西 英一郎にし えいいちろう
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医学系研究科 薬理学 教授
略歴
メッセージ
主な著書、論文
1. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration.
Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ
Neuron 93(1) 115-131 Jan. 2017
DOI:10.1016/j.neuron.2016.11.038
2. Nardilysin is Required for maintaining Pancreatic β-Cell Function.
Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E
Diabetes 65(10) 3015-3027 Jul. 2016
DOI:10.2337/db16-0178
3. Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
Ishizu-Higashi S, Seno H, Nishi E, Matsumoto Y, Ikuta K, Tsuda M, Kimura Y, Takada Y, Kimura Y, Nakanishi Y, Kanda K, Komekado H, Chiba T
PloS one 9(5) e98017 May 2014
DOI:10.1371/journal.pone.0098017