Selected Publications(2011年~現在)


Abdullah A, Hayashi Y, Morimura N, Hitoshi S (2024) Role of α1,3-fucosyltransferases in the mammalian brain and their association with neuropsychiatric disorders. Trend Glycosci Glycotechnol in press  


Zak ZMM, Kuroda A,Morimura N, Hayashi Y, Hitoshi S (2023) Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size. J Physiol Sci 17, 19  


Abdullah A, Hayashi Y, Morimura N, Kumar A, Ikenaka K, Togayachi A, Narimatsu H, Hitoshi S (2022) Fut9 deficiency causes abnormal neural development in the specific layer of the brain and retina. Neurochem Res 47, 2793-2804  


Oura S, Noda T, Morimura N, Hitoshi S, Nishimasu H, Nagai Y, Nureki O, Ikawa M (2021) Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG.
Commun Biol 4, 771  PubMed


*Tanaka A, *Ishida S, *Fuchigami T, Hayashi Y, Kuroda A, Ikenaka K, Hitoshi S (2020) Life-long neural stem cells are fate-specified at an early developmental stage. (*, equal contribution)
Cerebral Cortex 30, 6415–6425  研究紹介|PubMed

Daun KA, Fuchigami T, Koyama N, Maruta N, Ikenaka K, Hitoshi S (2020) Early maternal and social deprivation expands neural stem cell population size and reduces hippocampus/amygdala-dependent fear memory.
Front Neurosci 14, 22  PubMed


*Hayashi Y, *Jinnou H, Sawamoto K, Hitoshi S (2018) Adult neurogenesis and its role in brain injury and psychiatric diseases. (*, equal contribution)
J Neurochem 147, 584-594  PubMed

Kuroda A (登録研究医), Fuchigami T, Fuke S, Koyama N, Ikenaka K, Hitoshi S (2018) Minocycline directly enhances the self-renewal of adult neural precursor cells.
Neurochem Res 43, 219-226  PubMed


Morimura N, et al. (2017) Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.
Nature Communications 8, 15800  PubMed

Naruse M, Ishizaki Y, Ikenaka K, Tanaka A (登録研究医), Hitoshi S (2017) Origin of oligodendrocytes in mammalian forebrains: a revised perspective.
J Physiol Sci 67, 63-70  PubMed


Yamaguchi M, Seki T, Imayoshi I, Tamamaki N, Hayashi Y, Tatebayashi Y, Hitoshi S (2016) Neural stem cells and neuro/gliogeneis in the central nervous system: understanding the structural and functional plasticity of the developing, mature, and diseased brain.
J Physiol Sci 66, 197-206  PubMed

*Naruse M, *Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S (2016) The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window. (*, equal contribution)
Cerebral Cortex 26, 2800-2810  研究紹介|PubMed


Fuke S, Kametani M, Yamada K, Kubota-Sakashita M, Kasahara T, Kujoth GC, Prolla TA, Hitoshi S, Kato T (2014) A heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.
Annals of Clinical and Translational Neurology 1, 909-920  PubMed

*Zheng L-S, *Hitoshi S, *Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for interferon-α-induced depression and neural stem cell dysfunction. (*, equal contribution)
Stem Cell Reports 3, 74-83  研究紹介|PubMed

*Ishino Y, *Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi S (2014) Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells. (*, equal contribution)
J Neurosci 34, 3067-3078  研究紹介|PubMed


Kumar A, Torii T, Ishino Y, Muraoka D, Yoshimura T, Togayachi A, Narimatsu H, Ikenaka K, Hitoshi S (2013) The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
J Biol Chem 288, 28859-28868  研究紹介|PubMed

Fuchigami T, Sato Y, Tomita Y, Takano T, Miyauchi SY, Tsuchiya Y, Saito T, Kubo K, Nakajima K, Fukuda M, Hattori M, Hisanaga S (2013) Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.
Genes Cells 18, 410-420  PubMed


Iwashita N, Nosaka S, Koyama N (2012) Involvement of peripheral NMDA receptor in melittin-induced thermographic flare.
Neurochem Res 37, 2222-2228  PubMed

Hayashi Y, Nihonmatsu-Kikuchi N, Hisanaga S-i, Yu X, Tatebayashi Y. (2012) Neuropathological similarities and differences between schizophrenia and bipolar disorder : a flow cytometric postmortem brain study.
PLoS One 7, e33019  PubMed


Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K (2011) Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
Nat Neurosci 14, 957-964  研究紹介|PubMed

Hayashi Y, Nihonmatsu-Kikuchi N, Hisanaga S-i, Tatebayashi Y. (2011) A novel, rapid, cell-counting method for unfixed frozen brains comprehensively quantifies at least four neural cell populations.
Mol Psychiat 16, 1155  研究紹介|PubMed