Itoh Y. Establishment of a nonhuman primate model for development of vaccines and anti-viral drugs against COVID-19. Translational and Regulatory Sciences 3: 109–111, 2021
Itoh Y. Translational research on influenza virus infection using a nonhuman primate model. Pathol Int 66: 132-141, 2016.
Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A, Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates. Antimicrob Agents Chemother 59, 4962-4973, 2015.
Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K, Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Le QM, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A. Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection. PLoS Pathogens 10, e1004192, 2014.
Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460: 1021-1025, 2009.
Hirohito Ishigaki
Associate Professor
Specialty: Immunology, Pathology, Internal medicine
Selected papers
Ishigaki H, Itoh Y. Translational research on pandemic virus infection using nonhuman primate models. Virology 606, 110511, 2025.
Ishigaki H, Yamauchi T, Long MD, Hoki T, Yamamoto Y, Oba T, Ito F. Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma. Cancer Res Commun 4:1802-1814, 2024.
Ishigaki H, Ito S, Sasamura T, Ishida H, Nakayama M, Nguyen CT, Kinoshita T, Suzuki S, Iwatani C, Tsuchiya H, Yamanaka H, Kulski JK, Itoh Y, Shiina T. MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques. HLA 103:e15316, 2024.
Ishigaki H, Pham VL, Terai J, Sasamura T, Nguyen CT, Ishida H, Okahara J, Kaneko S, Shiina T, Nakayama M, Itoh Y, Ogasawara K. No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques. Cell Transplant 30:963689721992066, 2021.
Ishigaki H, Nakayama M, Kitagawa Y, Nguyen CT, Hayashi K, Shiohara M, Gotoh B, Itoh Y. Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. Virology 554:97-105, 2021.
Ishigaki H, Maeda T, Inoue H, Akagi T, Sasamura T, Ishida H, Inubushi T, Okahara J, Shiina T, Nakayama M, Itoh Y, Ogasawara K. Transplantation of iPS-derived tumor cells with a homozygous MHC haplotype induces GRP94 antibody production in MHC-matched macaques. Cancer Res. 77: 6001-6010, 2017.
Matsukawa Y, Kenichi Sakamoto, Yoko Shioda. Refractory Extracutaneous Juvenile Xanthogranuloma With Multiple Intracranial Nodular Lesions Successfully Treated With 2-Chlorodeoxyadenosine. Journal of Pediatric Hematology/Oncology 44(3):e823-e825,2022.
Matsukawa Y, Sakamoto K, Ikeda Y, Taga T, Kosaki K, Maruo Y. Familial hemophagocytic lymphohistiocytosis syndrome due to lysinuric protein intolerance: a patient with a novel compound heterozygous pathogenic Variant in SLC7A7. International Journal of Hematology 116(4):635-638,2022.
Oshima M, Matsukawa Y, Ikeda Y, Sakamoto K, Taga T, Maruo Y. Allogeneic hematopoietic cell transplantation ameliorated asymptomatic granulomatous and lymphocytic interstitial lung disease in a patient with XIAP deficiency. Journal of Pediatric Hematology/Oncology 46(2):e191-e194,2024.
Tanioka A, Matsukawa Y, Sakamoto K, Matsuda Y, Moritani S, Maruo Y. Challenges in the management of Turner syndrome with Y chromosome material: a case report of prophylactic gonadectomy revealing dysgerminoma. International Cancer Conference Journal 13(2):108-110,2024.
Kazuo Teramoto
Special Contract Assistant Professor
Specialty: Functional polymer chemistry
Selected papers
Teramoto K, Ueda Y, Murai R, Ogasawara K, Nakayama M, Ishigaki H, Itoh Y. A hemoperfusion column selectively adsorbs LAP+ lymphocytes to improve anti-tumor immunity and survival of tumor-bearing rats. PLOS ONE 20: e0305153, 2025.
Teramoto K. Fundamental knowledge of hemoperfusion and Plasmaperfusion. Regenerative medicine, artificial cells and Nanomedicine 4: 141-171, 2017.
Yamamoto Y, Ueda Y, Itoh T, Iwamoto A, Tamagishi H, Shimagaki M, Teramoto K. A novel immunotherapeutic modality with direct hemoperfusion targeting transforming growth factor-β prolongs the survival of tumor-bearing rats. Oncology Reports 16: 1277-1284, 2006.
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