業績

2018

1. Li P, Kurata Y, Endang M, Ninomiya H, Higaki K, Taufiq F, Morikawa K, Shirayoshi Y, Horie M, Hisatome I. Restoration of mutant hERG stability by inhibition of HDAC6. J Mol Cell Cardiol 115: 158-169, 2018
2. Wu J, Mizusawa Y, Ohno S, Ding W-G, Higaki T, Wang Q, Makiyama T, Itoh H, Toyoda F, James AF, Hancox JC, Matsuura H, Horie M. Who is the pathogenic culprit? A LQTS family with three compound genetic mutations. Scientific Reports. 08. 762, 2018
3. Ueshima S, Hira D, Kimura Y, Fujii R, Tomitsuka C, Yamane T, Tabuchi Y, Ozawa T, Itoh H, Ohno S, Horie M, Terada T, Katsura T. Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation. Br J Clin Pharmacol. 84 :1301-1312. 2018
4. Suzuki S, Arima H, Miyazaki S, Fujiyoshi A, Kadota A, Takashima N, Hisamatsu T, Kadowaki S, Zaid M, Torii S, Horie M, Murata K, Miura K, Ueshima H, for the SESSA Research Group. Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men. J Atheroscler Thromb 25: 186-198, 2018
5. Fukumoto D, Ding W-G, Wada Y, Fujii Y, Ichikawa M, Takayama K, Fukuyama M, Kato K, Itoh H, Makiyama T, Omatsu-Kanbe M, Matsuura H, Horie M, Ohno S. Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome. J Cardiol 71: 401-408, 2018
6. Tomita Y, Nakae I, Hayashi H, Ozawa T, Horie M. Utility of phase standard deviation and histogram bandwidth by "Heart Function View" analysis as a clinical indicator of heart failure. Ann Nucl Cardiol (in press)
7. Toyota T, Morimoto T, Shiomi H, Yamaji K, Ando K, Ono K, Shizuta S, Saito N, Kato T, Kaji S, Furukawa Y, Nakagawa Y, Kadota K, Horie M, Kimura T, CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators. Single-session versus staged procedures for elective multivessel percutaneous coronary intervention. Heart. 104: 936-944. 2018
8. Inoue Y, Aiba T, Sakaguchi T, Mitsuma W, Morita H, Takaki H, Toyohara K, Kanaya Y, Itoi T, Mitsuhashi T, Sumitomo N, Cho Y, Yasuda S, Ogawa H, Kamakura S, Kusano KF, Horie M, Shimizu W. Different responses of ventricular arrhythmias to exercise between andersen-tawil syndrome and catecholaminergic polymorphic ventricular tachycardia. Europace. 20: 1675-1682. 2018
9. Pham T, Fujiyoshi A, Arima H, Tanaka-Mizuno S, Hisamatsu T, Kadowaki S, Kadota A, Zaid M, Sekikawa A, Yamamoto T, Horie M, Miura K, Ueshima H, for the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group. Association of coronary artery calcification with estimated coronary heart disease risk from prediction models in a community-based sample of Japanese men: The shiga epidemiological study of subclinical atherosclerosis (SESSA). J Atheroscler Thromb. 1;25: 477-489. 2018
10. Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Nakazawa K, Tsuchiya T, Horie M, Ashihara T: Not all rotors, effective ablation targets for nonparoxysmal atrial fibrillation, are included in areas suggested by conventional indirect indicators of atrial fibrillation drivers: ExTRa Mapping project. J Arrhythm 34:176-184,2018
11. Yagi N, Itoh H, Hisamatsu T, Tomita Y, Kimura H, Fujii Y, Makiyama T, Horie M, Ohno S. A Challenge for mutation specific risk stratification in long QT syndrome type 1. J Cardiol. 72:56-65. 2018
12. Sonoda K, Ohno S, Ozawa J, Hayano M, Hattori T, Kobori A, Yahata M, Aburadani I, Watanabe S, Matsumoto Y, Makiyama T, Horie M. Copy number variations of SCN5A in brugada syndrome. Heart Rhythm .15 :1179-1188. 2018
13. Hisamatsu T, Miura K, Fujiyoshi A, Kadota A, Miyagawa N, Satoh A, Zaid M, Yamamoto T, Horie M, Ueshima H, for the SESSA Research Group. Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study. Atherosclerosis .273: 145-152. 2018
14. Miyata K, Ohno S, Itoh H, Horie M. Bradycardia is a specific phenotype of catecholaminergic polymorphic ventricular tachycardia induced by RYR2 mutations. Intern Med. 1; 57 : 1813-1817. 2018
15. Ashihara T. Real-time imaging of clinical non-paroxysmal atrial fibrillation by newly developed online real-time phase mapping system: The ExTRa Mapping project from Japan. APHRS Newsletter 36:3-6,2018
16. Murayama T, Ogawa H, Kurebayashi N, Ohno S, Horie M, Sakurai T. A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity. Communications Biology. 23; 1:98. 2018
17. Hisamatsu T, Miura K, Ohkubo T, Arima H, Fujiyoshi A, Satoh A, Kadota A, Zaid M, Takashima N, Ohno S, Horie M, Ueshima H, SESSA Research Group. Home blood pressure variability and subclinical atherosclerosis in multiple vascular beds: a population-based study. J Hypertens. 36 (11) :2193-2203. 2018
18. Ozawa J, Ohno S, Fujii Y, Makiyama T, Suzuki H, Saitoh A, Horie M. Differential diagnosis between catecholaminergic polymorphic ventricular tachycardia and long QT syndrome type 1- modified Schwartz score. Circ J. 82: 2269-2276, 2018
19. Hisamatsu T, Miura K, Arima H, Fujiyoshi A, Kadota A, Kadowaki S, Zaid M, Miyagawa N, Satoh A, Kunimura A, Horie M, Ueshima H; SESSA Research Group. Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study. Int J Cardiol 267:177-182, 2018
20. Wuriyanghai Y, Makiyama T, Sasaki K, Kamakura T, Yamamoto Y, Hayano M, Harita T, Nishiuchi S, Chen J, Kohjitani H, Hirose S, Yokoi F, Gao J, Chonabayashi K, Watanabe K, Ohno S, Yoshida Y, Kimura T, Horie M. Complex aberrant splicing in the induced pluripotent stem cell-derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation. Heart Rhythm .15 : 1566-1574. 2018
21. Baruteau A, Kyndt F, Behr ER, MD, Vink AS, Lachaud M, Joong A, Schott J-J, Horie M, Denjoy I, Crotti L, Shimizu W, Bos JM, Stephenson A, Wong L, Abrams DJ, Davis AM, Winbo A, Dubin AM, Sanatani S, Liberman L, Kaski JP, Rudic B, Kwok SY, Rieubland C, Tfelt-Hansen J, Van Hare GF, Guyomarc’h-Delasalle B, Blom NA, Gourraud J-B, Le Marec H, Ozawa J, Fressart V, Lupoglazoff J-M, Dagradi F, Spazzolini C, Aiba T, Tester DJ, Zahavich LA, Beauséjour-Ladouceur V, Jadhav M, Skinner J, Franciosi S, Krahn AD, Abdelsayed M, Ruben PC, Yung T-C, Ackerman MJ, Wilde AA, Schwartz PJ, Probst V. SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups. European Heart Journal. 14; 39 : 2879-2887. 2018
22. Horie M. Extensive diversity of molecular mechanisms underlying the congenital long QT syndrome type 1. Canadian Journal of Cardiology. 34.: 1108-1109､ 2018
23. Fujita S, Nishida K, Irabu H, Nakagawa R, Futatani T, Igarashi N, Usuda K, Nagata Y, Ohno S, Horie M, Hatasaki K. Catecholaminergic polymorphic ventricular tachycardia managed as orthostatic dysregulation and epilepsy in 11-and 15-year-old sisters. Pediatric International. 60: 998-1001. 2018
24. Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Kato K, Yamamoto Y, Doi T, Shizuta S, Onoue K, Yagihara N, Ishikawa T, Watanabe I, Kawakami H, Oginosawa Y, Murakoshi N, Nogami A, Aonuma K, Saito Y, Kimura T, Yasuda S, Makita N, Shimizu W, *Horie M*, Kusano K. Clinical Manifestations and Long-Term Mortality in Lamin A/C Mutation Carriers From a Japanese Multicenter Registry. Circ J. 25; 2707-2714. 2018
25. Aoki H. Horie M. Electrical disorders in atrial septal defect: genetics and heritability. J Thorac Dis. 10：S2848-S2853, 2018
26. Miyatake H, Fujino K, Tanaka S, Tsujita Y, Horie M, Eguchi Y. Association between lymphocyte count and neurological outcomes in post-cardiac arrest patients treated with mild therapeutic hypothermia. Acute Med Surg. 6: 30-39, 2018.

2018年症例報告

1. Saito A, Ohno S, Nuruki N, Nomura Y, Horie M, Yoshinaga M. Three cases of catecholaminergic polymorphic ventricular tachycardia with prolonged QT intervals including two cases of compound mutations. J Arrhythmia 6; 34 (3): 291-293.2018
2. Ozawa J, Ohno S, Saito H, Saitoh A, Matsuura H, Horie M. A novel CACNA1C mutation identified in a patient with Timothy syndrome without syndactyly exerts both marked loss-and-gain of function effects. Heart Rhythm Case Reports. 31; 4 (7):273-277. 2018
3. Kise H, Ohno S, Kono Y, Yoshizawa M, Harama D, Okafuji A, Toda T, Koizumi K, Hoshiai M, Sugita K, Horie M. Electrical storm in an infant with short-coupled variant of torsade de pointes.J Arrhythm 34:315-318, 2018
4. Nakagawa Y, Nishikimia T, Sakai H, Ohno S, Kinoshita H, Inazumi H, Moriuchi K, Kuwahara K, Horie M, Kimura T. Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP: Case report. Clin Biochem 52: 148-152, 2018

2017

1. Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochem Biophys Rep 9: 245–256, 2017
2. Kubo T, Ashihara T, Tsuboutchi T, Horie M. Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates. J Pharmacol Toxicol Methods 83: 30-41, 2017
3. Toyota T, Morimoto T, Shiomi H, Ando K, Ono K, Shizuta S, Kato T, Saito N, Furukawa Y, Nakagawa Y, Horie M, Kimura T, CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators. Ad hoc vs. Non-ad hoc percutaneous cronary intervention strategies in patients with stable coronary artery disease. Circ J 81: 458-467, 2017
4. Ishikawa T, Ohno S, Murakami T, Yoshida K, Mishima H, Fukuoka T, Kimoto H, Sakamoto R, Ohkusa T, Aiba T, Nogami A, Sumitomo N, Shimizu W, Yoshiura KI, Horigome H, Horie M, Makita N. Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction. Heart Rhythm 14: 717-724, 2017
5. Fujii Y, Matsumoto Y, Hayashi K, Ding WG, Tomita Y, Fukumoto D, Wada Y, Ichikawa M, Sonoda K, Ozawa J, Makiyama T, Ohno S, Yamagishi M, Matsuura H, Horie M, Itoh H. Contribution of a KCNH2 variant in genotyped long QT syndrome: Romano-Ward syndrome under double mutations and acquired long QT syndrome under heterozygote. J Cardiol 70: 74-79, 2017
6. Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Hayano M, Nishiuchi S, Kohjitani H, Hirose S, Chen J, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Motomura H, Yoshida Y, Horie M, Makita N, Kimura T. Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT Syndrome with a CALM2 Mutation. Hum Mol Genet 26: 1670-1677, 2017
7. Ishibashi K, Aiba T, Kamiya C, Miyazaki A, Sakaguchi H, Wada M, Nakajima I, Miyamoto K, Okamura H, Noda T, Yamauchi T, Itoh H, Ohno S, Motomura H, Ogawa Y, Goto H, Minami T, Yagihara N, Watanabe H, Hasegawa K, Terasawa A, Mikami H, Ogino K, Nakano Y, Imashiro S, Fukushima Y, Tsuzuki Y, Asakura K, Yoshimatsu J, Shiraishi I, Kamakura S, Miyamoto Y, Yasuda S, Akasaka T, Horie M, Shimizu W, Kusano K. Arrhtyhmia risk and β-blocker therapy in pregnant women with long QT syndrome. Heart 103: 1374-1379, 2017
8. Hayashi H, Wu Q, Horie M. The relationship between J waves and contact of lung cancer with the heart. Ann Noninvasive Electrocardiol 22, 2017
9. Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Fukuda K, Watanabe H, Morita H, Hayashi K, Kusano K, Kamakura S, Yasuda S, Ogawa H, Kapplinger JD, Ackerman MJ,  Shimizu W. Genotype-phenotype correlation of SCN5A mutation for the clinical and electrocardiographic characteristics of probands with Brugada syndrome: A Japanese multicenter registry. Circulation 135: 2255-2270, 2017
10. Aoki H, Nakamura T, Horie M, Ohno S, Makiyama T, Takemura T. Cardiac conduction defects and brugada syndrome: A Family with overlap syndrome carrying a nonsense SCN5A mutation. J Arrhythm 33: 35-39, 2017
11. Taniguchi T, Shiomi H, Morimoto T, Watanabe H, Ono K, Shizuta S, Kato T, Saito N, Kaji S, Ando K, Kadota K, Furukawa Y, Nakagawa Y, Horie M, Kimura T. Incidence and prognostic impact of heart failure hospitalization during follow-up after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. Am J Cardiol 119: 1729-1739, 2017
12. Aonuma K, Shiga T, Atarashi H, Doki K, Echizen H, Hagiwara N, Hasegawa J, Hayashi H, Hirao K, Ichida F, Ikeda T, Maeda Y, Matsumoto N, Sakaeda T, Shimizu W, Sugawara M, Totsuka K, Tsuchishita Y, Ueno K, Watanabe E, Hashiguchi M, Hirata S, Kasai H, Matsumoto Y, Nogami A, Sekiguchi Y, Shinohara T, Sugiyama A, Sumitomo N, Suzuki A, Takahashi N, Yukawa E, Homma M, Horie M, Inoue H, Ito H, Miura T, Ohe T, Shinozaki K, Tanaka K. Japanese circulation society and the Japanese society of therapeutic drug monitoring joint working group: Guidelines for therapeutic drug monitoring of cardiovascular drugs cinical use of blood drug concentration monitoring (JCS 2015) - Digest Version. Circ J 81: 581-612, 2017
13. Kimura Y, Noda T, Matsuyama T, Otsuka Y, Kamakura T, Wada M, Ishibashi K, Inoue Y, Miyamoto K, Okamura H, Nagase S, Aiba T, Kamakura S, Noguchi T, Anzai T, Satomi K, Wada Y, Ohno S, Horie M, Shimizu W, Yasuda S, Shimokawa H, Kusano K. Heart failure in patients with arrhythmogenic right ventricular cardiomyopathy: what are the risk factors? Int J Cardiol 241: 288-294, 2017
14. Hayano M, Makiyama T, Kamakura T, Watanabe H, Sasaki K, Funakoshi S, Wuriyanghai Y, Nishiuchi S, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Yokoi F, Chen J, Baba O, Horie T, Chonabayashi K, Ohno S, Toyoda F, Yoshida Y, Ono K, Horie M, Kimura T. Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy. Circ J 81: 1783-1791, 2017
15. Turker I, Ai T, Itoh H, Horie M. Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes. Pharmacol Ther 176: 48-59,  2017
16. Horie M. Long QT syndrome presents not only as QT prolongation but also as abnormal T-wave morphology. Heart Rhythm 14: 1171-1172,  2017
17. Ueshima S, Hira D, Fujii R, Kimura Y, Tomitsuka C, Yamane T, Tabuchi Y, Ozawa T, Itoh H, Horie M, Terada T, Katsura T. Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation. Pharmacogenet Genomics27: 329-336, 2017
18. Shirai Y, Goya M, Ohno S, Horie M, Doi S, Isobe M, Hirao K. Elimination of ventricular arrhythmia in catecholaminergic polymorphic ventricular tachycardia by targeting “catecholamine-sensitive area”: a dominant-subordinate relationship between origin sites of bidirectional ventricular premature contractions. Pacing Clin Electrophysiol. 40: 600-604, 2017
19. Sonoda K, Ohno S, Otsuki S, Kato K, Yagihara N, Watanabe H, Makiyama T, Minamino T, Horie M. Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion. Europace 19: 644-650, 2017
20. Hata J, Nagai A, Hirata M, Kamatani Y, Tamakoshi A, Yamagata Z, Muto K, Matsuda K, Kubo M, Nakamura Y, Biobank Japan Cooperative Hospital Group (Collaborators:Ashihara T), Kiyohara Y, Ninomiya T, Collaborator. Risk prediction models for mortality in patients with cardiovascular disease: The BioBank Japan project.　J Epidemiol 27: S71-S76, 2017
21. Seki A, Ishikawa T, Daumy X, Mishima H, Barc J, Sasaki R, Nishii K, Saito K, Urano M, Ohno S, Otsuki S, Kimoto H, Baruteau AE, Thollet A, Fouchard S, Bonnaud S, Parent P, Shibata Y, Perrin JP, Le Marec H, Hagiwara N, Mercier S, Horie M, Probst V, Yoshiura KI, Redon R, Schott JJ, Makita N. Progressive Atrial Conduction Defects Associated With Bone Malformation Caused by a Connexin-45 Mutation. J Am Coll Cardiol 70: 358-370, 2017
22. Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T. Gene-based risk stratification for cardiac disorders in LMNA mutation carriers. Circ Cardiovasc Genet 10: e001603, 2017
23. Li M, Kanda Y, Ashihara T, Sasano T, Nakai Y, Kodama M, Hayashi E, Sekino Y, Furukawa T, Kurokawa J. Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs. J Pharmacol Sci 134: 75-85, 2017
24. Inada S, Shibata N, Iwata M, Haraguchi R, Ashihara T, Ikeda T, Mitsui K, Dobrzynski H, Boyett MR, Nakazawa K. Simulation of ventricular rate control during atrial fibrillation using ionic channel blockers. J Arrhythm. 33: 302-309, 2017
25. Wada Y, Ohno S, Aiba T, Horie M. Unique genetic background and outcome of non-Caucasian Japanese probands with arrhythmogenic right ventricular dysplasia/cardiomyopathy. Mo Genet Genomic Med 5: 639-651, 2017
26. Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK. Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue. Nat Commun 8: 1078, 2017 
27. Kojima A, Shikata F, Okamura T, Higaki T, Ohno S, Horie M, Uchita S, Kawanishi Y, Namiguchi K, Yasugi T, Izutani H. Refractory ventricular fibrillations after surgical repair of atrial septal defects in a patient with CACNA1C gene mutation. J Cardiothorac Surg 12: 118, 2017
28. Fujii Y, Itoh H, Ohno S, Murayama T, Kurebayashi N, Aoki H, Blancard M, Nakagawa Y, Yamamoto S, Matsui Y, Ichikawa M, Sonoda K, Ozawa T, Ohkubo K, Watanabe I, Guicheney P, Horie M. A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsade de pointe ventricular arrhythmia. Heart Rhythm 14: 98-107, 2017
29. Komatsu Y, Nogami A, Kurosaki K, Morishima I, Masuda K, Ozawa T, Kaneshiro T, Hanaki Y, Shinoda Y, Talib AK, Kowase S, Sekiguchi Y, Aonuma K. Fascicular ventricular tachycardia originating from papillary muscles: Purkinje network involvement in the reentrant circuit. Circ Arrhythm Electrophysiol. 10, 2017
30. Watanabe E, Okajima K, Shimane A, Ozawa T, Manaka T, Morishima I, Asai T, Takagi M, Honda T, Kasai A, Fujii E, Yamashiro K, Kohno R, Abe H, Noda T, Kurita T, Watanabe S, Ohmori H, Nitta T, Aizawa Y, Kiyono K, Okumura K. Inappropriate implantable cardioverter defibrillator shocks-incidence, effect, and implications for driver licensing. J Interv Card Electrophysiol. 49:271-280, 2017

2017年症例報告

1. Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri HV, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AAM. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Europace 19: 665-694. 2017

2016

2. Ichikawa M, Ohno S, Fujii Y, Ozawa J, Sonoda K, Fukuyama M, Kato K, Kimura H, Itoh H, Hayashi H, Horie M. Multigenerational inheritance of long QT syndrome type 2 in a Japanese family. Internal Med 55: 259-262, 2016
3. Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Sasaki K, Hayano M, Harita T, Nishiuchi S, Yamamoto Y, Ueyama T, Shimizu A, Horie M, Kimura T. Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction. Heart Rhythm 13: 289-298, 2016
4. Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, for the ACCESS and SESSA Research Group. Lipoprotein-associated phospholipase A2 related to the risk of subclinical atherosclerosis independent of small low density lipoprotein particles in a general Japanese population. Athelosclerosis 246: 141-147,  2016
5. Kaitani K, Inoue k, Kobori A, Nakazawa Y, Ozawa T, Kurotobi T, Morishima I, Miura F, Watanabe T, Masuda M, Naito M, Fujimoto H, Nishida T, Furukawa Y, Shirayama T, Tanaka M, Okajima K, Yao T, Egami Y, Satomi K, Noda T, Miyamoto K, Haruna T, Kawaji T, Yoshizawa T, Toyota T, Yahata M, Nakai K, Sugiyama H, Higashi Y, Ito M, Horie M, Kusano K, Shimizu W, Kamakura S, Morimoto T, Kimura T, on behalf of the EAST-AF Trial Investigators. Efficacy of Antiarrhythmic drugs Short-Term use after catheter ablation for Atrial Fibrillation (EAST-AF) trial. Euro Heart J 37: 610-618, 2016
6. Wada Y, Aiba T, Tsujita Y, Itoh H, Wada M, Nakajima I, Ishibashi K, Okamura H, Miyamoto K, Noda T, Sugano Y, Kanzaki, T Anzai, Kengo Kusano H, Yasuda S, Horie M, Ogawa H. Practical applicability of landiolol, an ultra-short-acting β1-selective blocker, for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction. J Arrhythm 82–88, 2016
7. Toyota T, Shiomi H, Taniguchi T, Morimoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T. Culprit vessel only versus staged multivessel percutaneous coronary intervention strategies in patients with multivessel coronary artery disease undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Circ J 80: 371-378, 2016
8. Baruteau AE, Perryd JC, Sanatanie S, Horie M, Walshg EP, Dubin AM. Evaluation and management of bradycardia in neonates and children. Eur J Pediatr 175: 151-161, 2016
9. Zaid M, Miura K, Fujiyoshi A, Abbott RD, Hisamatsu T, Kadota A, Arima H, Kadowaki S, Torii S, Miyagawa N, Suzuki S, Takashima N, Ohkubo T, Sekikawa A, Maegawa H, Horie M, Nakamura Y, Okamura T, Ueshima H, for the SESSA Research group. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification. J Clin Lipidol 10: 1195-1202, 2016
10. Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y, Arandel L, Jollet A, Thibault C, Philipps M, Vicaire S, Jost B, Udd B, Day JW, Duboc D, Wahbi K, Matsumura T, Fujimura H, Mochizuki H, Deryckere F, Kimura T, Nukina N, Ishiura S, Lacroix V, Campan-Fournier A, Navratil V, Chautard E, Auboeuf D, Horie M, Imoto K, Lee KY, Swanson MS, Lopez de Munain A, Inada S, Itoh H, Nakazawa K, Ashihara T, Wang E, Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N. Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy. Nat Commun 7: 11067, 2016
11. Hayashi K, Konno T, Fujino N, Itoh H, Sakata K, Tada H, Tsuda T, Nagata Y, Teramoto R, Tanaka Y, Fujii Y, Imi-Hashida Y, Saito T, Kawashiri M, Ohta K, Horie M, Yamagishi M. Impact of updated diagnostic criteria for long QT syndrome on clinical detection of diseased patients: Results from study of patients carrying gene mutations. JACC Clin Electrophysiol 2: 279-287, 2016
12. Yamazoe M, Hisamatsu T, Miura K, Kadowaki S, Zaid M, Kadota A, Torii S, Miyazawa I, Fujiyoshi A, Abbott RD, Arima H, Sekikawa A, Maegawa H, Horie M, Ueshima H, for the SESSA Research Group. Relationship of insulin resistance to prevalence and progression of coronary artery calcification beyond metabolic syndrome components: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).Arteriosclerosis, Thrombosis, and Vascular Biology 36: 1703-1708, 2016
13. Itoh H, Crotti L, Aiba T, Spazzplini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M. The genetics underlying acquired long QT syndrome: Impact on genetic screening. Euro Heart J 37: 1456-1464, 2016
14. Nakatsuma K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Yamamoto T, Suwa S, Horie M, Kimura T, on behalf of the CREDO-Kyoto AMI investigators. Inter-facility transfer versus direct admission in patients with ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Circ J 80: 477-484, 2016
15. Kawata H, Ohno S, Sumitomo N, Funasako M, Kamakura T, Nakajima I, Sakaguchi H, Miyazaki A, Miyamoto K, Inoue YY, Okamura H, Noda T, Aiba T, Kusano KF, Kamakura S, Horie M, Shimizu W. Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) associated with Ryanodine Receptor (RyR2) gene mutations: Long term prognosis and utility of an exercise stress test after initiation of medical treatment. Circ J 80: 1907-1915, 2016
16. Fukuyama M, Ohno S, Makiyama T, Horie M. Novel SCN10A variants associated with Brugada syndrome. 
    Europace 18: 905-911, 2016
17. Horie M. Molecular genetics have opened a new era for arrhythmia research, but also Pandora’s Box? J Arrhythm 32: 313-314, 2016
18. Juang J-M, Horie M. Genetics of Brugada syndrome. J Arrhythm 32: 418-425, 2016
19. Ohno S. The genetic background of arrhythmogenic right ventricular cardiomyopathy. J Arrhythm 32: 398-403, 2016
20. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N. Variants in the SCN5A promoter associated with various arrhythmia phenotypes.  JAHA 5, 2016
21. Ozawa J, Ohno S, Hisamatsu T, Itoh H, Makiyama T, Suzuki H, Saitoh A, Horie M. Pediatric cohort with long QT syndrome: KCNH2 mutation carriers have late onset but severe symptoms. Circ J 80: 696-702, 2016.
22. Hisamatsu T, Miura K, Arima H, Kadota A, Kadowaki S, Torii S, Suzuki S, Miyagawa N, Sato A, Yamazoe M, Fujiyoshi A, Ohkubo T, Yamamoto T, Murata K, Abbott RD, Sekikawa A, Horie M, Ueshima H, for the SESSA Research Group. Smoking, smoking cessation, and measures of subclinical atherosclerosis in multiple vascular beds in Japanese men. JAHA 5, 2016
23. Turker I, Makiyama T, Vatta M, Sohma Y, Itoh H, Ueyama T, Shimizu A, Ai T, Horie M. A novel SCN5A variant associate with drug-induced Brugada Syndrome. Plos ONE 11: e0161872, 2016
24. Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AA. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Heart Rhythm 13:e295-324, 2016
25. Watanabe T, Ohno S, Shirai M, Endoh A, Hongo T, Ueta I, Yoshimoto J. Inherited catecholaminergic polymorphic ventricular tachycardia due to RYR2 mutation. Pediatr Int 58: 512-515, 2016
26. Hasegawa K, Watanabe H, Hisamatsu T, Ohno S, Itoh H, Ashihara T, Hayashi H, Makiyama T, Minamino T, Horie M. Early repolarization and risk of arrhythmia events in long QT syndrome. Int J Cardiol 223: 540-542, 2016
27. Ichikawa M, Aiba T, Ohno S, Shigemizu D, Ozawa J, Sonoda K, Fukuyama M, Itoh H, Minamoto Y, Tsunoda T, Makiyama T, Tanaka T, Shimizu W, Horie M. Phenotypic variability of ANK2 mutations in patients with inherited primary arrhythmia syndromes. Circ J 80: 2435- 2442, 2016
28. Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Itoh H, Kawamura M, Ohno S, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T. Patient-specificHuman induced pluripotent stem cell model assessed with electrical pacing validates S107 as a potential therapeutic agent for catecholaminergic polymorphic ventricular tachycardia. PlosOne 11: e0164795, 2016
29.  Itoh H, Berthet M, Fressart V, Denjoy I, Maugenre S, Klug D, Mizusawa Y, Makiyama T, Hofman N, Shimizu W, Wilde AAM, Schulze-Bahr E, Horie M, Tezenas du Montcel S, Guicheney P. Asymmetry of parental origin in long QT syndrome. Preferential maternal transmission of KCNQ1 variants linked to channel dysfunction Euro J Hum Genet 24: 1160-1166, 2016
30. Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Li M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T, Fukuda K. Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Sci Rep 6: 34198, 2016
31. Hayashi H, Iwai K, Tobita R, Matsumoto T, Horie M. The relationship between skeletal muscle and ventilatory response to exercise in myocardial infarction. IJC Metabolic and Endocrine 12: 14-18, 2016
32. Wu J, Ding W-G, Horie M. Molecular pathogenesis of long QT syndrome type 1. J Arrhythm 32: 381-388,2016
33. Okamura T, Miura K, Sawamura T, Kadota A, Hisamatsu T, Fujiyoshi A, Miyamatsu N, Takashima N, Miyagawa N, Kadowaki T, Ohkubo T, Murakami Y, Nakamura Y, Ueshima H, SESSA Research Group. Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese. J Clin Lipidol 10 :172-80, 2016
34. Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K, Fujimoto T, Sakurai T, Kurebayashi N. Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors
    caused by cytosolic and luminal Ca2+ hypersensitivity. J Gen Physiol 149:199-218, 2016
35. Hayashi H, Wu Q, Horie M. Association between progressive intraventricular conduction disturbance and cardiovascular events. PLOS ONE 12: 14-18, 2016
36. Sonoda K, Watanabe H, Hisamatsu T, Ashihara T, Ohno S, Hayashi H, Horie M, Minamino T. High frequency of early repolarization and Brugada-type electrocardiograms in hypercalcemia. Ann Noninvasive Electrocardiol 21:30-40, 2016
37. Aizawa Y, Takatsuki S, Kaneko Y, Noda T, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Fukumoto K, Niwano S, Kurita T, Mitsuhashi T, Kamakura S, Shimizu A, Horie M, Aizawa Y, Fukuda K. Comparison of circadian, weekly, and seasonal variations of electrical storms and single events of ventricular fibrillation in patients with Brugada syndrome. Int J Cardiol Heart Vasc 11: 104-110, 2016
38. Kato K,  Takahashi N, Fujii Y, Umehara A, Nishiuchi S, Makiyama T, Ohno S, Horie M.LMNA cardiomyopathy detected in Japanese arrhythmogenic right ventricular cardiomyopathy cohort. J Cardiol 68: 346-351,2016

2016年症例報告

1. Antzelevitch C, Yan G-X, Ackerman M-J, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam G-B, Sacher F, Shimizu W, Viskin S, Wilde AAM. J-wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Heart Rhythm 13: e295-324, 2016
2. Antzelevitch C, Yan G-X, Ackerman M-J, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam G-B, Sacher F, Shimizu W, Viskin S, Wilde AAM. J-wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. J Arrhythm 32: 315-339, 2016

2015

1. Hisamatsu T, Miura K, Fujiyoshi A, Okamura T, Ohkubo T, Nagasawa SY, Horie M, Okayama A, Ueshima H, for the NIPPON DATA80 Research Group. Long-term outcomes associated with prolonged PR interval in the general Japanese population. Int J Cardiol.184: 291-293, 2015
2. Miyamoto K, Aiba T, Kimura H, Hayashi H, Ohno S, Yasuoka C, Tanioka Y, Tsuchiya T, Yoshida Y, Hayashi H, Tsuboi I, Nakajima I, Ishibashi K, Okamura H, Noda T, Ishihara M, Anzai T, Yasuda S, Miyamoto Y, Kamakura S, Kusano K, Ogawa H, Horie M, Shimizu W. Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutation. Heart Rhythm 12: 596-603, 2015
3. Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y, Horie M. Mosaic KCNJ2 mutation in andersen-tawil syndrome: targeted deep sequencing is useful for the detection of mosaicism. Clinical Genetics 87: 279-283, 2015
4. Wada Y, Aiba T, Matsuyama T, Nakajima I, Ishibashi K, Miyamoto K, Yamada Y, Okamura H, Noda T, Satomi K, Morita Y, Kanzaki H, Kusano K, Anzai T, Kamakura S, Ishibashi-Ueda H, Shimizu W, Horie M, Yasuda S, Ogawa H. Clinical and pathological impact of tssue fibrosis on lethal arrhythmic events in hypertrophic cardiomyopathy patients with impaired systolic function. Circ J. 79: 1733-1741, 2015
5. Itoh H, Dochi K, Shimizu W, Ohno S, Aiba T, Kimura H, Kato K, Fukuyama M, Hasegawa K, Schulze-Bahr E, Guicheney P, Horie M. A common mutation of long QT Syndrome type 1 in Japan. Circ J. 79: 2026-2030, 2015
6. Ohno S, Hasegawa K, Horie M. Gender differences in the inheritance mode of RYR2 mutations in catecholaminergic polymorphic ventricular tachycardia patients. PLOS One 10: e0131517, 2015
7. Sawayama Y, Itoh H, Sakai H, Horie M. Löffler endocarditis and lacking heart. Intern Med. 54: 3093, 2015 
8. Torii S, Arima H, Ohkubo T, Fujiyoshi A, Kadota A, Takashima N, Kadowaki S, Hisamatsu T, Saito Y, Miyagawa N, Zaid M, Murakami Y, Abbott RD, Horie M, Miura K, Ueshima H. Association between pulse wave velocity and coronary artery calcification in Japanese men: the Shiga epidemiological study of subclinical atherosclerosis . J Atheroscler Thromb. 22: 1266-1277, 2015
9. Watanabe H, Shiomi H, Nakatsuma K, Morimoto T, Taniguchi T, FurukawaY, Nakagawa Y, Horie M, Kimura T, CREDO‐Kyoto AMI investigators, Kimura T, Sakata R, Marui A, Matsuda M, Mitsuoka H, Onoe M, Nakagawa Y, Yamanaka K, Fujiwara H, Takatsu Y, Ohno N, Nohara R, Murakami T,Takeda T, Nobuyoshi M, Iwabuchi M, Hanyu M, Tatami R, Matsushita T, Shirotani M, Nishiwaki N, Kita T, Furukawa Y, Okada Y, Kato H, Eizawa H, Is K, Tanaka M, Nakayama S, Lee JD, Nakano A, Koshiji T, Morioka K, Takizawa A, Shimamoto M, Yamazaki F, Takahashi M, Nishizawa J, Horie M, Takashima H, Tamura T, Aota M, Takahashi M, Tabata T, Tei C, Hamasaki S, Imoto Y, Yamamoto H, Kambara H, Doi O, Matsuda K, Nara M, Mitsudo K, Kadota K, Komiya T, Miki S, Mizoguchi T, Nakajima H, Ogawa H, Sugiyama S, Kawasuji M, Moriyama S, Hattori R, Aoyama T, Araki M, Suwa S, Tanbara K, Kitagawa K, Yamauchi M, Okamoto N, Fujino Y, Tezuka S, Saeki A, Hanazawa M, Sato Y, Hibi C, Sasae H, Takinami E, Uchida Y, Yamamoto Y, Nishida S, Yoshimoto M, Maeda S, Miki I, Minematsu S, Abe M, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Tokushige A, Natsuaki M, Nakajima T. Clinical efficacy of thrombus aspiration on 5-Year clinical outcomes in patients with ST-Segment elevation acute myocardial infarction undergoing percutaneous coronary intervention. J Am Heart Assoc 4: e001962, 2015
10. Watanabe H, Morimoto T, Natsuaki M, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Kato M, Suwa S, Takizawa A, Takatsu Y, Shinoda E, Eizawa H, Takeda T, Lee JD, Inoko M, Ogawa H, Hamasaki S, Horie M, Nohara R, Kambara H, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kastrati A, Kimura T, CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Antiplatelet therapy discontinuation and the risk of serious cardiovascular events after coronary stenting: observations from the CREDO-Kyoto Registry Cohort-2. PLoS One 10: e0124314, 2015
11. Hayashi H, Horie M. The association of J wave and ventricular tachycardia before device implantation with device interventions for ventricular tachyarrhythmia. J Electrocardiol 48: 721-728, 2015
12. Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, Ozawa T, Kurotobi T, Morishima I, Miura F, Watanabe T, Masuda M, Naito M, Fujimoto H, Nishida T, Furukawa Y, Shirayama T, Tanaka M, Okajima K, Yao T, Egami Y, Satomi K, Noda T, Miyamoto K, Haruna T, Kawaji T, Yoshizawa T, Toyota T, Yahata M, Nakai K, Sugiyama H, Higashi Y, Ito M, Horie M, Kusano K, Shimizu W, Kamakura S, Kimura T, on behalf of the UNDER-ATP Trial Investigators. Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking Dormant Electrical Reconduction by Adenosine TriPhosphate (UNDER-ATP) trial. European Heart Journal 36: 3276-3287, 2015
13. Zaid M, Miura K, Fujiyoshi A, Abbott RD, Hisamatsu T, Kadota A, Arima H, Kadowaki S, Torii S, Miyagawa N, Suzuki S, Takashima N, Ohkubo T, Sekikawa A, Maegawa H, Horie M, Nakamura Y, Okamura T, Ueshima H, for the SESSA Research group. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification. Journal of Clinical Lipidology 10(5): 1195-1202, 2015
14. Hayashi H, Horie M. Biphasic P wave in inferior leads and the development of atrial fibrillation. J Arrhythm31: 376-378, 2015
15. Kaitani K, Inoue k, Kobori A, Nakazawa Y, Ozawa T, Kurotobi T, Morishima I, Miura F, Watanabe T, Masuda M, Naito M, Fujimoto H, Nishida T, Furukawa Y, Shirayama T, Tanaka M, Okajima K, Yao T, Egami Y, Satomi K, Noda T, Miyamoto K, Haruna T, Kawaji T, Yoshizawa T, Toyota T, Yahata M, Nakai K, Sugiyama H, Higashi Y, Ito M, Horie M, Kusano K, Shimizu W, Kamakura S, Morimoto T, Kimura T, on behalf of the EAST-AF Trial Investigators. Efficacy of Antiarrhythmic drugs Short-Term use after catheter ablation for Atrial Fibrillation (EAST-AF) trial. European Heart Journal 37: 610-618, 2015
16. Fukuyama M, Ohno S, Makiyama T, Horie M. Novel SCN10A variants associated with Brugada syndrome．Europace 18: 905-911, 2015
17. Nakatsuma K, Shiomi H, Morimoto T, Ando K, Kadota K, Watanabe H, Taniguchi T, Yamamoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T, CREDO-Kyoto AMI investigators. Intravascular ultrasound guidance vs. angiographic guidance in primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Long-term clinical outcomes from the CREDO-Kyoto AMI registry. Circ J 80: 477-484, 2016
18. Harrell DT, Ashihara T, Ishikawa T, Tominaga I, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori SG, Makita N. Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome. Int J Cardiol 190: 393-402, 2015
19. Zaid M, Fujiyoshi A, Miura K, Abbott RD, Okamura T, Takashima N, Torii S, Saito Y, Hisamatsu T, Miyagawa N, Ohkubo T, Kadota A, Sekikawa A, Maegawa H, Nakamura Y, Mitsunami K, Ueshima H, SESSA Research group. High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men. Atherosclerosis 239(2): 444-50, 2015

2015年症例報告

2014

1. Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M. A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels. Heart Rhythm 11: 67-75, 2014
2. Hayashi H, Miyamoto A, Kawaguchi T, Naiki N, Xue J, Murakami Y, Horie M. P-pulmonale and the development of atrial fibrillation. Circ J. 78: 329-337, 2014
3. Kato K, Makiyama T, Wu J, Ding WG, Kimura H, Naiki N, Ohno S, Itoh H, Nakanishi T, Matsuura H, Horie M. Cardiac channelopathies associated with infantile fatal ventricular arrhythmias, from the cradle to the bench. J Cardiovasc Electrophysiol 25: 66-73, 2014
4. Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, Bai J, Hasegawa K, Shinohara T, Takahashi N, Shimizu A, Matsuura H, Horie M. Gain-of-Function KCNH2 Mutations in Patients with Brugada Syndrome.　J Cardiovasc Electrophysiol 25: 522-530, 2014
5. Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, Ushinohama H, Makita N, Horie M. Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction. Europace 16: 1646-1654, 2014
6. Kokunai Y, Nakata T, Furuta M, Sakata S, Kimura H, Aiba T, Yoshinaga M, Osaki Y, Nakamori M, Itoh H, Sato T, Kubota T, Kadota K, Shindo K, Mochizuki H, Shimizu W, Horie M, Okamura Y, Ohno K, Takahashi MP. A Kir3.4 mutation causes Andersen–Tawil syndrome by an inhibitory effect on Kir2.1. Neurology 82: 1058-1064, 2104
7. Sakata S, Kurata Y, Li P, Notsu T, Morikawa K, Miake J, Higaki K, Yamamoto Y, Yoshida A, Shirayoshi Y, Yamamoto K, Horie M, Ninomiya H, Kanzaki S, Hisatome I. Instability of KCNE1-D85N that causes long QT syndrome: stabilization by verapamil. PACE 37: 853-863, 2014
8. Zhou J, Ding WG, Makiyama T, Miyamoto A, Matsumoto Y , Kimura H, Tarutani Y, Zhao J, Wu J, Zang WJ, Matsuura H, Horie M. A Novel HCN4 Mutation, G1097W, is associated with atrioventricular block. Circ J.78: 938-942, 2014
9. Hayashi H, Kawaguchi T, Horie M. Effect of Flecainide on T-wave Alternans in Andersen-Tawil Syndrome. Ann Noninvasive Electrocardiol. 19: 383-386, 2014
10. Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G. Brugada syndrome in spinal and bulbar muscular atrophy (SBMA). Neurology 82: 1813-1821, 2014
11. Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M, Okayama A, Ueshima H, NIPPON DATA80 Research Group. High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population. J Cardiol. 64: 218-224,2014
12. Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int J Cardiol. 172: 519-522, 2014
13. Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Kato M, Suwa S, Takizawa A, Takatsu Y, Shinoda E, Eizawa H, Takeda T, Lee JD, Inoko M, Ogawa H, Hamasaki S, Horie M, Nohara R, Kambara H, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, on behalf of the CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Late Adverse Events After Implantation of Sirolimus-Eluting Stent and Bare-Metal Stent: Long-Term (5-7 Years) Follow-Up of the Coronary Revascularization Demonstrating Outcome Study-Kyoto Registry Cohort-2. Circ Cardiovasc Interv 7: 168-179, 2014
14. Wu J, Naiki N, Ding WG, Ohno S, Kato K, Zang WJ, Delisle BP, Matsuura H, Horie M. A molecular mechanism for adrenergic-induced long QT Syndrome. J Am Coll Cardiol 63: 819-827, 2014
15. Yoshinaga M, Kucho Y, Sarantuya J, Ninomiya Y, Horigome H, Ushinohama H, Shimizu W, Horie M. Genetic characteristics of children and adolescents with long QT syndrome diagnosed by school-based electrocardiographic screening programs. Circ Arrhythm Electrophysiol 7: 107-112, 2014
16. Bartos DC, Giudicessi JR, Tester DJ, Ackerman MJ, Ohno S, Horie M, Gollob MH, Burgess DE, Delisle BP. A KCNQ1 Mutation Contributes to the Concealed Type 1 Long QT Phenotype by Limiting the Kv7.1 Channel Conformational Changes Associated with PKA Phosphorylation. Heart Rhythm 11: 459-468, 2014
17. Fukuyama M, Ohno S, Wang Q, Shirayama T, Itoh H, Horie M. Nonsense-mediated mRNA decay due to a CACNA1C splicing mutation in a patient with Brugada syndrome. Heart Rhythm 11:629-634, 2014
18. Fukuyama M, Wang Q, Kato K, Ohno S, Ding WG, Toyoda F, Itoh H, Kimura H, Makiyama T, Ito M, Matsuura H, Horie M. Long QT syndrome Type8: novel CACNA1C mutations causing QT prolongation and variant phenotypes. Europace 16: 1828-1837, 2014
19. Abe Y, Sumitomo N, Okuma H, Nakamura T, Fukuhara J, Ichikawa R, Matsumura M, Miyashita M, Kamiyama H, Ayusawa M, Watanabe M, Joo K, Makita N, Horie M. Successful control of life-threatening polymorphic ventricular tachycardia by radiofrequency catheter ablation in an infant. Heart Vessels 29: 422-426, 2014
20. Hasegawa K, Ohno S, Itoh H, Makiyama T, Aiba T, Nakano Y, Shimizu W, Matsuura H, Horie M. A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome. J Arrhythm. 30: 161-166, 2014
21. Nakatsuma k, Shiomi H, Watanabe H, Morimoto T, Taniguchi T, Toyota T, Furukawa Y, Nakagawa Y, Horie M, Kimura T, on behalf of the CREDO-Kyoto AMI investigators.Comparison of Long-term Mortality After Acute Myocardial Infarction Treated by Percutaneous Coronary Intervention in Patients Living Alone versus Not Living Alone at the Time of Hospitalizatio. Am J Cardiol 114: 522-527, 2014
22. Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsuaki M, Yahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, Kadota K, Takatsu Y, Tamura T, Takizawa A, Inada T, Doi O, Nohara R, Matsuda M, Takeda T, Kato M, Shirotani M, Eizawa H, Ishii K, Lee JD, Takahashi M, Horie M, Takahashi M, Miki S, Aoyama T, Suwa S, Hamasaki S, Ogawa H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, CREDO-Kyoto Registry Cohort-2 Investigators. Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention Am J Cardiol. 114: 70-78, 2014
23. Fujii K, Ozeki Y, Okayasu H, Takano Y, Shinozaki T, Hori H, Orui M, Horie M, Kunugi H, Shimoda K. QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects. PLoS One9: e98555, 2014
24. Watanabe E, Tanabe T, Osaka M, Chishaki A, Takase B, Niwano S, Watanabe I, Sugi K, Katoh T, Takayanagi K, Mawatari K, Horie M, Okumura K, Inoue H, Atarashi H, Yamaguchi I, Nagasawa S, Moroe K, Kodama I, Sugimoto T, Aizawa Y. Sudden cardiac arrest recorded during Holter monitoring: Prevalence, antecedent electrical events, and outcomes. Heart Rhythm 11: 1418-1425, 2014
25. Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Kadota A, Kadowaki S, Kadowaki T, Yamamoto T, Miyagawa N, Zaid M, Torii S, Takashima N, Murakami Y, Okamura T, Horie M, Ueshima H, for the SESSA Research Group. Lipoprotein particle profiles compared with stazdard lipids in association with coronary artery calcification in the general Japanese population. Atherosclerosis 236(2): 237-243, 2014
26. Nakae I, Hayashi H, Matsumoto T, Mitsunami K, Horie M. Clinical usefulness of a novel program "Heart Function View" for evaluating cardiac function from gated myocardial perfusion SPECT. Ann Nucl Med 28: 812-823, 2014
27. Furukawa S, Morita S, Okunaga H, Wingenfeld L, Takaya A, Nakagawa T, Sakaguchi I, Yamamoto Y, Ashihara T, Horie M, Nishi K, Hitosugi M. An autopsic examination case of diagnosed Brugada syndrome. J Intern Med 2: 79-82, 2014
28. Kaneko Y, Horie M, Niwano S, Kusano K, Takatsuki S, Kurita T, Mitsuhashi T, Nakajima T, Irie T, Hasegawa K, Noda T, Kamakura S, Aizawa Y, Yasuoka R, Torigoe K, Suzuki H, Ohe T, Shimizu A, Fukuda K, Kurabayashi M, Aizawa Y. Electrical Storm in Patients with Brugada syndrome is Associated with Early Repolarization. Circ Arrhythm Electrophysiol 7: 1122-1128, 2014
29. Aizawa Y, Sato M, Ohno S, Horie M, Takatsuki S, Fukuda K, Chinushi M, Usui T, Aonuma K, Hosaka Y, Haissaguerre M, Aizawa Y. Circadian Pattern of Fibrillatory Events in non-Brugada-Type Idiopathic Ventricular Fibrillation with a Focus on J waves. Heart Rhythm 11: 2261-2266, 2014
30. Taniguchi T, Shiomi H, Toyota T, Morimoto T, Akao M, Nakatsuma K, Ono K, Makiyama T, Shizuta S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Horie M, Kimura T. Effect of Preinfarction Angina Pectoris on Long-term Survival in Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention. Am J Cardiol 114: 1179-1186, 2014
31. Shiomi H, Morimoto T, Makiyama T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Onodera T, Takatsu Y, Mitsudo K, Kita T, Sakata R, Okabayashi H, Hanyu M, Komiya T, Yamazaki F, Nishiwaki N, Kimura T; CREDO-Kyoto Investigators. Evolution in practice patterns and long-term outcomes of coronary revascularization from bare-metal stent era to drug-eluting stent era in Japan. Am J Cardiol 113: 1652-1659, 2014
32. Mizusawa Y, Horie M, Wilde AA. Genetic and Clinical Advances in Congenital Long QT Syndrome. Circ J 78: 2827-2833, 2014
33. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class i antiarrhythmic drugs: A simulation study.PLoS ONE 9: e109271, 2014
34. Konishi S, Minaguchi H, Masuda M, Ashihara T, Okuyama Y, Ohtani T, Sakata Y. Self-terminated long-lasting ventricular fibrillation: What is the mechanism? J Cardiol Cases 10:136-139, 2014

2014年症例報告

1. Hasegawa K, Ashihara T, Kimura H, Jo H, Itoh H, Yamamoto T, Aizawa Y, Horie M. Long-term Pharmacological Therapy of Brugada Syndrome: Is Attenuation of J waves a Marker of Drug Efficacy? Intern Med 53: 1523-1526, 2014
2. Wijeyeratne YD, Muggenthaler M, Batchvarov V, Tanck M, Schott JJ, Kyndt F, Probst V, Shimizu W, Borggrefe M, McKeown P, Papadakis M, Veltmann C, Horie M, Crotti L, Schwartz P, Sharma S, Makita N, Roden D, Behr ER. Ethnicity and phenotype in the SCN5A E1784K mutation. Europace 16 (suppl_3): iii7, 2014

2013

1. Villafane J, Atallah J, Gollob MH, Maury P, Wolpert C, Gebauer R, Watanabe H, Horie M, Anttonen O, Kannankeril P, Faulknier B, Bleiz J, Makiyama T, Hamilton R, Young M-L. Long Term Follow-up of a Pediatric Cohort with Short QT Syndrome. J Am Coll Cardiol 61: 1183-1191, 2013
2. Wu J, Ding WG, Zhao J, Zang WJ, Matsuura H, Horie M. Irbesartan-mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes. J Renin Angiotensin Aldosterone Syst. 15: 341-347, 2014
3. Nakano Y, Chayama K, Ochi H, Toshisige M, Hayashida Y, Miki D, Hayes C. N, Suzuki H, TokuyamaT, Oda N, Suenari K, Uchimura-MakitaY, KajiharaK, Sairaku A, Motoda C, Fujiwara M, WatanabeY, YoshidaY, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ono S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y. A nonsynonymous polymorphism in Semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLOS Genetics 9: e1003364, 2013
4. Wang Q, Ohno S, Kato K, Fukuyama M, Makiyama T, Kimura H, Naiki N, Kawamura M, Hayashi H, Horie M. Genetic Screening of KCNJ8 in Japanese Patients with J-wave Syndromes or Idiopathic Ventricular Fibrillation. J Arrhythm. 29: 261-264, 2013
5. Ohno S, Nagaoka I, Fukuyama M, Kimura H, Itoh H, Makiyama T, Shimizu A, Horie M. Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/ dysplasia. Circ J. 77: 1534-1542, 2013
6. Duchatelet S, Crotti L, Peat R, Denjoy I, Itoh H, Berthet M, Ohno S, Fressart V, Monti C, Crocamo C, Pedrazzini M, Dagradi F, Vicentini A, Klug D, Brink P, Goosen A, Heikki S, Toivonen L, Lahtinen A, Kontula K, Shimizu W, Horie M, George Jr. AL, Tregouet DA, Guicheney P, Schwartz PJ. Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long QT syndrome. Circ Cardiovasc Genet. 6: 354-361, 2013
7. Takagi M, Aonuma K, Sekiguchi Y, Yokoyama Y, Aihara N, Hiraoka M, FHRS. The prognostic value of early repolarization (J wave) and ST- segment morphology after J wave in Brugada syndrome: Multicenter study in Japan. Heart Rhythm 10: 533-539, 2013
8. Dochi K, Watanabe H, Kawamura M, Miyamoto A, Ozawa T, Nakazawa Y, Ashihara T, Ohno S, Hayashi H, Ito M, Sakazaki H, Kawata H, Ushinohama H, Kaszynski RH, Minamino T, Sumitomo N, Shimizu W, Horie M. Flecainide reduces ventricular arrhythmias via different actions from β-blockers in catecholaminergic polymorphic ventricular tachycardia. J Arrhythm. 29: 255-260, 2013
9. Fukuyama M, Ohno S, Wang Q, Kimura H, Makiyama T, Itoh H, Ito M, Horie M. L-type calcium channel mutations in Japanese patients with inherited arrhythmias. Circ J. 77: 1799-1806, 2013
10. Kawamura M, Ohno S, Naiki N, Nagaoka I, Dohchi K, Wang Q, Hasegawa K, Kimura H, Miyamoto A, Mizusawa Y, Itoh H, Makiyama T, Sumitomo N, Ushinohama H, Oyama K, Murakoshi N, Aonuma K, Horigome H, Honda T, Yoshinaga M, Ito M, Horie M. Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan. Circulation J. 77: 1705-1713, 2013
11. Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H; NIPPON DATA90 Research Group. The Association between J-point elevation and death from coronary heart disease: a 15-year follow-up of the NIPPON DATA90. Circ J 77: 1260-1266, 2013
12. Aizawa Y, Chinushi M, Hasegawa K, Naiki N, Horie M, Kaneko Y, Kurabayashi M, Ito S, Imaizumi T, Aizawa Y, Takatsuki S, Joo K, Sato M, Ebe K, Hosaka Y, Haissaguerre M, Fukuda K. Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization. J Am Coll Cardiol 62: 1015-1019, 2013
13. Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Matsumura Y, Yoshita K, Kita Y, Murakami Y, Okamura T, Horie M, Okayama A, Ueshima H for the NIPPON DATA80 Research Group. Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men. Heart 99: 1024-1029, 2013
14. Watanabe H, van der Werf C, Roses-Noguer F, Adler A, Sumitomo N, Veltmann C, Rosso R, Bhuiyan ZA, Bikker H, Kannankeril PJ, Horie M, Minamino T, Viskin S, Knollmann BC, Till J, Wilde AA. Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 10: 542-547, 2013
15. Horie M, Ohno S. Genetic basis of Brugada syndrome. J Arrhythm 29: 71–76, 2013
16. Tazaki J, Shiomi H, Morimoto T, Imai M, Yamaji K, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T. Three-year outcome after percutaneous coronary intervention and coronary artery bypass grafting in patients with triple vessel coronary artery disease: observations from the CREDO-Kyoto PCI/CABG registry cohort-2. Eurointervention 9: 437-445, 2013
17. Morikami Y, Natsuaki M, Morimoto T, Ono K, Nakagawa Y, Furukawa Y, Sakata R, Aota M, Okada Y, Onoe M, Kawasuji M, Koshiji T, Nakajima H, Nishizawa J, Yamanaka K, Yamamoto H, Kimura T; CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revascularization: An observation from the CREDO-Kyoto Registry Cohort-2. Atherosclerosis 228: 426-431, 2013
18. Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T. Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture. Circ J. 77: 1307-1314, 2013
19. Nakae I, Hayashi H, Mitsunami K, Horie M. Clinical significance of lung iodine-123 metaiodobenzylguanidine uptake assessment in Parkinson's and heart diseases. Ann Nucl Med 27: 737–747, 2013
20. Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Marec HL, Wilde AA, Probst V, Schott JJ, Dina C, Redon R. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature Genetics 45: 1044-1049, 2013
21. Hayashi H, Murakami Y, Horie M. Pitfall of the meta-analysis regarding early repolarization pattern. J Am Coll Cardiol 62: 86, 2013
22. Smith JL, Reloj AR, Nataraj PS, Bartos DC, Schroder EA, Moss AJ, Ohno S, Horie M, Anderson CL, January CT, Delisle BP. Pharmacological Correction of Long QT-linked Mutations in KCNH2 (hERG) Increases the Trafficking of Kv11.1 Channels Stored in the Transitional ER. Am J Physiol Cell Physiol 305:C919-930, 2013
23. Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5. Circ J 77: 959-967, 2013
24. Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa A, Kadota A, Takashima N, Nagasawa S, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H. Is more aggressive prevention of coronary artery disease required for patients with early repolarization syndrome?--Reply. Circ J 77: 1643, 2013
25. Kawaguchi T, Hayashi H, Naiki N, Sakai H, Yamamoto T, Fujita M, Horie M. Spontaneous coronary artery spasm accidentally detected by 320-row multi-detector computed tomography．J Cardiology Cases8:e85-e87, 2013
26. Nakae I, Hayashi H, Mitsunami K, Horie M. Clinical significance of lung iodine-123 metaiodobenzylguanidine uptake assessment in Parkinson’s and heart diseases. Ann Nucl Med 27: 737-747,2013
27. Barc J, Bezzina C, Mizusawa Y, Remme C, Gourraud J, Verkerk A, Schwartz P, Guicheney P, Antzelevitch C, Schulze-Bahr E, Behr E, Tfelt-Hanson J, Kaab S, Watanabe H, Horie M, Makita N, Shimizu W, Roden D, Christoffels V, Gessler M, Wilde A, Probst V, Schott J, Dina C, Redon R. Genome-wide association analysis identifies 3 common variants predisposing to brugada syndrome, a rare disease with high risk of sudden cardiac death. Heart Rhythm 10: 1743-1744, 2013
28. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C. HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes: Document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 10: 1932-1963, 2013
29. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C, Document Reviewers, Ackerman M, Belhassen B, Estes NA, Fatkin D, Kalman J, Kaufman E, Kirchhof P, Schulze-Bahr E, Wolpert C, Vohra J, Refaat M, Etheridge SP, Campbell RM, Martin ET, Quek SC. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace 15: 1389-1406, 2013
30. Hayashi H, Shibukawa T, Horie M. Restoration of aberrant conduction induced by premature ventricular contractions. Intern Med 52:1425, 2013
31. Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H, SESSA Research Group, NIPPON DATA80/90 Research Group. Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). J Atheroscler Thromb 20: 755-766, 2013
32. Okamura T, Sekikawa A, Sawamura T, Kadowaki T, Barinas-Mitchell E, Mackey RH, Kadota A, Evans RW, Edmundowicz D, Higashiyama A, Nakamura Y, Abbott RD, Miura K, Fujiyoshi A, Fujita Y, Murakami Y, Miyamatsu N, Kakino A, Maegawa H, Murata K, Horie M, Mitsunami K, Kashiwagi A, Kuller LH, Ueshima H, ERA JUMP Study Group. LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. Atherosclerosis 229:240-245, 2013
33. Abe A, Fujino T, Fukunaga S, Yuzawa H, Sato H, Suzuki T, Kobayashi K, Okano Y, Nakamura K, Yusu S, Yoshino H, Ashihara T, Nakazawa K, Ikeda T. Prevalence and prognosis of patients with lone and paroxysmal atrial tachyarrhythmias showing Brugada-type electrocardiograms after class IC antiarrhythmic drug administration but no risk-stratifying factors. J Arrhythm 29:138-142, 2013
34. Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Mitsui K, Boyett MR, Dobrzynski H, Nakazawa K. Simulation study of complex action potential conduction in atrioventricular node. Conf Proc IEEE Eng Med Biol Soc 2013: 6850-6853, 2013

2013年症例報告

1. Watanabe H, Ohkubo K, Watanabe I, Matsuyama M, Ishibashi-Ueda H, Yagihara N, Shimizu W, Horie M, Minamino T, Makita N. SCN5A mutation associated with ventricular fibrillation, early repolarization, and concealed myocardial abnormalities. Int J Cardiol 165: e21-3, 2013
2. Nakajima S, Makiyama T, Hanazawa K, Kaitani K, Amano M, Hayama Y, Onishi N, Tamaki Y, Miyake M, Tamura T, Kondoh H, Motooka M, Izumi C, Nakagawa Y, Horie M. A novel SCN5A mutation presenting a variety of clinical phenotypes in familial sick sinus syndrome. Inter Med 52: 1805-1808, 2013

2012

1. Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Ito M, Horie M, Trayanova NA. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation implications for electrogram-based catheter ablation. Circ Res 110: 275-284, 2012
2. Ijiri T, Ashihara T, Umetani N, Igarashi T, Haraguchi R, Yokota H, Nakazawa K. A kinematic approach for efficient and robust simulation of cardiac beating motion. PLoS ONE 7: e36706, 2012
3. Yamazaki M, Honjo H, Ashihara T, Harada M, Sakuma I, Nakazawa K, Trayanova N, Horie M, Kalifa J, Jalife J, Kamiya K, Kodama I. Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts. Heart Rhythm 9: 107-114, 2012
4. Kato S, Honjo H, Takemoto Y, Takanari H, Suzuki T, Okuno Y, Opthof T, Sakuma I, Inada S, Nakazawa K, Ashihara T, Kodama I, Kamiya K. Pharmacological blockade of IKs destabilizes spiral-wave reentry under β-adrenergic stimulation in favor of its early termination. J Pharmacol Sci 119: 52-63, 2012
5. Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Ito H, Sugimoto Y, Ito M, Makiyama T, Xue JQ, Murakami Y, Horie M. Clinical and electrocardiographic characteristics of patients with short QT interval in a largehospital-based population. Heart Rhythm 9: 66-74, 2012
6. Shizuta S, Ando K, Nobuyoshi M, Ikeda T, Yoshino H, Hiramatsu S, Kazatani Y, Yamashiro K, Okajima K, Kajiya T, Kobayashi Y, Kato T, Fujii S, Mitsudo K, Inoue K, Ito H, Haruna Y, Doi T, Nishio Y, Ozasa N, Nishiyama K, Kita T, Morimoto T, Kimura T, for the PREVENT-SCD Investigators. Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction: the PREVENT-SCD study. Clin Res Cardiol 101: 89-99, 2012
7. Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H, Yokode M, Kita T, Horie M, Kimura T. A novel gain-of-function KCNJ2 mutation associated with short QT syndrome impairs inward rectification of Kir2.1 currents. Cardiovasc Res 93: 666-673, 2012
8. Makita N, Seki A, Sumitomo N, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR., Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AAM, Probst V, Marec HL, Delmar M, Roden DM, Mochizuki N, Schott JJ. A Connexin 40 mutation associated with a malignant variant of familial progressive heart block type-1. Circ Arrhythm Electrophysiol 5: 163-172, 2012
9. Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M, Shizuta S, Tomohisa Tada T, Tazaki J, Shiomi H, Kato Y, Hayano M, Abe M, Ehara N, Mizoguchi T, Mitsuoka H, Inada T, Araki M, Kaburagi S, Taniguchi R, Eizawa H, Nakano A, Tei C, Horie M, Ogawa H, Tamura T, Shirotani M, Takahashi M, Ishii I, Tatami R, Suwa T, Takizawa A, Takahashi M, Takeda T, Nohara R, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, on behalf of the CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Comparison of three-year clinical outcomes after transradial versus transfemoral percutaneous coronary intervention. Am J Cardiol110: 924-932, 2012
10. Wu J, Ding WG, Matsuura H, Horie M. Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors. Pflugers Arch 463: 625-633, 2012
11. Aizawa Y, Sato A, Watanabe H, Chinushi M, Furushima H, Horie M, Kaneko Y, Imaizumi T, Okubo K, Watanabe I, Shinozaki T, Aizawa Y, Fukuda K, Joo K, Haissaguerre M. Dynamicity of the J wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J wave. J Am Coll Cardiol 59: 1948-1953, 2012
12. Okayasu H, Ozeki Y, Fujii K, Takano Y, Saeki Y, Hori H, Horie M, Higuchi T, Kunugi H, Shimoda K. Pharmachotherapeutic determinants for QTc interval prolongation in Japanese patients with mood disorder. Pharmacopsychiatry 45: 279-283, 2012
13. Kinoshita T, Asai T, Suzuki T, Matsubayashi K, Horie M. Time course and prognostic implications of QT interval in patients with coronary artery disease undergoing coronary bypass surgery. J Cardiovasc Electrophysiol 23: 645-649, 2012
14. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Response to letter regarding article, "Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization". Circ Arrhythm Electrophysiol 5: e60-e61, 2012
15. Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang WJ, Ito M, Matsuura H, Horie M. Phenotype variability in patients carrying KCNJ2 mutations. Circ Cardiovasc Genet 5: 344-353, 2012
16. Shiomi H, Morimoto T, Hayano M, Furukawa Y, Nakagawa Y, Tazaki J, Imai M, Yamaji K, Tada T, Natsuaki M, Saijo S, Funakoshi S, Nagao K, Hanazawa K, Ehara N, Kadota K, Iwabuchi M, Shizuta S, Abe M, Sakata R, Okabayashi H, Hanyu M, Yamazaki F, Shimamoto M, Nishiwaki N, Imoto Y, Komiya T, Horie M, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators. Comparison of long-term outcome after percutaneous coronary intervention versus coronary artery bypass grafting in patients with unprotected left main coronary artery disease (from the CREDO-Kyoto PCI/CABG Registry Cohort-2). Am J Cardiol 110: 924-932, 2012
17. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol 159: 238-240, 2012
18. Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie M, Kamiya K, Kodama I, Ogawa S, Fukuda K. Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc Res 95: 419-429, 2012
19. Tokushige A, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M, Shizuta S, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Ehara N, Inada T, Kaburagi S, Hamasaki S, Tei C, Nakashima H, Ogawa H, Tatami R, Suwa S, Takizawa A, Nohara R, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Incidence and outcome of surgical procedures after coronary bare-metal and drug-eluting stent implantation: a report from the CREDO-Kyoto PCI/CABG registry cohort-2. Circ Cardiovasc Interv 5: 237-246, 2012
20. Tada T, Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Byrne RA, Kastrati A, Kadota K, Iwabuchi M, Shizuta S, Tazaki J, Shiomi H, Abe M, Ehara N, Mizoguchi T, Mitsuoka H, Inada T, Araki M, Kaburagi S, Taniguchi R, Eizawa H, Nakano A, Suwa S, Takizawa A, Nohara R, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators. Duration of dual antiplatelet therapy and long-term clinical outcome after coronary drug-eluting stent implantation: landmark analyses from the CREDO-Kyoto PCI/CABG Registry Cohort-2. Circ Cardiovasc Interv 5: 381-391, 2012
21. Shiomi H, Nakagawa Y, Morimoto T, Furukawa Y, Nakano A, Shirai S, Taniguchi R, Yamaji K, Nagao K, Suyama T, Mitsuoka H, Araki M, Takashima H, Mizoguchi T, Eisawa H, Sugiyama S, Kimura T, CREDO-Kyoto AMI investigators. Association of onset to balloon and door to balloon time with long term clinical outcome in patients with ST elevation acute myocardial infarction having primary percutaneous coronary intervention: observational study. BMJ 344: e3257, 2012
22. Takigawa M, Kawamura M, Noda T, Yamada Y, Miyamoto K, Okamura H, Satomi K, Aiba T, Kamakura S, Sakaguchi T, Mizusawa Y, Itoh H, Horie M, Shimizu W. Seasonal and circadian distributions of cardiac events in genotyped patients with congenital long QT syndrome. Circ J 76: 2112-2118, 2012
23. Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding WG, Matsuura H, Kurabayashi M, Horie M. KCNE3 T4A as a genetic background of Brugada-pattern electrocardiogram. Circ J 76: 2763-2772, 2012
24. Kawaguchi T, Hayashi H, Miyamoto A, Yoshino T, Taniguchi A, Naiki N, Sugimoto Y, Ito M, Xue J-Q, Murakami Y, Horie M. Prognostic implications of progressive cardiac conduction disease. Circ J 77: 60-7, 2012
25. Momomura S, Tsutsui H, Sugawara Y, Ito M, Mitsuhashi T, Fukamizu S, Noro M, Matsumoto N, Tejima T, Sugi K. Clinical efficacy of cardiac resynchronization therapy with an implantable defibrillator in a Japanese population: results of the MIRACLE-ICD outcome measured in Japanese indication (MOMIJI) study. Circ J76: 1911-1919, 2012
26. Isono T, Matsumoto T, Wada A, Suzaki M, Chano T. A global transcriptome analysis of a dog model of congestive heart failure with the human genome as a reference. J Card Fail 18: 872-8, 2012
27. Burgess DE, Bartos DC, Reloj AR, Campbell KS, Johnson JN, Tester DJ, Ackerman MJ, Fressart V, Denjoy I, Guicheney P, Moss AJ, Ohno S, Horie M, Delisle BP. High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K(+) permeation. Biochemistry 51: 9076-85, 2012

2012 年症例報告

1. Horie M, Nakazawa Y, Ito M, Ozawa T. Prolonged ventricular asystole and acquired Brugada syndrome. Intern Med 51: 1799, 2012
2. Kaneshiro T, Naruse Y, Nogami A, Tada H, Yoshida K, Sekiguchi Y, Murakoshi N, Kato Y, Horigome H, Kawamura M, Horie M, Aonuma K. Successful catheter ablation of bidirectional ventricular premature contractions triggering ventricular fibrillation in catecholaminergic polymorphic ventricular tachycardia with RyR2 mutation. Circ Arrhythm Electrophysiol 5: e14-e17, 2012
3. Hayashi H, Kitoh K, Mitsunami K, Horie M. Agranulocytosis immediately after oral administration of cibenzoline and dabigatran in a patient with paroxysmal atrial fibrillation. Intern Med 51: 1987-1990, 2012
4. Lin L, Horigome H, Nishigami N, Ohno S, Horie M, Sumazaki R. Drug-induced QT-interval prolongation and recurrent torsade de pointes in a child with heterotaxy syndrome and KCNE1 D85N polymorphism. J Electrocardiol 45: 770-773, 2012
5. Yoshino T, Hayashi H, Nakae I, Horie M. J-point elevation induced by double master two-step test. Intern Med 51: 1941, 2012

2011

1. Haraguchi R, Ashihara T, Namba T, Tsumoto K, Murakami S, Kurachi Y, Ikeda T, Nakazawa K. Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias. Circ J75: 80-88, 2011
2. Trayanova N, Constantino J, Ashihara T, Plank G. Modeling defibrillation of the heart: Approaches and insights. IEEE Rev Biomed Eng 4: 89-102, 2011
3. Takanari H, Honjo H, Takemoto Y, Suzuki T, Kato S, Harada M, Okuno Y, Ashihara T, Opthof T, Sakuma I, Kamiya K, Kodama I. Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling. J Pharmacol Sci 115: 15-26, 2011
4. Matsumoto T, Eguchi Y, Oda H, Yamane T, Tarutani Y, Ozawa T, Hayashi H, Nakae I, Horie M, Urade Y. Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. Circ J 75: 897-904, 2011
5. Li P, Ninomiya H, KurataY, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Shirayoshi Y, Hiraoka M, Hisatome I. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res 108: 458-468, 2011
6. Miyamoto A, Hayashi H, Makiyama T, Yoshino T, Mizusawa Y, Sugimoto Y, Ito M, Xue JQ, Murakami Y, Horie M. Risk determinants in individuals with a spontaneous type 1 Brugada ECG. Circ J 75: 844-851, 2011
7. Matsumoto T, Horie M. Angiotensin-converting enzyme inhibition and fibrinolytic balance. Hypertens Res34: 448-449, 2011
8. Nishiyama K, Tsutamoto T, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie M. Biological variation of brain natriuretic peptide and cardiac events in stable outpatients with nonischemic chronic heart failure. Circ J 75: 341-347, 2011
9. Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M. KCNE5 (KCNE1L) variants are novel modulators of brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm Electrophysiol4: 352-361, 2011
10. Doi T, Makiyama T, Morimoto T, Haruna Y, Tsuji K, Ohno S, Akao M, Takahashi Y, Kimura T, Horie M. A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of andersen-tawil syndrome. Circ Cardiovasc Genet 4: 253-260, 2011
11. Shimizu W, Horie M. Phenotypical manifestations of mutations in genes encoding subunits ofcardiac potassium channels. Circ Res 109: 97-109, 2011
12. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H, Japanese Coronary Spasm Association. Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest: multicenter registry study of the Japanese Coronary Spasm Association. Circ Arrhythm Electrophysiol 4: 295-302, 2011
13. Kawahara C, Tsutamoto T, Nishiyama K, Yamaji M, Sakai H, Fujii M, Yamamoto T, Horie M. Prognostic role of high-sensitivity cardiac troponin T in patients with nonischemic dilated cardiomyopathy. Circ J 75: 656-661, 2011
14. Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. Roles of subcellular Na+ channel distributions in the mechanism of cardiac conduction. Biophys J 100: 554-563, 2011
15. Nishiyama K, Tsutamoto T, Kawahara C, Yamaji M, Sakai H, Yamamoto T, Fujii M, Horie M. Relationship between biological variation in B-type natriuretic peptide and plasma renin concentration in stable outpatients with dilated cardiomyopathy. Circ J 75: 1897-1904, 2011
16. Tsuji K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Nishio Y, Sakaguchi T, Matsuura H, Horie M. Identification and functional characterization of KCNQ1 mutations around the exon7-intron7 junction affecting the splicing process. Biochim Biophys Acta 1812: 1452-1459, 2011
17. Yoshino T, Nakae I, Matsumoto T, Mitsunami K, Horie M. Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function. Clin Exp Pharmacol Physiol 38: 34-41, 2011
18. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol 4: 874-881, 2011
19. Kawahara C, Tsutamoto T, Sakai H, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie M: Prognostic value of serial measurements of highly sensitive cardiac troponin I in stable outpatients with nonischemic chronic heart failure. Am Heart J 162: 639-645, 2011
20. Funakoshi S, Furukawa Y, Ehara N, Morimoto T, Kaji S, Yamamuro A, Kinoshita M, Kitai T, Kim K, Tani T, Kobori A, Nasu M, Okada Y, Kita T, Kimura T, CREDO-Kyoto Investigators. Clinical characteristics and outcomes of Japanese women undergoing coronary revascularization therapy. Circ J. 75: 1358-1367, 2011
21. Tsutamoto T, Sakai H, Ibe K, Yamaji M, Kawahara C, Nakae I, Fujii M, Yamamoto T, Horie M. Effect of atorvastatin vs. rosuvastatin on cardiac sympathetic nerve activity in non-diabetic patients with dilated cardiomyopathy. Circ J 75: 2160-2166, 2011
22. Kimura H, Mizusawa Y, Itoh H, Miyamoto A, Kawamura M, Kawaguchi T, Naiki N, Oka Y, Ohno S, Makiyama T, Ito M, Horie M. Carvedilol, a non-selective β-with α1-blocker is effective in long QT syndrome type 2. J Arrhythm 27: 324-331, 2011
23. Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Tatami R, Suwa S, Takizawa A, Takatsu Y, Takahashi M, Kato H, Takeda T, Lee J-D, Nohara R, Tei C, Horie M, Kambara H, Fujiwara H, Mitsudo Km Nobuyoshi M, Kita T. Association of the use of proton pump inhibitors with adverse cardiovascular and bleeding outcomes after percutaneous coronary intervention in the Japanese real world clinical practice. Cardiovasc Interv Ther 26: 222-233, 2011
24. Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Tatami R, Suwa S, Takizawa A, Takatsu Y, Takahashi M, Kato H, Takeda T, Lee JD, Nohara R, Ogawa H, Tei C, Horie M, Kambara H, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T. Long-term safety and efficacy of sirolimus-eluting stents versus bare-metal stents in real world clinicalpractice in Japan. Cardiovasc Interv Ther 26: 234-245, 2011
25. Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Itoh H, Sugimoto Y, Itoh M, Makiyama T, Xue JQ, Murakami Y, Horie M. Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population. Heart Rhythm 9: 66-74, 2011
26. Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Tatami R, Suwa S, Takizawa A, Takatsu Y, Takahashi M, Kato H, Takeda T, Lee JD, Nohara R, Tei C, Horie M, Kambara H, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, on behalf of the CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Association of the use of proton pump inhibitors with adverse cardiovascular and bleeding outcomes after percutaneous coronary intervention in the Japanese real world clinical practice. Cardiovasc Interv Ther 26, 222-233, 2011
27. Zhu B, Iwata M, Haraguchi R, Ashihara T, Umetani N, Igarashi T, Nakazawa K. Sketch-based dynamic illustration of fluid systems. ACM Transactions on Graphics 30: 134, 2011

2011年症例報告

1. Miyamoto A, Hayashi H, Ito M, Horie M. Remission of abnormal conduction and repolarization in the right ventricle after chemotherapy in patients with anterior mediastinal tumor. J Cardiovasc Electrophysiol 22: 350, 2011

2010

2. Ozeki Y, Fujii K, Kuromoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Narita M, Ishida N, Saito O, Horie M, Kunugi H. QTc prolongation and antipsychotic medication in 1017 patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 34: 401-405, 2010
3. Tsutamoto T, Kawahara C, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie M: Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure. Am Heart J 15: 63-67, 2010
4. Tsutamoto T, Nishiyama K, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie M. Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension. Hypertens Res 3: 118-122, 2010
5. Wu J, Shimizu W, Ding W-G, Ohno S, Toyada F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee J, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M. KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. Heart Rhythm 7: 199-205,2010
6. Horigome H, Nagashima M, Sumitomo N, Yoshinaga M, Ushinohama H, Iwamoto M, Shiono J, Ichihashi K, Hasegawa S, Yoshikawa T, Matsunaga T, Goto H, Waki K, Arima M, Takasugi H, Tanaka Y, Miura M, Ogawa K, Suzuki H, Yamagishi H, Ikoma M, Suda K, Takagi J, Sato J, Shimizu H, Saiki H, Hoshiai M, Ichida F, Takeda S, Takigiku K, Inamura N, Kajino H, Murakami T, Shimizu W, Horie M. Clinical characteristics and genetic background of congenital long QT syndrome diagnosed in fetal, neonatal and infantile life. A nation-wide questionnaire survey in Japan. Circ Arrhythm Electrophysiol 3: 10-17, 2010
7. Ishida K, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Murakami Y, Horie M. P-wave and the development of atrial fibrillation. Heart Rhythm 7: 289-294, 2010
8. Matsumoto T, Fujita M, Sawamura T, Kakino A, Sato Y, Fujita Y, Matsuda H, Nakanishi M, Uchida K, Nakae I, Kanda H, Yoshida A, Miwa K, Hayashi H, Mitsunami K, Horie M. Pitavastatin reduces Lectin-Like oxidized low-density lipoprotein Receptor-1 ligands in hypercholesterolemic humans. Lipids 45: 329-335, 2010
9. Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H, Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W. High prevalence of early repolarization in short QT syndrome. Heart Rhythm 7: 647-652, 2010
10. Constantino J, Long Y, Ashihara T, Trayanova NA. Tunnel propagation following defibrillation with ICD shocks: Hidden postshock activations in the left ventricular wall underlie isoelectric window. Heart Rhythm7: 953-961, 2010
11. Toyoda F, Ding W-G, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H. Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes. J Membr Biol235: 73-87, 2010
12. Yasuda S, Hiramatsu S, Odashiro K, Maruyama T, Tsuji K, Horie M. A family of hereditary long QT syndrome caused by Q738X HERG mutation. Int J Cardiol 144: 69-72, 2010
13. Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T. A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome. Int J Cardiol 145: 61-64, 2010
14. Horie M. Bi-directional ventricular tachycardia revised. J Arrhythm 26: 3-4, 2010
15. Itoh H, Shimizu W, Hayashi K, Yamagata K, Sakaguchi T, Ohno S, Makiyama T, Akao M, Ai T, Noda T, Miyazaki A, Miyamoto Y, Yamagishi M, Kamakura S, Horie M. Long QT syndrome with compound mutations is associated with a more severe phenotype: A Japanese multicenter study. Heart Rhythm 7: 1411-1418, 2010
16. Matsumoto T, Takashima H, Nakae I, Yamane T, Hayashi H, Horie M, for the SPAIC (Shiga tissue Plasminogen Activator In Coronary circulation) Investigators. Angiotensin-converting enzyme inhibition augments coronary release of tissue plasminogen activator in women but not in men. Hypertension 56: 364-368, 2010
17. Yoshino T, Nakae I, Matsumoto T, Mitsunami K, Horie M. Relationship between exercise capacity and cardiac diastolic function assessed by time-volume curve from 16-frame gated myocardial perfusion SPECT. Ann Nucl Med 24: 469-476, 2010
18. Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Akashi M, Kawamura M, Matsuura H, Horie M. Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to ongenital long QT syndrome. Circ J 74: 2562-71, 2010
19. Nagaoka I, Shimizu W, Mizusawa Y, Sakaguchi T, Itoh H, Ohno S, Makiyama T, Yamagata K, Makimoto H, Miyamoto Y, Kamakura S, Horie M. Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome. Europace 12: 1623-1629, 2010
20. Hayashi H, Miyamoto A, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M: Prevalence and QT interval of early repolarization in a hospital-based population. J Arrhythm 26: 127-133, 2010
21. Nakae I, Mitsunami K, Yoshino T, Omura T, Tsutamoto T, Matsumoto T, Morikawa S, Inubushi T, Horie M. Clinical features of myocardial triglyceride in different types of cardiomyopathy assessed by proton magnetic resonance spectroscopy: Comparison with myocardial creatine. J Card Fail 16: 812-822, 2010
22. Yamaji M, Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M. Effect of eplerenone versus spironolactone on cortisol and hemoglobin a1(c) levels in patients with chronic heart failure. Am Heart J 160: 915-921, 2010
23. Makiyama T, Shizuta S, Akao M, Kimura T, Horie M. Genetic background of arrhythmic disorders: Genetic background of familial arrhythmic disorders. The Japanese Society of Electrocardiology 30: 200-208, 2010

2010年症例報告

2009

1. Ikrar T, Hanawa H, Watanabe H, Aizawa Y, Ramadan MM, Chinushi M, Horie M, Aizawa Y. Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel. BBRC 378: 589-594, 2009
2. Kawamura M, Ozawa T, Yao T, Ashihara T, Sugimoto Y, Yagi T, Itoh H, Ito M, Makiyama T, Horie M. Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up. Circ J 73: 584-588, 2009
3. Wu J, Ding WG, Matsuura H, Tsuji K, Zang WJ, Horie M. Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel. Brit J Pharm 156: 377-387, 2009
4. Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M. Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients. Heart Rhythm6: 1038-1046, 2009
5. Itoh H, Sakaguchi T, Ashihara T, Ding G W, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ito M, Matsuura H, Horie M. A novel KCNH2 mutation as a modifier for short QT interval. Int J Cardiol 137: 83-85, 2009
6. Nakazawa Y, Ashihara T, Tsutamoto T, Ito M, Horie M: Endothelin-1 as a predictor of atrial fibrillation recurrence after pulmonary vein isolation. Heart Rhythm 6: 725-730, 2009
7. Ohno S, Toyoda F, Zankov D, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Matsuura H, Shimizu W, Miyamoto Y, Kamakura S, Kita T, Horie M. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Hum Mutat 30: 557-563, 2009
8. Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H, J-RHYTHM Investigators. Optimal treatment strategy for patients with paroxysmal atrial fibrillation: J-RHYTHM Study. Circ J 73: 242-248, 2009
9. Yamashita T, Ogawa S, Sato T, Aizawa Y, Atarashi H, Fujiki A, Inoue H, Ito M, Katoh T, Kobayashi Y, Koretsune Y, Kumagai K, Niwano S, Okazaki O, Okumura K, Saku K, Tanabe T, Origasa H; J-BAF Investigators. Collaborators: Ito M, Ashihara T, Itoh H, Sugimoto Y. Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled, double-blind study (J-BAF Study). Circ J 73: 1020-1027, 2009
10. Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura M, Horie M. Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium. Pflugers Arch 458: 837-849, 2009
11. Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong Y-Z, Yamamoto S, Ozawa T, Ding W-G, Toyoda F, Kawamura M, Akao M, Matsuura H, Kita T, Horie M. D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. J Am Coll Cardiol 54: 812-819, 2009
12. Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kanda H, Kita Y, Kadowaki T, Tsujita Y, Chowdhury Turin T, Horie M, Miki T, Ueshima H. Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). Int J Cardiol 136: 354-355, 2009
13. Inoue H, Fujiki A, Origasa H, Ogawa S, Okumura K, Kubota I, Aizawa Y, Yamashita T, Atarashi H, Horie M, Ohe T, Doi Y, Shimizu A, Chishaki A, Saikawa T, Yano K, Kitabatake A, Mitamura H, Kodama I, Kamakura S. Prevalence of atrial fibrillation in the general population of Japan: An analysis based on periodic health examination. Int J Cardiol 137: 102-107, 2009
14. Okamura T, Sekikawa A, Kadowaki T, El-Saed A, Abbott DR, Curb JD, Edmundowicz D, Nakamura Y, Murata K, Kashiwagi A, Sutton-Tyrrell K, Evans RW, Zmuda JM, Maegawa H, Hozawa A, Mitsunami K, Nisio Y,Miljkovic-Gacicl I, Horie M, Miyamatsu N, Murakami Y, Kuller LH, Ueshima H. Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-aged Japanese men. Am J Cardiol 104: 818-822, 2009
15. Nishiyama K, Tsutamoto T, Tanaka T, Fujii M, Yamamoto T, Yamaji M, Horie M. Plasma NT-proBNP as a more reliable biomarker of endogenous cardiac natriuretic peptides Than BNP during carperitide infusion. Int Heart J 50: 183-190, 2009
16. Yamaji M, Tsutamoto T, Tanaka T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M. Effect of carvedilol on plasma adiponectin concentration in patients with chronic heart failure. Circ J 73: 1067-1073, 2009.
17. Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, Ogawa S, Okumura K, Tsuchihashi K, Sugi K, Makita N, Hagiwara N, Inoue H, Atarashi H, Aihara N, Shimizu W, Kurita T, Suyama K, Noda T, Satomi K, Okamura H, Tomoike H. Long-term prognosis of probands with Brugada-pattern ST-Elevation in leads V1-V3. Circ Arrhythm Electrophysiol 2: 495-503, 2009
18. Itoh H, Sakaguchi T, Ding WS, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M. Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome. Circ Arrhythm Electrophysiol 2: 511-523, 2009
19. Tsutamoto T, Kawahara C, Yamaji M, Nishiyama K, Fujii M, Yamamoto T, Horie M. Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure. Eur J Heart Fail 1: 653-658, 2009
20. Tsutamoto T, Tanaka T, Nishiyama K, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie M. Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension. Hypertens Res 32: 670-674, 2009
21. Yamaji M, Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M. Serum cortisol as a useful predictor of cardiac events in patients with chronic heart failure: The impact of oxidative stress. Circ Heart Fail 2: 608-615, 2009
22. Nishiyama K, Tsutamoto T, Yamaji M, Kawahara C, Yamamoto T, Fujii M, Horie M. Dose- Dependent prognostic effect of carvedilol in patients with chonic heart failure: Special reference to ranscardiac gragient of norepinephrine. Circ J 73: 2270-2275, 2009
23. Yamaji M, Tsutamoto T, Tanaka T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M. Effect of carperitide on plasma adiponectin levels in acute decompensated heart failure patients with diabetes mellitus. Circ J 73: 2264-2269, 2009
24. Tsutamoto T, Yamaji M, Kawahara C, Nishiyama K, Fujii M, Yamamoto T, Horie M. Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failure. Eur J Heart Fail 11: 1195-1201, 2009
25. Furukawa Y, Ehara N, Taniguchi R, Haruna Y, Ozasa N, Saito N, Doi T, Hoshino K, Tamura T, Shizuta S, Abe M, Toma M, Morimoto T, Teramukai S, Fukushima M, Kita T, Kimura T, CREDO-Kyoto Investigators. Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. Circ J73: 1459-1465. 2009
26. Furukawa Y, Taniguchi R, Ehara N, Ozasa N, Haruna Y, Saito N, Doi T, Hoshino K, Shizuta S, Morimoto T, Imai Y, Teramukai S, Fukushima M, Kita T, Kimura T, CREDO-Kyoto Investigators. Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease: perspectives from the CREDO-Kyoto registry. Circ J 73: 1937-1945, 2009

2009年症例報告

1. Kawamura M, Ozawa T, Yao T, Ashihara T, Sugimoto Y, Yagi T, Itoh H, Ito M, Makiyama T, Horie M. Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up. Circ J 73: 584-588, 2009
2. Miyazawa I, Wada A, Sugimoto T, Nitta N, Horie M. Emerging acute unilateral pulmonary edema in a patient with pheochromocytoma. Int J Cardiol 133: e50-e51, 2009
3. Itoh H, Yamamoto T, Sugihara H, Saotome T, Eguchi Y, Asai T, Horie M. Aortopulmonary artery dissection.J Am Coll Cardiol 54: 1990, 2009
4. Miyazawa I, Wada A, Sugimoto T, Nitta N, Horie M. Emerging acute unilateral pulmonary edema in a patient with pheochromocytoma. Int J Cardiol 133: e50-e51, 2009

2008

1. Ashihara T, Constantino J, Trayanova NA. Tunnel propagation of postshock activations as a unified hypothesis for fibrillation induction and isoelectric window. Circ Res 102: 737-745, 2008
2. Harada M, Honjo H, Yamazaki M, Nakagawa H, Ishiguro Y, Okuno Y, Ashihara T, Sakuma I, Kamiya K, Kodama I. Moderate hypothermia increases the chance of spiral wave collision in favor of self termination of ventricular tachycardia/fibrillation. Am J Physiol Heart Circ Physiol 294: H1896-H1905, 2008
3. Ijiri T, Ashihara T, Yamaguchi T, Takayama K, Igarashi T, Namba T, Shimada T, Haraguchi R, Nakazawa K: A procedural method for modeling the purkinje fibers of the heart. J Physiol Sci 58: 481-486, 2008
4. Takayama K, Ashihara T, Ijiri T, Igarashi T, Haraguchi R, Nakazawa K. A sketch-based interface for modeling myocardial fiber orientation that considers the layered structure of the ventricles. J Physiol Sci58: 487-492, 2008
5. Matsumoto T, Fujita M, Tarutani Y, Yamane T, Takashima H, Nakae I, Horie M. Whole-body periodic acceleration enhances brachial endothelial function. Circ J 72: 139-143, 2008
6. Ohno S, Kubota T, Yoshida H, Tsuji K, Makiyama T, Yamada S, Kuga K, Yamaguchi I, Kita T, Horie M. A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family. Circ J 72: 687-693, 2008
7. Sakaguchi T, Shimizu W, Itoh H, Noda T, Miyamoto A, Nagaoka I, Oka Y, Ashihara T, Ito M, Tsuji K, Ohno S, Makiyama T, Kamakura S, Horie M. Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long-QT syndrome. J Cardiovasc Electrophysiol 19: 794-799, 2008
8. Nagaoka I, Shimizu W, Itoh H, Yamamoto S, Sakaguchi T, Ashihara T, Ito M, Yoshida H, Ohno S, Miyamoto Y, Kamakura S, Akao M, Horie M. Mutation site dependent variability of cardiac events in LQT2 form of congenital long-QT syndrom. Circ J 72: 694-699, 2008
9. Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K, Itoh H, Kimura T, Kita T, Horie M. A novel SCN5Again-of-function mutation M1875T associated with familial atrial fibrillation. J Am Coll Cardiol 52: 1326-1334, 2008
10. Yasue H, Mizuno Y, Harada E, Itoh T, Nakagawa H, Nakayama M, Ogawa H, Tayama S, Honda T, Hokimoto S, Ohshima S, Hokamura Y, Kugiyama K, Horie M, Yoshimura M, Harada M, Uemura S, Saito Y.Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition on coronary spasm after withdrawal of Ca-channel blockers. J Am Coll Cardiol 51: 1742-1748, 2008
11. Tsutamoto T, Tanaka T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Nakae I, Ohnishi M, Wada A, Horie M. Beneficial effect of perindopril on cardiac sympathetic nerve activity and brain natriuretic Peptide in patients with chronic heart failure. Circ J 72: 740-746, 2008
12. Nakae I, Matsuo S, Matsumoto T, Mitsunami K, Horie M. Augmentation Index and Pulse Wave Velocity as Indicators of Cardiovascular Stiffness. Angiology 59: 421-426, 2008
13. Matsuo S, Nakajima K, Horie M, Nakae I, Nishimura T,The J-ACCESS Investigators. Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population. Circ J72: 611-617, 2008
14. Tanaka T, Tsutamoto T, Nishiyama K, Sakai H, Fujii M, Yamamoto T, Horie M. Impact of oxidative stress on plasma adiponectin in patients with chronic heart failure. Circ J 72: 563-568, 2008
15. Tanaka T, Tsutamoto T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Horie M. Effect of atrial natriuretic peptide on adiponectin in patients with heart failure. Eur J Heart Fail 10: 360-366, 2008
16. Tamaki S, Nakamura Y, Teramura M, Sakai M, Takayama T, Okabayashi T, Kawashima T, Horie M. The factors contributing to whether or not hypertensive patients bring their home blood pressure record to the outpatient exam. Intern Med 47: 1561-1565, 2008
17. Makiyama T, Akao M, Haruna Y, Tsuji K, Doi T, Ohno S, Nishio Y, Kita T, Horie M. Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome. Circ J 72: 1705-1706, 2008
18. Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Fukuhara S, Mochizuki N, Makiyama T, Itoh H, Christiansen M, McKeown P, Miyamoto K, Kamakura S, Tsutsui H, Schwartz P J, George Jr.A, Roden D. The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest 118: 2219-2229, 2008
19. Yamada H, Yoshida M, Nakano Y, Suganami T, Satoh N, Mita T, Azuma K, Itoh M, Yamamoto Y, Kamei Y, Horie M, Watada H, Ogawa Y: In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid. Arteroiscler Thromb Vasc Biol 28: 2173-2179, 2008
20. Gong YZ, Ding WG, Wu J, Tsuji K, Horie M, Matsuura H. Cinnamyl-3, 4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. Eur J Pharmacol 600: 18-25, 2008
21. Takayama T, Teramura M, Sakai H, Tamaki S, Okabayashi T, Kawashima T, Yamamoto T, Horie M, Suzuki T, Asai T. Perforated mitral valve aneurysm associated with Libman-Sacks endocarditis. Intern Med 47: 1605-1608, 2008
22. Nakae I, Matsuo S, Matsumoto T, Horie M. Clinical significance of diastolic function as an indicator of myocardial ischemia assessed by 16-frame gated myocardial perfusion SPECT. Ann Nucl Med 22(8): 677-683, 2008
23. Inoue T, Eguchi Y, Matsumoto T, Kijima Y, Kato Y, Ozaki Y, Waseda K, Oda H, Seiki K, Node K, Urade Y: Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. Atherosclerosis 201: 385-391, 2008
24. Sakaguchi T, Itoh H, Ding WG, Tsuji K, Nagaoka I, Oka Y, Ashihara T, Ito M, Yumoto Y, Zenda N, Higashi Y, Takeyama Y, Matsuura H, Horie M. Hydroxyzine, a first generation H1-receptor antagonist, inhibits human ether-a-go-go related gene (HERG) current and causes syncope in a patient with the HERG mutation. J Pharmacol Sci 108: 462-471, 2008
25. Tsutamoto T, Nishiyama K, Sakai H, Tanaka T, Fujii M, Yamamoto T, Yamaji M, Horie M. Transcardiac increase in norepinephrine and prognosis in patients with chronic heart failure. Eur J Heart Fail 10: 1208-1214, 2008
26. Horie M, Ishida K, Nishio Y, Nagaoka I, Matsui K. Genetic background of arrhythmogenic right ventricular dysplasia/Cardiomyopathy: Time to start asian registry. J Arrhythm 24: 195-199, 2008

2008年症例報告

1. Tsujita Y, Kunitomo T, Fujii M, Furukawa S, Otsuki H, Fujino K, Hamamoto T, Tabata T, Matsumura K, Sasaki T, Saotome T, Kawai H, Matsumoto T, Maeda K, Horie M, Eguchi Y. A surviving case of mitochondrial cardiomyopathy diagnosed from the symptoms of multiple organ dysfunction syndrome. Int J Cardiol128(1): e43-e45, 2008
2. Matsuo S, Sato Y, Higashida R, Shiraishi S, Asai T, Nakae I, Horie M. A giant main pulmonary artery aneurysm associated with infundibular pulmonary stenosis. Cardiovasc Revasc Med 9(3): 188-189, 2008
3. Sugimoto T, Morita Y, Isshiki K, Yamamoto T, Uzu T, Kashiwagi A, Horie M, Asai T. Constrictive pericarditis as an emerging manifestation of hyper-igg4 disease. Int J Cardiol 130(3): e100-e101, 2008
4. Sugimoto T, Morita Y, Isshiki K, Yamamoto T, Uzu T, Kashiwagi A, Horie M, Asai T. Constrictive pericarditis was an emerging manifestation of IgG4-associated multifocal systemic fibrosis. Int J Cardiol 130(3): e100- e101, 2008
5. Matsuo S, Nakajima K, Kinuya S, Sato Y, Matsumoto N, Horie M. Cardiac scintigraphic findings of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: A case report. Exp Clin Cardiol 13(2): 93-95, 2008

2007

1. Ohno S, Zankov D, Yoshida H, Tsuji K, Makiyama T, Itoh H, Akao M, Hancox JC, Kita T, Horie M. N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm 4(3): 332-340, 2007
2. Tsuji K, Akao M, Ishii T, Ohno S, Makiyama T, Doi T, Haruna Y, Yoshida H, Nakashima T, Kita T, Horie M. Mechanistic basis for the pathogenesis of long QT syndrome caused by a splicing mutation in KCNQ1 gene. J Mol Cell Cardiol 42(3): 662-669, 2007
3. Tsujita Y, Nakamura Y, Zhang Q, Tamaki S, Nozaki A, Amamoto K, Kadowaki T, Kita Y, Okamura T, Horie M, Ueshima H. The association between high-density lipoprotein cholesterol level and cholestery1 ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample. Atherosclerosis 191(1): 199-205, 2007
4. Nagatani Y, Takahashi M, Takazakura R, Nitta N, Murata K, Ushio N, Matsuo S, Yamamoto T, Horie M. Multidetector-row computed tomography coronary angiography: optimization of image reconstruction phase according to the heart rate. Circ J71(1): 112-121, 2007
5. Toda H, Ding WG, Yasuda Y.Toyoda F, Ito M, Matsuura H, Horie M. Stimulatory action of protein kinase Cvarepsilon isoform on the slow component of delayed rectifier K(+) current in guinea-pig atrial myocytes. Br J Pharmacol 150(8): 1011-1021, 2007
6. Sakai H, Tsutamoto T, Ishikawa C, Tanaka T, Fujii M, Yamamoto T, Takashima H, Horie M: Direct comparison of brain natriuretic peptide (BNP) and N-terminal pro-BNP secretion and extent of coronary artery stenosis in patients with stable coronary artery disease. Circ J 71(4): 499-505, 2007
7. Matsuo S, Nakae I, Tsutamoto T, Okamoto N, Horie M. A novel clinical indicator using Tc-99m sestamibi for evaluating cardiac mitochondrial function in patients with cardiomyopathies. J Nucl Cardiol 14(2): 215-220, 2007
8. Itoh H, Tsuji K, Sakaguchi T, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ashihara T, Ito M, Horie M, Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardiol 121:239-248, 2007
9. Takashima H, Matsumoto T, Nakae I, Yamane T, Horie M. Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Thrombo Res 120(6): 791-796. 2007
10. Todo T, Haraguchi R, Namba T, Yao T, Ashihara T, Higashi M, Inada H, Nakazawa K. Development of “Cardiac Arrhythmia Risk Evaluation” system based on computer simulation. Proc IEEE/ICME Int Conf Complex Med Eng 182-185, 2007
11. Haraguchi R, Igarashi T, Owada S, Yao T, Namba T, Ashihara T, Ikeda T, Nakazawa K. Electrophysiological heart simulator equipped with sketchy 3-D modeling. Complex Medical Engineering 107-116, 2007
12. Tsutamoto T, Tanaka T, Sakai H, Ishikawa C, Fujii M, Yamamoto T, Horie M. Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J28(14): 1723-1730. 2007
13. Nakae I, Mitsunami K, Matsuo S, Horie M. Creatine Depletion and Altered Fatty Acid Metabolism in Diseased Human Hearts: Clinical Investigation Using (1)H Magnetic Resonance Spectroscopy and (123)I BMIPP Myocardial Scintigraphy. Acta Radiol 48(4): 436-443, 2007
14. Tsutamoto T, Sakai H, Ishikawa C, Fujii M, Tanaka T, Yamamoto T, Takashima H, Ohnishi M, Wada A, Horie M. Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N-terminal pro-BNP in patients with chronic heart failure. Eur J Heart Fail 9(6-7): 667-673, 2007
15. Tsutamoto T, Sakai H, Tanaka T, Fujii M, Yamamoto T, Wada A, Ohnishi M, Horie M. Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure. Circ J 71(6): 915-921, 2007
16. Lu J, Zhu SM, Zang WJ, Xu XL, Luo HL, Yu XJ, Wang SP, Kong SS, Wu J, Horie M, Sun L. Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide. Biol Pharm Bull 30(7): 1206-1211, 2007
17. Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T, Horie M. Effect of efonidipine versus amlodipine on aldosterone in patients with hypertension. Hypertens Res 30(8): 691-697, 2007
18. Tsutamoto T, Asai S, Tanaka T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Ohnishi M, Wada A, Saito Y, Horie M. Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure. Eur J Heart Fail 9(10): 1032-1037, 2007
19. Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T, Horie M. Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension. Hypertens Res 30(8): 691-697, 2007
20. Crotti L, Spazzolini C, Schwartz P, Shimizu W, Denjoy I, Schulze-Bahr E, Zaklyazminskaya E, Swan H, Ackerman M, Moss A, Wilde A, Horie M, Brink P, Insolia R, Ferrari G, Crimi G. The common long QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification. Circulation 116(21): 2366-2375, 2007
21. Tsutamoto T, Sakai H, Nishiyama K, Tanaka T, Fujii M, Yamamoto T, Horie M. Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and N-terminal proBNP and prognosis in patients with chronic heart failure. Circ J 71(12): 1873-1878, 2007
22. Sumitomo N, Sakurada H, Taniguchi K, Matsumura M, Abe O, Miyashita M, Kanamaru H, Karasawa K, Ayusawa M, Fakamizu S, Nagaoka I, Horie M, Harada K, Hiraoka M. Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia. Circ J 71(10): 1606-1609, 2007
23. Sugimoto T, Hajiro T, Fujimoto T, Kojyo N, Horie M, Kashiwagi A. Thrombotic microangiopathy in an adult patient with clinically amyopathic dermatomyositis complicated with interstitial lung disease. Lupus16(12): 1004-1005. 2007
24. Hayashi H, Shiferaw Y, Sato D, Nihei M, Lin S, Chen P, Garfinkel A, Weiss N J, Qu Z. Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J 92(2): 448-460, 2007
25. Namba T, Haraguchi R, Igarashi T, Owada S, Yao T, Ashihara T, Todo T, Ikeda T, Nakazawa K. Development of graphical interface for modeling excitation map in the electrophysiological heart simulator. Proc IEEE/ICME Int Conf Complex Med Eng 168-171, 2007
26. Takagi M, Yokoyama Y, Aonuma K, Aihara N, Hiraoka M, for the Japan Idiopathic ventricular fibrillation study (J-IVFS) investigators. Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with Brugada syndrome. J Cardiovasc Electrophysiol 18(12): 1244-1251, 2007
27. Nakae I, Matsuo S, Tsutamoto T, Matsumoto T, Mitsunami K, Horie M. Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT. Ann Nucl Med 21(6): 315-323, 2007

2007年症例報告

1. Matsuo S, Sato Y, Nakae I, Masuda D, Yomota M , Ashihara T, Horie M. Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy demonstrated by multidetector-row computed tomography. Int J Cardiol 115(3): e129-e131, 2007
2. Matsuo S, Sato Y, Matsumoto T, Naiki N, Horie M. Churg-Strauss syndrome presenting with massive pericardial effusion. Heart Vessels 22(2), 128-130, 2007
3. Sugimoto T, Okamoto M, Koyama T, Takashima H, Saeki M, Kashiwagi A, Horie M. The occurrence of systemic lupus erythematosus in an asymptomatic carrier of human T-cell lymphotropic virus type I. Clin Rheumatol 26(6):1005-1007, 2007
4. Haruna Y, Kobori A, Makiyama T, Yoshida H, Akao M, Doi T, Tsuji K, Ono S, Nishio Y, Shimizu W, Inoue T, Murakami T, Tsuboi N, Yamanouchi H, Ushinohama H, Nakamura Y, Yoshinaga M, Horigome H, Aizawa Y, Kita T, Horie M. Genotype-phenotype correlations of KCNJ2 mutations in Japanese patients with Andersen-Tawil syndrome. Hum Mutat 28(2): 208, 2007
5. Horie M, Ito H. Disorders of cardiac repolarization: Long QT and short QT syndromes. Circ J 71 Suppl A: A50-A53. 2007
6. Namba T, Todo T, Yao T, Ashihara T, Haraguchi R, Nakazawa K, Ikeda T, Ohe T. Identification of local myocardial repolarization time by bipolar electrode potential. J Electrocardiol 40(6 Suppl): S97-S102, 2007

2006

1. Dohke, Wada A, Isono T, Fujii M, Yamamoto T, Tsutamoto T, Horie M. Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure. J Cardiac Fail12(1): 77-84, 2006
2. Hatada K, Washizuka T, Horie M, Watanabe H, Yamashita F, Chinushi M, Aizawa Y. Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway. Biochem Biophys Res Commun 344(1): 189-193, 2006
3. Ishikawa C, Tsutamoto T, Fujii M, Sakai H, Tanaka T, Horie M. Prediction of mortality by high-sensitivity C-reactive protein and brain natriuretic Peptide in patients with dilated cardiomyopathy. Circ J 70(7): 857-863, 2006
4. Lu J, Nishi T, Ashihara T, Schnider N, Amano A, Matsuda T, Kotera H. The influence of activation time on the contraction force of myocardial tissue: A simulation study. Conf Proc IEEE Eng Med Biol Soc 1: 2900-2903, 2006
5. Itoh H, Horie M, Ito M, Imoto K. Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects: A simulation study. Circ J 70(4): 502-508, 2006
6. Matsuo S, Nakae I, Matsumoto T, Horie M. Impact of endothelial dysfunction on left ventricular remodeling after successful primary coronary angioplasty for acute myocardial infarction: Analysis by quantitative ECG-gated SPECT. Ann Nucl Med 20(1): 57-62, 2006
7. Matsuo S, Sato Y, Nakae I, Masuda D, Matsumoto N, Horie M. Evaluation of cardiac resynchronization therapy in drug-resistant dilated-phase hypertrophic cardiomyopathy by means of Tc-99m sestamibi ECG-gated SPECT. Ann Nucl Med 20(9): 643-647, 2006
8. Nakae I, Matsuo S, Koh T, Mitsunami K, Horie M. Iodine-123 BMIPP scintigraphy in the evaluation of patients with heart failure. Acta Radiol 47(8): 810-816, 2006
9. Ozawa T, Ito M, Tamaki S, Yao T, Ashihara T, Kita Y, Okamura T, Ueshima H, Horie M. Gender and age effects on ventricular repolarization abnormality in Japanese general carriers of G643S common single nucleotide polymorphism of KCNQ1 gene. Circ J 70(6): 645-650, 2006
10. Sakai H, Tsutamoto T, Tsutsui T, Tanaka T, Ishikawa C, Horie M. Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure. Circ J 70(8): 1006-1011, 2006
11. Schwartz PJ, Spazzolini C, Crotti L, Bathen J, Denjoy I, Schulze-Bahr E, Amlie JP, Timothy K, Shkolnikova M, Berul C, Bitner-Glindzicz M, Toivonen L, Horie M. The Jervell and Lange-Nielsen Syndrome. Molecular basis, natural history, and clinical outcome. Circulation 113: 783-790, 2006
12. Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kita Y, Kadowaki T, Tsujita Y, Horie M, Miki T, Ueshima H. Relationship between metabolic syndrome and Trp64arg polymorphism of the beta-adrenergic receptor gene in a general sample: the Shigaraki study. Hypertens Res 29(11): 891-896, 2006
13. Tamaki S, Nakamura Y, Yoshino T, Matsumoto Y, Tarutani Y, Okabayashi T, Kawashima T, Horie M. The association between morning hypertension and metabolic syndrome in hypertensive patients. Hypertens Res 29(10): 783-788, 2006
14. Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA. Nuclear Targeting of Akt Antagonizes Aspects of Cardiomyocyte Hypertrophy. Proc Natl Acad Sci U S A 103(32): 11946-11951,2006
15. Tsutamoto T, Wada A, Sakai H, Ishikawa C, Tanaka T, Hayashi M, Fujii M, Yamamoto T, Dohke T, Ohnishi M, Takashima H, Kinoshita M, Horie M. Relationship between renal function and plasma brain natriuretic Peptide in patients with heart failure. J Am Coll Cardiol 47(3): 582-586, 2006
16. Yamane T, Matsumoto T, Nakae I, Takashima H, Tarutani Y, Tamaki S, Horie M. Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation. Hypertens Res 29(6): 417-422, 2006
17. Zhang CT, Yasuno S, Kuwahara K, Zankov D, Kobori A, Makiyama T, Horie M. Blockade of Angiotensin II type 1 receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy. Circ J 70(3): 335-341, 2006
18. Zankov DP, Toyoda F, Ding WG, Matsuura H, Horie M. Angiotensin II potentiates IKs potassium current via AT1 receptors in guinea-pig atrial myocytes. Circulation 113(10): 1278-1286, 2006
19. Zankov DP, Omatsu-Kanbe M, Toyoda F, Ding WG, Matsuura H, Isono T, Horie M. Response to letter regarding article, "Angiotensin II potentiates the slow component of delayed rectifier K+ Current via the AT1 receptor in guinea pig atrial myocytes". Circulation 113(10): 1278-1286, 2006
20. Kinoshita H, Kuwahara K, Harada M, Horie M, Nakagawa Y, Nakanishi M, Usami S, Fujiwara M, Ueshima K, Nakao K. Blockade of T-type Calcium Channel Suppressed the Arrhythmogenicity in Dominant Negative NRSF Transgenic Mice. Journal of Cardiac Failure 12(8): S163, 2006

2006年症例報告

1. Matsuo S, Nakae I, Masuda D, Matsumoto T, Horie M. Scintigraphic evaluatin of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. Intern Med 45(7): 465-467, 2006
2. Matsuo S, Sato Y, Miyamoto S, Nakae I, Saeki M, Hodohara K, Horie M. Primary malignant lymphoma of the right atrium resulting in superior vena cava syndrome in a HIV positive patient: depiction at multi-detector computed tomography and magnetic resonance imaging. Cardiovasc Revasc Med 7: 255-257,2006
3. Nagaoka I, Matsui K, Ueyama T, Kanemoto M, Wu J, Matsuzaki M, Horie M, Shimizu A. A novel mutation of plakophilin-2 associated with arrhythmogenic right ventricular cardiomyopathy. Circ J 70(7): 933-935, 2006

2005

1. Aiba T, Shizimu W, Inagaki M, Noda T, Miyoshi S, Ding W-G, Zankov DP, Toyoda F, Matuura H, Horie M, Sunagawa K. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil. J Am Coll Cardiol 45(2): 300-307, 2005
2. Hamamoto T, Tanaka H, Mani H, Tanabe T, Fujiwara K, Nakagami T, Horie M, Oyamada M, Takamatsu T. In situ Ca2+ dynamics of Purkiinje fibers and its interconnection with subjacent ventricular myocytes. J Mol Cell Cardiol 38(4): 561-569, 2005
3. Haraguchi R, Igarashi T, Owada S, Yao T, Namba T, Ashihara T, Ikeda T, Nakazawa K. Electrophysiological heart simulator equipped with sketchy 3-D modeling. Proc IEEE/ICME Int Conf Complex Med Eng 293-296, 2005
4. Isikawa C, Tsutamoto T, Wada A, Fujii M, Ohno K, Sakai H, Yamamoto T, Horie M. Inhibition of aldosterone and endothelin-1 by carperitide was attenuated more than one week Infusion in patients with congestive heart failure. J Cardiovasc Pharmacol 46(4): 513-518, 2005
5. Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA. Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest 115(10): 2716-2730, 2005
6. Makiyama T, Akao M, Tsuji K, Doi T, Ohno S, Takenaka K, Kobori A, Ninomiya T, Yoshida H, Takano T, Makita N, Yanagisawa F, Higashi Y, Takeyama Y, Kita T, Horie M. High-risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutations. J Am Coll Cardiol 46(11): 2100-2106, 2005
7. Matsuo S, Nakamura I, Yamada T, Uchida I, Nakae I, Horie M. Effect of statin therapy on arterial stiffness in patients with hyperlipidemia: Shiga pravastatin atherosclerosis study (SHIPAS) group. J Appl Res 5: 397-401, 2005
8. Nakae I, Mitsunami K, Matsuo S, Inubushi T, Morikawa S, Tsutamoto T, Koh T, Horie M. Myocardial creatine concentration in various nonischemic heart diseases assessed by 1H magnetic resonance spectroscopy. Circ J 69(6): 711-716, 2005
9. Nakae I, Mitsunami K, Matsuo S, Inubushi T, Morikawa S, Koh T, Horie M. Detection of calf muscle alterations in patients with chronic heart failure by 31P magnetic resonance spectroscopy: Impaired adaptation to continuous exercise. Exp Clin Cardiol 10(1): 4-8, 2005
10. Nakae I, Matsuo S, Koh T, Mitsunami K, Horie M. Left ventricular systolic/diastolic function evaluated by quantitative ECG-gated SPECT: comparison with echocardiography and plasma BNP analysis. Ann Nucl Med 19(6): 447-454, 2005
11. Nakae I, Matsuo S, Koh T, Mitsunami K, Horie M. Clinical significance of plasma BNP measurement in patients with psychiatric disease. International Med J 12: 181-184, 2005
12. Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kita Y, Kadowaki T, Tsujita Y, Horie M, Miki T, Ueshima H. Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese population: The Shigaraki Study. Hypertens Res 28(8): 645-650, 2005
13. Tanaka H, Hamamoto T, Takamatsu T. Toward an integrated understanding of the Purkinje fibers in the heart: the functional and morphological interconnection between the purkinje fibers and ventricular muscle. Acta Histochem Cytoc 38: 257-265, 2005
14. Tarutani Y, Matsumoto T, Takashima H, Yamane T, Horie M. Brachial artery flow-mediated vasodilation is correlated with coronary vasomotor and fibrinolytic responses induced by bradykinin. Hypertens Res28(1): 59-66, 2005
15. Tsujita Y, Kato T, Sussman MA. Evaluation of left ventricular function in cardiomyopathic mice by tissue Doppler and color M-mode Doppler echocardiography. Echocardiography 22(3): 245-253, 2005
16. Yao T, Ashihara T, Ito M, Nakazawa K, Horie M. Refractory gradient is responsible for the increase in ventricular vulnerability under sodium channel blockade. Circ J 69(3): 345-353, 2005
17. Yasuda Y, Matuura H, Ito M, Matsumoto T, Ding W-G, Horie M. Regulation of the muscarinic K channel by extracellular ATP through membrane phosphatidylinositol 4, 5-biphsopahte in guinea-pig atrial myocytes. Br J Pharmacol 145(2): 156-165, 2005
18. Zankov DP, Ding W-G, Matsuura H, Horie M. Open-state unblock characterizes acute inhibition of IKS potassium current by amiodarone in guinea-pig ventricular myocytes. J Cardiovasc Electrophysiol 16(3): 314-322, 2005
19. Zhang L, Benson DW, Tristani-Firouzi M, Ptacek LJ, Tawil R, Schwartz PJ, George AL, Horie M, Andelfinger G, Snow GL, Fu Y-Ackerman MJ, Vincent GM. Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype. Circulation111(21): 2720-2726, 2005

2005年症例報告

1. Matsuo S, Nakae I, Masuda D, Matsumoto T, Horie M. Dilated cardiomyopathy relieved as a result of β - blocker therapy: A case report - key points in assessment of prognosis based on MIBG myocardial scintigraphy and BNP levels. Ann Nucl Med 19(3): 243-246, 2005
2. Matsuo S, Matsumoto T, Nakae I, Masuda D, Takada M, Murata K, Horie M. Noninvasive identification of myocardial sympathetic and metabolic abnormalities in a patient with "Takotsubo" cardiomyopathy. Intern Med J 12: 143-144, 2005
3. Matsuo S, Matsumoto T, Nakae I, Ito M, Horie M. Anomaly of the left atrium in patients with atrial fibrillation detected by ECG-gated multi-slice computed tomography. Int J Cardiovasc Imaging 21(4): 455-458, 2005
4. Matsuo S, Nakae I, Matsumoto T, Horie M. Noninvasive evaluation of coronary artery plaque with electrocardiographically-gated multislice computed tomography. Comput Med Imag Grap Extra Cases29: 13-18, 2005
5. Yokoi H, Makita N, Sasaki K, Takagi Y, Okumura Y, Nishino T, Makiyama T, Kitabatake A, Watanabe I, Horie M. Double SCN5A mutation underlying asymptomatic Brugada syndrome. Heart Rhythm 2(3): 285-292, 2005
6. Ashihara T, Trayanova NA: Cell and tissue responses to electric shocks. Europace 7 Suppl 2: 155-165,2005

2004

1. Ashihara T, Trayanova NA. Asymmetry in membrane responses to electric shocks: Insights from bidomain simulations. Biophys J 87(4): 2271-2282, 2004
2. Ashihara T, Namba T, Ito M, Ikeda T, Nakazawa K, Trayanova N. Spiral wave control by a localized stimulus: A bidomain model study. J Cardiovasc Electrophysiol 15(2): 226-233, 2004
3. Ashihara T, Namba T, Ikeda T, Ito M, Nakazawa K, Trayanova N. Mechanisms of myocardial capture and temporal excitable gap during spiral wave reentry in a bidomain model. Circulation 109(7): 920-925,2004
4. Kobori A, Sarai N, Shimizu W, Nakamura Y, Murakami Y, Makiyama T, Ohno S, Takenaka K, Ninomiya T, Fujiwara Y, Matsuoka S, Takano M, Noma A, Kita T, Horie M. Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome. J Cardiovasc Electrophysiol 15(2): 190-199, 2004
5. Matsumoto T, Takashima H, Ohira N, Tarutani Y, Yasuda Y, Yamane T, Matsuo S, Horie M. Plasma level of oxidized LDL is an independent determinant of coronary macro-and microvasomotor responses induced by bradykinin. J Am Coll Cardiol 44(2): 451-457, 2004
6. Matsuo S, Matsumoto T, Nakae I, Ito M, Nakamura Y, Takada M, Murata K, Horie M. Evaluation of cardiac resynchronization therapy in drug-resistant idiopathic dilated cardiomyopathy by means of technetium-99m tetrofosmin electrocardiography-gated single-photon emmision computed tomography. Exp Clin Cardiol 9(4): 248-250, 2004
7. Matsuo S, Matsumoto T, Takashima H, Ohira N, Yamane T, Yasuda Y, Tarutani Y, Horie M. The relationship between flow-mediated brachial artery vasodilation and coronary vasomotor responses to bradykinin: comparison with those to acetylcholine. J Cardiovasc Pharmacol 44(2): 164-170, 2004
8. Matsuo S, Nakamura Y, Matsumoto T, Nakae I, Nagatani H, Takazakura R, Takahashi M, Murata K, Horie M. Visual assessment of coronary artery stenosis with electrocardiographically-gated multislice computed tomography. Int J Cardiovasc Imaging 20(1): 61-66, 2004
9. Matsuo S, Matsumoto T, Nakae I, Koh T, Masuda D, Takada M, Murata K, Horie M. Prognostic value of ECG-gated thallium-201 single-photon emission tomography in patients with coronary artery disease. Ann Nucl Med 18(7): 617-622, 2004
10. Nakae I, Mitsunami K, Yabe T, Inubushi T, Morikawa S, Matsuo S, Koh T, Horie M. Detection of metabolic abnormality in asynergic regions of ischemic human myocardium using 31P and 1H magnetic resonance spectroscopy. J Cardiovasc Magn Reson 6(3): 685-696, 2004
11. Nakae I, Mitsunami K, Matsuo S, Matsumoto T, Morikawa S, Inubushi T, Koh T, Horie M. Assessment of myocardial creatine concentration in dysfunctional human heart by proton magnetic resonance spectroscopy. Magn Reson Med Sci 3(1): 19-25, 2004
12. Nakamura Y, Tamaki S, Uchida Y, Ohmichi N, Yamaoka O, Miyauchi N, Fukuhara T, Sayama H, Yamada T, Matsuo S, Yamada Y: Angiotensin converting enzyme genotype influences the response to the angiotensin II receptor antagonist losartan in patients with hypertension. Hypertens Res 27(3): 137-140, 2004
13. Niimi A, Matsumoto H, Takemura M, Ueda T, Nakano Y, Mishima M. Clinical assessment of airway remodeling in asthma: utility of computed tomography. Clin Rev Allergy Immunol 27(1): 45-58, 2004
14. Ohira N, Matsumoto T, Tamaki S, Takashima H, Tarutani Y, Yamane T, Yasuda Y, Horie M. Angiotensin-converting enzyme insertion / deletion polymorphism modulates coronary release of tissue plasminogen activator in response to bradykinin. Hypertens Res 27(1): 39-45, 2004
15. Shimizu W, Horie M, Ohno S, Takenaka K, Yamaguchi M, Shimizu M, Washizuka T, Aizawa Y, Nakamura K, Ohe T, Aiba T, Miyamoto Y, Yoshimasa Y, Towbin J, Priori S, Kamakura S. Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulaion in the LQT1 Form of congenital long QT syndrome. J Am Coll Cardiol 44(1): 117-125, 2004
16. Takayama T, Wada A, Tsutamoto T, Ohnishi M, Fujii M, Isono T, Horie M. Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor. Circ J 68(11): 1067-1075, 2004
17. Tsutamoto T, Sakai H, Wada A, Ishikawa C, Ohno K, Fujii M, Yamamoto T, Takayama T, Dohke T, Horie M. Torasemide inhibits transcardiac extraction of aldosterone in patients with congestive heart failure. J Am Coll Cardiol 44(11): 2252-2253, 2004
18. Tsutamoto T, Wada A, Ohnishi M, Tsutsui T, Ishii C, Ohno K, Fujii M, Matsumoto T, Yamamoto T, Takayama T, Dohke T, Horie M. Transcardiac increase in tumor necrosis factor-alpha and left ventricular end-diastolic volume in patients with dilated cardiomyopathy. Eur J Heart Fail 6(2): 173-180, 2004
19. Yamamoto T, Wada A, Tsutamoto T, Ohnishi M, Horie M. Long-term treatment with a phosphodiesterase type 5 inhibitor improves pulmonary hypertension secondary to heart failure through enhancing the natriuretic peptides-cGMP pathway. J Cardiovasc Pharmacol 44(5): 596-600, 2004
20. Yasumura Y, Miyatake K, Okamoto H, Miyauchi T, Kawana M, Tsutamoto T, Kitakaze M, Matsubara H, Takaoka H, Anzai T, Himeno H, Yokoyama H, Yokoya K, Shintani U, Hashimoto K, Koretsune Y, Nakamura Y, Imai K, Maruyama S, Masaoka Y, Sekiya M, Shiraki T, Shinohara H, Ozono K, Matsuoka T, Miyao Y, Nomura F. Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure. Circ J68(4): 361-366, 2004
21. Yumoto Y, Horie M, Kubota T, Ninomiya T, Kobori A, Takenaka K, Takano M, Niwano S, Izumi T. Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock. J Cardiovasc Pharmacol 43: 178-182, 2004

2004年症例報告

1. Matsuo S, Nakamura Y, Nakae I, Matsumoto T, Takada M, Murata K, Horie M. Scintigraphic evaluation of cardiac metabolism in multicentric Castleman's disease. Intern Med 43(6): 490-492, 2004
2. Fujii M, Wada A, Ohnishi M, Tsutamoto T, Matsumoto T, Yamamoto T, Takayama T, Dohke T, Isono T, Eguchi Y, Horie M. Endogenous bradykinin suppresses myocardial fibrosis though the cardiac-genetated endothelin system under chronic angiotensin-converting enzyme inhibition in heart failure. J Cardiovasc Pharmacol 44(Suppl.1): S346-S349, 2004

2003

1. Ashihara T, Namba T, Yao T, Ozawa T, Kawase A, Ikeda T, Nakazawa K, Ito M. Vortex cordis as a mechanism of postshock activation: Arrhythmia induction study using a bidomain model. J Cardiovasc Electrophysiol 14(3): 295-302, 2003
2. Kawase A, Ikeda T, Nakazawa K, Ashihara T, Namba T, Kubota T, Sugi K, Hirai H. Widening of the excitable gap and enlargement of the core of reentry during atrial fibrillation with a pure sodium channel blocker in canine atria. Circulation 107(6): 905-910, 2003
3. Hayashi M, Tsutamoto T, Wada A, Tsutsui T, Ishii C, Ohno K, Fujii M, Taniguchi A, Hamatani T, Nozato Y, Kataoka K, Morigami N, Ohnishi M, Kinoshita M, Horie M. Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction. Circulation 107(20): 2559-2565, 2003
4. Horie M, Takenaka K, Ai T, Haruna T, Kono Y, Yoshida H, Kubota T, Ninomiya T, Kobori A, Ono S, Makiyama S, Otani and Takano M, Takaki H, Kamakura S, Shimizu W. Potassium Channels and Channelopathy-Clinical Cardiac Pacinc and Electrophysiology. Monduzzi Editore 347-349, 2003
5. Katsuta H, Ozawa S, Ninomiya T, Shimoyama T, Ito E, Tanaka T, Yamaguchi S, Katahira H, Nagamatsu S, Horie M, Ishida H. Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN6 beta cells. Biochem Biophys Res Commun 311(3): 660-664, 2003
6. Konishi H, Nishio S, Tsutamoto T, Minouchi T, Yamaji A. Serum carvediol concentation and its relation to change in plasma brain natriuretic peptide level in the treatment of heart failure: a preliminary study. Int J Clin Pharmol Ther 41(12): 578-586, 2003
7. Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J 22(23): 6310-6321, 2003
8. Matsumoto T, Minai K, Horie H, Ohira N, Takashima H, Tarutani Y, Yasuda Y, Ozawa T, Matsuo S, Kinoshita M, Horie M. Angiotensin-converting enzyme inhibition but not angiotensin II type 1 receptor antagonism augments coronary release of tissue plasminogen activator in hypertensive patients. J Am Coll Cardiol 41(8): 1373-1379, 2003
9. Matsumoto T, Wada A, Tsutamoto T, Ohnishi M, Isono T, Kinoshita M. Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation 107(20): 2555-2558, 2003
10. Matsuo S, Matsumoto T, Nakae I, Takashima H, Nakamura Y, Horie M. Non-invasive detection of endothelial dysfunction in femoral artery using thallium-201 scintigraphy. International Med J 10: 39-42, 2003
11. Matsuo S, Nakamura Y, Kinoshita M, Horie M. Plasma B-type natriuretic peptide measurement in asymptomatic population. International Med J 10: 105-108, 2003
12. Matsuo S, Nakamura Y, Matsumoto T, Nakae I, Murata K, Horie M. Prognostic value of iodine-123 metaiodobenzylguanidine imaging in patients with heart failure. Exp Clin Cardiol 8(2): 95-98, 2003
13. Nakae I, Matsumoto T, Omura T, Takashima H, Ohira N, Tarutani Y, Yasuda Y, Matsuo S, Koh T, Nakamura Y, Kinoshita M, Horie M. Endothelial modulation and tolerance development in the vasorelaxant responses to nitrate of rabbit aorta. Life Science 73(24): 3083-3094, 2003
14. Nakae I, Mitsunami K, Omura T, Yabe T, Tsutamoto T, Matsuo S, Takahashi M, Morikawa S, Inubushi T, Nakamura Y, Kinoshita M, Horie M. Proton magnetic resonance spectroscopy can detect creatine depletion associated with the progression of heart failure in cardiomyopathy. J Am Coll Cardiol 42(9): 1587-1593, 2003
15. Ninomiya T, Takano M, Haruna T, Kono Y, Horie M. Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6.2). J Cardiovasc Pharmacol 42(2): 161-168, 2003
16. Sekikawa A, Horiuchi BH, Edmundowicz D, Ueshima H, Curb DJ, Kim ST, Okamura T, Kadowaki T, Kashiwagi A, Mitsunami K, Nakamura Y, Murata K, Kuller LH, Okamura T. A "natural experiment" in cardiovascular epidemiology in the early-21st century. Heart 89(3): 255-257, 2003
17. Takenaka K, Ai T, Shimizu W, Kobori A, Ninomiya T, Otani H, Kubota T, Takaki H, Kamakura S, Horie M. Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long QT syndrome. Circulation 107(6): 838-844, 2003
18. Tsutamoto T, Wada A, Hayashi M, Tsutsui T, Maeda K, Ohnishi M, Sawaki M, Fujii M, Matsumoto T, Yamatoto T, Takayama T, Ishii C, Kinoshita M. Relationship between transcardiac gradient of endothelin-1 and left ventricular remodelling in patients with first anterior myocardial infarction. Eur Heart J 24(4): 346-355, 2003

2003年症例報告

1. Matsuo S, Nakae I, Nakamura Y, Horie M. Viable but denervated myocardium in a patient with eosinophilic myocarditis. International Med J 10: 57, 2003
2. Tsutamoto T, Tsutsui T, Maeda K, Hayashi M, Wada A, Ohnishi M, Fujii M, Ishii C. Effects of long-acting calcium channel antagonists on neurohumoral factors: comparison of nifedipine coat-core with amlodipine. J Cardiovasc Pharmacol 41 Suppl 1: S77-81, 2003
3. Tsutamoto T, Wada A, Maeda K, Hayashi M, Tsutsui T, Ohnishi M, Fujii M, Matsumoto T, Yamamoto T, Takayama T, Ishii C. Transcardiac gradient of aldosterone before and after spironolactone in patients with congestive heart failure. J Cardiovasc Pharmacol 41 Suppl 1: S19-22, 2003