Welcome to Hitoshi Lab.

Prof. Hitoshi









Prof. Hitoshi here




Our research is focused on the stem cell biology, especially on the generation, proliferation, maintenance and differentiation of neural stem cells.

We are interested in how neural stem cells are selected and induced from precursor cells with broader potency (or pluripotent cells) in very early mouse embryos. We recently discovered that epigenetic regulation plays important roles in the generation of neural stem cells.

It is well known that neural stem cells exist in adult mammalian brains, including humans, and provide new neurons in the olfactory bulb and the dentate gyrus of hippocampus throughout the lifetime of the animal. We are studying the behaivior of neural stem cells in pathological conditions using animal models for chronic demyelination or depression. Our research might provide in the future insight into the pathogenesis of those diseases and the development of new treatment.

Recent publications

*Naruse M, *Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S (2015) The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window. Cerebral Cortex in press (*, equal contribution)
*Zheng L-S, *Hitoshi S, *Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for interferon-α-induced depression and neural stem cell dysfunction. Stem Cell Reports 3, 74-83 (*, equal contribution)
*Ishino Y, *Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi S (2014) Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells. J Neurosci 34, 3067-3078 (*, equal contribution)
Kumar A, Torii T, Ishino Y, Muraoka D, Yoshimura T, Togayachi A, Narimatsu H, Ikenaka K, Hitoshi S (2013) The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. J Biol Chem 288, 28859-28868
Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K (2011) Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells. Nat Neurosci 14, 957-964
Higashi M, Maruta N, Bernstein A, Ikenaka K, Hitoshi S (2008) Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of Notch signaling. Stem Cells 26, 1758-1767
Hitoshi S, Alexon T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D (2002) Notch pathway molecules are essential for the maintenance, but not for the generation, of mammalian neural stem cells. Genes & Dev 16, 846-858

and more...




Last Update : 2015.10.22