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Welcome to our Laboratory !
講座紹介当教室は，心筋細胞のイオンチャネル・輸送体の制御機構および心筋幹細胞の分化・分裂のメカニズムの 解明を主要な研究テーマとしており，その他の細胞における機能解析も幅広く行っています。これまでに研究対象となった細胞は， 心筋細胞，脂肪細胞，褐色脂肪細胞，後根神経節細胞，視細胞，軟骨細胞，子宮筋細胞，ES細胞，および種々の株細胞で，様々な臨床医学講座との共同研究を行っています。
また，研究医コースの学部学生を積極的に受け入れ，学会発表の代表者や論文の共著者として研究成果を発表できるようサポートしています。
Recent publications
Yamada K, Ding W-G, Omatsu-Kanbe M, Toyoda F, Ysuki S, Katsura D, Kinura F, Matsuura H, Murakami T. Expression and functional maintenance of volume-regulated anion channels in myometrial smooth muscles of pregnant mice. Experimental Animals 2021:
Yuasa M, Kojima A, Mi X, Ding, WG, Omatsu-Kanbe M, Kitagawa H, Matsuura H. Characterization and functional role of rapid- and slow-activating delayed rectifier K+ currents in atrioventricular node cells of guinea pigs.Pflügers Archiv 2021: 473(12) 1885-1898
Mi X, Ding WG, ToyodaF, Kojima A, Omatsu-KanbeM, Matsuura H. Selective activation of adrenoceptors potentiates I Ks current in pulmonary vein cardiomyocytes through the protein kinase A and C signaling pathways. Journal of Molecular and Cellular Cardiology 2021: 161:86-97,
Ishihara M, Kojima A, Ding WG, Kitagawa H, Matsuura H. Dexmedetomidine exerts a negative chronotropic action on sinoatrial node cells through the activation of imidazoline receptors. Journal of Cardiovascular Pharmacology
Mi X, Ding WG, Toyoda F, Kojima A, Omatsu-Kanbe M, Matsuura H. Selective activation of adrenoceptors potentiates IKs current in pulmonary vein cardiomyocytes through the protein kinase A and C signaling pathways. Journal of Molecular and Cellular Cardiology 2021: 161 86-97
Kojima A, Mi X, Fukushima Y, Ding WG, Omatsu‐Kanbe M, Matsuura H Elevation of propofol sensitivity of cardiac I Ks channel by KCNE1 polymorphism D85N British Journal of Pharmacology 2021: 178(13) 2690-2708.
Omatsu-Kanbe M, Fukunaga R, Mi X, Matsuura H. An Antegrade Perfusion Method for Cardiomyocyte Isolation from Mice Journal of Visualized Experiments 2021: 171:e61866.
Matsuura H, Kojima A, Fukushima Y, Xie Y, Mi X, Sabirov RZ, Okada Y. Positive Inotropic Effects of ATP Released via the Maxi-Anion Channel in Langendorff-Perfused Mouse Hearts Subjected to Ischemia-Reperfusion. Frontiers in Cell and Developmental Biology 2021: 9 597997-597997.
Fukushima Y, Kojima A, Mi X, Ding W-G, Kitagawa H, Matsuura H. Open‐channel blocking action of volatile anaesthetics desflurane and sevoflurane on human voltage‐gated K v 1.5 channel. British Journal of Pharmacology 2020: 177(16) 3811-3827.
Shimizu A, Zanko DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S Horie M, Ogita H. Identification of transmembrane protein 168 mutation in familial Brugada syndrome. FASEB journal 2020: 34(5) 6399-6417.
Ding WG, Tano A, Mi X, Kojima A, Seto T, Matsuura H. Identification of verapamil binding sites within human Kv1.5 channel using mutagenesis and docking simulation. Cell Physiol Biochem 2019; 52:302-314.
Xie Y, Ding WG, Liu Y, Yu M, Sun X, Matsuura H. Long-term 4-AP treatment facilitates functional expression of human Kv1.5 channel. Eur J Pharmacol 2019;844:195-203.
Wu J, Sakaguchi T, Takenaka K, Toyoda F, Tsuji K, Matsuura H, Horie M. A trafficking-deficient KCNQ1 mutation, T587M, causes a severe phenotype of long QT syndrome by interfering with intracellular hERG transport. J Cardiol 2019;73:343-350.
Takayama K, Ohno S, Ding WG, Ashihara T, Fukumoto D, Wada Y, Makiyama T, Kise H, Hoshiai M, Matsuura H, Horie M. A de novo gain-of-function KCND3 mutation in early repolarization syndrome. Heart Rhythm 2019;16:1698-1706.
Hashimoto E, Kojima A, Kitagawa H, Matsuura H. Anesthetic management of a patient with type 1 long QT syndrome using combined epidural-spinal anesthesia for Caesarean section: Perioperative approach based on ion channel function. J Cardiothorac Vasc Anesth 2020;34:465-469.
Tanigawa H, Toyoda F, Kumagai K, Okumura N, Maeda T, Matsuura H, Imai S. P2X7 ionotropic receptor is functionally expressed in rabbit articular chondrocytes and mediates extracellular ATP cytotoxicity. Purinergic Signal 14(3) 245-258
Ozawa J, Ohno S, Saito H, Saitoh A, Matsuura H, Horie M. A novel CACNA1C mutation identified in a patient with Timothy syndrome without syndactyly exerts both marked loss-and-gain of function effects. HeartRhythm Case Rep 2018;4(7):273-277
Omatsu-Kanbe M, Yoshioka K, Fukunaga R, Sagawa H, Matsuura H. A simple antegrade perfusion method for isolating viable single cardiomyocytes from neonatal to aged mice. Physiol Rep 2018;6(9):e13688.
Kojima A, Fukushima Y, Ito Y, Ding WG, Kitagawa H, Matsuura H. TRPC channel blockers improve ventricular contractile functions after ischemia/reperfusion in a Langendorff-perfused mouse heart model. J Cardiovasc Pharmacol 2018;71:248-255.
Sagawa H, Hoshino S, Yoshioka K, Ding WG, Omatsu-Kanbe M, Nakagawa M, Maruo Y, Matsuura H. Postnatal developmental changes in the sensitivity of L-type Ca2+ channel to inhibition by verapamil in a mouse heart model. Pediatr Res 2018;83:1207-1217.
Fukumoto D, Ding WG, Wada Y, Fujii Y, Ichikawa M, Takayama K, Fukuyama M, Kato K, Itoh H, Makiyama T, Omatsu-Kanbe M, Matsuura H, Horie M, Ohno S. Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome. J Cardiol 2018;71:401-408.
Toyoda F, Ding WG, Matsuura H. Heterogeneous functional expression of the sustained inward Na+ current in guinea pig sinoatrial node cells. Pflügers Arch. 2018;470:481-490.
Wu J, Mizusawa Y, Ohno S, Ding WG, Higaki T, Wang Q, Kohjitani H, Makiyama T, Itoh H, Toyoda F, James AF, Hancox JC, Matsuura H, Horie M. A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations. Sci Rep 2018;8:3129.
Kojima A, Fukushima Y, Ito Y, Ding WG, Ueda R, Seto T, Kitagawa H, Matsuura H. Interactions of propofol with human voltage-gated Kv1.5 channel determined by docking simulation and mutagenesis analyses. J Cardiovasc Pharmacol 2018;71:10-18.
