1. Kojima A, Fukushima Y, Ito Y, Ding WG, Kitagawa H, Matsuura H. TRPC channel blockers improve ventricular contractile functions after ischemia/reperfusion in a Langendorff-perfused mouse heart model. J Cardiovasc Pharmacol 2018 (in press).
  2. Sagawa H, Hoshino S, Yoshioka K, Ding WG, Omatsu-Kanbe M, Nakagawa M, Maruo Y, Matsuura H. Postnatal developmental changes in the sensitivity of L-type Ca2+ channel to inhibition by verapamil in a mouse heart model. Pediatr Res 2018 (in press).
  3. Fukumoto D, Ding WG, Wada Y, Fujii Y, Ichikawa M, Takayama K, Fukuyama M, Kato K, Itoh H, Makiyama T, Omatsu-Kanbe M, Matsuura H, Horie M, Ohno S. Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome. J Cardiol 2018;71:401-408.
  4. Toyoda F, Ding WG, Matsuura H. Heterogeneous functional expression of the sustained inward Na+ current in guinea pig sinoatrial node cells. Pflügers Arch. 2018;470:481-490.
  5. Wu J, Mizusawa Y, Ohno S, Ding WG, Higaki T, Wang Q, Kohjitani H, Makiyama T, Itoh H, Toyoda F, James AF, Hancox JC, Matsuura H, Horie M. A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations. Sci Rep 2018;8:3129.
  6. Kojima A, Fukushima Y, Ito Y, Ding WG, Ueda R, Seto T, Kitagawa H, Matsuura H. Interactions of propofol with human voltage-gated Kv1.5 channel determined by docking simulation and mutagenesis analyses. J Cardiovasc Pharmacol 2018;71:10-18.


  1. Sabirov RZ, Merzlyak PG, Okada T, Islam MR, Uramoto H, Mori T, Makino Y, Matsuura H, Xie Y, Okada Y. The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel. EMBO J 2017;36:3309-3324.
  2. Kojima A, Matsuura H. Ionic mechanisms of the action of anaesthetics on sinoatrial node automaticity. Eur J Pharmacol 2017;814:63-72.
  3. Toyoda F, Mesirca P, Dubel S, Ding WG, Striessnig J, Mangoni ME, Matsuura H. CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current. Sci Rep 2017;7:7869.
  4. Fujii Y, Matsumoto Y, Hayashi K, Ding WG, Tomita Y, Fukumoto D, Wada Y, Ichikawa M, Sonoda K, Ozawa J, Makiyama T, Ohno S, Yamagishi M, Matsuura H, Horie M, Itoh H. Contribution of a KCNH2 variant in genotyped long QT syndrome: Romano-Ward syndrome under double mutations and acquired long QT syndrome under heterozygote. J Cardiol 2017; 70:74-79.
  5. Omatsu-Kanbe M, Nozuchi N, Nishino Y, Mukaisho K, Sugihara H, Matsuura H. Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death. Sci Rep 2017; 7: 41318.


  1. Wang S, Ding WG, Bai JY, Toyoda F, Wei MJ, Matsuura H. Regulation of human cardiac Kv1.5 channels by extracellular acidification.
    Pflugers Arch 2016;468:1885-1894.
  2. Kumagai K, Toyoda F, Staunton CA, Maeda T, Okumura N, Matsuura H, Matsusue Y, Imai S, Barrett-Jolley R. Activation of a chondrocyte volume-sensitive Cl- conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model. Osteoarthritis Cartilage 2016; 24:1786-1794.
  3. Maeda T, Toyoda F, Imai S, Tanigawa H, Kumagai K, Matsuura H, Matsusue Y. Lidocaine induces ROCK-dependent membrane blebbing and subsequent cell death in rabbit articular chondrocytes. J Orthop Res 2016; 34:754-762.
  4. Kojima A, Bai JY, Ito Y, Ding WG, Kitagawa H, Matsuura H. Serum albumin attenuates the open-channel blocking effects of propofol on the human Kv1.5 channel. Eur J Pharmacol 2016;783:117-126.


  1. Kubo T, Ding WG, Toyoda F, Fujii Y, Omatsu-Kanbe M, Matsuura H. Phosphatidylinositol 4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation. J Pharmacol Sci 2015;127:127-34.
  2. Omatsu-Kanbe M, Matsuura H. The presence of LC3 and LAMP1 is greater in normal sino-atrial nodal cells than in ordinary cardiomyocytes, indicating a constitutive event. In Autophagy: Cancer, other pathologies, inflammation. immunity, infection and aging. volume 7 (Elsevier, edited by Hayat, M.), chapter 14. pages 219-226, 2015.
  3. Kojima A, Ito Y, Kitagawa H, Matsuura H. Ionic mechanisms underlying the negative chronotropic action of propofol on sinoatrial node automaticity in guinea-pig heart. Br J Pharmacol 2015;172:799-814.
  4. Xie Y, Ding WG, Matsuura H. Ca2+/calmodulin potentiates IKs in sinoatrial node cells by activating Ca2+/calmodulin-dependent protein kinase II. Pflügers Arch 2015;467:241-51.
  5. Kojima A, Ito Y, Ding WG, Kitagawa H, Matsuura H. Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region. Eur J Pharmacol 2015;764:622-32..
  6. Bai J-Y, Ding WG, Kojima A, Seto T, Matsuura H. Putative binding sites for arachidonic acid on the human cardiac Kv1.5 channel. Br J Pharmacol 2015;172: 5281-92.. 


  1. Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M. A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels. Heart Rhythm 2014;11:67-75.
  2. Kato K, Makiyama T, Wu J, Ding WG, Kimura H, Naiki N, Ohno S, Itoh H, Nakanishi T, Matsuura H, Horie M. Cardiac channelopathies associated with infantile fatal ventricular arrhythmias: from the cradle to the bench. J Cardiovasc Electrophysiol 2014;25:66-73.
  3. Wu J, Naiki N, Ding WG, Ohno S, Kato K, Zang W-J, Delisle BP, Matsuura H, Horie M. A molecular mechanism for adrenergic-induced long QT syndrome. J Am Coll Cardiol 2014;63:819-27.
  4. Ding WG, Xie Y, Toyoda F, Matsuura H. Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment. PLoS One 2014;9:e92923.
  5. Hasegawa K, Ohno S, Itoh H, Makiyama T, Aiba T, Nakano Y, Shimizu W, Matsuura H, Makita N, Horie M. A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome. Journal of Arrhythmia 2014;30:161-6
  6. Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, Bai J, Hasegawa K, Shinohara T, Takahashi N, Shimizu A, Matsuura H, Horie M. Gain-of-function KCNH2 mutations in patients with Brugada syndrome. J Cardiovasc Electrophysiol
  7. Kojima A, Ito Y, Kitagawa H, Matsuura H, Nosaka S. Direct negative chronotropic action of desflurane on sinoatrial node pacemaker activity in the guinea pig heart. Anesthesiology 2014;120:1400-13.
  8. Zhou J, Ding WG, Makiyama T, Miyamoto A, Matsumoto Y, Kimura H, Tarutani Y, Zhao J, Wu J, Zang WJ, Matsuura H, Horie M. A novel HCN4 mutation, G1097W, is associated with atrioventricular block. Circ J 2014;78:938-42.
  9. Wu J, Ding WG, Zhao J, Zang W-J, Matsuura H, Horie M. Irbesartan-mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes. J Renin Angiotensin Aldosterone Syst 2014;15:341-7.
  10. Fukuyama M, Wang Q, Kato K, Ohno S, Ding WG, Toyoda F, Itoh H, Kimura H, Makiyama T, Ito M, Matsuura H, Horie M. Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes. Europace 2014;16:1828-37.
  11. Omatsu-Kanbe M, Matsuura H. Novel intracellular mediator of adiponectin secretion from adipocytes. J Physiol 2014;592:5141.
  12. Omatsu-Kanbe M, Nishino Y, Nozuchi N, Sugihara H, Matsuura H. Prion protein- and cardiac troponin T-marked interstitial cells from the adult myocardium spontaneously develop into beating cardiomyocytes. Sci Rep 2014;4:7301.2014;25:522-30.


  1. Omatsu-Kanbe M, Matsuura H. Ischemic survival and constitutively active autophagy in self-beating atypically-shaped cardiomyocytes (ACMs): characterization of a new subpopulation of heart cells. J Physiol Sci 2013;63:17-29.
  2. Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. Sevoflurane protects ventricular myocytes against oxidative stress-induced cellular Ca2+ overload and hypercontracture. Anesthesiology 2013;119:606-620.
  3. Kumagai K, Kubo M, Imai S, Toyoda F, Maeda T, Okumura N, Matsuura H, Matsusue Y. The COX-2 selective blocker etodolac inhibits TNFα-induced apoptosis in isolated rabbit articular chondrocytes. Int J Mol Sci 2013;14:19705-19715.
  4. Kojima A, Ito Y, Kitagawa H, Matsuura H, Nosaka S. Remifentanil has a minimal direct effect on sinoatrial node pacemaker activity in the guinea pig heart. Anesth Analg 2013;117:1072-1077.
  5. Kiyonaka S, Kajimoto T, Sakaguchi R, Shinmi D, Omatsu-Kanbe M, Matsuura H, Imamura H, Yoshizaki T, Hamachi I, Morii T, Mori Y. Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nat Methods 2013;10:1232-1238.


  1. Han X, Yan DM, Zhao XF, Matsuura H, Ding WG, Li P, Jiang S, Du BR, Du PG, Zhu X. GHGKHKNK octapeptide (P-5m) inhibits metastasis of HCCLM3 cell lines via regulation of MMP-2 expression in in vitro and in vivo studies. Molecules 2012;17:1357-1372.
  2. Wu J, Ding WG, Matsuura H, Horie M. Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors. Pflügers Arch 2012;463:625-633.
  3. Kumagai K, Imai S, Toyoda F, Okumura N, Isoya E, Matsuura H, Matsusue Y. 17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl- current in rabbit articular chondrocytes. Br J Pharmacol 2012;166:702-720.
  4. Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H. Postnatal developmental decline in IK1 in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method. Pflügers Arch 2012;463:649-668.
  5. Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M. Phenotype variability in patients carrying KCNJ2 mutations. Circ Cardiovasc Genet 2012;5:344-353.
  6. Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea-pig heart. Br J Pharmacol 2012;166:2117-2135.
  7. Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. Presence of store-operated Ca2+ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane. Br J Anaesth 2012;109:352-360.
  8. Kojima A, Matsuura H. Electrophysiological importance of embryonic stem cell-derived cardiac progenitors. Circ J 2012;76:2746-2747.
  9. Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding WG, Matsuura H, Kurabayashi M, Horie M. KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram. Circ J 2012;76:2763-2772.
  10. Amagai A, Macwilliams H, Isono T, Omatsu-Kanbe M, Urano S, Yamamoto K, Maeda Y. PKC-mediated ZYG1 phosphorylation induces fusion of myoblasts as well as of Dictyostelium cells. Int J Cell Biol. 2012;2012:657423.


  1. Ding WG, Toyoda F, Ueyama H, Matsuura H. Lysophosphatidylcholine enhances IKs currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. J Mol Cell Cardiol 2011;50:58-65.
  2. Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A. Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells. Am J Physiol 2011;300:H251-H261.
  3. Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res 2011;108:458-468.
  4. Himeno Y, Toyoda F, Matsuura H, Noma A. Reply to "Letter to the editor: 'Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity'". Am J Physiol 2011;300:H2325-H2326.
  5. Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M. KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm Electrophysiol 2011;4:352-361.
  6. Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. Sevoflurane protects ventricular myocytes from Ca2+ paradox-mediated Ca2+ overload by blocking the activation of transient receptor potential canonical channels. Anesthesiology 2011;115:509-522.
  7. Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M. Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process. Biochim Biophys Acta 2011;1812:1452-1459.
  8. Omatsu-Kanbe M, Yamamoto T, Matsuura H. Autophagy is constitutively active in normal mouse sino-atrial nodal cells. Acta Histochem Cytochem 2011;44:223-231.


  1. Wu J, Shimizu W, Ding WG, Ohno S, Toyoda F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M. KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. Heart Rhythm 2010;7:199-205.
  2. Omatsu-Kanbe M, Yamamoto T, Mori Y, Matsuura H. Self-beating atypically shaped cardiomyocytes survive a long-term postnatal development preserving expression of fetal cardiac genes in mice. J Histochem Cytochem 2010;58:543-551.
  3. Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H. Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes. J Membr Biol 2010;235:73-87.
  4. Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes. Br J Pharmacol 2010;161:1734-1750.
  5. Nakamura H, Ding WG, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H. Presence and functional role of the rapidly activating delayed rectifier K+ current in left and right atria of adult mice. Eur J Pharmacol 2010;649:14-22.
  6. Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M. Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome. Circ J 2010;74:2562-2571.


  1. Wu J, Ding WG, Matsuura H, Tsuji K, Zang WJ, Horie M. Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel. Br J Pharmacol 2009;156:377-387.
  2. Isoya E, Toyoda F, Imai S, Okumura N, Kumagai K, Omatsu-Kanbe M, Kubo M, Matsuura H, Matsusue Y. Swelling-activated Cl- current in isolated rabbit articular chondrocytes: inhibition by arachidonic acid. J Pharmacol Sci 2009;109:293-304.
  3. Omatsu-Kanbe M, Matsuura H. A novel type of self-beating cardiomyocytes in adult mouse ventricles. Biochem Biophys Res Commun
  4. Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Hum Mutat 2009;30:557-563.
  5. Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M. Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients. Heart Rhythm 2009;6:1038-1046.
  6. Okumura N, Imai S, Toyoda F, Isoya E, Kumagai K, Matsuura H, Matsusue Y. Regulatory role of tyrosine phosphorylation in the swelling-activated chloride current in isolated rabbit articular chondrocytes. J Physiol 2009;587:3761-3776.
  7. Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong YZ, Yamamoto S, Ozawa T, Ding WG, Toyoda F, Kawamura M, Akao M, Matsuura H, Kimura T, Kita T, Horie M. D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. J Am Coll Cardiol 2009;54:812-819.
  8. Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura H, Horie M. Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium. Pflügers Arch 2009;458:837-849.
  9. Itoh H, Sakaguchi T, Ashihara T, Ding WG, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ito M, Nakamura K, Ohe T, Matsuura H, Horie M. A novel KCNH2 mutation as a modifier for short QT interval. Int J Cardiol 2009;137:83-85.
  10. Itoh H, Sakaguchi T, Ding WG, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M. Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome. Circ Arrhythm Electrophysiol 2009;2:511-523.
  11. Sato T, Takeuchi S, Saito A, Ding WG, Bamba H, Matsuura H, Hisa Y, Tooyama I, Urushitani M. Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons. Neuroscience 2009;164:1565-1578. 2009;381:361-366.