疾患制御病態学部門の構成メンバー　|　滋賀医科大学　｜　病理学講座　｜　疾患制御病態学部門

私たち、滋賀医科大学病理学講座疾患制御病態学部門は、日本の基礎病理学研究の一助となるべく日々頑張っています。

伊藤　靖

伊藤　靖教授

所属学会: 日本免疫学会　日本病理学会　日本ウイルス学会　日本癌学会　日本ワクチン学会

業績

文献

Yasushi Itoh. Establishment of a nonhuman primate model for development of vaccines and anti-viral drugs against COVID-19. Translational and Regulatory Sciences, 3(3): 109–111, 2021
伊藤靖、小笠原一誠、カニクイザルモデルを用いた免疫抑制状態における鳥インフルエンザウイルスの病原性の解明、臨床免疫・アレルギー科、第68巻第1号、31-37, 2017.
Itoh Y. Translational research on influenza virus infection using a nonhuman primate model. Pathol Int 66: 132-141, 2016.
Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460: 1021-1025, 2009.

学会発表

伊藤　靖「霊長類モデルを用いたインフルエンザウイルスの病原性の解明と予防・治療法の開発」第60回日本病理学会秋期特別総会A演説、平成26年11月21日、沖縄
Itoh Y, Nakayama M, Ishida H, Shichinohe S, Ishigaki H, Kitagawa N, Sasamura T, Sasada M, Endo M, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Efficacy of a vaccine and neuraminidase inhibitors against H7N9 influenza virus in cynomolgus macaques. 3rd ISIRV Anti-viral Group Conference. June 5, 2014, Tokyo.
Itoh Y, Arikata M, Maeda T, Shiina T, Ishigaki H, Takada A, Okamatsu M, Sakoda Y, Nakayama M, Kida H, Ogasawara K. Identification of pandemic influenza virus NP peptides bound to cynomolgus macaque MHC class I Mafa-A1*5202 and stimulating CTL responses. XV International Congress of Virology, September 15, 2011, Sapporo.
Itoh Y. An H1N1 influenza virus vaccine selected from a non-pathogenic influenza virus library prevents cynomolgus macaques from infection with a newly emerging swine-origin H1N1 influenza virus, 第3回日中科学フォーラム、March 15, 2010, 武漢、中国
Itoh Y, Ozaki H, Ishigaki H, Sakoda Y, Nagata T, Soda K, Ishida H, Tsuchiya H, Okamoto K, Torii R, Kida H, Ogasawara K. Pathogenesis of H7N7 Highly Pathogenic Avian Influenza Virus in Cynomolgus Macaques and Protective Effects of a Vaccine Derived from a Virus Library. Asian-African Research Forum on Emerging and Reemerging Infections, December 16, 2008, Sapporo.

石垣　宏仁

石垣　宏仁准教授

所属学会: 日本免疫学会　日本病理学会　日本癌学会　日本内科学会　日本消化器病学会　日本消化器内視鏡学会

業績

主著論文

Terada K, Kondo K, Ishigaki H, Nagashima A, Satooka H, Nagano S, Masuda K, Kawamura T, Hirata T, Ogasawara K, Itoh Y, Kawamoto H, Agata Y.
Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.
Molecular Therapy: Oncolytics 2022 doi: https://doi.org/10.1016/j.omto.2021.12.003.
Ishigaki H, Pham VL, Terai J, Sasamura T, Nguyen CT, Ishida H, Okahara J, Kaneko S, Shiina T, Nakayama M, Itoh Y, Ogasawara K. No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques. Cell Transplant. 2021 Jan-Dec;30:963689721992066. doi: 10.1177/0963689721992066. PMID: 33588604.
Ishigaki H, Nakayama M, Kitagawa Y, Nguyen CT, Hayashi K, Shiohara M, Gotoh B, Itoh Y. Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. Virology. 2020 Dec 29;554:97-105. doi: 10.1016/j.virol.2020.12.013.
Ishigaki H, Itoh Y. Embryonal Carcinoma and Glioblastoma Cell Lines Derived from Monkey Induced Pluripotent Stem Cells. Methods Mol Biol. 2020 Aug 25. doi: 10.1007/7651_2020_303. Epub ahead of print. PMID: 32833131.
Satooka H, Ishigaki H, Todo K, Terada K, Agata Y, Itoh Y, Ogasawara K, Hirata T. Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model. Sci Rep. 2020 May 21;10(1):8414. doi: 10.1038/s41598-020-65488-x.
Iori Kisu, Hirohito Ishigaki, Katsura Emoto, Yojiro Kato, Yohei Yamada, Kentaro Matsubara, Hideaki Obara, Yohei Masugi, Yusuke Matoba, Masataka Adachi, Kouji Banno, Yoko Saiki, Iori Itagaki, Ikuo Kawamoto, Chizuru Iwatani, Takahiro Nakagawa, Hideaki Tsuchiya, Takako Sasamura, Hiroyuki Urano, Masatsugu Ema, Kazumasa Ogasawara, Daisuke Aoki, Kenshi Nakagawa, Takashi Shiina Long-term outcome and rejection after allogeneic uterus transplantation in cynomolgus macaques J Clin Med. 2019 Oct 1;8(10). pii: E1572. doi: 10.3390/jcm8101572.
Histological analysis of fundic gland polyps secondary to PPI therapy.
Fukuda M, Ishigaki H, Sugimoto M, Mukaisho KI, Matsubara A, Ishida H, Moritani S, Itoh Y, Sugihara H, Andoh A, Ogasawara K, Murakami K, Kushima R.
Histopathology. 2019 May 14. doi: 10.1111/his.13902. [Epub ahead of print]
No transformation of a fundic gland polyp with dysplasia into invasive carcinoma after 14 years of follow-up in a proton pump inhibitor-treated patient: A case report.
Fukuda M, Ishigaki H, Ban H, Sugimoto M, Tanaka E, Yonemaru J, Kuroe S, Namura T, Matsubara A, Moritani S, Murakami K, Andoh A, Kushima R.
Pathol Int. doi: 10.1111/pin.12739. [Epub ahead of print], 2018
MHC-identical and transgenic cynomolgus macaques for preclinical studies.
Ishigaki H, Shiina T, Ogasawara K.
Inflamm Regen. 38:30. doi: 10.1186/s41232-018-0088-3. eCollection 2018.
Transplantation of iPS-derived tumor cells with a homozygous MHC haplotype induces GRP94 antibody production in MHC-matched macaques.
Ishigaki H, Maeda T, Inoue H, Akagi T, Sasamura T, Ishida H, Inubushi T, Okahara J, Shiina T, Nakayama M, Itoh Y, Ogasawara K.
Cancer Res. 2017;77(21): 6001-6010. doi: 10.1158/0008-5472.CAN-17-0775.
Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case.
Ishigaki H, Miyauchi J, Yokoe A, Nakayama M, Yanagi T, Taga T, Ohta S, Itoh Y, Ogasawara K.
Hum Pathol. 2011 Jan;42(1):141-5. doi: 10.1016/j.humpath.2010.06.012.
Analysis of splenic Gr-1int immature myeloid cells in tumor-bearing mice.
Yamamoto Y, Ishigaki H, Ishida H, Itoh Y, Noda Y, Ogasawara K.
Microbiol Immunol. 2008 Jan;52(1):47-53. doi: 10.1111/j.1348-0421.2008.00009.x.
Preparation and functional analysis of tumor-infiltrating stroma cells using bone marrow chimera mice.
Ishigaki H, Yamamoto Y, Ishida H, Kajino K, Itoh Y, Fujiyama Y, Ogasawara K. Microbiol Immunol. 2006;50(8):655-62.

仲山美沙子

仲山　美沙子助教

所属学会: 日本免疫学会　日本病理学会　日本癌学会

業績

主著論文

Hayashi K, Nakayama M, Iwatani C, Tsuchiya H, Nakamura S, Nonoguchi K, Itoh Y, Tsuji S, Ishigaki H, Mori T, Murakami T, Ogasawara K. The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years. Tohoku J Exp Med. 2020 Aug;251(4):241-253. doi: 10.1620/tjem.251.241. PMID: 32713879
Potential Risk of Repeated Nasal Vaccination that Induces Allergic Reaction with Mucosal IgE and Airway Eosinophilic Infiltration in Cynomolgus Macaques infected with H5N1 Highly Pathogenic Avian Influenza Virus.
Misako Nakayama, Yasushi Itoh, Shintaro Shichinohe, Rumi Nakabayashi, Hirohito Ishigaki, Yoshihiro Sakoda, Quynh Mai Le, Yoshihiro Kawaoka, Hiroshi Kida, Kazumasa Ogasawara. Vaccine 35: 1008-1017, 2017.
Vaccination against H9N2 avian influenza virus reduces bronchus-associated lymphoid tissue formation in cynomolgus macaques after intranasal virus challenge infection.
Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho Park, Hideaki Tsuchiya, Hiroshi Kida, Kazumasa Ogasawara. Pathol Int 66: 678-686, 2016.
胸腺癌のマーカー分子を発現した胸腺腫type B3の1例(原著論文/症例報告)
仲山美沙子, 尾柳大樹, 竹村しづき, 馬野真次, 林裕司, 吉田章子, 石垣宏仁, 伊藤靖, 小笠原一誠, 杉原洋行　診断病理　31巻2号 Page152-159, 2014
Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N, Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Ito M, Kawaoka Y, Kida H, Ogasawara K. PLoS One. 2013 Dec 23;8(12):e82740. doi: 10.1371/journal.pone.0082740. eCollection 2013.

寺本和雄

寺本　和雄特任講師

所属学会: 日本化学会　日本高分子学会　日本人工臓器学会　日本アフェレシス学会　日本癌学会　日本バイオセラピー学会

専門分野: 機能高分子化学、体外循環

業績

敗血症治療用エンドトキシン吸着カラムの研究開発
1998年　人工臓器学会賞受賞
2001年　日本化学会化学技術賞受賞

文献

Teramoto K. Fundamental knowledge of hemoperfusion and Plasmaperfusion. Regenerative medicine, artificial cells and Nanomedicine 4: 141-171, 2017.
寺本和雄、上田祐二、小笠原一誠：がん治療を目指すアフェレシス　人工臓器　４６：180-182, 2017.
Yamamoto Y, Ueda Y, Itoh T, Iwamoto A, Tamagishi H, Shimagaki M, Teramoto K. A novel immunotherapeutic modality with direct hemoperfusion targeting transforming growth factor-β prolongs the survival of tumor-bearing rats. Oncology Reports 16: 1277-1284, 2006.

石田　英晃

石田　英晃技術職員

業務内容

1. 教育・研究用標本の作成及び保存等に関する技術業務並びに技術開発業務
2. 教育・研究用情報の収集、処理及びシステム開発・提供に関する技術業務
3. 学部学生・大学院生等の実験・実習の指導に関する技術業務及び試料収集業務

研究内容

T細胞移入による腫瘍免疫療法の開発
樹状細胞のサブタイプや活性化の差異によるT細胞活性化に与える影響の解析

北川　直子

北川　直子教務補佐員

笹村　孝子

笹村　孝子教務補佐員

永田　智也

永田　智也客員助教

所属学会: 日本耳鼻咽喉科学会　耳鼻咽喉科臨床学会　日本免疫学会　宇宙航空環境医学会　など

業績

主著論文

Nagata T, Toyota T, Ishigaki H, Ichihashi T, Kajino K, Kashima Y, Itoh Y, Mori M, Yamamura H, Taneuchi M, Uchida T, Ogasawara K. Peptides coupled to the surface of a kind of liposome protect infection of influenza viruses. Vaccine, 25:4914-4921, 2007.

塩原　正規

塩原　正規病理診断科　医員

業績

主要論文

Shiohara M, Suzuki S, Shichinohe S, Ishigaki H, Nakayama M, Nomura N, Shingai M, Sekiya T, Ohno M, Iida S, Kawai N, Kawahara M, Yamagishi J, Ito K, Mitsumata R, Ikeda T, Motokawa K, Sobue T, Kida H, Ogasawara K, Itoh Y. Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques. Vaccine 40, 4026-4037, 2022.

國分　拓大学院生

Oahida Akter 大学院生

藤井　義大

藤井　義大学部学生

森河　友里学部学生　研究医養成コース

木下　千佳子

木下　千佳子秘書

小笠原

小笠原　一誠滋賀医科大学　名誉教授

OB・OG

スタッフ

木下貴明（特任助教）
（現長崎大学）
鈴木紗織（特任助教）
（現北海道大学）
七戸新太郎（特任助教）
（現大阪大学）
岡本貴世子（助手）
（現国立感染症研究所）
瀧北幹子（助手）
（現洛和会音羽リハビリテーション病院）
西尾斉（特任助手）
（元近畿大学）
Nguyen Thanh Cong（特任助教）
（現近畿大学）
梶野喜一（助手）
梶野由里（医員）
横江章（技官）
南幸枝（秘書）
藤田説子（実験補佐員）
大石俊恵（実験補佐員）
田中由美（実験補佐員）
三ツ石弥千代（実験補佐員）
今井百合香（実験補佐員）
上林早苗（実験補佐員）
小林美保子（実験補佐員）
柏原宏香（実験補佐員）
千早直美（実験補佐員）
佐々木香月（実験補佐員）
塚本真由美（動物センター所属）

博士課程（学位論文）

Nguyen Thanh Cong

（現　近畿大学　助教）

Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model. Antimicrob Agents Chemother 64: e02561-19, 2020.
林香里

（滋賀医科大学産婦人科学講座助教 →　現笠原レディースクリニック）

The natural history of spontaneously occurred endometriosis in cynomolgus monkeys by monthly follow-up laparoscopy for two years. Tohoku J Exp Med 251, 241-253, 2020.
村井亮介

（現市立長浜病院泌尿器科責任部長）

Prediction of intravesical recurrence of non-muscle-invasive bladder cancer by evaluation of intratumoral Foxp3+ T cells in the primary transurethral resection of bladder tumor specimens. PLoS One 13(9): e0204745, 2018.
有方雅彦

（現ありかた耳鼻咽喉科院長）

Memory immune responses against pandemic (H1N1) 2009 influenza virus induced by a whole particle vaccine in cynomolgus monkeys carrying Mafa-A1*052:02. PLoS ONE 7(5): e37220, 2012.
Pham Van Loi

（Cho Ray Hospital　→　現Ottawa University）

Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. PLoS ONE 8: e75910, 2013.
北野光崇

（塩野義製薬　→　現AMED）

Establishment of a cynomolgus macaque model of influenza B virus infection. Virology 407: 178-184, 2010.
鹿島祥隆

（現かしまクリニック院長）

Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration routes of vaccines. Vaccine 27:7402-7408, 2009.
三宅太一郎

（現勝川三宅眼科院長）

Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model. J Med Primatol 39: 58-70, 2010.
澤井俊宏

（現滋賀医科大学小児科学講座講師）

Induction of cytotoxic T lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin. Immunology 124: 155-165, 2008.
山本依志子

（現国立成育医療研究センター政策科学研究部）

Analysis of splenic Gr-1int immature myeloid cells in tumor-bearing mice. Microbiol Immunol 52:47-53, 2008.
馬場弘道

（現長浜赤十字病院第一消化器内科部長）

B1-B cells are the main antigen presenting cells in CpG-ODN-stimulated peritoneal exudate cells. Microbiol Immunol 49:89-95, 2005.
牧野仁

（現柴田内科医院）

Suppressive effects of a new anti-inflammatory agent, IS-741, on dextran sulfate sodium-induced experimental colitis in rats. Int J Mol Med 9391-6, 2002.
中村一郎

（現長浜赤十字病院第二外科部長）

Phenotypic stability of mature dendritic cells tuned by TLR or CD40 to control the efficiency of cytotoxic T cell priming. Microbiol Immunol 48:211-219, 2004.
藤本徳毅

（現滋賀医科大学皮膚科学講座教授）

Quantities of interleukin-12p40 in mature CD8α negative dendritic cells correlate with strength of TCR signal and determine Th cell development. Microbiol Immunol 47: 1017-1024, 2003.

学部学生

森　優也

1. Tsukumo S, Subramani PG, Seija N, Tabata M, Maekawa Y, Mori Y, Ishifune C, Itoh Y, Ota M, Fujio K, Javier M. Noia D, Yasutomo K. AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination. Science Advances 8: eabq0008, 2022.

2. Shingai M, Nomura N, Sekiya T, Ohno M, Fujikura D, Handabile C, Omori R, Ohara Y, Nishimura T, Endo M, Kimachi K, Mitsumata R, Ikeda T, Kitayama H, Hatanaka H, Sobue T, Muro F, Suzuki S, Thanh Nguyen C, Ishigaki H, Nakayama M, Mori Y, Itoh Y, Koutsakos M, Chua BY, Kedzierska K, Brown LE, Jackson DC, Ogasawara K, Kino Y, Kida H. Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells. Vaccine 39: 3940-3951, 2021.

3. Suzuki S, Shichinohe S, Itoh Y, Nakayama M, Ishigaki H, Mori Y, Ogata-Nakahara A, Nguyen CT, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza A virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution. Antiviral Research 178: 104790, 2020.
雪上晴加

1. Morimune T, Tano A, Tanaka Y, Yukiue H, Yamamoto T, Tooyama I, Maruo Y,Nishimura M, Mori M. Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence. PLoS One. 16(4):e0248517, 2021.

2. Kadota Y, Jam FA, Yukiue H, Terakado I, Morimune T, Tano A, Tanaka Y, Akahane S, Fukumura M, Tooyama I, Mori M. Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice. iScience. 23(3):100929, 2020.

3. Tano A, Kadota Y, Morimune T, Jam FA, Yukiue H, Bellier JP, Sokoda T, Maruo Y, Tooyama I, Mori M. The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence. J Cell Sci. 132(8):jcs227801, 2019.
寺井　淳

Ishigaki H, Pham VL, Terai J, Sasamura T, Nguyen CT, Ishida H, Okahara J, Kaneko S, Shiina T, Nakayama M, Itoh Y, Ogasawara K. No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques. Cell Transplant. 30: 963689721992066, 2021.
緒方綾子

1. Suzuki S, Nguyen CT, Ogata-Nakahara A, Shibata A, Osaka H, Ishigaki H, Okamatsu M, Sakoda Y, Kida H, Ogasawara K, Itoh Y. Efficacy of a cap-dependent endonuclease inhibitor and neuraminidase inhibitors against H7N9 highly pathogenic avian influenza virus causing severe viral pneumonia in cynomolgus macaques. Antimicrob Agents Chemother 65, e01825-20, 2021.

2. Suzuki S, Shichinohe S, Itoh Y, Nakayama M, Ishigaki H, Mori Y, Ogata-Nakahara A, Nguyen CT, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza A virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution. Antiviral Research 178: 104790, 2020.

3. カニクイザルを用いたH7N9亜型高病原性鳥インフルエンザウイルスの病原性解析. 第109回日本病理学会総会
穂積　宙
五十川賢司
松下智紀
高石亮太
Distribution of inflammatory and immunosuppressive macrophages in healthy cynomolgus macaques. 第105回日本病理学会総会
竹内佳代
中林瑠美

1. Nakayama M, Itoh Y, Shichinohe S, Nakabayashi R, Ishigaki H, Sakoda Y, Le QM, Kawaoka Y, Kida H, Ogasawara K. Potential Risk of Repeated Nasal Vaccination that Induces Allergic Reaction with Mucosal IgE and Airway Eosinophilic Infiltration in Cynomolgus Macaques infected with H5N1 Highly Pathogenic Avian Influenza Virus. Vaccine 35: 1008-1017, 2017.

2. Histological analysis of macaques intranasally administrated with an H5N1 whole particle vaccine. 第104回日本病理学会総会
阿久澤大智
山中千尋
中村恵理子
朴鮮玲
池田瑞穂

Kashima Y, Ikeda M, Itoh Y, Sakoda Y, Nagata T, Miyake T, Soda K, Ozaki H, Nakayama M, Shibuya H, Okamatsu M, Ishigaki H, Ishida H, Sawai T, Kawaoka Y, Kida H, Ogasawara K. Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration routes of vaccines. Vaccine 27:7402-7408, 2009.
山口史
山口智美
西井洋一
安達晋吾