Selected Publications
Abdullah A, Hayashi Y, Morimura N, Hitoshi S (2024) Role of α1,3-fucosyltransferases in the mammalian brain and their association with neuropsychiatric disorders. Trend Glycosci Glycotechnol in press
Zak ZMM, Kuroda A,Morimura N, Hayashi Y, Hitoshi S (2023) Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size. J Physiol Sci 17, 19
Abdullah A, Hayashi Y, Morimura N, Kumar A, Ikenaka K, Togayachi A, Narimatsu H, Hitoshi S (2022) Fut9 deficiency causes abnormal neural development in the specific layer of the brain and retina. Neurochem Res 47, 2793-2804
Oura S, Noda T, Morimura N, Hitoshi S, Nishimasu H, Nagai Y, Nureki O, Ikawa M (2021) Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG.
Commun Biol 4, 771 PubMed
*Tanaka A, *Ishida S, *Fuchigami T, Hayashi Y, Kuroda A, Ikenaka K, Hitoshi S (2020) Life-long neural stem cells are fate-specified at an early developmental stage. (*, equal contribution)
Cerebral Cortex 30, 6415–6425 PubMed
Daun KA, Fuchigami T, Koyama N, Maruta N, Ikenaka K, Hitoshi S (2020) Early maternal and social deprivation expands neural stem cell population size and reduces hippocampus/amygdala-dependent fear memory.
Front Neurosci 14, 22 PubMed
*Hayashi Y, *Jinnou H, Sawamoto K, Hitoshi S (2018) Adult neurogenesis and its role in brain injury and psychiatric diseases. (*, equal contribution)
J Neurochem 147, 584-594 PubMed
Kuroda A, Fuchigami T, Fuke S, Koyama N, Ikenaka K, Hitoshi S (2018) Minocycline directly enhances the self-renewal of adult neural precursor cells.
Neurochem Res 43, 219-226 PubMed
Morimura N, et al. (2017) Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.
Nature Communications 8, 15800 PubMed
Naruse M, Ishizaki Y, Ikenaka K, Tanaka A, Hitoshi S (2017) Origin of oligodendrocytes in mammalian forebrains: a revised perspective.
J Physiol Sci 67, 63-70 PubMed
Yamaguchi M, Seki T, Imayoshi I, Tamamaki N, Hayashi Y, Tatebayashi Y, Hitoshi S (2016) Neural stem cells and neuro/gliogeneis in the central nervous system: understanding the structural and functional plasticity of the developing, mature, and diseased brain.
J Physiol Sci 66, 197-206 PubMed
*Naruse M, *Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S (2016) The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window. (*, equal contribution)
Cerebral Cortex 26, 2800-2810 PubMed
Fuke S, Kametani M, Yamada K, Kubota-Sakashita M, Kasahara T, Kujoth GC, Prolla TA, Hitoshi S, Kato T (2014) A heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.
Annals of Clinical and Translational Neurology 1, 909-920 PubMed
*Zheng L-S, *Hitoshi S, *Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for interferon-α-induced depression and neural stem cell dysfunction. (*, equal contribution)
Stem Cell Reports 3, 74-83 PubMed
*Ishino Y, *Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi S (2014) Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells. (*, equal contribution)
J Neurosci 34, 3067-3078 PubMed
Kumar A, Torii T, Ishino Y, Muraoka D, Yoshimura T, Togayachi A, Narimatsu H, Ikenaka K, Hitoshi S (2013) The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
J Biol Chem 288, 28859-28868 PubMed
Iwashita N, Nosaka S, Koyama N (2012) Involvement of peripheral NMDA receptor in melittin-induced thermographic flare.
Neurochem Res 37, 2222-2228 PubMed
Hayashi Y, Nihonmatsu-Kikuchi N, Hisanaga S-i, Yu X, Tatebayashi Y. (2012) Neuropathological similarities and differences between schizophrenia and bipolar disorder : a flow cytometric postmortem brain study.
PLoS One 7, e33019 PubMed
Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K (2011) Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
Nat Neurosci 14, 957-964 PubMed
Hayashi Y, Nihonmatsu-Kikuchi N, Hisanaga S-i, Tatebayashi Y. (2011) A novel, rapid, cell-counting method for unfixed frozen brains comprehensively quantifies at least four neural cell populations.
Mol Psychiat 16, 1155 PubMed
Higashi M, Maruta N, Bernstein A, Ikenaka K, Hitoshi S (2008) Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of Notch signaling.
Stem Cells 26, 1758-1767 PubMed
Hitoshi S, Maruta N, Higashi M, Kumar A, Kato N, Ikenaka K (2007) Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
J Neurosci Res 85, 3574-3585 PubMed
Hitoshi S, Seaberg RM, Koscik C, Alexson T, Kusunoki S, Kanazawa I, Tsuji S, van der Kooy D (2004) Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling.
Genes & Dev 18, 1806-1811 PubMed
Hitoshi S, Alexon T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D (2002) Notch pathway molecules are essential for the maintenance, but not for the generation, of mammalian neural stem cells.
Genes & Dev 16, 846-858 PubMed
Hitoshi S, Tropepe V, Sirard C, Ekker M, van der Kooy D (2002) Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.
Development 129, 233-244 PubMed
Koyama N, Hirata K, Hori K, Dan K, Yokota T (2002) Biphasic vasomotor reflex responses of the hand skin following intradermal injection of melittin into the forearm skin.
Eur J Pain 6, 447-453 PubMed
Tropepe V, Hitoshi S, Sirard C, Mak TW, Rossant J, van der Kooy D (2001) Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.
Neuron 30, 65-78 PubMed
