<html> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-16"> <meta name="keywords" content="uh0u00f[v0000, u, un0xvz, u0, u0h0o0, u0n000000"> <title>u0h0un0WywX - Pain Relief00G0000qQy_WS[SO</title> </head> <body text="#000000" bgcolor="#ffffff" link="#cd1039" vlink="#1c74ff" alink="#0000dd"> <table border=0><tr> <td bgcolor="#cceeff"><font color="#0000cc">%</font><a href="anatomy3.html" target="_parent">i h0_j</a></td> <td nowrap><font size=+1 color="#0000cc"><b>%u0#S[SO2%</b></font>0!!<a href="anat-receptor.html">S[SO</a></td></tr></table><ul> !<a href="#gpcr">G0000qQy_WS[SO</a>0!<a href="#kinase">u };m'`Q5WS[SO</a></ul><br> <a name="gpcr"></a> <font size=+1 color="#0000cc"><b>%G0000qQy_WS[SO G Protein-Coupled Receptors: GPCR</b></font>0!!<a href="nr-transgenesis.html#DREADD">DREADD</a> <ul><table border=1 cellpadding=3 cellspacing=0><tr><td>0<font color="#0000cc">Alfred Goodman Gilman</font>1941/7/100s|Vn0yf[ h0<font color="#0000cc">Martin Rodbell</font>1925/12/101998/12/70s|Vn0uSf[0QRlf[ o00G0000k0Y00zvk00001994t^k0<a href="history-nobel.html#1994">0000utf[0;Sf[ތ</a>0SތW0_00<br> 0Rodbello01960t^Nk0GTPL00}ހ000000k0OW0f0D00S0h00:yW00GilmanL00}ހQg0GTPh0vN\O(uW000000000000000YY000000ꌒ0[k0zvW0_00</td></tr> <tr><td><a name="gp"></a>G00000000000000P}T0000 <ul><li>0}ހQn0uSf[vS_0R0fH00 00000 0h0W0f0<a href="#GTP">GTP</a>0GDPx0fH000 <li>00000000000000000k0#Y000000n0000000 <li>G0000o00}ހ Nn0S[hVn0;m'`Sh00}ހn0R\On0͑j0ZNh0j000 <li>RP[ϑ }100kDa0!!<a href="anat-gprotein.html#PTK">NORP[ϑGTPase</a>n0RP[ϑ20-30kDa </ul></td></tr></table><br> <li>G0000o00;m'`SU00_0S[SOK00n00000k0S_W000}ހn0b_0ui'`00}ހQn0ir80{Y00 00000n0 0n0y_rR0g_0W0f0D000<br> <table border=0 cellspacing=0 cellpadding=3><tr><td nowrap valign=top rowspan=2>G0000</td><td nowrap>%!<a href="#GTP-r">3ϑSOGTP0000ꌒ0;m'`SY007VWS[SO</a></td></tr> <tr><td nowrap>%!<a href="#PTK">NORP[ϑGTPase0;m'`SY00S[SO00000000</a></td></tr></table> <li>^4Xg0qbF0n0}JSpeL00GPCR#n0`1XOTn06R_0vvh0Y00_000}Tvk00_jzvsn0000000tY00S0h0L07_O0g~00f0D000 <li>1986t^k0}k0X[(WW00IQ00000SQ0S0S[SO 000000 0h0_Ӂk0X[(WY00 0<a href="anat-receptor.html#adr">2000000S[SO</a> 0L0zvU00_00S0n02d0n0RP[o00@\(WY00D}T~0_j0hQO0puj000000g0B00k00K0K000Z00 007VY00 0h0D0F0i vk0qQp0cc0f0D0_00<br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="GTP"></a>00000300x guanosine triphosphateGTP<br> ck_ T00000-5'-300x <ul><li>uirSOQk0X[(WY00000000 <li>RP[ϑ 523.18 <li>00000200xguanosine diphosphateGDP K00GTPn000x0S[W0f0uTbU0000 <li>^ATP</a>L0uirSOQg0ؚ0000000xP}Tn0000000)R(uW0f00i0j0uTb080KRj0i0n0S_k0(uD0000n0k0[W00GTP o0;Nh0W0f00}ހQ0000OT00000n0_jn0{k0(uD00000 <li>0000x00000<a href="subs-enzyme.html#gc">GC</a> k0000GTPK00<a href="subs-enzyme.html#cGMP">cGMP</a>L0TbU000cGMPo000000000000h0W0f0_jY000<br> 0!!<a href="subs-inflamm.html#PDE5-inhibitor">PDE5;[</a>cGMPR㉑b6R</td></tr></table></ul><br> <a name="GTP-r"></a><font color="#0000cc">%3ϑSOGTP0000ꌒ0;m'`SY007VWS[SO</font> <ul><li>G0000qQy_WS[SOo00<a href="anat-channel.html">0000000</a>WS[SO0000c0O00\O(uY00L00^yL}0}ހk0J0D0f00^D0{Vn0{vj0_T{0YY000 <li>G0000qQy_WS[SOo000}ހYn0N+gzk0}O0<font color="#ff0000">7Vn00}ހ</font>00000cd00 <li>7d0n0x00000i L00}ހꌜ0W00N+gzo00}ހYk0C+gzWo00}ހQk0MOnY000 <li>  K00j00<font color="#ff0000">0003ϑSO</font>0000 <ul><li>ObkrKak0o0000000(G)L0GDPh0P}TW00, 000000(G)h0h00k0ϑSO0b_bW0f0D000 <li>0}ހYn0S[SOk00000L0P}TW00;m'`SY00h00ϑSOWG0000o0GDP-GTPNcS_k00c0f0GTPP}TWk0 YcU0000Go0GTPP}TW00Go0GK00Y000 <li>GTPasen0;m'`Sk000G Nn0GTPL0GDPk0 YcU000h00Gh0GL0QOTY000</ul> <li>0000x00000 (<a href="subs-enzyme.html#ac">AC</a> ) </font>0000000000000000C (<a href="subs-enzyme.html#plc">PLC</a> )0;m'`SY000 <li>;m'`WTSOo00<a href="anat-channel.html#GIRK">K0000</a>j0i0k0P}TW0f0000000>eY000;m'`W000000L00P}TW0f0D00GTP0R4lRW0f00GDPP}TWn0 N;m'`W000000k0j00h00TSOh0Qs0OTW0f00 N;m'`WG0000k0;b00 <li>YO0n0GPCRo0Mitogen-activated protein kinase (<a href="subs-enzyme.html#mapk">MAPK</a>)0;m'`SY00S0h0L0g0M00L00S0n00000o0GPCRn00000000000000000000n0000000xSL0NW0f0D00h0H000f0D000<br><br> <li>Gn00j00Z0G00}ހQ`1XOT0bS_Y000<br> 0<b font style="color:black;background-color:#ffffcc">!</b>GPCRn0<a href="anat-antinoci.html#desensitization" font style="color:black;background-color:#ffffcc">00000000000k0001a\O</a> <br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td valign=top nowrap>000000000</td> <td valign=top align=middle bgcolor="#ffcc99" width=20%><a name="gs"></a><font color="#0000cc"><b>Gs</b></font>0S<a href="http://park12.wakwak.com/~pharma1/textbook/Receptors/gprotein3.html" target=new>1</a></td> <td valign=top nowrap align=middle bgcolor="#cceeff" width=20%><a name="gi"></a><font color="#ff0000"><b>Gi</b></font></td> <td valign=top nowrap colspan=2 align=middle bgcolor="#ffccff" width=40%><a name="gq"></a><font color="#0000cc"><b>Gq/G11</b></font>0S<a href="http://park12.wakwak.com/~pharma1/textbook/Receptors/PLCr-1.html" target=new>1</a></td></tr> <tr><td valign=top nowrap>S[SO</td> <td valign=top><a href="anat-receptor.html#pg">00000000</a><br><a href="anat-receptor.html#adr">000000-1,2</a><br><a href="anat-receptor.html#histamine">00000-H2</a><br><a href="anat-receptor.html#ATP">00000S[SOP1A2a, P1A2b</a><br><a href="anat-receptor.html#serotonin">000005HT4,6,7<br></a><a href="#vip">VIP</a><br><a href="#pacap">PACS[SO</a></td> <td valign=top><a href="anat-receptor.html#adr">000000-2</a><br><a href="anat-receptor.html#serotonin">000005HT1</a><br><a href="anat-receptor.html#histamine">00000H3,</a><br><a href="anat-receptor.html#ATP">00000-P1A1</a><br><a href="anat-receptor.html#ATP">ATP-P2x</a><br><a href="anat-receptor.html#opioid">00000S[SO</a><br><a href="anat-receptor.html#CB1">CB1S[SO</a><br><a href="anat-receptor.html#GAL">GalR1</a></td> <td valign=top colspan=2><a href="anat-receptor.html#bk">000000B1, B2</a><br><a href="anat-receptor.html#adr">000000-1</a><br><a href="anat-receptor.html#histamine">00000H1</a><br><a href="anat-receptor.html#ATP">00000-P1A3</a><br><a href="anat-receptor.html#sp">00000</a><br><a href="anat-receptor.html#mglu">NW00000xS[SO</a><br><a href="anat-receptor.html#et">000000-ETA,B</a><br><a href="anat-receptor.html#par">000000;m'`SS[SO</a><br><a href="anat-receptor.html#GAL">GalR2</a></td></tr> <tr><td valign=top nowrap>000000</td> <td valign=top nowrap align=middle><a href="subs-enzyme.html#ac">AC</a>!</td><td valign=top nowrap align=middle><a href="subs-enzyme.html#ac">AC</a>!</td><td valign=top nowrap colspan=2 align=middle><a href="subs-enzyme.html#plc">PLC</a>!</td></tr> <tr><td valign=top nowrap><a name="second-messenser"></a>0000<br>00000000</td><td valign=top nowrap align=middle>cAMP</td><td valign=top nowrap align=middle>cAMP</td><td valign=top nowrap align=middle><a href="anat-receptor.html#ip3">IP3</a></td><td valign=top nowrap align=middle><a href="subs-lipid.html#dag">DAG</a></td></tr> <tr><td valign=top nowrap>\O(uRP[</td><td valign=top nowrap align=middle><a href="subs-enzyme.html#pka">PKA</a></td><td valign=top nowrap align=middle><a href="subs-enzyme.html#pka">PKA</a></td><td valign=top nowrap align=middle><a href="subs-enzyme.html#camk">CaMK</a></td><td valign=top nowrap align=middle><a href="subs-enzyme.html#pkc">PKC</a></td></tr> <tr><td>0</td> <td valign=top><ul><li><a href="subs-enzyme.html#ac">AC</a>L0ATP0cAMPk0 YcW00cAMPo0cAMPOX['`A0000 (protein kinase A: <a href="subs-enzyme.html#pka">PKA</a>)0;m'`SW0f0i0j0ut\O(u0zvcY000 <li>Gso0<a href="#choleratoxin">000k }</a>k00c0f0 N;m'`SU0000</ul></td> <td valign=top><ul><li><a href="#gs"><font color="#ff0000">Gs</font></a>k0bbW00<a href="subs-enzyme.html#ac">AC</a>n0;m'`S0b6RY000 <li><a href="anat-channel.html#ca">Ca<sup>2+</sup>0000</a>0W00<a href="anat-channel.html#GIRK">QTM0teAm'`K<sup>-</sup>0000</a>0;m'`SW0f00000000NRuiU0[000 <li><a href="anat-channel.html#GIRK">GIRK0000</a>h0qQy_W0f0D000 <li>Gio0<a href="#pertussis-toxin">~veTk }</a>k00c0f0 N;m'`SU0000 </ul></td> <td valign=top colspan=2><ul><li><a href="subs-enzyme.html#plc">PLC</a>L00<a href="subs-lipid.html#PIP2">PIP<font size=-1>2</font></a>0RW0f00<a href="anat-receptor.html#ip3">IP3</a>h0 <a href="subs-lipig.html#dag">DAG</a>0ubY000 <li>IP3o000000000K00Ca<sup>2+</sup>0JU0[0_000\ހSOn0Ca<sup>2+</sup>0000g0B00<a href="anat-receptor.html#ip3">IP3S[SO</a>k0P}TW0f00Ca<sup>2+</sup>-0000000OX['`0000(<a href="subs-enzyme.html#camk">CaMK</a>)0;m'`SW0f00jv0000000xSY000 <li>DGo00<a href="subs-enzyme.html#pkc">PKC</a>0;m'`SW00PKCo00jv0000n0000/00000000xSW0f0yr[zOP[n0⎙Q0O2Y000</ul></td></tr> </table><br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td nowrap valign=top>G12</td> <td><ul><li>G0000qQy_WS[SOL0<a href="#PTK">NORP[ϑG0000</a>n0SH2 SH3 PH PZD Zn00000j0i0n00000i x000000OTY00S0h0L00K0c0f0M0_00 <li>S00L0<a href="#PTK">NORP[G0000</a>n0;m'`Sk0NW0f0D000</ul></td></table><br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="orphan"></a><font color="#0000cc">00000G0000qQy_WS[SO Orphan G-Protein Coupled Receptorsorphan GPCR</font> <ul><li>00000S[SO0000L0 T[U00f0D0j0D0S[SO0 <li>GPCRo0uirsan0B00004Xbg0-N_vj0_j0ca00g0͑j0uR00000n0Nd0g0B000 <li>GPCRn0YO0o00000L0*gwg0B00000000hQSOg0GPCRo0700K00800яO0X[(WW0f0D00S'`L0:yUU00f0D00L000000ewn0S[SOL0}250 z^g0B000k0o000000S[SOg0B000 <li>zOP[`1Xn0ĄMzj0i0k00c0f0e_0k0D0`0U00_000000GPCRo00*gwj00uirsan0fk0K~L00S0h0L0g_U000ievj0;SuRQn0_00n0e_0j000000h0W0f0n0ERL0B000e_0j00000L0zvU00d0d0B000 <table border=1 cellspacing=0 cellpadding=3> <tr><td nowrap valign=top>00000(G0000qQy_W)S[SO</td><td valign=top>Q(W'`0000</td></tr> <tr><td nowrap valign=top><a href="anat-receptor.html#orl1">ORL1S[SO</a></td><td valign=top><a href="subs-endorphin.html#nociceptin">000000/000000FQ</a></td></tr> <tr><td nowrap valign=top><a href="anat-receptor.html#orexin">00000S[SO</a></td><td valign=top><a href="subs-transm.html#orexin">00000</a></td></tr> <tr><td nowrap valign=top>GPR7<br>GPR8</td><td valign=top><a href="subs-transm.html#NPB-NPW">neuropeptide B<br>neuropeptide W</a></td></tr> <tr><td nowrap valign=top><a href="anat-receptor.html#Mrg">Mas</a></td><td valign=top><a href="basic-vasc.html#A1-7">00000000-(1-7)</a></td></tr> <tr><td nowrap valign=top><a href="anat-receptor.html#c-Ret">c-RetS[SO</a></td><td valign=top><a href="subs-neurotrophin.html#gdnf">GDNF</a></td></tr></table> 0!!Retinoic acid receptor-related Orphan Receptor<a href="anat-receptor.html#ROR">ROR</a></ul> </td></tr></table> </ul><br> <hr> G0000O0!<a href="analg-venom.html">TOXIN</a><ul> <table border=1 cellspacing=0 cellpadding=3> <tr><td>G0000bb;[dR---<font color="#0000cc">GDP--S</font></td></tr> <tr><td><a name="choleratoxin"></a><font color="#0000cc">000k } cholera toxin</font><a href="http://ja.wikipedia.org/wiki/%E3%82%B3%E3%83%AC%E3%83%A9%E8%8F%8C" target=new>*</a> <ul><li>000k }o00k }#uuW000̃L0#uuW0f0̃SOYk0RlY000000'`n0Yk }g0B000k }h0W0f0n0;m'`0cd0A000000(Active000000)1 Ph000}ހh0n0P}T;m'`0cd0B000000(Binding000000)5 PK00ibU0000A1B5Wh0|Tp000k }0000g0B000A000000o000}ހQg0A1h0A2h0D0F02d0n0000000k0U00k0RU000[k0k };m'`0:yY0n0o0A1000000n0eg0B000 <li>A1000000o000}ހQn0NAD00000000h0ADP0000k0RW00]0n0ADP00000G0000n0N.zg0B000S[SO;m'`SGs0000k0P}TU0[00PM00cd00 <li>'0000<font color="#ff0000"><a href="#gs">Gs</a>n00000000ADP-0000S</font>W00GTPase0 N;m'`SY00S0h0k0000^Svj0;m'`S0wS0W008^k0;m'`SU00_0rKak0j000]0n0P}g0S0n0Gs0000h0P}TW0f0D00<font color="#ff0000"><a href="subs-enzyme.html#ac">0000x00000</a></font>L0D0d0~0g00;m'`S</a>U00d0e0Q00S0n0u }n0PM0k00c0f00}ހQn0<font color="#ff0000">cAMPn0o^L0 Nf</font>W0_0~0~0n0rKak0j000 <li>3k0o00000k }k0</td></tr> <tr><td><a name="pertussis-toxin"></a><font color="#0000cc">~veTk } pertussis toxinPTX</font> <ul><li>'0000<font color="#ff0000"><a href="#gi">Gi</a>n00000000sADP-0000S</font>W00S[SOh0vN\O(ug0M0j0O0Y000 <li>s(Ww00f0D00'n000000hQ18.z^n0F0a00Gi00000k0^\Y008.z^n000Wh0Y000 <li>Gin0C+gzK004juvn0000xL000000j00~veTk }n0Wh0j000</ul></td></tr> <tr><td><a name="diphtheria-toxin"></a><font color="#0000cc">00000diphtheria toxin</font> <ul><li>000ϑSOG0000g0o0j0O00<a href="#PTK">NORP[ϑG0000</a>g0B00000000n0_j6R_k0NY00w8huirn0b5_VP[elongation factor2: eEF-20ADP-0000SW0f0 N;m'`SY000</ul></td></tr> <tr><td><a name="forskolin"></a><font color="#0000cc">0000000 Forskolin</font> <ul><li>1968t^k00000S#un000y iir000000000000n09hK00K00XSU00_00!!<a href="analg-venom.html#alkaloid">000000</a><li>000000000000o00000g0o0Oq}vk0n 7_X0vvh0W0f0ߘ(uk0(uD000f0M0_00 <li>S[SOJ00s0G0000h0!qOk0<a href="subs-enzyme.html#ac">0000x00000</a>0;m'`SY000 <li><font color="#ff0000">Gih0Go0000000ADP-0000S</font>W00000000n0P}T0[[SU0[00S0h0k000 N;m'`SU0[00k } </ul></td></tr> <tr><td><a name="phorbol-ester"></a><font color="#0000cc">0000000000 Phorbol Ester</font><br> <ul><li>000000yEuphorbiaceae iirn0kZbR <li>1934t^k0000000yn0000000000l Croton tiglium oil00<i>Croton tiglium Linne</i>n0.zP[K00h0c0_0l n0R4lRirK00XSU00_00Flaschentrger B, v. Wolffersdorff R (1934). "ber den Giftstoff des Crotonles. 1. Die Suren des Crotonles". Helvetica Chimica Acta 17 (1): 1444 1452. <li>{0h00i0n0ui'` g_jnZJ00s04lk00O0nY000 <li><a href="subs-enzyme.html#pkc">PKC</a>;m'`Sir <li>0}ހn0L00S0O2Y00000000 <li>0000000000j0i0n0:Rok00c0f0<a href="subs-enzyme.html#mapk">MAP0000</a>0NW0f0⎙Q\U0000 <hr> <li><a name="PMA"></a>PMAPhorbol-12-myristate-13-acetate 0000000000n0Nd0000y iirk0+T~000irg000000000n0 gRbR00000n0Nn0s0WNo0S0n0 iir000n0N00k0)R(uW0f0D0f00 L00L0YO0zvuW0f0D0_00<br> <li><a name="TPA"></a>TPA000000000000000000 i o0<a href="subs-lipid.html#dag">DAG</a>k0<a name="4-PDD"></a>4-PDD(4-phorbo1,4-phorbol,4-phorbol-12,13-didecanoate </ul></td></tr> <tr><td><a name="mast"></a>!<a href="analg-venom.html#mastoparan">000000</a>---00000n0<a href="analg-venom.html#venom">venom</a><br> <ul><li>;m'`n0Nd0k0G0000h0n0vcP}Th00]0n0;m'`SL0B000 <li>000000n0GTPase0;m'`SY00S0h0k0000GTPn0P}TW0_0;m'`W000000n0c}Bf0w.~Y00\O(uL0B000</ul></td></tr></table></ul><hr> <a name="GTP-binding-protein"></a>GTPP}T00000!!<a href="#GTP">GTP</a>/<a href="#GTP">GTP</a>/<a href="subs-gene.html#sept">0000</a> <ul><table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="arrestin"></a><font size=+1 color="#0000cc"><b> %-00000 -arrestin</b></font>0!!<a href="anat-antinoci.html#nk1">00000000000</a>0S<a href="http://www.cosmobio.co.jp/aaas_signal/archive/cm_20051122.asp" target=new>1</a> <ul><li>G0000qQy_WS[SOn000xSh0]00k0}O00}ހQ;m'`{00000000004X0000 <li>00000o0s(W~0g0k0'YM0O04.z^n000000visual arrestin  arrestin1  arrestin2J00s0conespecific arrestin L0 T[U00f0D000 <hr> <li>-00000o00wn0 TX0O0Y00G0000qQy_WS[SO<a href="anat-gprotein.html#gpcr">GPCR</a>07VWS[SO h0P}TY00000 NϑSOn00000000000P}T0000G0000 0;[Y000000h0W0f00h00h0 T[U00_00 <li> 000001J00s02o0.z0n0D}T~k0^O0R^W0f0D00L00yrk0-Ng^yL}|k0J0D0f0ؚ[^k0R^Y00S0h0L0w00f0D000 <li>-00000o00Neg0o0i0j00}ހhbS[SOn0ckn00000OT0000000h0W0f0UOU00f0D000 <li>000000;m'`S0000ꌭ0000<a href="subs-enzyme.html#mapk">MAPK</a> 0yrk00}ހY0000{'`00001J00s02<a href="subs-enzyme.html#erk">ERK</a>1/2 n0;m'`So00i0j0XkVP[S[SOJ00s07TMRn0:Rok0wVY000}ހQ0000OTn0yr_h0j0c0f0D000P}gh0W0f0uX00ERK;m'`o00pen0s^LY000B00D0o0S_gY00000000NW0f0_M0wS0U000S'`L0B000 <li>GPCRn000xSh0]00k0}O0-000000<a href="#dynamin">00000</a>j0i0h0n0P}Tn0P}g0S[SOn00}ހQx0n0yLsequestration h0]00k0NW0f0uX000}ހꌅQx0n0yR<a href="anat-antinoci.html#nk1">internalization</a> L0͑h0U00f0D00Am J Respir Crit Care Med 158, 146 153, 1998  <li>-000001J00s02o0.zn0GPCR:Rok0[Y000}ހ_T{n0n1_k0NY00L0000000k0J0Q00_jvy_rRk0d0D0f0o0K0j00puj00S0h0L0cXdU00f0D00Proc Natl Acad Sci USA 98, 1601 1606 2001 0 <li>-000002o0<a href="analg-opioid.html#tolerance">00000'`</a>zvsk0NY000 <li>00000S[SOk0W0f000_egK00-000001L0 00000S[SO<a href="anat-receptor.html#1-3">KOP</a> J00s0 00000S[SO<a href="anat-receptor.html#1-2">DOP</a> J Biol Chem 273, 24328 34333, 1998 0-000002L0-00000S[SO<a href="anat-receptor.html#1-2">MOR</a> Science 286, 2495 2498, 1999 n01a\Ok0]00^00NY00h0D0F01XJTL0j0U00f0D00Proc Natl Acad Sci USA 94, 377 384, 1997 0 </ul></td></tr> <tr><td><a name="dynamin"></a><font size=+1 color="#0000cc"><b> %00000 dynamin</b></font> <ul><li>00000o0100kDn0GTPP}T0000 <li>00000o00<a href="subs-gene.html#microtubules">_\{</a>P}T0000h0W0f0 T[U00_00 <li>3.z^n000000I IIJ00s0III L0 T[U00f0D0f00]0n0D0Z000L0-Ng^yL}|k0R^W00<a href="anat-gprotein.html#gpcr">G0000qQy_WS[SO</a>n0_j YSk0NW0f0D00S0h0L01XJTU00f0D000 <li><a href="subs-dependence.html#opioid">00000WirOX[</a>k0NY00S'`L0:yUU00f0D000 <li>-00000S[SO<a href="anat-receptor.html#1-2">MOR</a> 0NW0_0<a href="subs-dependence.html#opioid">0000OX[</a>b_bBfk0J0D0f0o000003Qk0J0D0f000000n0NpRzvsL0uX0f0D00Mol Pharmacol 58, 159 166, 2000 0</ul></td></tr></tr></table></ul><br><br><hr> <a name="kinase"></a> <font size=+1 color="#0000cc"><b>%u }qQy_WS[SO</b></font> <ul>%<a href="#serine-threonine">0000000000000WS[SO</a><br> #%<a href="#tyrosine">00000000WS[SO</a><br> #%00000000OTWS[SO<br> #%00000000000WS[SO<br> %<a href="subs-enzyme.html#mGC">P}TW0000x00000WS[SO</a></ul> <a name="serine-threonine"></a> <font color="#0000cc"><b>%0000000000000S[SO Serine/threoninekinase receptors</b></font>0!!<a href="subs-enzyme.html#serine-threonine">0000000000000</a> <ul><li><a href="anat-receptor.html#il">000000S[SO</a>n0<a href="basic-os.html#BMP">BMP</a>0<a href="subs-inflamm.html#TGF">TGF</a>-0000000000XkVP[ 0<a href="#activin">0000000000</a>j0i0n0S[SOo000000000000000S[SOg0B000 <li>b_b0000 Bone Morphogenetic Protein: <a href="basic-os.html#BMP">BMP</a>n0\O(uo00<a href="anat-gprotein.html#serine-threonine">000/000000000S[SO</a>0X0f000}ހQk0OH00000IIWS[SOk0BMPL0P}TY00h00IWS[SOL000xS0;m'`SU0000;m'`SU00_0IWS[SOo00<a href="subs-gene.html#smad">Smad</a>⎙QVP[ 000xSY000 <li><a href="subs-inflamm.html#cytokine">000000</a>n0TGF-000000000n0S[SOk0o02.z^B000TGF-h0P}TW0_02WS[SOo001WS[SOh0TSO0b_bY000 <table border=1 cellspacing=0 cellpadding=3> <tr><td>2WS[SO <ul><li>0}ހQWk00000000000000;m'`0 gW0f0J000P}TW0_01WS[SOn00}ހQGSW000xSY000</ul></td></tr> <tr><td>1WS[SO <ul><li>1WS[SO00000000000000WS[SOg0B00L00GSWL000xSU00f0R0f0;m'`W0000h0j0000}ހn0-Nk000000OH00S0h0L0g0M000F0k0j000 <li>1WS[SO0000L0;m'`SU000h00}ހQ`1XOTRP[g0B00<a href="subs-gene.html#R-Smads">R-Smads</a>n0C+gzSXSn0000kW000xSY000</ul></td></tr></table> <tr><td></ul><br> <a name="tyrosine"></a> <font color="#0000cc"><b>%S[SOW00000000 receptor tyrosine kinase: RTK</b></font>0!!<a href="subs-enzyme.html#tyrosine">00000000</a> <ul><li><a href="anat-receptor.html#TrkA">TrkA</a>0<a name="RET"></a><a href="anat-receptor.html#c-Ret">c-Ret</a>0<a href="anat-receptor.html#RET>RET</a>0<a href="anat-receptor.html#cytokine">000000S[SO</a>/<a href="subs-inflamm.html#SCF">SCF</a>/<a href="subs-inflamm.html#EGF">EGF</a>/<a href="subs-inflamm.html#FGF">FGF</a>/<a href="basic-vasc.html#PDGF">PDGF</a>/<a href="subs-inflamm.html#M-CSF">M-CSF</a>/<a href="subs-inflamm.html#IGF">IGF</a>/<a href="#Eph">Eph</a>j0i0n0S[SOo0000000000WS[SOg0B000 <li>00000000WS[SOo0WS[SOg0B0000}ހ0000k000000000;m'`MOL0B0000}ހYk00000P}TMOL0B000 <li>TsNRirg0o050.z^N Nn000000000WS[SOL0w00f0D0f00S[SOkk00000L0P}TY000}ހY0000n0i L0puj000 <li>00000000Q(WWS[SO00000o000}ހYK00n0Xk00000RS00000S[Y00S0h0k00c0f0;m'`SW000}ހQ0000OTRP[x0`1X0OH000 <li>0}ހn0Rˆ0RS0b_Kab_bg0͑j0y_rR0oZ000 <li>W,gvk0o00000OX[vk0;m'`SU0000</ul> <font color="#0000cc">0[i ]</font> <ul><li>YO0o000}ހ01VY00XSϑSOh0W0f0X[(WY000 <li>MOo0XSNn000000K00j000 <li>0}ހY0000o00000n0S[SOh0W0f0PO0L00S0n0RL0%Rn00000g0000000P}Tg0,gSOk0P}TW0f0D000n00B000 <li>S[SOk00000L0P}TY00h0M00 TX0Stg02 Pn0S[SORP[L0P}TW0f002ϑSO000000~0_0o00000000 h0j000n00B000 <li>S[SOL02ϑSOSY00S0h00k0000S[SOk0Q(WY0000000000L0;m'`SU000ꁫL000xSU000h000000000000000000000XW0f00 NAmk0`1X0OTY00n0L0yr_g0B000 <li>0}ހY0000o00|0NxSg0OU000S0h0L0B000 </ul> <font color="#0000cc">0[6R_]</font> <ul><li>0000n0P}Tk000wS00S_k00c0f002.z^k0RK000 <table border=1 cellspacing=0 cellpadding=3> <tr><td valign=top nowrap><a href="anat-receptor.html#TrkA">TrkA</a><br>PDGFS[SO<br>0j0i0</td> <td valign=top><ul><li>2 Pn0S[SORP[n02ϑSOS0B00D0o000D02ϑSOn0[[S0000000000S[SOh0Y000000o0YO0L00 0YO'` multivalent 00d0~001RP[L0pen0S[SORP[k0P}TY000 <li>PDGF<a href="basic-vasc.html#PDGF">@\g1uegXkVP[</a> n0S[SOj0i0o00%Rn0^TrkAn04XTo000}ހYk0B00NGFP}T0000k0NGFL0P}TY00h00TrkAn0OTL0O2U000TrkAn0002ϑSOL0b_bU0000</ul></td></tr> <td valign=top nowrap>00000S[SO<br>0j0i0</td> <td valign=top><ul><li>0000]00xS(2ϑSOn0NeL00F0Ne000xSY00S0h0) N;m'`Wg0o00000n02d0n0000000L00ATPL0;m'`-N_k0eQ0j0D00F0j0Mn0Sc0f0D000 <li>]00xSk00c0f0000000L0Z000ATPL0eQc0f0S_g0M000F0k0j000 <li>00xS0SQ00000xL000000000k0D0O0d0K0B00p0B0D0(_0h0H0p000000iXkVP[S[SOj0i0)000xSU00_0000xL0YD0{0i00000;m'`o0 NfY000S0n04XTgRn000xSo000]00xSh0D0D00S00g00000o0 000 0K00 000000 0rKak0R0f000</ul></td></tr> </table><hr><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="Eph"></a>EphS[SO0Ephrin receptor0S<a href="https://bsd.neuroinf.jp/wiki/Eph%E5%8F%97%E5%AE%B9%E4%BD%93" target=new>1</a> <ul>erythropoietin-producing human hepatocellular receptors <li>Wn0<a href="#tyrosine">S[SOW00000000</a>n01.zg0B000<a href="#ephrin">0000</a> h0|Tp0000}ހk0X[(WY000000h0P}TY00S0h0k00c0f00}ހQk000000OTY000 <li>EphS[SO-0000n00000o00}ހXk00}ހyR0<a href="subs-gene.html#axon-guidance-proteins">^yL}"}00000</a>00000SQX'`h0D0c0_0i0j0sak0NW0f0J000 iRirJ00s0!q iRirn0-Ng^yL}|n0zvuh0zvTN zk0J0D0f0͑j0y_rR0g_0W0f0D000 <li>EphS[SOo00]0n0000xMRSs0h00000h0n0T'`n0UD0k0000EphAh0EphBn02d0n000000k0R^U00f0D000 <li>EphA0EphB00000h00k0qQW0f000}ހYWk000000000000<a href="subs-gene.html#fibronectin">00000000</a>000III000000}ހQWk00000000000000SAM00000 PDZP}T00000 gW0f0D000 <li>EphS[SOL00}ހQk000000OTY00_00k0o0000000000h0n0P}Tk0RH0f00}ހ Ng0S[SO TXL0J0ND0k0P}TY00S0h0 (clustering) L0_g0B0000000n0P}Tk0000Wn0яPk0MOnY000000h0000L000xSU000000000000000L0;m'`SU000S0h0g00 NAmRP[k000000OTY000EphS[SOo0i0j00}ހQ0000|06R_W0f0D00L00yrk0<a href="subs-gene.html#ras">Ras</a>/<a href="subs-gene.html#Rho">Rho</a>00000n0NORP[ϑG0000ꌒ0NW0_00000o00<a href="subs-gene.html#actin">0000</a>000000n0i{06R_W000}ހn0b_Ka YS0c@w'`n0NO N0B00D0o0N20\Y000 <br><br> <li>-Ng^yL}|n0zvu0zvTN zk0J0D0f00EphS[SO0NW0_00000o0yrk00Rg-Ng^yL}|n0WSk0J0Q00D}T~XLun0b_b0^yL}MRƙ0}ހn0Xkh00}ހ{k0<a href="subs-gene.html#axon-guidance-proteins">^yL}"}00000</a>h0D0c0_0sak0mO0NW0f0D000~0_0u_0bSO3g0o000000b_bn06R_0^yL}y^0}ހn0Xkh0RSk00͑j0y_rR0g_0W0f0D000 <li>΀ug^yL}MRƙ0}ހn0XkJ00s00}ހ{kn06R_ <ul><li>EphS[SOh000000000o0΀ugn0<a href="basic-neuralstemcell.html#neuroepithelial">^yL} Nv0}ހ</a>^yL}MRƙ0}ހ k0zvsW0f0J000yrk0EphA4h0ephrin-B10NW0_00000o0^yL}MRƙ0}ހn0Xk0ckk06R_W0f0D000 <li>΀ugn0<a href="basic-neuralstemcell.html#GE">'Y3vꌟSW</a>k0J0D0f00EphA7h0ephrin-A50NW0_00000o00}ހ{k0N2U0[000</ul> <li>bSO^yL}y^0}ހn0Xk0RS6R_ <ul><li>EphS[SOh000000000o0bSO3k0X[(WY00<a href="basic-neuralstemcell.html#NSC">^yL}y^0}ހ</a>h0<a href="basic-neuralstemcell.html#germinal-niche">000</a>0}ހk00zvsW0f0D000 <li>bSO<a href="basic-cortex.html#SEZ">tP3[X</a>g0o00EphA7S[SOL0<a href="basic-glia.html#ependymal"> Nc0}ހ</a>k0zvsW00^yL}y^0}ހJ00s0MRƙ0}ހk0zvsW0f0D00ephrin-A200000NW0_0eT'`0000k0000}ހXk0k06R_W0f0D000 <li><a href="basic-glia.html#astrocyte">0000000</a>J00s0yR-Nn0<a href="basic-neuralstemcell.html#neuroblast">00000000</a>k0zvsW0f0D00EphBS[SOJ00s0ephrin-BL00^yL}y^0}ހn0Xkh000000000n0yRi_06R_W0f0D000 <li>bSO<a href="basic-neuralstemcell.html#SGZ">wmokrV</a>k0J0D0f0o00^yL}MRƙ0}ހk0zvsY00EphB1J00s0EphB2L00MRƙ0}ހn0Xkh0yR0zw2U\06R_W0f0D00S0h0L01XJTU00f0D000</ul><br><br> <table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="ephrin"></a>0000 ephrin0S<a href="https://bsd.neuroinf.jp/wiki/%E3%82%A8%E3%83%95%E3%83%AA%E3%83%B3" target=new>1</a> <ul><li>S[SOW0000000000000n0Nd0g0B00<a href="#Eph">EphS[SO</a>n00000RP[n0}y <li>1994t^k0EphS[SOn00000RP[g0B00S0h0L0f0K0k0U00_0L00 Eph family receptor interacting proteins h0D0F0S0h0K0001997t^k0i0j0 Ty0q}NW0f0 0ephrin 0h0}T TU00_00 <li>TsN^g0o08.z^n00000L0X[(WW0f0J000S000o0i Nn0UD0K000<a href="#ephrin-A">AW0000</a>h0<a href="#ephrin-B">BW0000</a>k0R^U000 <table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="ephrin-A"></a>AW00000class A ephrins <ul><li>0000A10A5 <li>RP[ϑL025030 kDag0B000<a href="subs-lipid.html#GPI">000000000000000000</a>0NW0f00}ހk0P}TW0f0J000;Nk0000k0R^Y000 <li>AW0000o0^O0AWn0EphS[SOk0P}TY000 <li>0000A5o0BWEphS[SOg0B00EphB2k00P}TY000</ul></td></tr> <tr><td><a name="ephrin-B"></a>BW00000class Bephrins <ul><li>0000B10B3 <li>RP[ϑL030045 kDa <li>0}ހYW0W0]0W0f0C+gzk0PDZP}TMR0 gY000}ހQW0k00c0f0ibU000NW0000g0B000 <li>BW0000o0^O0BWn0EphS[SOk0P}TY000 <li>0000B10B3o0AWEphS[SOg0B00EphA4k00P}TY00h0D0F0OYL0w00f0D000</ul></td></tr></table> <li>00000zvsY000}ހh0EphS[SO0zvsY000}ހL0cY00h00N,k0!N0}ހk0SzvS_L0uX0!No0VNY000S0n0S_o00!N0}ހQk0J0Q000}ހ000000</a>k000R㉄0000000000k00c0f0cbK00dSU000S0h0L0_g0B00h0H000f0D000 <li>^yL}|n0zvuN zk0J0D0f000000h0EphS[SOo0W0p0W0p0puj00Wn00}ހk0zvsW0f0J000!N0}ހn0ck0000000h0EphS[SOn0vN\O(uo00^yL}0}ހn0yR0<a href="subs-gene.html#axon-guidance-proteins">^yL}"}00000</a>0 N_j0"}n0R0000000b_bj0i0k0J0D0f0͑j0y_rR0g_0W0f0D000~0_00bSOn0^yL}|k0J0D0f0000000SQX'`n0{j0i0k0_jW0f0D00S0h0L0f0K0k0j0c0f0D000 </ul></td></tr></table> </ul></td></tr> <tr><td><a name="HER2"></a>HER2/ErbB20!!<a href="analg-cancer.html#trastuzumab">0000000</a> <ul><li>0}ހhbk0X[(WY00}185 kDan0<a href="react-signal.html#glycoprotein">|0000</a>g00<a href="anat-gprotein.html#tyrosine">S[SOW00000000</a>g0B000 <li> NvbwVP[S[SO (<a href="subs-inflamm.html#EGF">EGF</a>R0%R TERBB1) k0^HER2 o00human epidermal growth factor receptor (HER/EGFR/ERBB) family(EGFR00000)k0^\Y000000g0B000 <li>HER20000o0ck8^0}ހk0J0D0f00}ހn0Xk0RSj0i0n0{k0NW0f0D00L00UO0K0n0t1ug0HER2zOP[n0XE^0zOP[ YpuL0wS00h000}ހn0Xk0RSn06R_L0g0M0j0O0j0000}ހo0`'`SY000 <li>1985t^000EGFRk0^k</a> neuroglioblastoma 0}ހ*hK00d0K0c0_0L00zOP[ neu k0NW0f0D0f00 TNn00n0h0H000_00 <li>~0_0 TBfg000<a href="pain-cancer.html#breast-cancer">sNL00</a>0}ހ0>UmzzL00g0000dtu0000 avian erythroblastic leukemia virus n00d0L00zOP[ v-erbB k0^HER2zOP[o0<a href="subs-gene.html#oncogene1">L00zOP[</a>g00B000YO0n0.z^n0L00g0zOP[XE^L000000 </ul></td></tr></table><hr><br> </ul> <a name="PTK"></a><b><font color="#0000cc">NORP[ϑGTPase0;m'`SY00S[SOW00000000 receptor tyrosine kinase</b></font>0!!<a href="subs-enzyme.html#tyrosine">00000000</a> <ul><table border=1 cellspacing=0 cellpadding=3> <tr><td><a name="Small-GTPases"></a>NORP[ϑGTPase0Small GTPases0NORP[GTPP}T0000 <ul><li>Nn0GTPP}T0000g00NORP[ϑ20-25 kDa n00n00D0F00 <li>RP[ϑL020-30kDah0<a href="anat-gprotein.html#gpcr">G0000</a>00\U0D0_00k0 S0F0|Tp00f0D000 <li>00000 N00x<a href="#GTP">GTP</a> 0P}TW00R4lRW0f0GDP00000N00x h0W00U00k0]0n0GDP0GTPk0NcY00S0h0g000}ހQ0000OTn00000_j0g_0Y00 <li>000 NϑSOG0000h0o0puj000GDPP}TW N;m'`W B00D0o0GTPP}TW;m'`W h0W0f0XSϑSOg0X[(WW0f0D000 <li>;m'`SU00_0G0000o000}ހn0ui'`0KR00}ހQir806R_Y000PTK NAmn000xS00000k0008hQk00RTW0_00000o0⎙Q6R_VP[0{Y00S0h0g0zOP[n0zvs06R_Y000 <li>G0000h0 Tik00GDPh0P}TW0f0D00o0_j0c_0Z0OFF 0GTPk0P}TW0f0;m'`WON h0j0c0f000000OTY000 <li>S0n0NORP[G0000n0 YcONh0OFF o00GDP/GTP Exchange ProteinGEPh00GTPase activating proteinGAPh0k00c0f0Lj00000<li>Nhvj00n0h0W0f0L00zOP[<a href="subs-gene.html#ras">ras</a>n0#uirL0B000D0Z000S00h0n0v T'`L0ؚD0n0g00Ras000000000h00|Tv00<br><br> <a name="Ras"></a> <li>Ras0000000005d0n00000000L0s(Ww00f0D000 <table border=1 cellspacing=0 cellpadding=3> <tr><td valign=top>Ras000000!!<a href="subs-gene.html#ras">ras</a>/<a href="subs-gene.html#Rho">Rho</a>/<a href="subs-gene.html#Rac">Rac</a> <ul><li>C+gzL03_O0000Sprenylation 0SQ0f0D00n0g00ꌌN͑k0@\(WW0f0D000 <li>zOP[zvsk0N <li><a href="anat-gprotein.html#tyrosine">00000000WS[SO</a>K00n00000OTL}k0B0000}ހXk{k0NY000 <li>vcS[SOk000;m'`SU000S0h0L0^O0<fU00f0D00NORP[ϑGTPo00<a nhref="sybs-gene.html#Ras">Ra</a>sn00g0B000Ras0;m'`SY00S[o0000000S[SOk0NhU00000000000WS[SOg0B000</ul></td></tr> <tr><td valign=top><a name="Rho"></a>Rho000000!!<a href="subs-enzyme.html#Rhok">Rho-k</a> <ul><li>C+gzL03_O0000Sprenylation)0SQ0f0D00n0g00ꌌN͑k0@\(WW0f0D000 <li><a href="#PTK">NORP[ϑGTPase</a>n01d0g00<a href="#GTP">GTP</a>h0P}TW0_0;m'`Wh0GDPh0P}TW0_0 N;m'`Wg0X[(WY000 <li>zOP[zvsk0N00}ހ000000000x<a href="subs-lipid.html#LPA">LPA</a> j0i0n00}ހY0000n0 NAmg0;Nk0<a href="subs-gene.html#actin">0000</a>|n0<a href="subs-gene.html#CSK">0}ހ0NW0f00<a href="react-nervinj.html">^yL} dP</a>0<a href="subs-gene.html#stress-fiber">000000000</a>0c@wen0b_b0s^nK{S.~j0i006R_W0f0D00S0h0L0w00f0D000</ul></td></tr> <tr><td valign=top>Rab00000 <ul><li>C+gzL03_O(0000Sprenylation)0SQ0f0D00n0g00ꌌN͑k0@\(WW0f0D000 <li>\ހ8k0N</ul></td></tr> <tr><td valign=top>Arf/Sar00000 <ul><li>\ހ8k0N <li>8h00}ހꌓ8k0N</ul></td></tr> <tr><td valign=top><a name="Ran"></a>Ras-related nuclear proteinRan000000RanGTP0!!<a href="subs-gene.html#ras">ras</a> <ul><li><a href="subs-gene.html#NLS">8hyL</a>k0NY00<a href="anat-gprotein.html#PTK">NORP[ϑGTPP}T0000</a> <li>Rano00}ހ"8hn080 g|Rˆn0!}SOƖT0<a href="subs-gene.html#microtubules">_\{</a>i{08hb_b06R_Y000 <li>8hQk0Kp00_00000ꌒ0080000g0B00<a href="subs-gene.html#importin">000000</a>K00U0[000 <li>0}ހXk0L00Sh0n0#01XJTU00f0D000</ul></td></tr></table></ul></td></tr></table> <li>J0n0J0n0n0NORP[ϑGTPaseo000}ހQn0E^^D0;mRk0V gn0_j0zvcW0f0J000S[SO0000n0F|k0X[(WY000n0L0YD00n0h0N`U00f0D000 </ul> <br><br><table border=0 align=right vlaign=bottom><tr> <td bgcolor="#0000cc"><a href="index.html" target="_top"><font color="#ffffff"><b>Pain Relief</b></font></a></td> <td><a href="../index.html" target="_top"><img src="../IMG/bee.gif" border=0 width=20 height=21></a></td></tr></table> </body> </html>