<html> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-16"> <meta name="keywords" content="uh0u00f[v0000, u, un0xvz, u0, u0h0o0, u0n000000"> <title>u0h0un0WywX - Pain Relief00uir1uegir</title> </head> <body text="#000000" bgcolor="#ffffff" link="#cd1039" vlink="#1c74ff" alink="#0000dd"> <table border=0><tr> <td nowrap><font color="#0000cc" size=+1><b>%TOXINh0VENOMh0uir1uegir%</b></font></td></tr></table> <ul><li> 0<a href="http://www3.nhk.or.jp/kaigai/gtv/chikai/index.html" target=new>[^sY[00000n0D0</a> 0 ,{34q 0sn0`0 0g0o00 0h0k 0o0:SRg0M0j0D00 00kk0j000k0~0_0k0j000 0 00OD0e00p0kk0j000k0OD0e0 YH00p0k00j000 0<br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td nowrap valign=top><a href="#toxin">toxin</a></td><td valign=top colspan=2><a href="anat-gprotein.html#choleratoxin">000k }</a>/<a href="anat-gprotein.html#pertussis-toxin">~veTk }</a>/<a href="anat-gprotein.html#diphtheria-toxin">00000</a>/<a href="#ttx">00000000</a>/<a href="#hypnotoxin">0000000</a>/<a href="#conotoxin">000000</a>/<a href="analg-virus.html#botulinum">00000k }</a>/<a href="method-hist-marker.html#sp-sap">0000</a>/<a href="subs-lipid.html#LPS">LPS</a></td></tr> <tr><td nowrap valign=top><a href="#venom">venom</a></td><td valign=top colspan=2><a href="subs-algo.html#cantharidin">000000</a>/<a href="#snakevenos">00k</a>-<a href="subs-algo.html#bk">000000</a>-<a href="#-bungarotoxin">-bungalotoxin</a>/<a href="#spivenom">00k</a>/<a href="#scorpion">000k</a> /<a href="#beevenom">00k</a>/<a href="#frogvenom">000k</a></td></tr> <tr><td nowrap valign=top>0</td><td valign=top colspan=2><a href="#maggot">0000</a></td></tr> <tr><td nowrap valign=top rowspan=4> iir<br><br><a href="#alkaloid">000000</a></td><td valign=top>u\O(uj0i0</td><td valign=top><a href="analg-nsaids.html#aspirin">000</a>/<a href="analg-opioid.html#morphine">000</a><a href="#quinine">0000</a>/<a href="analg-venom.html#yadoku">wk</a> </td></tr> <tr><td valign=top>{^\O(uj0i0</td><td valign=top><a href="analg-cannabinoid.html#cannabis">'Y</a>/<a href="subs-dependence.html#cocaine">00</a>/<a href="subs-dependence.html#mescarine">00000</a>/<a href="subs-dependence.html#psilocybin">000000</a>/</td></tr> <tr><td valign=top>zvu\O(u</td><td valign=top> <a href="subs-algo.html#capsaicin">000000</a>/<a href="method-stimulation.html#carageenan">00000</a>/<a href="method-stimulation.html#mustard">00000000</a></td></tr> <tr><td valign=top>ut;m'`/k</td><td valign=top> <a href="#amino-acid">00000x#</a>/<a href="#gaba">GABAS[SO#</a>/<a href="#ach">0000000#</a></td></tr> </table><br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td nowrap valign=top>k }</td> <td nowrap valign=top><a href="#toxin">toxin</a></td> <td valign=top><ul><li>0000n0toxikonk k01uegW0_0 tocinkn0 + -inSf[ir <li>0000n0toxonh0o00h00h0_wn0S0h0g00tocikono0 0wn0 0h0D0F0b_[^toxikosn0-N'`b_0 <li>Ók0WX^Y00k0toxikon pharmakonh0D00 T^L0weuU00_0toxon0wk0U00k0k0asTY000F0k0j0000000񂞊g0o0#P}b_n0tox(o)-, toxic(o)-L0O0000 <li><font style="color:black;background-color:#ffffcc">i0a00K0h0H0p06qk0</font>uS̃j0i0uirk01uegY00k }0<hr> <li>toxikon pharmakon<a href="#yadoku">wk</a> n0pharmakono0kn0asTg0O00f0D00L00S0n0o0pharmaceuticsf[ 0pharmacologytf[ 0pharmacy@\ 0pharmacop(o)eia@\e j0i0n0nh0j0c0f0D000F0k00sNg0o00c0q000asTY000W0K0W0SN0000g0o00TR0cd0 iir'`irꌒ0cW00uln0lBvk0OF0n0{0K00kPRn0B00kir0N0Zk0 YH000F0j0Tln0irꌂ0+T~00f0D0_00W0_0L0c0f00pharmakeiao0TSh00dRSh00h000W00phamakeuso0kkg0B000pharmakopoloio0VLn0;Sg00pharmakoio0{kRV0 </ul></td></tr> <tr><td nowrap valign=top rowspan=3>k</td> <td nowrap valign=top><a href="#venom">venom</a></td> <td valign=top><ul><li>000n0venenumm0kir k01uegY00L00<font style="color:black;background-color:#ffffcc">yrk0Rirn0kzK00RlU000k</font>0:yY00 <li>venenumo0venus'`a0'`2k k01uegY00h0U000]0n0Sao0{000</ul></td></tr> <tr><td nowrap valign=top><a href="#poison">poison</a></td> <td valign=top><ul><li>000n0potion0[CQeg 00S0h00R 00asTY00L000irk0D00D00j00n00eQ0_0 0Z04l0kj0i0n0 0N g 00hY0S0h0k00b00d0D0k0o0k0asTY000F0k0j0c0_00W0D00 <li>portionh0F0񂞊k004l0kn0 0N g 0n0asT04lkn0asTL0B000 <li>poisono0<font style="color:black;background-color:#ffffcc">)Y6qkh0Sf[TbU00_0kY0y0f0</font>0hY0L00i0a00K0h0H0p0N]k0</ul></td></tr> <tr><td valign=top colspan=2><ul><li>"oW[n0 0k 0o00uIn0uH0 kP[0 #u00n0g0\O0000h00h0In00000h0c0f07_XdRh0W0f0(uD000_00n0`0L008^(uY00h0[0S|0Y0S0h0K000kn0asTk0j0c0_0h0D0F00</ul></td></tr></table></ul><hr><br> <a name="toxin"></a><font size=+1 color="#0000cc"><b>%TOXIN</b></font><br> 0G0000#[!<a href="anat-gprotein.html#choleratoxin">000k }</a>0!<a href="anat-gprotein.html#pertussis-toxin">~veTk }</a>0!<a href="anat-gprotein.html#diphtheria-toxin">00000</a>]<br><br> 0!wm m_uirL0QY0TOXIN <ul><table border=1 cellspacing=0 cellpadding> <tr><td valign=top nowrap>!<a href="#ttx">00000000</a></td> <td valign=top><ul><li>Staphyloccus,Bacillus, Micrococcus, Alteromonas, 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<li>000000o0]0n0SVirh0W0f01967t^k0RU0001989t^k0i zl[U00_00 <li>2001t^y0qgS'Yn0s^ckZSYecn00000L0000000n0hQTb0TbW00s|Vg0ؚD0UO0__00 </ul></td></tr> <tr><td valign=top nowrap>000000<br>0saxitoxin</td> <td valign=top><ul><li>Alexandrium tamarense (c) Larry Fritzn0k }<br> <li>Ngn0kh0j000</ul></td></tr> <tr><td valign=top nowrap>000000<br>0palytoxin: PTX</td> <td valign=top><ul><li>&nk Ostreopsis siamensin0k }<br> <li>TxRir02uk^0^k0+T~0000 <li>0000Nq/^0WWj0i0k0uo`Y00U00T0yn0TxRir0000000000000Palythoa tuberculosa K00iQU00_0n0g00 Palytoxinh0}T TU00_00 <li>e,g0,g]WS0WWNWSk0o0uo`W0f0D000 <li>000yk0h0000000j0i000000n0kh0W0f00<a href="#ciguatoxin">CTX</a>h0o0puj00irn0X[(WL00w00f0D000 <li style="background-color:#ffffcc">Na<sup>+</sup>n0N'`0ؚ00<a href="anat-channel.html#nachannel">Na<sup>+</sup>0000</a>0;m'`SY000<a href="#ttx">TTX</a>h0o0S[n0\O(ug0Y00</li> <li>1971t^k0bRL0iQU00_0_01981t^k0i f01994t^k0\k000hQTbU00_00</ul></td></tr> <tr><td valign=top nowrap>!<a href="#conotoxin">000000</a></td> <td 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Portier</font>0o00000000K00k }0XSW0_00Richeto0Anemonia sulcataK003d0n0STir0XSW0_00Hyptpxin, thalaxin, congestin </td></tr> <tr><td nowrap valign=top><a name="hypnotoxin-Pieron"></a><a href="react-sleep.html#hypnotoxin">1907t^</a></td><td><font color="#0000cc">Legendre and Pieron</font>0000 L0e w00sleep-deprived dogsn0@nK00aw wk }0bQW00 0hypnotoxin 0h0 Te0Q0_001913t^k0Pierono0 0Le Probleme Physiologique du Sommeil 00QHrW0_00</td></tr></table> !S0n02d0o00hypnotoxino00 T Tn0puj00irK0</ul></td></tr></table></ul> <a name="ttx"></a><font color="#0000cc"><b>%00000000 tetrodotoxin: TTX</b></font>0!!<a href="anat-channel.html#nachannel">Na0000</a> <ul><li>Sf[_ C<font size=-1>11</font>H<font size=-1>17</font>O<font size=-1>8</font>N<font size=-1>3</font>0RP[ϑ319.27 <li>Rx00n0500 Pn07_U0L0B00sk <li>0000^\00000000^\j0i0n0Nn0wck0}̃k00c0f0u#uU000STirStaphyloccus,Bacillus, Micrococcus, Alteromonas, Acinetobacter, Vibrio ^\n00}̃j0i0L0SVirh0W0f0XSU00f0D000 <li>00n0Ӂ0uS]k0ĄMzU00f0D0000000000o0000-Nkn0SVir0 <li>00ꁫL0k }0TbY00n0g0o0j0O0000000L0d0O00N!kN#uir0ߘir#g0o.~U00000j0i0L0'Yϑk0_00S00g0D00000kn0+Tϑk0o0 PSO]00WW]L0UWk0000N]vk0 kW0_000o0!qkg0B000 <table border=1 cellspacing=0 cellpadding=3> <tr><td nowrap valign=top>1909t^</td><td><font color="#0000cc">0uSo}</font>1855/8/1801935/10/6/3,0e,gg0gRn0f[ZSX L000n0uS]K000.2%n000k0bQW0000000000h0}T TW0_00<br> 000yn0f[ T<i>Tetraodontidae</i> 000yo04gn0okg0cd0 toxin</td></tr> <tr><td nowrap valign=top>1952t^</td><td><font color="#0000cc">%m0um`N</font>1907/2/1001999/6/24 0L01952t^k0000000000bQY00R▾|l0zvW00Sf[i c<font size=-1>12</font>h<font size=-1>19</font>o<font size=-1>9</font>n<font size=-1>3</font>0zl[W0_00</td></tr> <tr><td nowrap valign=top>1964t^</td><td>Ng0K00_0V)Y6qirSf[Opk0J0D0f003d0n00000L0 TBfk000000000n0i 0zvhW0_00<font color="#0000cc">s^0uck</font>0191502000, T'Yf[ 0<font color="#0000cc">%m0um`N</font>01907/2/1001999/6/2, qgN'Y 0<font color="#0000cc">Robert Burns 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<tr><td>2uk^</td><td>00000000000000000000</td></tr> <tr><td nowrap valign=top>wm#un0ߎSORir</td><td>000000000000000000^</td></tr> <tr><td nowrap valign=top>x0Wn0ߎSORir</td><td>0000000000000000000Atelopus^\n00000000000000000000</td></tr> </table><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td>00000000-Nk <ul><li>00kn0-Nkuro00mS{K00n08TSL0D0_00k030RK004Bf_k0urL0s00%`k02LW024BfNQk0{kNY004XTL0YD00 <li>gRo0 0UL0W0s000cHQn0W0s00k0K~L000-u0yu0VTj0i00wS0W00ikL0zvXL0Vk0j000 <li>͑^n04XT0@'Wn0NO Nj0i0L0wM00|T8Tu0aX[k0j00{kNk000~00k0N{krKak0e0S0h0L0B000 <li>kdRo0d0K0c0f0D0j0D0n0g00SK00k0o0M0QU0[00NYk0[Qelo0j0D00 <li>00000000n0bNn0{kϑo00ߘy0irh0W0f0BdSW0_04XTo0103mgh0c[U00f0D00000n0Ӂ100gk0vS_W00000k0c{Y00h01N9Sn0{kϑk0vS_Y000000n04XTo0LD50=0.01 mg/kgh0U000000N9SB0_001gN Nh0D0F0ui_ϑg0{kk000 <li>00000000o0200^N Ng0j0D0h0RU00j0D0_000nqf00RU00j0D00 <li>00n0Na0000k0o000000000P}TMOL0D0n0g0000ꁫo0000000000g0-Nk{kY00S0h0o0j0D00 </ul></td></tr> </table> </ul><hr><br> <a name="conotoxin"></a><font color="#0000cc"><b>%000000 conotoxin</b></font>!!0<a href="anat-channel.html#vscc">Ca0000</a>/<a href="analg-vasc.html#ca-antagonist">00000</a><br> <ul><li style="background-color:#ffffcc">wm#u]M00000L0\O0k }000000k0o00YO0n00000L0+T~00f0D0f00<a href="#">-conotoxin</a>L07_Rj0u\O(u0cd0S0h0L0f0K0k0U00_00 0From Venoms to Drugsk00c0f0k06RY0 0h0D0F0S0h0g000lvU00_00 0!S0<a href="http://www.nature.com/NSU/020715/020715-11.html" target="new">1</a>/ <a href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCS-43K2G13-1&_coverDate=10%2F31%2F2001&_alid=236990563&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5178&_sort=d&view=c&_acct=C000050562&_version=1&_urlVersion=0&_userid=1029206&md5=240d4cc163e1e40bb62f085aaa6f78ae" target="new">2</a>/ <a href="http://www.thenakedscientists.com/HTML/Columnists/barrygibbcolumn3.htm" target="new">3</a>/ <a href="http://www.dojindo.co.jp/letterj/100/reviews_01_main.html" target="new">4</a>/<br> Ngn0ko00000001uegn00n0L0{0h00i0g0B00L000000n0ko00000L0\O0k0 </li><br> <li style="background-color:#ffffcc">0000k0f007_Rj0uh0W0f0g_U00f0D00<a href="#ziconotide">ziconotide</a>o000000n0*Ys^ mk0ho`Y00Conus magusk0X[(WY00)Y6qn0conopeptideh0 TX0bR0TbW0_00n0g00uu0000OTk0NY00NWCa00000neY00h0H000f0D000</li><br> <li style="background-color:#ffffcc"><a href="anat-channel.html#can">NWCa0000</a>k0[W0f00<br> <a href="http://www.bigai.ne.jp/pic_book/data11/r001071.html" target=new">Conus magus</a>T T0000 <br> <a href="http://www.bigai.ne.jp/pic_book/data15/r001497.html" target=new">Conus geographus</a>T T00000 <br> <a href="http://www.coneshell.net/pages/c_consors.htm" target=new">Conus consors</a>j0i0k01uegn0kL000000h0j000</li><br> <li style="background-color:#ffffcc">2004t^n0t^+gk00s|Vn0ߘT;ST@\FDA o00<a href="analg-bl-epi.html#subarachnoid">IT</a>0<a href="analg-opioid.html#morphine1">0000</a>j0i0n0Nn0lBvlk0 N'`~0_0o0bb'`0:yY0'`uun0lBvn0_00k00<a href="anat-channel.html#can">NWCa<sup>2+</sup>000000000</a>n0<a href="#ziconotide">ziconotide</a>ĚTQbN</b></font>FUT T<a href="http://www.PRIALT.com/" target="new">Prialt</a>0000000Dublin, Ireland n0000>y<a href="http://www.elan.com/" target="new">Elan Corporation</a>>y (The <a href="http://www.medtronic.com/patients/pain.html" target="new">Medtronic</a> SynchroMed- EL, SynchroMedh II Infusion System and Simms Deltec Cadd Micro(R) External Microinfusion Device and Cathetern0O(uk0P[)0bW0_00 0!S0<a href="https://secure.globeadvisor.com/servlet/ArticleNews/story/PRNEWS/20041228/2004_12_28_17_0616_1282346" target="new">1</a>/ <a href="http://biz.yahoo.com/bw/041228/285192_1.html" target="new">2</a>/ <a href="http://www.docguide.com/news/content.nsf/news/8525697700573E1885256F79005C690C" target="new">3</a><br> 0!͑#0<a href="http://physrev.physiology.org/cgi/content/full/84/1/41" target=new">Physiol. 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