滋賀医科大学・生理学講座・細胞機能生理学部門(旧・生理学第二講座)のホームページへようこそ!


 Welcome to our Laboratory !

講座紹介

当教室は,心筋細胞のイオンチャネル・輸送体の制御機構および心筋幹細胞の分化・分裂のメカニズムの 解明を主要な研究テーマとしており,その他の細胞における機能解析も幅広く行っています。これまでに研究対象となった細胞は, 心筋細胞,脂肪細胞,褐色脂肪細胞,後根神経節細胞,視細胞,軟骨細胞,子宮筋細胞,ES細胞,および種々の株細胞で,様々な臨床医学講座との共同研究を行っています。

また,研究医コースの学部学生を積極的に受け入れ,学会発表の代表者や論文の共著者として研究成果を発表できるようサポートしています。

Recent publications

Ozawa J, Ohno S, Saito H, Saitoh A, Matsuura H, Horie M. A novel CACNA1C mutation identified in a patient with Timothy syndrome without syndactyly exerts both marked loss-and-gain of function effects. HeartRhythm Case Rep 2018 (in press)

Omatsu-Kanbe M, Yoshioka K, Fukunaga R, Sagawa H, Matsuura H.
A simple antegrade perfusion method for isolating viable single cardiomyocytes from neonatal to aged mice. Physiol Rep 2018 (in press)

Kojima A, Fukushima Y, Ito Y, Ding WG, Kitagawa H, Matsuura H. TRPC channel blockers improve ventricular contractile functions after ischemia/reperfusion in a Langendorff-perfused mouse heart model. J Cardiovasc Pharmacol 2018 (in press).

Sagawa H, Hoshino S, Yoshioka K, Ding WG, Omatsu-Kanbe M, Nakagawa M, Maruo Y, Matsuura H. Postnatal developmental changes in the sensitivity of L-type Ca2+ channel to inhibition by verapamil in a mouse heart model.
Pediatr Res 2018 (in press).

Fukumoto D, Ding WG, Wada Y, Fujii Y, Ichikawa M, Takayama K, Fukuyama M, Kato K, Itoh H, Makiyama T, Omatsu-Kanbe M, Matsuura H, Horie M, Ohno S. Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome. J Cardiol 2018;71:401-408.

Toyoda F, Ding WG, Matsuura H. Heterogeneous functional expression of the sustained inward Na+ current in guinea pig sinoatrial node cells. Pflügers Arch. 2018;470:481-490.

Wu J, Mizusawa Y, Ohno S, Ding WG, Higaki T, Wang Q, Kohjitani H, Makiyama T, Itoh H, Toyoda F, James AF, Hancox JC, Matsuura H, Horie M. A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations. Sci Rep 2018;8:3129.

Kojima A, Fukushima Y, Ito Y, Ding WG, Ueda R, Seto T, Kitagawa H, Matsuura H. Interactions of propofol with human voltage-gated Kv1.5 channel determined by docking simulation and mutagenesis analyses. J Cardiovasc Pharmacol
2018;71:10-18.