Original articles(2006~present) 

2016 

Seita Y, Tsukiyama T, Iwatani-Tsuchiya C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Imamura T, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M (2016) Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body.
Sci Rep in press        PubMed|Journal

Yamaguchi M, Seki T, Imayoshi I, Tamamaki N, Hayashi Y, Tatebayashi Y, Hitoshi S (2016) Neural stem cells and neuro/gliogeneis in the central nervous system: understanding the structural and functional plasticity of the developing, mature, and diseased brain.
J Physiol Sci 66, 197-206        PubMed|Journal

*Naruse M, *Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S (2016) The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window. (*, equal contribution)
Cerebral Cortex 26, 2800-2810        PubMed|Journal

2014 

Torii T, Yoshimura T, Narumi M, Hitoshi S, Takaki Y, Tsuji S, Ikenaka K (2014) Determination of major sialylated N-glycans and identification of branched sialylated N-glycans that dynamically change their content during development in the mouse cerebral cortex.
Glycoconj J 31, 671-683        PubMed|Journal

Fuke S, Kametani M, Yamada K, Kubota-Sakashita M, Kasahara T, Kujoth GC, Prolla TA, Hitoshi S, Kato T (2014) A heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.
Annals of Clinical and Translational Neurology 1, 909-920        PubMed|Journal

*Zheng L-S, *Hitoshi S, *Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for interferon-α-induced depression and neural stem cell dysfunction. (*, equal contribution)
Stem Cell Reports 3, 74-83        PubMed|Journal

*Ishino Y, *Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi S (2014) Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells. (*, equal contribution)
J Neurosci 34, 3067-3078         PubMed|Journal

2013 

Kumar A, Torii T, Ishino Y, Muraoka D, Yoshimura T, Togayachi A, Narimatsu H, Ikenaka K, Hitoshi S (2013) The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
J Biol Chem 288, 28859-28868        PubMed|Journal

Deguchi A, Hitoshi S, Yoshimura T, Fujimoto I, Ikeda T, Ishii A, Higashi M, Masaki T, Kuriyama S, Ikenaka K (2013) GnT V-catalyzed N-glycan products are not increased in hepatomas.
J Glycomics Lipidomics S5:003        

Shimizu T, Tanaka KF, Takebayashi H, Higashi M, Ono K, Hitoshi S, Ikenaka K (2013) Olig2-lineage cells preferentially differentiate into oligodendrocytes but fail to survive in the chronic demyelinating lesion.
J Neurosci Res 91, 178-186        PubMed|Journal

2012 

Iwashita N, Nosaka S, Koyama N (2012) Involvement of peripheral NMDA receptor in melittin-induced thermographic flare.
Neurochem Res 37, 2222-2228        PubMed|Journal

Tatebayashi Y, Nihonmatsu-Kikuchi N, Hayashi Y, Yu X, Soma M, Ikeda K. (2012) Abnormal fatty acid composition in the frontopolar cortex of patients with affective disorders.
Transl Psychiatry 2, e204        PubMed|Journal

Hayashi Y, Nihonmatsu-Kikuchi N, Hisanaga S-i, Yu X, Tatebayashi Y. (2012) Neuropathological similarities and differences between schizophrenia and bipolar disorder : a flow cytometric postmortem brain study.
PLoS One 7, e33019        PubMed|Journal

2011 

Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K (2011) Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
Nat Neurosci 14, 957-964        PubMed|Journal

Fuke S, Kubota-Sakashita M, Kasahara T, Shigeyoshi Y, Kato T. (2011) Regional variation in mitochondrial DNA copy number in mouse brain.
Biochim Biophys Acta – Bioenergetics 1807, 270-274        PubMed|Journal

Hayashi Y, Nihonmatsu-Kikuchi N, Hisanaga S-i, Tatebayashi Y. (2011) A novel, rapid, cell-counting method for unfixed frozen brains comprehensively quantifies at least four neural cell populations.
Mol Psychiat 16, 1155        PubMed|Journal

Kato S, Kuramochi M, Takasumi K, Kobayashi K, Inoue KI, Takahara D, Hitoshi S, Ikenaka K, Shimada T, Takada M, Kobayashi K (2011) Neuron-Specific Gene Transfer through Retrograde Transport of Lentiviral Vector Pseudotyped with a Novel Type of Fusion Envelope Glycoprotein.
Hum Gene Ther 22, 1511-1523        PubMed|Journal

Kamitani-Kawamoto A, Hamada M, Moriguchi T, Miyai M, Saji F, Hatamura I, Nishikawa K, Takayanagi H, Hitoshi S, Ikenaka K, Hosoya T, Hotta Y, Takahashi S, Kataoka K (2011) MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development.
J Bone Miner Res 26, 2463-2472        PubMed|Journal

2010 

Espinosa-Jeffrey A, Hitoshi S, Zhao P, Awosika O, Agbo C, Olaniyan E, Garcia J, Valera R, Thomassian A, Chang-Wei R, Yamaguchi M, de Vellis J, Ikenaka K (2010) Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression.
J Neurosci Res 88, 1682-1694        PubMed|Journal

2008 

Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y (2008) Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
Cell Stem Cell 3, 555-567        PubMed|Journal

Higashi M, Maruta N, Bernstein A, Ikenaka K, Hitoshi S (2008) Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of Notch signaling.
Stem Cells 26, 1758-1767        PubMed|Journal

Sasaki N, Okishio K, Ui-Tei K, Saigo K, Kinoshita-Toyoda A, Toyoda H, Nishimura T, Suda Y, Hayasaka M, Hanaoka K, Hitoshi S, Ikenaka K, Nishihara S (2008) Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.
J Biol Chem 283, 3594-3606        PubMed|Journal

Fuke S, Kametani M, Kato T. (2008) Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia.
Neurosci Lett 439, 173-177        PubMed|Journal

2007 

Hitoshi S, Maruta N, Higashi M, Kumar A, Kato N, Ikenaka K (2007) Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
J Neurosci Res 85, 3574-3585        PubMed|Journal

Karpowicz P, Inoue T, Runciman S, Deveale B, Seaberg R, Gertsenstein M, Byers L, Yamanaka Y, Tondat S, Slevin J, Hitoshi S, Rossant J, van der Kooy D (2007) Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency.
J Neurosci 27, 5437-5447        PubMed|Journal

Ishii A, Ikeda T, Hitoshi S, Fujimoto I, Torii T, Sakuma K, Nakakita SI, Hase S, Ikenaka K (2007) Developmental Changes in the Expression of Glycogenes and the Content of N-glycans in the Mouse Cerebral Cortex.
Glycobiology 17, 261-276        PubMed|Journal

Hasegawa A, Naruse M, Hitoshi S, Iwasaki Y, Takebayashi H & Ikenaka K (2007) Regulation of glial development by cystatin C.
J Neurochem 100, 12-22        PubMed|Journal

2006 

Wada T, Haigh JJ, Ema M, Hitoshi S, Chaddah R, Rossant J, Nagy A, van der Kooy D (2006) Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival.
J Neurosci 26, 6803-6812        PubMed|Journal

Naruse M, Nakahira E, Miyata T, Hitoshi S, Ikenaka K, Bansal R (2006) Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2.
Dev Biol 297, 262-273        PubMed|Journal

Alexson TO, Hitoshi S, Coles BL, Bernstein A, van der Kooy D (2006) Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche.
Dev Neurosci 28, 34-48        PubMed|Journal

Sakuma K, Fujimoto I, Hitoshi S, Tanaka F, Ikeda T, Tanabe K, Toyokuni S, Wada H, Mio T, Mishima M, Ikenaka K (2006) An N-glycan structure correlates with pulmonary metastatic ability of cancer cells.
Biochem Biophys Res Commun 340, 829-835        PubMed|Journal

 

Original articles

2006~present

1997~2005

        ~1996

Reviews

Address

Prof. Seiji Hitoshi

Seta Tsukinowa-cho
Otsu, Shiga 520-2192
Japan

TEL: +81-77-548-2148
FAX: +81-77-548-2146