研究目的 　スタッフ 研究論文
Hiroshi KIMURA
Research Interests
　
Publications
1 Saito A, Sato T, Okano H, Toyoda K, Bamba H, Kimura S, Bellier J-P, Matsuo A, Hisa Y, Tooyama I. Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve. J Comp Neurol 513:237-48, 2009.
2 Yasuhara O, Aimi Y, Matsuo A, Kimura H. Distribution of a splice variant of choline acetyltransferase in the trigeminal ganglion and brainstem of the rat: comparison with calcitonin gene-related peptide and substance P. J Comp Neurol 509(4):436-48, 2008.
3 D’Este L, Kimura S, Casini A, Matsuo A, Bellier J-P, Kimura H, Renda TG. First visualization of cholinergic cells and fibers by immunohistochemistry for choline acetyltransferase of the common type in the optic lobe and peducle complex of octopus vulgaris. J. Comp. Neurol. 509(6):566-79, 2008.
4 Yasuhara O, Aimi Y, Shibano A, Kimura H. Primary sensory neurons containing choline acetyltransferase of the peripheral type in the rat trigeminal ganglion and their relation to neuropeptides-, calbindin- and nitric oxide synthase-containing cells. Brain Research, 1141: 92-98, 2007.
5 Wang L, Martinez V, Kimura H, Tache YF. 5-Hydroxytryptophan activates colonic my enterric neurons and propulsive motor function through 5-HT4 receptors in conscious mice. Am J Physiol Gastrointest Liver Physiol. 292: G419-G428, 2007.
6 Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H. The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type. Neurochem Int 50:251-255, 2007.
7 Bellier J-P, Kimura H. Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion. J Neurochem 101:1607-1618, 2007.
8 Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I. Localization of fibroblast growth factor-1 in cholinergic neurons innervating the rat larynx. J Histochem Cytochem, 54: 1061-1071, 2006.
9 Hazama G, Yasuhara O, Morita H, Aimi Y, Tooyama I, Kimura H: Mouse brain IgG like immunoreactivity: Strain specific occurrence in microglia and biochemical identification of IgG. J. Comp. Neurol. 492: 234-249, 2005.
10 Yuan PQ, Kimura H, Million M, Bellier JP, Wang L, Ohning GV, Tache Y. Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats. Peptides. 26(4): 653-64. 2005.
11 Matsuo A, Bellier J-P, Hisano T, Aimi Y, Yasuhara O, Tooyama I, Saito N, Kimura H: Rat choline acetyltransferase of the peripheral type differs from that of the common type in translocation. Neurochem. Int. 46: 423-433, 2005.
12 Casini A, Pinna I , Tooyama I, Kimura H, Chiara Di G, Renda TG: Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain. Eur. J. Histochem. 48: 135-140, 2004.
13 Sasaki K, Ishibashi M, Yasui F, Matsugo S, Tooyama I , Kimura H, Oomura Y: Ameliorative effects of acetyl-L-carnitine and acidic fibroblast growth factor fragment analog on brain lipid hydroperoxide level, passive avoidance learning and/or immunoreactivity for choline acetyltransferse in the medial septum in senesence-accelerated mice. International Congress Series 1260: 123-128, 2004.
14 Yasuhara O, Aimi Y, Shibano A, Matsuo A, Bellier J-P, Park M, Tooyama I , Kimura H: Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase. J. Comp. Neurol. 472: 232-245, 2004.
15 Brehmer A, Schr?dl F, Neuhuber W, Tooyama I, Kimura H: Coexpression pattern of neuronal nitric oxide synthase and two variants of choline acetyltransferase in myenteric neurons of porcine ileum. J. Chem. Neuroanat. 27: 33-41, 2004.
16 Iwami M, Tooyama I, Kinoshita A, Matsuo A, Oomura Y, Sasaki K, Kimura H: Demonstration of fibroblast growth factor receptor-1 in rat adrenal gland as revealed by reverse transcription-polymerase chain reaction and immunohistochemistry. Acta Histochem. Cytochem. 36: 353-359, 2003.
17 Tsuji S, Tooyama I, Kato T, Peltre G, Kimura H: Binding avidity of immunoglobulin G for acetylcholine. Biomed. Res. 24: 217-221, 2003.
18 Yasuhara O, Tooyama I, Aimi Y, Bellier J-P, Hisano T, Matsuo A, Park M, Kimura H: Demonstration of cholinergic ganglion cells in rat retina: Expression of an alternative splice variant of choline acetyltransferase. J. Neurosci. 23:2872-2881, 2003.
19 Chiocchetti R, Poole DP, Aimi Y, Kimura H, Aimi Y, Robbins HL, Castelucci P, Furness JB: Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons. Cell Tissue Res 311:11-22, 2003.
20 Kanayama H, Yasuhara O, Matsuo A, Tooyama I, Aimi Y, Bellier J-P, Nagy JI, Fukui K, Kimura H: Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat. Neuroscience 118: 243-251, 2003.
21 Kimura H, Aimi Y, Minnasch P, Yasuhara O, Bellier J-P, Tooyama I: Molecular mechanisms in Alzheimer's disease. Research in legal Medicine 27:161-174, 2002.
22 Tooyama I, Bellier JP, Park M, Minnasch P, Uemura S, Hisano T, Iwami M, Aimi Y, Yasuhara O, Kimura H: Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy. Epilepsia , 43:Suppl 9:39-43, 2002.
23 D’Este L, Casini A, Puglisi-Allegra S, Cabib S, Tooyama I, Kimura H, Renda TG: Immunoreactive neurons in the brain of two mouse strains after incubation with an antiserum recognizing Asp-Val-Val-Gly.NH2 (DVVG), the C-terminal fragment of (D-Ala2)-deltorphin I. J. Chem. Neuroanat. 24:189-198 2002.
24 Kage M, Yang Q, Sato H, Matsumoto S, Kaji R, Akiguchi I, Kimura H, Tooyama I: Acidic fibroblast growth factor (FGF-1) in the anterior horn cells of ALS and control cases. NeuroReport 12: 3799-3803, 2001.
25 Sunday ME, Haley KJ, Emanuel RL, Torday JS, Asokananthan N, Sikorski KA, Tooyama I, Kimura H, Renda T, Erspamer V. : Fetal Alveolar Epithelial Cells Contain [D-Ala(2)]-Deltorphin I-like　Immunoreactivity. Delta- and & mu-opiate receptors mediate opposite effects in developing lung. Am J Respir Cell Mol Biol. 25: 447-456, 2001.
26 Kitamura Y, Spleiss O, Li H, Tanjguchi T, Kimura H, Nomura Y, Gebicke-Haerter P. J.: Lipopolysaccharide-induced switch between retinoid receptor（RXR）? and glucocorticoid attenuated response gene（GARG）-16 messenger RNAs in cultured rat microglia. J. Neurosci. Res. 64: 553-563, 2001.
27 Kitano H, Takeda T, Takeda S, Suzuki M, Kitanishi T, Kitajima K, Kimura H, Tooyama I: Endolymphatic hydrops by Administration of vasopressin in the rat. Acta Histochem. Cytochem. 34: 229-233, 2001.
28 Terada H, Nagai T, Okada S, Kimura H, Kitahama K: Ontogenesis of neurons immunoreactive for nitric oxide synthase in rat forebrain and midbrain. Dev. Brain Res. 128: 121-137, 2001.
29 Komai H, Naito Y, Aimi Y, Kimura H: Nitric oxide synthase expression in lungs of pulonary hypertensive patients with heart disease. Cardiovasc Pathol. 10: 29-32, 2001.
30 Tooyama I, Sato H, Yasuhara O, Kimura H, Konishi Y, Shen Y, Walker DG, Beach TG, Sue LI, Rogers J: Correlation of the expression level of C1q mRNA and the number of C1q-positive plaques in the Alzheimer disease temporal cortex. Dement Geriatr Cogn Disord 12: 237-242, 2001.
31 Matsuoka Y, Aimi Y, Kimura H, Taniguchi T, Oomura Y, Sasaki K, Tooyama I: Demonstration of acidic fibroblast growth factor (FGF-1) in rat adrenal gland. Acta histochem cytochem 34: 129-134, 2001.
32 Yu S, Zhao T, Fan M, Tooyama I, Kimura H, Renda TG: Production of monoclonal antibody to deltorphin-I and its immunocytochemical application to adult rat brain and cultured rat brain neurons. Peptides 21: 1657-1662, 2000.
33 Tooyama I, Abe H, Renda TG, Kimura H: Production and immunohitochemical application of antiserum against Tyr-D-Ala-Phe, a N-terminal tripeptide common to dermorphin/deltorphin family. Peptides 21: 1649-1655, 2000.
34 Kuriyama K, Hirouchi M, Kimura H: Neurochemical and molecular phamacological aspects of the GABAB receptor. Neurochem. Res. 25: 1233-1239, 2000.
35 Suzuki M, Kitanishi T, Kitano H, Yazawa Y, Kitajima K, Takeda T, Tokunaga Y, Maeda T, Kimura H, Tooyama I: C-type natriuretic peptide-like immunoreactivity in the rat inner ear. Hear. Res. 139: 51-58, 2000.
36 Park M, Tokunaga Y, Kimura H, Tooyama I, Maeda T, Renda TG: Ontogeny of (D-Ala2)-deltorphin I-like immunoreactive neurones in foetal rat brain. J. Chem. Neuroanat. 18: 11-22, 2000.
37 Kitamura Y, Taniguchi T, Kimura H, Nomura Y, Gebicke-Haerter P.J.: Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures. J.Neuroimmunol. 106: 95-104, 2000.
38 Nakajima K, Tooyama I, Yasuhara O, Aimi Y, Kimura H: Immunohistochemical demonstration of choline acetyltransferase of a peripheral type (pChAT) in the enteric nervous system of rats. J Chem Neuroanat 18: 31-40, 2000.
39 Tooyama I, Kimura H: A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibers. J. Chem. Neuroanat. 17: 217-226, 2000.
40 Nakagawa E, Aimi Y, Yasuhara O, Tooyama I, Shimada M, McGeer P.L, Kimura H: Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy. Epilepsia 41: 10-18, 2000.
41 Kimura H, Aste N, Nakajima K, Aimi Y, Yasuhara O, Tooyama I: Peripheral type choline acetyltransferase: molecular neuroanatomy. Ital J Anat Embryol. 104: S1, 1999.
42 Nakanishi Y, Tooyama I, Yasuhara O, Aimi Y, Kitajima K, Kimura H: Immunohistochemical localization of choline acetyltransferase of a peripheral type in the rat larynx. J Chem Neuroanat 17: 21-32, 1999.
43 Matsuoka Y, Okazaki M, Kitamura Y, Takata K, Tooyama I, Kimura H, Taniguchi T: Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation. Brain Res. 836: 213-217, 1999.
44 Kitano H, Suzuki M, Kitanishi T, Yazawa Y, Kitajima K, Isono T, Takeda T, Kimura H, Tooyama I: Regulation of inner ear fluid in the rat by vasopressin. NeuroReport 10: 1205-1207, 1999.
45 Matsukawa N, Tooyama I, Kimura H, Yamamoto T, Tsugu Y, Oomura Y, Ojika K: Increased expression of hippocampal cholinergic neurostimulating peptide-related compounds and their messenger RNAs in the hippocampus of aged senescence-accelerated mice. Neuroscience 88: 79-92, 1999.
46 Sasaki K, Tooyama I, Oomura Y, Li A-J, Kimura H: Effect of acidic fibroblast growth factor fragment analog on learning and memory, and medial septum cholinergic neurons in senescence accelerated mice. Neuroscience 92: 1287-1294, 1999.
47 Tooyama I, Nishimura T, Nakagawa E, Morita H, Uemura S, Aimi Y, Yasuhara O, Kimura H: Microglial reaction and neuronal death in the hippocampus of rat models of epilepsy. Neuropathol 19: 203-208, 1999.
48 Matsuoka Y, Kitamura Y, Taniguchi H, Tooyama I, Kimura H, Gebicke-Haerter PJ, Nomura Y, Taniguchi T: Interferon-g plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus. Neurochem Int 34: 91-99, 1999.
49 Kitano H, Kitanishi T, Nakanishi Y, Suzuki M, Takeuchi E, Yazawa Y, in Kitajima K, Kimura H, Tooyama I: Expression of inducible nitric oxide synthase human thyroid papillary carcinoma. Thyroid 9: 113-117, 1999.
50 Aisaka A, Aimi Y, Yasuhara O, Tooyama I, Kimura H, shimada M: Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters. Neuroscience 90: 53-67, 1999.
51 Kitamura Y, Ota T, Matsuoka Y, Tooyama I, Kimura H, Shimomura S, Nomura Y, Gebicke-Haerter PJ, Taniguchi T: Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia 25:154-164, 1999.
52 Kitamura T, Ota T, Matsuoka Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Shimohama S, Gebicke-Haerter PJ, Nomura U, Taniguchi T: Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. Neurosci. Lett. 255:57-60, 1998.
53 Nagata A, Nakao s, Miyamoto e, Inada T, Tooyama I, Kimura H, Shingu K: Propofol inhibits ketamine-induced c-fos expression in the rat posterior cingulate cortex. Aneth. Analg. 87:1416-1420, 1998.
54 Nagata A, Nakao s, Miyamoto e, Inada T, Tooyama I, Kimura H, Shingu K: Propofol inhibits ketamine-induced c-fos expression in the rat posterior cingulate cortex. Aneth. Analg. 87:1416-1420, 1998.
55 Suzuki M, Kitano H, Kitanishi T, Yazawa Y, Kitajima K, Takeda T, Kimura H, Tooyama I: RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear. Mol. Brain Res. 55:165-168, 1998.
56 Doi T, Terai K, Tooyama I, Sakata T, Kimura H: Production of monoclonal antibody against histamine and its application to immunohistochemical study in the stomach. Histochem. J. 30:425-434, 1998.
57 Ishii H, Arai T, Morikawa S, Inubushi T, Tooyama I, Kimura H, Mori K: Evaluation of focal cerebral ischemia in rats by magnetic resonance imaging and immunohistochemical analyses. J Cereb. Blood Flow. Matab. 18:931-934, 1998
58 Li A-J, Oomura Y, Sasaki K, Hori N, Tooyama I, Nomura Y, Hanai K, Kimura H, Yanaihara N, Yoshii H, Yamazaki Y, Take T, Hori T: Actions of aFGF in senescence-accelerated mice: proctive effects against deficits of learning and memory, and effects on immunological functions. In: Taniguchi Symposia on Brain Sciences, Brain and Biodefence (eds. Oomura Y et al.), 21:51-61, 1998.
59 Li A-J, Oomura Y, Sasaki K, Suzuki K, Tooyama I, Hanai K, Kimura H, Hori T: A single pre-training glucose injection induces memory facilitation in rodents performing various tasks: contribution of acidic fibroblast growth factor. Neuroscience 85:785-794, 1998.
60 Kitano H, Takeda T, Suzuki M, Kitanishi T, Yazawa Y, Kitajima K, Kimura H, Tooyama I: Presence of mRNA for vasoactive intestinal polypeptide (VIP) and its receptor in the rat inner ear. Hear. Res. 121:109-111, 1998.
61 Matsuoka Y, Kitamura Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Taniguchi T: Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience 85:1223-1233, 1998.
62 Kage M, Ikemoto A, Akiguchi I, Kimura J, Matsumoto S, Kimura H, Tooyama I: Primary structure of GAP-43 mRNA expressed in the spinal cord of ALS patients. Neuroreport 9:1403-1406, 1998.
63 Funahashi A, Fujimiya M, Kimura H, Maeda T: Abnormal development of serotonin nerve fibers in the visual cortex in rats with methylazoxymethanol-induced microcephaly. Acta. Neuropathol. 95:5-14, 1998.
64 Kitamura Y, Furukawa M, Matsuoka Y, Tooyama I, Kimura H, Nomura Y, Taniguchi T: In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase. Glia 22:138-148, 1998.
65 Ding W-G, Guo L-D, Kitasato H, Fujimura M, Kimura H: Phylogenic study of calcitonin gene-related peptide-immunoreactive structures in the pancreas. Histochem Cell Biol. 109:103-109, 1998.
66 Terai K, Tooyama I, Kimura H:Immunohistochemical localization of GABA-immunoreactive structures in the nucleus tractus solitarii of the rat. Neuroscience 82:843-852, 1998.
67 Renda T, Erspamer V, Tooyama I, Kimura H: Mesencephalic ?-opioid peptidergic ascending projection with special reference to the mesolimbocortical system. In: Motta P. M. ed. Recent Advances in Microscopy of Cells, Tissues and Organs. (Antonio Delfino Editore, Rome) PP.239-246, 1997.
68 Ding WG, Kimura H, Fujimura H, Fujimiya M: Neuropeptide Y and peptide YY immunoreactivities in the pancreas of various vertebrates. Peptides 18:1523-1529, 1997.
69 Ding WG, Kirassato H, Kimura H: Development of neuropeptide Y innervation in the liver. Microscopy Research and Technique 39:365-371, 1997.
70 Aimi Y, Wakabayashi Y, Yasuhara O, Matsuo A, Kwok YN, McGeer PL, Kimura H: Immunohistochemical localization of low-affinity nerve growth factor receptor in the enteric nervous system of adult rats. Histochem. J. 29:529-537, 1997.
71 Kimura H, Yasuhara O, Tooyama I: Recent advances in neuroscience for Alzheimer's disease. Adv. Legal. Med. 3:280-283, 1997.
72 Takenaka H, Kishimoto S, Tooyama I, Kimura H, Yasuno H: Protein expression of fibroblast growth factor receptor-1 in keratinocytes during wound healing in rat skin. J. Invest. Dermatol. 109:108-112,1997.
73 Matsuoka Y, Kitamura Y, Tooyama I, Kimura H, Taniguchi T: In vivo hypothermia-induced neuronal damage with an enhancement of neuronal nitric oxide synthase immunoreactivity in hippocampus. Exp. Neurol. 146:57-66, 1997.
74 Matsuoka Y, Kitamura Y, Fukunaga R, Shimohama S, Nabeshima T, Tooyama I, Kimura H, Taniguchi T: In vivo hypothermia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801. Neurochem. Int. 30:533-542, 1997.
75 Kitano H, Takeda T, Suzuki M, Kitanishi T, Yazawa Y, Kitajima K, Kimura H, Tooyama I: Vasopressin and oxytocin receptor mRNAs are expressed in the rat inner ear. Neuroreport 8:2289-2292, 1997.
76 Arai R, Kimura H, Nagatsu I, Maeda T: Preferential localization of monoamine oxidase type A activity in neurons of the locus coeruleus and type B activity in neurons of the dorsal raphe nucleus of the rat: a detailed enzyme histochemical study. Brain Res. 745:352-356, 1997.
77 Tooyama I, Sasaki K, Oomura Y, Li AJ, Kimura H: Effect of acidic fibroblast growth factor on basal forebrain cholinergic neurons in senescence accelerated mice. Exp. Gerontol. 32:171-179, 1997.
78 Suzuki M, Kitano H, Kitanishi T, Yazawa Y, Kitajima K, Takeda T, Kimura H, Tooyama I: Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptides (ANP-B) receptor mRNAs in rat inner ear. Neuroreport 8:439-443, 1997.
79 Nakao S, Adachi T, Murakawa M, Shinomura T, Kurata J, Shichino T, Shibata M, Tooyama I, Kimura H, Mori K: Halotheane and diazepam inhibit katamine-induced c-fos expression in the rat cingulate cortex. Anesthesiology 85:874-882, 1996.
80 Takeichi Y, Nakasu Y, Tooyama I, Kimura H: Basic FGF partially prevents degeneration of paraventricular vasopressin neurons after hypophysectomy. Restr. Neurol. Neurosci. 10:161-166, 1996.
81 Kitamura Y, Takahashi H, Matsuoka Y, Tooyama I, Kimura H, Nomura Y, Taniguch T: In vivo induction of inducible nitric oxide synthase by microinjection with interferon-gamma and lipopolysaccharide in rat hippocampus. Glia 18:233-243, 1996.
82 Miyara M, Sakumoto T, Takamiyagi N, Nakama K, Kimura H, Kanazawa K: Relationship between endometrial histology, morphometry and ultrasound texture in the follicular phase of infertile women with natural menstrual cycles. Hum Reprod 11:1719-1723, 1996.
83 Terada H, Nagai T, Kimura H, Kitahama K, Okada, S: Distribution of nitric oxide synhase- immunoreactive neurons in fetal rat brains at embryonic day 15 and day 19. J. Chem. Neuroanat. 10: 273-278, 1996.
84 Kimura H, Terai K, Tooyama I, Kuriyama K: Immunohistochemical demonstration of GABA-B receptors in the rat brain. Pharmacol. Rev. Comm. 8:167, 1996.
85 Hirouchi M, Tooyama I, Kimura H, Kuriyama K: Molecular biological approaches to the GABA-B receptor. Pharmacol. Rev. Comm. 8:151, 1996.
86 Nakajima K, Tooyama I, Kuriyama K, Kimura H: Immunohistochemical demonstration of GABA-B receptors in the rat gastrointestinal tract. Neurochem. Res. 21:211-215, 1996.
87 Oomura Y, Sasaki K, Li A, Kimura H, Tooyama I, Hanai K, Nomura Y, Kitamura Y, Yanaihara N, Yago H: Memory facillitation by an endogenous satiety substance, acidic fibroblast growth factor (aFGF). Prog. Obes. Res. 7:433-438, 1996.
88 Oomura Y, Sasaki K, Li A, Yoshi H, Fukata Y, Yago H, Kimura H, Tooyama I, Hanai K, Nomura Y, Yanaihara N: Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor. Ann. N.Y. Acad. Sci. 786: 337-347, 1996.
89 Li A-J, Oomura Y, Hori T, Aou S, Sasaki K, Kimura H, Tooyama I: Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake. Exp. Neurol. 137: 318-323, 1996.
90 Takahashi M, Yamada T, Tooyama I, Morro I, Kimura H, Yamamoto T, Okada H: Insulin receptor mRNA in the substantia nigra in Parkinson's disease. Neurosci. Lett. 204:201-204, 1996.
91 Sasaki K, Oomura Y, Li AJ, Hanai K, Tooyama I, Kimura H, Yanaihara N, Hori T: Actions of acidic fibroblast growth factor fragments on food intake in rats. Obesity Res. 3:697S-706S, 1995.
92 Yu S, Tooyama I, Ding WG, Kitasato H, Kimura H: Immunohistochemical localization of glucose transporters (GLUT1 and GLUT3) in the rat hypothalamus. Obesity Res. 3:753S-760S, 1995.
93 Matsuoka Y, Kitamura Y, Tsukihara T, Terai K, Tooyama I, Kimura H, Taniguchi T: Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus. Neuroreport 6:2205-2208, 1995.
94 Araki M, Tone S, Akagawa K, Kimura H: High potassium promptes differentiation of retinal neurons but does not favor rod differentiation. Develop. Brain Res. 89:103-114, 1995.
95 Hamaguchi A,Tooyama I,Yoshiki T, Kimura H: Demonstration of fibroblast growth factor receptor-1 in human prostate by polymerase chain reaction and immunohistochemistry. Prostate 27:141-147, 1995.
96 Tooyama I, Kawamata T, Akiyama H, Kimura H, Moestrup SK, Gliemann J, Matsuo A, McGeer PL: Subcellular localization low density lipoprotein receptor-related protein (alpha-2 macroglobulin receptor) in human brain. Brain Res. 691:235-238, 1995.
97 Nakayasu H, Kimura H, Kuriyama K: Cerebral GABA-A and GABA-B receptors. Ann. NY Acad. Sci., 757:516-527, 1995.
98 Kitamura Y, Uemura S, Sato T, Yamada N, Morimoto K, Mori A, Kimura H: Induction of c-fos and reduction of dynorphin in dentate granule cells of a rat model of epilepsy produced by systemic administration of kainic acid: An immunohistochemical study. Psychiatr. Clin. Neurosci. 49:S213-S216, 1995.
99 Fujimiya M, Miyazaki M, Fujimura M, Kimura H: Effect of carbachol on the release of peptide YY from isolated vascularly and luminally perfused rat ileum. Peptides 16:939-944, 1995.
100 Yasuhara O, Matsuo A, Tooyama I, Kimura H, McGeer EG, McGeer PL: Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparisons. Acta Neuropathol. 89:322-330, 1995.
101 Ding WG, Kitasato H, Fujimiya M, Tooyama I, Kimura H: Neuropeptide Y-containing nerves in the mammalian liver and liver disease. Biomed.Res.15(supple 2):283-287,1994.
102 Ding WG, Tooyama I, Kimura H, Kuriyama K: Immunohistochemical localization of taurine-conjugated bile acids in the liver of mouse, rat, monkey and human. Adv. Exp. Med. Biol. 359:91-98, 1994.
103 Kimura H, Tooyama I, McGeer PL: Acidic FGF expression in the surroundings of senile plaques. Tohoku J. Exp. Med. 174:279-293, 1994.
104 Ding WG, Tooyama I, Kitasato H, Fujimura M, Kimura H: Phylogenetic and ontogenetic study of neuropeptide Y-containing nerves in the liver. Histochem. J. 26:453-459, 1994.
105 Hara Y, Tooyama I, Yasuhara O, Akiyama H, McGeer PL, Hande J, Kimura H: Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction. Brain Res. 664:101-107, 1994.
106 Nakao S, Kurata J, Arai T, Murakawa M, Adachi T, Avramov M.N., Mori K, Yasuhara O, Tooyama I, Kimura H: Lignocaine-induced convulsion does not induce c-fos protein (c-Fos) in rat hippocampus. Acta Anaesth. Scand. 38:845-851, 1994.
107 Matsui J, Fujimiya M, Matsui S, Amakata Y, Renda T, Kimura H, Maeda T: Transient expression on [D-Ala2]dltorphin I-like immunoreactivity in prenatal rat small intestine. J. Histochem. cytochem. 42:1377-1381, 1994.
108 Fujimiya M, Okumiya K, Renda T, Kimura H, Maeda T: Demonstration of [D-Ala2]dltorphin I-like immunoreactivity in mucosal epithelial cells of the rat gastrointestinal tract. Peptides 15:1095-1100, 1994.
109 Araki M, Nonaka T, Akagawa K, Kimura H, Mashiko T: Developing rat pineal cells manifest potential of neuronal differentiation in vitro. Neurosci. Res. 20:57-69, 1994.
110 Sasaki K, A.J. Li, Oomura Y, Muto T, Hanai K, Tooyama I, Kimura H,Yanaihara N, Yagi H, Hori T: Effects of fibroblast growth factors and related peptides on food intake by rats. Physiol. Behav. 56:211-218, 1994.
111 Matsui S, Fujimiya M, Matsui J, Amakata Y, Renda T, Kimura H, Maeda T: Localization of [D-Ala2]deltorphin I-like immunoreactivity in perinatal rat respiratory system. Histochem. J. 26:648-654, 1994.
112 Tooyama I, Kawamata T, Kimura H, McGeer PL, McGeer EG: Retention of basic fibroblast growth facter immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrasts with loss in Parkinson's disease. Brain Res.656:165-168, 1994.
113 Nonomura K, Tooyama I, Abe H, Renda T, V Erspamer, Shibata M, Kimura H: Postnatal development of [D-Ala2]deltorphin-I immunoreactive structures in the rat brain. J. Comp. Neurol. 349:223-243, 1994.
114 Arai T, Watanabe K, Nakao S, Mori H, Mori K, I Tooyama, Kimura H, Kojima S: Effects of neopterin on ischemic neuronal damage in gerbils. Neurosci. Lett. 173:107-110, 1994.
115 Minami Y, Kimura H, Aimi Y, SR Vincent: Projections of nitric oxide synthase-containing fibers from the sphenopalatine ganglion to cerebral arteries in the rat. Neuroscience 60:745-759, 1994.
116 Fujimiya M, Okumiya K, Nakazawa M, Kitahama K, Kimura H, Maeda T: Effect of reserpine on 5-hydroxytryptophan [5HTP]-immunoreactive neurons in the rat brain. Histochemistry 101:21-26, 1994.
117 Kinoshita T, Fujimura M, Kimura H: Histochemical localization of nitric oxide synthase in mouse biliary ducts. Biomed. Res. 15(Suppl 2): 187-193, 1994.
118 Matsuo A, Tooyama I, Isobe S, Oomura Y, Akiguch I, Hanai K, Kimura J, Kimura H: Immunohistochemical localization in the rat brain of an epitope corresponding to fibroblast growth factor receptor I. Neuroscience 60:49-66, 1994.
119 Abe H, Tooyama I, Renda T, Erspamer V, Kimura H: Immunohistochemical demonstration of [D-Ala2]deltorphin I in amacrine cells of rat retina. Peptides 15:49-54, 1994.
120 Taniguchi T, Fukunaga R, Matsuoka Y, Terai K, Tooyama I, Kimura H: Delayed expression of c-fos protein in rat hippocampus and cerebral cortex after transient exposure to hypoxia. Brain Res. 640:119-125, 1994.
121 Akiyama H, Tooyama I, Kondou H, Ikeda K, Kimura H, EG.Mcgeer, PL.Mcgeer : Early response of brain resident microglia to kainic acid-induced hippocampal lesions. Brain Res. 635:257-268, 1994.
122 Yoshida K, Okamura T, Kimura H, Bredt DS, Snyder SH, Toda N: Nitric oxide synthase-immunoreactive nerve fibers in dog cerebral and peropheral arteries. Brain Res. 629:67-72, 1993.
123 Aimi Y, Kimura H, Kinoshita T, Minami Y, Fujimura M, SR.Vincent: Histochemical localization of nitric oxide synthase in rat enteric nervous system. Neuroscience 53:553-560, 1993.
124 Matsuyama K, Kobayashi Y, Takakusaki K, Mori S, Kimura H: Termination mode and branching patterns of reticuloreticular and reticulospinal fibers of the nucleus reticularis pontis oralis in the cat: an anterograde PHA-L tracing study.Neurosci. Res. 17:9-21, 1993.
125 Snow BJ, Tooyama I, EG. Mcgeer, Yamada T, DB. Calne, Takahasi H, Kimura H : Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels. Ann. Neurol. 34:324-330, 1993.
126 Yasuhara O, Hanai K, Ohkubo I, Sasaki M, Mcgeer PL, Kimura H: Expression of cystatin C in rat, monkey and human brains. Brain Res. 628:85-92, 1993.
127 Tooyama I, Abe H, Renda T, Erspamer V, Kimura H: Immunohistochemical localization of [D-Ala2]deltorphin I in adult rat brain. Proc Natl Acad Sci 90:9635-9639, 1993.
128 Nonaka T, Araki M, Kimura H, Nagatsu I, Satoh F, Masuzawa T: The capacity of central and peripheral catecholaminergic neurons to innervate the peripheral organ and cerebral cortex of the rat: in vitro immunohistochemical observations. Cell Tissue Res. 273:525-531, 1993.
129 Uemura S, Watanabe Y, Kimura H: Mossy fiber sprouting in amygdala and perforant path kindled rats. Jap. J. Psych. Neurol. 47:385-386, 1993.
130 Nakao S-H, Arai T, Mori K, Yasuhara O, Tooyama I, Kimura H: High-dose ketamine does not induce c-Fos protein expression in rat hippocampus. Neurosci. Lett. 151:33-36, 1993.
131 Nakayasu H, Nishikawa M, Mizutani H, Kimura H, Kuriyama K: Immunoaffinity purification and characterization of gamma-aminobutyric acid (GABA)B receptor from bovine cerebral cortex. J. Bio. Chem. 268:8658-8664, 1993.
132 Tooyama I, Kawamata T, Walker D, Yamada T, Hanai K, Kimura H, Igarashi K, McGeer EG, McGeer PL: Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease. Neurology 43:372-376, 1993.
133 Ding WG, Tooyama I, Kimura H, Kuriyama K, Ochi J: Distribution of taurine-like immunoreactivity in the mouse liver during ontogeny and after carbon tetrachloride or phenobarbital intoxication. Histochem. J. 25:376-383, 1993.
134 Toda N, Ayajiki K, Yoshida K, Kimura H, OkamuraT: Impairment by damage of the pterygopalatine ganglion of nitroxidergic vasodilator nerve function in canine cerebral and retinal arteries. Circ. Res. 72:206-213, 1993.
135 Tooyama I, Kremer HPH, Hayden MR, Kimura H, McGeer EG, McGeer PL: Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease. Brain Res. 610:1-7, 1993.
136 Uemura S, Ienaga K, Higashiura K, Kimura H: g-glutamyltaurine has potent and long-lasting antiepileptic acition as demonstrated by intra-amygdaloid injection in amygdala-kindled rats. Brain Res. 594:347-350, 1992.
137 Tago H, Maeda T, McGeer PL, Kimura H: Butyrylcholinesterase-rich neurons in rat brain demonstrated by a sensitive histochemical method. J. Comp. Neurol. 325:301-312, 1992.
138 Tooyama I, Walker D, Yamada T, Hanai K, Kimura H, McGeer EG, McGeer, PL: High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain. Brain Res. 593:274-280, 1992.
139 Fujimiya M, McIntosh CHS, Kimura H, Kwok YN: Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum. Neurosci. Lett. 145:229-233, 1992.
140 Yamada S, Kimura H, Fujimaki A, Strohman R: Expression of fibroblast growth factors in exercise-induced muscle hypertrophy with special reference to the role of muscle satellite cells. Med. Sport Sci. 37:67-83, 1992.
141 Abe H, Tooyama I, Renda T, Ersparmer V, Kimura H: Production of antiserum to [D-Ala2]deltorphin I and its immunohistochemical application to the mouse brain. Neuroreport 3:669-672, 1992.
142 McGeer PL, Harada N, Kimura H, McGeer EG, Schulzer M: Prevalence of dementia amongst elderly Japanese with leprosy: apparent effect of chronic drug therapy. Dementia. 3:146-9, 1992.
143 Okamura T, Aimi Y, Kimura H, Murakami K, Toda N: Existence of renin in the endothelium of human artery. J. Hypertens. 10:49-53, 1992.
144 Yamamoto A, Ienaga K, Nakamura K, Nishimura N, Higashiura Y, Kurimoto Y, Inoue A, Kimura H: First isolation of g-L-gulutamyl-g-aminobutyric acid from bovine brains. Neuroreport 3:330-2, 1992.
145 Kimura H: Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients. Molecular Basis of Neuronal Connectivity. 104-6, 1992.
146 Vincent SR, Kimura H: Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience. 46:755-84, 1992.
147 Oomura Y, Sasaki K, Suzuki K, Muto T, Li A-J., Ogita Z, Hanai K, Tooyama I, Kimura H, Yanaihara N: A New brain glucosensor and its physiological significance. Am. J. Clin. Nutr. 55:278S-82S, 1992.
148 Tanaka H. Mori S, Kimura H: Developmental changes in the serotoninergic innervation of hindlimb extensor motoneurons in neonatal rats. Devel. Brain Res.65:1-12, 1992.
149 Nakayasu H,Mizutani H, Hanai K, Kimura H, Kuriyama K: Monoclonal antibody to GABA binding protein, a possible GABAB receptor, Biochem. Biophys. Res. Comm. 182:722-726, 1992.
150 Sasaki K, Oomura Y, Suzuki K, Muto T, Hanai K, Tooyama I, Kimura H, Ynaihara N: Effect of fibroblast growth factors and platelet-derived growth factor on food intake rats. Brain Res Bull. 27:327-32, 1991.
151 Maeda T, Kojima Y, Arai R, Fujimiya M, Kimura H, Kitahama K, Geffard M: Monoaminergic interaction in the central nervous system: a morphological analysis in the locus coeruleus of the rat. Comp Biochem Physiol [C]. 98:193-202, 1991.
152 Aimi Y, Fujimura M, Vincent SR, Kimura H: Localization of NADPH-diaphorase-containing neurons in sensory ganglia of the rat. J. Comp. Neurol. 306:382-92, 1991.
153 Ding WG, Fujimura M, Mori A, Tooyama I, Kimura H: Light and electron microscopy of neuropeptide Y-containing nerves in human liver, gallbladder, and pancreas. Gastroenterology. 101:1054-9, 1991.
154 Fujimiya M, Kimura H: Effect of lateral hypothalamic area lesions on serotonin-containing epithelial cells in rat duodenum. Brain Res. Bull. 27:521-8, 1991.
155 Yasuhara O, Tooyama I, Akiyama H, Akiguchi I, Kimura J, McGeer PL, Hara Y, Kimura H: Reactive astrocytes express acidic fibroblast growth factor in Alzheimer's disease brain. Dementia 2:64-70, 1991.
156 Nakamura S, Kawamata T, Yasuhara O, Akiguchi I, Kimura J, Kimura H: The histochemical demonstration of monoamine oxidase-containing neurons in the human hypothalamus. Neuroscience. 44:457-63, 1991.
157 Uemura S, Ienaga K, Higashiura K, Kimura H: Effects of intraamygdaloid injection of taurine and valyltaurine on amygdaloid kindled seizure in rats. Jpn. J. Psychiatr. Neurol. 45:383-5, 1991.
158 Uehara-Kunugi Y, Terai K, Taniguchi T, Tooyama I, Kimura H: Time course of in vitro expression of NADPH-diaphorase in cultured rat brain neurons: comparison with in vivo expression. Devel. Brain Res. 59:157-62, 1991.
159 Araki M, Kimura H: GABA-like immunoreactivity in the developing chick retina: differentiation of GABAergic horizontal cell and its possible contacts with photoreceptors. J Neurocytol. 20:345-55, 1991.
160 Fujimiya M, Maeda T, Kimura H: Serotonin-containing epithelial cells in rat duodenum. II. Quantitative study of the effect of 5HTP administration. Histochemistry. 95:225-9, 1991.
161 Fujimiya M, Maeda T, Kimura H: Serotonin-containing epithelial cells in rat duodenum. I. Quantitative morphometric study of the distribution density. Histochemistry. 95:217-24, 1991.
162 Yamada T, Hirayama K, Kimura H: Differential responses of noradrenaline and dopamine neurons in the mouse forebrain induced by continuous parenteral infusion of haloperidol. Eur Neurol. 31:28-33, 1991.
163 Tooyama I, Hara Y, Yasuhara O, Oomura Y, Sasaki K, Muto T, Suzuki K, Hanai K, Kimura H: Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in rat brain. Neuroscience. 40:769-79, 1991.
164 Ding WG, Fujimura M, Tooyama I, Kimura H: Phylogenetic study of serotonin-immunoreactive structures in the pancreas of various vertebrates. Cell Tissue Res. 263:237-43, 1991.
165 Tooyama I, Akiyama H, McGeer PL, Hara Y, Yasuhara O, Kimura H: Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients. Neurosci. Lett. 121:155-8, 1991.
166 Yamada T, Kimura H: Regional effects of ceruletide, a cholecystokinin-8 analog, on the striatal monoaminergic systems in food-deprived mice. Brain Res. 540:25-30, 1991.
167 Nakamura S, Kawamata T, Akiguchi I, Kameyama M, Nakamura N, Kimura H: Expression of monoamine oxidase B activity in astrocytes of senile plaques. Acta Neuropathol Berl. 80:419-25, 1990.
168 Kimura H: Functional control of visceral organs by the central nervous system. J Clin Electron Microscopy. 23:521-4, 1990.
169 Kimura H, Tago H, Akiyama H, Hersh LB, Tooyama I, McGeer PL: Choline acetyltransferase immunopositive neurons in the lateral septum. Brain Res. 533:165-70, 1990.
170 Uemura S, Kimura H: Common epileptic pathway in amygdaloid bicuculline and electrical kindling demonstrated by transferability. Brain Res. 537:315-7, 1990.
171 Kawamata T, Nakamura S, Akiguchi I, Kimura J, Kameyama M, Kimura H, Takeda T: Effect of aging on NADPH-diaphorase neurons in laterodorsal tegmental nucleus and striatum of mice. Neurobiol Aging. 11:185-92, 1990.
172 Niijima K, Araki M, Ogawa M, Nagatsu I, Sato F, Kimura H, Yoshida M: Enhanced survival of cultured dopamine neurons by treatment with soluble extracts from chemically deafferentiated striatum of adult rat brain. Brain Res. 528:151-4, 1990.
173 Nakamura K, Higashiura K, Nishimura N, Yamamoto A, Tooyama I, Kimura H, Ienaga K: Isolation of glutamyltaurine from bovine brains and proof of its g-linkage by the B/E linked scan SIMS technique. J Neurochem. 55:1064-6, 1990.
174 Tooyama I, Kimura H, Akiyama H, McGeer PL: Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain Res. 523:273-80, 1990.
175 Nonaka T, Araki M, Kimura H, Nagatsu I, Satoh F, Masuzawa T: Transplantation of the rat pineal organ to the brain: pinealocyte differentiation and innervation. Cell Tissue Res. 260:273-8, 1990.
176 Shingai R, Itoh E, Harada K, Kimura H: Acetylcholinesterase-containing neurons in the striatum, septum and hippocampus of the rat in embryonic culture and adult in situ. Brain Res Dev Brain Res. 53:200-7, 1990.
177 Maeda T, Fujimiya M, Kitahama K, Imai H, Kimura H: Serotonin neurons and their physiological roles. Arch Histol Cytol. 52 Suppl: 113-20, 1989.
178 Kimura H, Saito Y, Ochi J: A histochemical study of cholinesterases in mammalian veins. Biomed Res. 10:457-465, 1989.
179 Saito Y, Kimura H, Ochi J: Visualization of detailed structures containing cholinesterases in rat intestine by a sensitive histochemical method. Biomed Res. 10:497-508, 1989.
180 Shigematsu K, Kamo H, Akiguchi I, Kimura H: Intracerebral transplantation of dissociated central nervous system tissue suspensions: use of phaseolus vulgaris leucoagglutinin as a cell marker. J Neurosci Res. 24:384-90, 1989.
181 Shigematsu K, Kamo H, Akiguchi I, Kimura J, Kameyama M, Kimura H: Neovascularization in kainic acid-induced lesions of rat striatum. An immunohistochemical study with laminin. Brain Res. 501:215-22, 1989.
182 Fukui K, Nakajima T, Kariyama H, Kashiba A, Kato N, Tohyama I, Kimura H: Selective reduction of serotonin immunoreactivity in some forebrain regions of rats induced by acute methamphetamine treatment; quantitative morphometric analysis by serotonin immunocytochemistry. Brain Res. 482:198-203, 1989.
183 Shigematsu K, Kamo H, Akiguchi I, Kameyama M, Kimura H: Neovascularization of transplanted central nervous tissue suspensions: an immunohistochemical study with laminin. Neurosci Lett. 99:18-23, 1989.
184 Kimura H, Tohyama I, Mizutani K, Ochi J: Fibronectin-like immunoreactive structures in embryonic rat brain. Acta Histochem Cytochem. 22:243-58, 1989.
185 Arita T, Kishimoto S, Kobayashi K, Konishi K, Tohyama I, Kimura H: Analysis of basic proteins isolated from various tumors of the peripheral nervous system. Proc Jpn Soc Invest Dermatol. 12:68-9, 1988.
186 Uemura S, Kimura H: Amygdaloid kindling with bicuculline methiodide in rats. Exper Neurol. 102:346-353, 1988.
187 Tohyama I, Kameyama M, Kimura H: Quantitative morphometric analysis of two types of serotonin-immunoreactive nerve fibres differentially responding to p-chlorophenylalanine treatment in the rat brain. Neuroscience. 26:971-91, 1988.
188 Araki M, McGeer PL, Kimura H: The efferent projections of the rat lateral habenular nucleus revealed by the PHA-L anterograde tracing method. Brain Res. 441:319-30, 1988.
189 Fukuda H, Hara K, Nakamura S, Kimura H, Kameyama M: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) enhances tryptophan hydroxylase activity in mouse striatum, but not in the frontal cortex. Brain Res. 449:399-402, 1988.
190 Nakamura S, Kawamata T, Kimura T, Akiguchi I, Kameyama M, Nakamura N, Wakata Y, Kimura H: Reduced nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry in the pontomesencephalic region of the human brainstem. Brain Res. 455:144-7, 1988.
191 Ibuki T, Okamura H, Miyazaki M, Kimura H, Yanaihara N, Ibata Y: Colocalization of GABA and [Met]enkephalin-Arg6-Gly7-Leu8 in the rat cerebellum. Neurosci Lett. 91:131-5, 1988.
192 Uemura S, Kimura H, Kashiba A, Kumashiro H, Wada JA: Bifunctional roles of catecholamines in the development of amygdala kindling demonstrated by continuous intra-amygdala infusion of 6-hydroxydopamine. Brain Res. 448:162-6, 1988.
193 Ienaga K, Nakamura K, Higashiura K, Toyomaki Y, Kimura H: Simple peptides. III. Syntheses and properties of taurine-oligopeptides containing an acidic a-amino acid. Chem Pharm Bull Tokyo. 36:2796-801, 1988.
194 Ohta Y, Mori S, Kimura H: Neuronal structures of the brainstem participating in postural suppression in cats. Neurosci Res. 5:181-202, 1988.
195 Ienaga K, Higashiura K, Toyomaki Y, Matsuura H, Kimura H: Simple peptides. II. Syntheses and properties of taurine-dipeptides containing neutral a-amino acid. Chem Pharm Bull Tokyo. 36:70-7, 1988.
196 Kamo H, Haebara H, Akiguchi I, Kameyama M, Kimura H, McGeer PL: A distinctive distribution of reactive astroglia in the precentral cortex in amyotrophic lateral sclerosis. Acta Neuropathol Berl. 74:33-8, 1987.
197 Nagai T, Mimaki T, Yabuuchi H, Uemura S, Itagaki S, Shirouzu M, Kimura H, Imai H: Effect of amygdaloid kindling on the GABA system in rats studied by GABA transaminase (GABA-T) histochemistry. Advances in Epileptol. 16:63-6, 1987.
198 Morimoto N, Kawakami F, Makino S, Uda K, Hasegawa M, Kimura H, Nagatsu I, Ibata Y: Age-related changes in noradrenergic neuronal perikarya of the male Sprague Dawley rat. Biogenic Amines. 4:431-41, 1987.
199 Ienaga K, Higashiura K, Toyomaki Y, Tomida Y, Kimura H: Immunocrossreactivities of taurine oligopeptides with antisera against haptenic taurine or r-glutamyltaurine. Peptide Chem. 791-4, 1987 (Eds. Shiba & S,Sakakibara) Protein Res Found. (Osaka).
200 Ida S, Kuriyama K, Tomida Y, Kimura H: Antisera against taurine: quantitative characterization of the antibody specificity and its application to immunohistochemical study in the rat brain. J Neurosci Res. 18:626-31, 1987.
201 Okoyama S, Tago H, McGeer PL, Hersh LB, Kimura H: Cholinergic divergent projections from rat basal forebrain to the hippocampus and olfactory bulb. Neurosci Lett. 83:77-81, 1987.
202 Ienaga K, Nakamura K, Higashiura K, Kimura H: Linked scan mass spectrometry useful to distinguish isomers of taurine-peptides containing acidic amino acid(s). Peptide Chem. 93-6, 1987 (Eds. Shiba & S, Sakakibara)Protein Res Found (Osaka).
203 Takasu N, Nakatani T, Arikuni T, Kimura H: Immunocytochemical localization of g-aminobutyric acid in the hypoglossal nucleus of the macaque monkey, Macaca fuscata: a light and electron microscopic study. J Comp Neurol. 263:42-53, 1987.
204 Tomimoto H, Kamo H, Kameyama M, McGeer PL, Kimura H: Descending projections of the basal forebrain in the rat demonstrated by the anterograde neural tracer Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res. 425:248-55, 1987.
205 Tomimoto H, Kamo H, Araki M, Kimura H: An economic anterograde axonal tracing method using Phaseolus vulgaris agglutinin (PHA) P-form. J Neurosci Methods. 22:1-8, 1987.
206 Hara K, Tohyama I, Kimura H, Fukuda H, Nakamura S, Kameyama M: Reversible serotoninergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse striatum studied by neurochemical and immunohistochemical approaches. Brain Res. 410:371-4, 1987.
207 Kamo H, Kim SU, McGeer PL, Araki M, Tomimoto H, Kimura H: Transplantation of cultured human spinal cord cells in the rat motor cortex:use of Phaseolus vulgaris leucoagglutinin as a cell marker. Neurosci Lett. 76:163-7, 1987.
208 Maeda T, Imai H, Arai R, Tago H, Sakumoto T, Onteniento B, Kimura H: An improved coupled peroxidatic oxidation method of MAO histochemistry for neuroanatomical research at light and electron microscopic levels. Cell Mol Biol. 33:1-11, 1987.
209 Ienaga K, Higashiura K, Kimura H: Syntheses and properties of dipeptides containing g-aminobutyric acid or its analogues at the C-terminal. Chem Pharm Bull Tokyo. 35:1249-54, 1987.
210 Beach TG, Tago H, Nagai T, Kimura H, McGeer PL, McGeer EG: Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation. J Neurosci Methods. 19:183-92, 1987.
211 Kitahama K, Kimura H, Maeda T, Jouvet M: Distribution of two types of monoamine oxidase-containing neurons in the cat medulla oblongata demonstrated by an improved histochemical method. Neuroscience. 20:991-9, 1987.
212 Tomida Y, Kimura H: Immunohistochemical and biochemical studies of substances with taurine-like immunoreactivity in the brain. Acta histochem cytochem. 20:31-40, 1987.
213 Mizutani K, Kimura H: Immunohistochemical study of fibronectin immunoreactive structures demonstrated in response to brain injury of adult rats. Acta histochem cytochem. 20:87-99, 1987.
214 Itagaki S, Uemura S, Kimura H: GABAergic system and amygdaloid kindling studied by immunohistochemistryusing antibody against GABA. Jap J Psych Neurol. 40:341-4, 1986.
215 Akiyama H, Kamiyama M, Akiguchi I, Sugiyama H, Kawamata T, Fukuyama H, Kimura H, Matsushita M, Takada T: Periodic acid-Schiff (PAS)-positive, granular structures increase in thebrain of senescence accelerated mouce (SAM). Acta Neuropathol.72:124-9, 1986.
216 Ontenient B, Tago H, Kimura H, Maeda T: Distribution of g-aminobutylic acid-immunoreactive neurons in the septal region of the rat brain. J comp Neurol. 248:422-30, 1986.
217 Fujimiya M, Hosoda S, Kitahama K, Kimura H, Maeda T: Early development of serotonin neuron in the rat brain as studied by immunohistochemistry combined with tryptophan administration. Brain Develop. 8:335-42, 1986.
218 Arai R, Kimura H, Maeda T: Topographic atlas of monoamine oxidase-containing neurons in the rat brain studied by an improved histochemical method. Neuroscience. 19:905-25, 1986.
219 Sakai K, Luppi PH, Salvert D, Kimura H, Maeda T, Juvet M: Localisation des neurones cholinergiques dans le tronc cerebral inferieur chez le chat. C R Acad Sci Paris. 303:317-24, 1986.
220 Kishimoto S, Miyashita A, Arita T, Koishi K, Hirano S, Yasuno H, Kimura H: Serotonin in human skin of both normal and cancer patients. Proc Jpn Soc Invest Dermatol. 10:73-4, 1986.
221 Yoshimoto Y, Arai R, Sakumoto T, Miyake A, Kimura H, Aono T, Tanizawa O, Maeda T: Monoamine oxidase in rat ovary during the estrous cycle. A histochemicaltudy by a new coupled peroxidatic oxidation method. Endocrinology. 119:1800-4, 1986.
222 Mizukawa K, McGeer PL, Tago H, Peng JH, McGeer EG, Kimura H: The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Brain Res. 379:39-55, 1986.
223 Fukui K, Kariyama H, Kashiba A, Kato N, Kimura H: Further confirmation of heterogeneity of the rat striatum: different mosaic patterns of dopamine fibers after administration of methamphetamine or reserpine. Brain Res. 382:81-6, 1986.
224 Itagaki S, Kimura H: Retardation in resynthesis of GABA-transaminase in some brain regions of amygdala-kindled rats. Brain Res. 381:77-84, 1986.
225 Fujimiya M, Kimura H, Maeda T: Postnatal development of serotonin nerve fibers in the somatosensory cortex of mice studied by immunohistochemistry. J comp Neurol. 246:191-201, 1986.
226 Tago H, Kimura H, Maeda T: Visualization of Detailed acetylcholinesterase fiber and neural staining in rat brain by a new and highly sensitive histochemical procedure. J Histochem Cytochem. 34:1431-9, 1986.
227 Inokuchi A, Tomida Y, Yanaihara C, Yui R, Oomura Y, Kimura H, Hase T, Matsumoto T, Yanaihara N: Glucagon-related peptides in the rat hypothalamus. Cell Tiss Res. 246:71-5, 1986.
228 Hase T, Kimura H: Distribution of neuronal cell bodies and axons containing glicentin-likeimmunoreactivity. Acta histochem cytochem. 18:581-8, 1985.
229 Itagaki S, Uemura S, Nagai T, Kimura H: Effect of amygdala kindling on GABA neurons: histochemical and biochemical detection of GABA-T activity. Folia Psychi Neurol Jap.39:297-300, 1985.
230 Yoshimoto Y, Sakumoto T, Aono T, Kimura H, Maeda T, Tanizawa O: Histochemical studies on human placental and chorionic monoamine oxidase. Obst Gynecol.67:344-8, 1985.
231 Kishimoto S, Kobayashi K, Miyashita A, Koishi K, Hirao S, Kimura H: Immunohistochemical demonstration for myelin basic protein in intact human skin of the adult. Acta Dermatol Kyoto.80:233-336, 1985.6
232 Itakura T, Yokota H, Kimura H, Kamei I, Nakakita K, Naka Y, Nakai K, Imai H, Komai N: 5-Hydroxytryptamine innervation of vessels in the rat cerebral cortex. Immunohistochemical findings and hydrogen clearance study of RCBF. J Neurosurg.62:42-7, 1985.
233 Kojima M, Matsuura T, Kimura H, Nojyo Y, Sano Y: Fluorescence histochemical study on the noradrenergic control to the anterior column of the spinal lumbosacral segments of the rat and dog, with special reference to motoneurons innervating the perineal striated muscles (Onuf's nucleus). Histochemistry.81:237-41, 1984.
234 Nagai T, Mimaki T, Yabuuchi H, Uemura S, Shirouzu M, Imai H, Kimura H, Maeda T: Effect of amygdaloid kindling on GABA metabolism as revealed by histochemical staining of GABA-transaminase. Foria Psychi Neurol Jap.38:313, 1984.
235 Tago H, Kimura H, Kitahama K, Sakai K, Jouvet M, Maeda T: Cortical projections of monoamine oxidase-containing neurons from the posterior hypothalamus in the rat. Nurosci Lett.52:281-6, 1984.
236 Kitahama K, Sakai K, Tago H, Kimura H, Maeda T, Jouvet M: Monoamine oxidase-containing neurons in the cat hypothalamus:distribution and ascending projection to the cerebral cortex. Brain Res.324:155-9, 1984.
237 Sakumoto T, Sakai K, Jouvet M, Kimura H, Maeda T: 5-HT immunoreactive hypothalamic neurons in rat and cat after 5-HTP administration. Brain Res Bull.12:721-33, 1984.
238 Araki M, Saito T, Takeuchi Y, Kimura H: Differentiation of monoamine accumulating neuron system in cultured chick retina:an immunohistochemical and fluorescence histochemical study. Develop Brain Res.15:229-37, 1984.
239 Maeda T, Kimura H, Nagai T, Imai H, Arai R, Sakumoto T, Sakai K, Kitahama K, Jouvet M: Histochemistory of the magnocellular neurons in the posterior hypotHistochemistory of the magnocellular neurons in the posterior hypothalamus, with special reference to MAO activity and ability of 5HTP uptake and decarboxylation. Acta histochem cytochem. 17:179-93, 1984.
240 Itakura T, Okuno T, Nakakita K, Kamei I, Naka Y, Nakai K, Imai H, Komai N, Kimura H, Maeda T: A light and electron mecroscopic immunohistochemical study of vasoactive intestinal polypeptied- and substance P-containing nerve fibers along the cerebral blood vessels:comparison with aminergic and cholinergic nerve fibers. J Cereb Blood Flow Metab.4:407-14, 1984.
241 Sakumoto T, Sakai K, Kimura H, Maeda T, Jouvet M: Possible role of serotonin in the secretory activity of the subcommissural organ of the cat. Neurosci Res.1:191-7, 1984.
242 Scherer SU, Vincent SR, Kimura H, McGeer EG: Demonstration of a unique population of neurons with NADPH-diaphorase histochemistory. J Neuosci Methods. 9:229-34,1983.
243 Kashiba A, Hashimoto H, Kimura H: Electron microscopic alterations in noradrenaline nerve terminals in vas deferens of the rat following chronic administration of reserpine and chlorpromazine. Acta histochem cytochem.16:207-15, 1983.
244 Ibata Y, Fukui K, Obatatsuto HL, Okamura H, Tanaka M, Kimura H, Hashimura E, Sin S, Imagawa K: The luteinizing hormone-releasing hormone (LHRH) neuron system in the rat central nervous system. An Immunohistochemical study. Biomed Res. 4:161-8, 1983.
245 Kishimoto S, Kimura H, Maeda T: Histochemical demonstration for monoamine oxidase (MAO) by a new coupledperoxidation method. Cell Molecul Biol.29:61-9, 1983.
246 Akiguchi I, Fukuyama H, Kameyama M, Koyama T, Kimura H, Maeda T: Sympathetic nerve terminals in the tunica media of human superficial temporal and middle cerebral arteries: wet histoflueorescence. Stroke. 14:62-6, 1983.
247 Shirouzu K, Kimura H, Yamamoto T, Ochi J, Inanaga K: Poduction of new type of antisera to thyrotropin releasing hormone (TRH) using carbodiimide couping and an application to immunohistochemistry. Kurume Med J. 30 (Supl.): S1-S9, 1983.
248 Shimizu M, Kimura H, Yamamoto T, Ochi J: Immunohistochemical demonstration of the serotonin-containing subependymal cells in the frog hypothalamus. Histochemistry. 79:23-9,1983.
249 Sakai K, Salvert D, Kitahama K, Kimura H, Maeda T, Jouvet M: Projections ascendantes et descendantes des neurones de 1'hypothalamus posterieur immunoreactifs a la serotonine apres adminisration de 5-hydroxytryptophane chez le chat. C R Acas Sci. 296:1013-8, 1983.
250 Ontenient B, Kimura H, Maeda T: Comparative study of the glial fibrillary acidic protein in vertebrates by PAP immunohistochemistry. J Comp Neurol.215:427-36, 1983.
251 Takeuchi Y, Kimura H, Mastuura T, Yonezawa T, Sano Y: Distribution of serotonergic neurons in the central nervous system: A peroxidase-antiperoxidase study with anti-serotonin antibodies. J Histochem Cytochem. 31:181-5, 1983.
252 Araki M, Maeda T, Kimura H: Dopaminergic cell differentiation in the developing chick retina. Brain Res Bull. 10:97-102, 1983.
253 Takeuchi Y, Kimura H, Matsuura T, Sano Y: Immunohistochemical demonstration of the organization of serotonin neurons in the brain of the monkey (Macaca fuscata). Acta anat. 114:106-124, 1982.
254 Sakumoto T, Sakai K, Jouvet M, Kimura H, Maeda T: APUD-like neurons in the central nervous system: Evidence for the presence of a group of neurons in the ventrolateral hypothalamus of rats and cats revealed by serotonin immunohistochemistry after administration of 5-hydroxyfryptophan. C R Acad Sci Paris. 295:631-5, 1982.
255 Vincent SR, Kimura H, McGeer EG: GABA-transaminase in the basal ganglia: A pharmacohistochemical study. Brain Res. 251:93-104, 1982.
256 Kishimoto S, Kimura H, Maeda T: The role of sympathetic catecholaminergic nerves in wound healing. Burns. 9:135-141, 1982.
257 Imai H, Kimura H, Maeda T: A stable and simple method of "FAGLUPAGAS fixation" for catecholamines for routine examination. Acta histochem cytochem. 15:798-806, 1982.
258 Kashiba A, Kimura H: Alterations in noradrenaline nerve terminals in the periventricular hypothalamus of the rat during regeneration after administration of 6-OH dopamine. Acta histochem cytochem. 15:734-45, 1982.
259 Sano Y, Takeuchi Y, Kimura H, Goto M, Kawata M, Kojima M, Matuura T, Ueda S, Yamada S: Immunohistochemical studies on the processes of serotonin neurons and their ramification in the central nervous system - with regard to the possibility of the existence of Golgi's Rete Nervosa Diffusa. Arch Histol Jap. 45:305-16, 1982.
260 Kimura H, Maeda T: Aminergic and cholinergic system in the dorsolateral pontine tegmentum. Brain Res Bull. 9:493-9, 1982.
261 Simizu K, Kinoshita H, Yamamoto T, Kimura H, Ochi J: Silver impregnation and fluorescence histochemistry of the subependymalcells in the preoptic recess of the bullfrog (Rana Catesbeiana). Acta histochem cytochem. 15:520-6, 1982.
262 Tange A, Takeuchi Y, Kimura H, Sano Y: Immunohistochemical studies on serotonin containing cells in the gastricand duodenal mocosa of the dog. Okajimas Folia Anat Japan 58:945-56, 1982.
263 Vincent SR, Kimura H, McGeer EG: A histochemical study of GABA-transaminase in the efferents of the pallidum. Brain Res. 241:162-5, 1982.
264 Takeuchi Y, Kimura H, Sano Y: Immunohistochemical demonstration of serotonin nerve fibers in the olfactory bulb of the rat, cat and monkey. Histochemistry. 75:461-71, 1982.
265 Takeuchi Y, Kimura H, Sano Y: Immunohistochemical demonstration of serotonin-containing nerve fibers in the cerebellum. Cell Tissue Res. 226:1-12, 1982.
266 Takeuchi Y, Kimura H, Sano Y: Immunohistochemical demonstration of the distribution of serotonin neurons in the brain stem of the rat and cat. Cell Tissue Res. 224:247-67, 1982.
267 Kishimoto S, Maruo M, Ohse C, Yasuno H, Kimura H, Nagai T, Maeda T: The regeneration of the sympathetic catecholaminergic nerve fibers in the process of burn wound healing in guinea pig. J Invest Dermatol. 79:141-6, 1982.
268 Kishimoto S, Maruo M, Kimura H, Nagai T, Maeda T: The regeneration of cholinesterases-positive structures in the process of burn wound healing in the skin of the guinea-pig. Burns 9:121-127, 1982.
269 Nagai T, Kimura H, Maeda T, McGeer PL, Peng F, McGeer EG: Cholinergic projections from the basal forebrain of rat to the amygdala. J Neuroscience. 2:513-20, 1982.
270 Kashiba A, Hashimoto H, Kimura H, Maeda T: Postnatal alterations in noradrenaline nerve terminals in the periventricular hypothalamus of the rat. Acta histochem cytochem. 15:691-700, 1982.
271 Satoh K, Kashiba A, Kimura H, Maeda T: Noradrenergic axon terminals in the substantia gelationsa of the rat spinal cord. An electron microscopic study using glyoxylic acid potassium permanganate fixation. Cell Tissue Res. 222:359-78, 1982.
272 Nakai K, Imai H, Itakura T, Komai N, Kimura H, Nagai T, Maeda T: Microangioarchitecture of rat parietal cortex with special reference to vascular "sphincters". Scanning electron microscopic and dark field microscopic study. Stroke 12:653-9, 1981.
273 Noda Y, Kimura H, McGeer PL: Glycolysis in rat neostriatal slices following kainic acid injections. Brain Res. 214:451-4, 1981.
274 Vincent SR, Kimura H, McGeer EG: Organization of substance P fibers within the hippocampal formation demonstrated with a biotin-avidin immunoperoxidase technique. J Comp Neurol. 199:113-23, 1981.
275 Peng JH, Kimura H, McGeer PL, McGeer EG: Anti-choline acetyltransferase fragments antigen binding (Fab) for immunohistochemistry. Neurosci Lett. 21:281-5, 1981.
276 Kimura H, McGeer PL, Peng JH, McGeer EG: The central cholinergic system studied by choline acetyltransferase Immunohistochemistry in the cat. J Comp Neurol. 200:151-201, 1981.
277 Kimura H, McGeer EG, McGeer PL: Metabolic alterations in an animal model of Huntington's disease using the 14C-2-deoxyglucose method. J Neural Transmiss Supp1. 16:103-9, 1980.
278 Peng JH, McGeer PL, Kimura H, Sung SC, McGeer EG: Purification and immunochemical properties of choline acetyltransferase from human brain. Neurochem Res. 5:943-62, 1980.
279 Kimura H, McGeer PL, Peng F, McGeer EG: Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry. Science. 208:1057-9, 1980.
280 Vincent SR, Kimura H, McGeer EG: The pharmacohistochemical demonstration of GABA-transaminase. Neurosci Lett. 16:345-8, 1980.
281 Staines WA, Kimura H, Fibiger HC, McGeer EG: Peroxidase-labeled lectin as a neuroanatomical tracer: evaluation of a CNS pathway. Brain Res. 197:485-90, 1980.
282 Imamoto K, Nagai T, Kimura H, Maeda T: Effect of neonatal administration of 6-OHDA on the brain development I. Alteration in the striatum. Arch Hist Jap. 42:347-64, 1980.
283 Nakai K, Imai H, Kamei I, Itakura T, Kimura H, Nagai T, Maeda T: Scanning electron microscopic investigation on the plastic cast model of small cerebral blood vessels. Neurologia medico chirurgica. 20:155-61, 1980.
284 Imai H, Nakai K, Kamei I, Itakura T, Komai N, Nagai T, Kimura H, Imamoto K, Maeda T: Simultaneous detection method of amine and acetylcholinesterase containing nerve fibers in pial Vessels-II. Electron microscopic study. Cell Molec Biol. 26:207-10, 1979.
285 Imai H, Nakai K, Kamei I, Itakura T, Komai N, Nagai T, Kimura H, Imamoto K, Maeda T: Simultaneous detection method of amine and acetylcholinesterase containing nerve fibers in pial vessels- I. Light microscopic study. Cell Molecul Biol. 26:201-6, 1979.
286 Sakumoto T, Nagai T, Kimura H, Maeda T: Electron microscopic visualization of tetramethylbenzidine reaction product on horseradish peroxidase neurohistochemistry. Cell Molec Biol. 26:211-6, 1979.
287 Kato N, Miyamamoto Y, Imai H, Arima S, Kimura H: Are there biological deficits in Schizophrenia? Biol Psychi Today. 424-33, 1979.
288 Kinoshita H, Kimura H, Maeda T, Ibata Y: The origin of the eferent projections from the amygdaloid complex to the preoptic area of the rat, studied by the retrograde transport of horseradish peroxidase (HRP). Acta Histochem Cytochem. 12:120-4, 1979.
289 Ibata Y, Watanabe K, Kimura H: Distribution of LH-RH nerve ending in the median eminence of proesterus female rats: fluorescence and peroxidase anti-peroxidase (PAP) immunohistochemistry. Endocrinol. Japon. 25:141-8, 1978.
290 Kimura H, Kuriyama K: Distribution of g-aminobutylic acid (GABA) system in rat hypothalamus: functional correlation of GARA with activity of appetite controling mechanism. Neurochem. 24:903-7, 1975.
291 Kimura H, Kuriyama K: A new microassay method for L-glutamic acid decarboxylase (GAD) activity. Japan. J. Pharmacol. 25:189-96, 1975.
292 Kimura H, Naitoh K, Nakagawa K, Kuriyama K: Activation of hexose monophosphate pathway in brain by electrical stimulation in vitro. J. Neurochem. 23:79-84, 1974.
293 Israel M.A., Kimura H, Kuriyama K: Changes in activity and hormonal sensitivity of brain adenylcyclase following chronic ethanol administration. Experientia. 28:1322-3, 1972.