Trung VN, Yamamoto H, Yamaguchi T, Murata S, Akabori H, Ugi S, Maegawa H, Tani T.
J Surg Res. 2013 May 28. doi:pii: S0022-4804(13)00471-X. 10.1016/j.jss.2013.05.019.

抗癌剤感受性に関する基礎研究

主な担当研究者
目片 英治
塩見 尚礼
Hoang Dinh Tuy(大学院生)

Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Mekata E, Murata S, Sonoda H, Shimizu T, Umeda T, Shiomi H, Naka S, Yamamoto H, Abe H, Edamatsu T, Fujieda A, Fujioka M, Wada T, Tani T.
Oncol Rep. 2013 Oct 4. doi: 10.3892/or.2013.2788. [Epub ahead of print]

Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer.
Okumura K, Shiomi H, Mekata E, Kaizuka M, Endo Y, Kurumi Y, Tani T.
Oncol Rep. 2006;15(4):875-82.

臨床研究紹介

大建中湯による腸管運動とエンドトキシンに関する研究

Daikenchuto enhances intestinal motility and reduces circulating endotoxin levels.
Hiroshi Yamamoto1, Akitoshi Inoue2, Akira Furukawa3, Makoto Kadowaki4, Tohru Obata1, Sachiko Kaida1, Tsuyoshi Yamaguchi1, Satoshi Murata1, Masaji Tani1
1Shiga University of Medical Science, Department of Surgery, Otsu, Japan.
2Shiga University of Medical Science, Department of Radiology, Otsu, Japan.
3Tokyo Metropolitan University, Faculty of Health Science- Division of Radiological Sciences, Tokyo, Japan.
4University of Toyama, Department of Gastrointestinal Pathophysiology, Toyama, Japan.
DDW San Diego 2016

抗癌剤感受性試験に関する臨床研究

Stratified phase II trial to establish the usefulness of the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) for advanced gastric cancer.
Naitoh H, Yamamoto H, Murata S, Kobayashi H, Inoue K, Tani T.
Gastric Cancer. 2013 Dec 8. [Epub ahead of print]

Clinical potential of the anticancer drug sensitivity test for patients
with synchronous stage IV colorectal cancer.
Takebayashi K, Mekata E, Sonoda H, Shimizu T, Endo Y, Tani T. 
Cancer Chemother Pharmacol. 2013 Jul;72(1):217-22. doi: 10.1007/s00280-
013-2189-7. Epub 2013 Jun 1.

Differences in Chemosensitivity between Primary and Metastatic Tumors in Colorectal Cancer.
Takebayashi K, Mekata E, Sonoda H, Shimizu T, Shiomi H, Naka S, Endo Y, Tani T.
PLoS One. 2013 Aug 28;8(8):e73215. doi: 10.1371/journal.pone.0073215.

腹腔内温熱化学療法に関する臨床研究

Hyperthermic intraperitoneal chemotherapy using a combination of mitomycin C,5-fluorouracil, and oxaliplatin in patients at high risk of colorectal peritoneal metastasis: A Phase I clinical study.
Shimizu T, Sonoda H, Murata S, Takebayashi K, Ohta H, Miyake T, Mekata E, Shiomi H, Naka S, Tani T.
Eur J Surg Oncol. 2013 Dec 18. pii: S0748-7983(13)00943-8. doi: 10.1016/j.ejso.2013.12.005.

高感度エンドトキシン測定法に関する研究

臨床医学における,ESP法によるエンドトキシン測定法の応用開発を行っています.

主な担当研究者
小幡 徹 obatat@belle.shiga-med.ac.jp
清水 智治

研究紹介ページ

Diagnostic potential of endotoxin scattering photometry for sepsis and septic shock.
Shimizu T, Obata T, Sonoda H, Akabori H, Miyake T, Yamamoto H, Tabata T, Eguchi Y, Tani T.
Shock. 2013 Oct 1.


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