目次
2)成果報告
・2020年 ・2019年 ・2018年 ・2017年
1) 論文リスト
【英文】
Yamaguchi A, Takahashi T, Kato T, Tanaka T, Nishi E, Fujimoto N.
Immunohistochemical and clinicopathological study regarding nardilysin
on extramammary Paget's disease.
Arch Dermatol Res. 2023 Sep;315(7):1979-1987.
doi: 10.1007/s00403-023-02579-5. Epub 2023 Mar 3.
PMID: 36867223
Li SY, Yoshida Y, Kubota M, Zhang BS, Matsutani T, Ito M, Yajima S, Yoshida
K, Mine S, Machida T, Hayashi A, Takemoto M, Yokote K, Ohno M, Nishi E,
Kitamura K, Kamitsukasa I, Takizawa H, Sata M, Yamagishi K, Iso H, Sawada
N, Tsugane S, Iwase K, Shimada H, Iwadate Y, Hiwasa T.
Utility of atherosclerosis-associated serum antibodies against colony-stimulating
factor 2 in predicting the onset of acute ischemic stroke and prognosis
of colorectal cancer
Front Cardiovasc Med. 2023 Feb 10;10:1042272. doi: 10.3389/fcvm.2023.
1042272. eCollection 2023 PMID: 36844744
Tomita I, Tsuruta H, Yasuda-Yamahara M, Yamahara K, Kuwagata S, Tanaka-Sasaki
Y, Chin-Kanasaki M, Fujita Y, Nishi E, Katagiri H, Maegawa H, Kume S.
Ketone bodies: A double-edged sword for mammalian life span.
Aging Cell. 2023 Jun;22(6):e13833. doi: 10.1111/acel.13833.
Epub 2023 Apr 14. PMID: 37060184
Nishimura K, Fujita Y, Ida S, Yanagimachi T, Ohashi N, Nishi K, Nishida
A, Iwasaki Y, Morino K, Ugi S, Nishi E, Andoh A, Maegawa H.
Glycaemia and body weight are regulated by sodium-glucose cotransporter
1 (SGLT1) expression via O-GlcNAcylation in the intestine
Mol Metab. 2022 May;59:101458. doi: 10.1016/j.molmet.2022.101458.
Epub 2022 Feb 19. PMID: 35189429
Saijo S, Ohno M, Iwasaki H, Matsuda S, Nishi K, Hiraoka Y, Ide N, Kimura
T, Nishi E.
Nardilysin in adipocytes regulates UCP1 expression and body temperature
homeostasis
Sci Rep. 2022 Mar 2;12(1):3449. doi: 10.1038/s41598-022-07379-x.
PMID: 35236897
Hiwasa T, Wang H, Goto KI, Mine S, Machida T, Kobayashi E, Yoshida Y, Adachi
A, Matsutani T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kunimatsu
M, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Muto M, Kuwabara S, Kobayashi
Y, Ohno M, Nishi E, Hattori A, Yamamoto M, Maezawa Y, Kobayashi K, Ishibashi
R, Takemoto M, Yokote K, Takizawa H, Kishimoto T, Matsushita K, Kobayashi
S, Nomura F, Arasawa T, Kagaya A, Maruyama T, Matsubara H, Tomiita M, Hamanaka
S, Imai Y, Nakagawa T, Kato N, Terada J, Matsumura T, Katsumata Y, Naito
A, Tanabe N, Sakao S, Tatsumi K, Ito M, Shiratori F, Sumazaki M, Yajima
S, Shimada H, Shirouzu M, Yokoyama S, Kudo T, Doi H, Iwase K, Ashino H,
Li SY, Kubota M, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate
Y.
Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk
markers for acute ischemic stroke.
BMC Med. 2021 Jun 9;19(1):131.
doi: 10.1186/s12916-021-02001-9. PMID: 34103026
Yasuda D, Hiraoka Y, Ohno M, Nishi K, Iwasaki H, Kita T, Nishi E, Kume
N.
Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels.
Biol Pharm Bull. 2021;44(3):363-371.
doi: 10.1248/bpb.b20-00722. PMID: 33642545
Iwasaki H, Ichihara Y, Morino K, Lemecha M, Sugawara L, Sawano T, Miake
J, Sakurai H, Nishi E, Maegawa H, Imamura T.
MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting
E1A-binding protein p300 in human-induced pluripotent stem cells.
Sci Rep. 2021 Jan 13;11(1):1161.
doi: 10.1038/s41598-020-80742-y. PMID: 33441918
Ohno M, Nishi K, Hiraoka Y, Niizuma S, Matsuda S, Iwasaki H, Kimura T,
and *Nishi E
Nardilysin controls cardiac sympathetic innervation patterning through
regulation of p75 neurotrophin receptor
FASEB J. 2020; 34 (9): 11624-11640
Li, SY, Yoshida Y, Kobayashi E, Adachi A, Hirono S, Matsutani T, Mine S,
Machida T, Ohno M, Nishi E, Maezawa Y, Takemoto M, Yokote K, Kitamura K,
Sumazaki M, Ito M, Shimada H, Takizawa H, Kashiwado K, Tomiyoshi G, Shinmen
N, Nakamura R, Kuroda H, Zhang XM, Wang H, Goto K, Iwadate Y, Hiwasa T
Association between serum anti ASXL2 antibody levels and acute ischemic
stroke, acute myocardial infarction, diabetes mellitus, chronic kidney
disease and digestive organ cancer, and their possible association with
atherosclerosis and hypertension.
Int. J. Mol. Med. 2020; 46, 1274-1288.
Yoshida Y, Zhang XM, Wang H, Machida T, Mine S, Kobayashi E, Adachi A,
Matsutani T, Kamitsukasa I, Wada T, Aotsuka A, Iwase K, Tomiyoshi G, Nakamura
R, Shinmen N, Kuroda H, Takizawa H, Kashiwado K, Shin H, Akaogi Y, Shimada
J, Nishi E, Ohno M, Takemoto M, Yokote K, Kitamura K, Iwadate Y, Hiwasa
T
Elevated levels of autoantibodies against DNAJC2 in sera of patients with
atherosclerotic diseases.
Heliyon. 2020; 6(8): e04661.
Sumazaki M, Shimada H, Ito M, Shiratori F, Kobayashi E, Yoshida Y, Adachi
A, Matsutani T, Iwadate Y, Mine S, Machida T, Kamitsukasa I, Mori M, Sugimoto
K, Uzawa A, Kuwabara S, Kobayashi Y, Ohno M, Nishi E, Maezawa Y, Takemoto
M, Yokote K, Takizawa H, Kashiwado K, Shin H, Kishimoto T, Matsushita K,
Kobayashi S, Nakamura R, Shinmen N, Kuroda H, Zhang XM, Wang H, Goto KI,
Hiwasa T
Serum Anti-LRPAP1 is a Common Biomarker for Digestive Organ Cancers and
Atherosclerotic Diseases.
Cancer Sci. 2020;111(12):4453-4464.
Ikuta K,*Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto
Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi
S, Chiba T, Nishi E and Seno H
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma
initiation in mice
GUT 2019; 68: 882-892
doi: 10.1136/gutjnl-2017-315425
Yoh T, *Hatano E, Kasai Y, Fuji H, Nishi K, Toriguchi K, Sueoka H, Ohno
M, Seo S, Iwaisako K, Taura K, Yamaguchi R, Kurokawa M, Fujimoto J, Kimura
T, Uemoto S, and *Nishi E
Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition,
predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection
Clin Cancer Res 2019; 25:619-628. (Featured in Highlights of This Issue)
Ohno M, Chen PM, Kimura T and *Nishi E
Response to Letter of Stephenson et al.: Nardilysin: a potential biomarker
for the early diagnosis of acute coronary syndrome
Int J Cardiol. 2019; 277: 249
Gotoh D, Torimoto K, Iwasaki H, Iwamoto T, Morizawa Y, Hori S, Miyake M,
Tanaka N, Hirayama A, Nishi E, Fujimoto K.
Tadalafil, a phosphodiesterase type 5 inhibitor, restores urethra and detrusor
function in the initial phase of diabetes in rats.
Low Urin Tract Symptoms. 2019; 11:241-247.
Ito Y, Nakamura S, Shigemori T, Sugimoto N, Kato Y, Ohno M, Sakuma S, Ito
K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K,
Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa
M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, *Eto
K
Turbulence activates platelet biogenesis to enable clinical scale ex vivo production
Cell in press
doi: 10.1016/j.cell.2018.06.011
Chen PM, Ohno M, Kimura T and *Nishi E
Reply: Nardilysin is a promising biomarker for the early diagnosis of Acute
Coronary Syndrome
Int J Cardiol. 2018; 265: 236.
https://doi.org/10.1016/j.ijcard.2018.04.056
Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi
K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada
K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, *Nishi E and *Seno H
Nardilysin controls intestinal tumorigenesis through HDAC1/p53–dependent
transcriptional regulation
JCI Insight 2018; 3(8): e91316
doi: 10.1172/jci.insight.91316
Yoshida Y, Wang H, Hiwasa T, Machida T, Kobayashi E, Mine S, Tomiyoshi
G, Nakamura R, Shinmen N, Kuroda H, Takizawa H, Kashiwado K, Kamitsukasa
I, Shin H, Wada T, Aotsuka A, Nishi E, Ohno M, Takemoto M, Yokote K, Takahashi
S, Matsushima J, Zhang XM, Takiguchi M, Iwadate Y.
Elevation of autoantibody level against PDCD11 in patients with transient
ischemic attack.
Oncotarget 2017; 9: 8836-8848.
doi: 10.18632/oncotarget.23653.
Wang H, Zhang XM, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kimura
R, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Yoshida Y, Kobayashi E, Matsutani
M, Iwadate Y, Sugimoto K, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto
M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Ohno M, Chen PM, Nishi
E, Ono K, Kimura T, Machida T, Takizawa H, Kashiwado K, Shimada H, Ito
M, Goto K, Iwase K, Ashino H, Taira A, Arita E, Takiguchi M, Hiwasa T
Association of serum levels of antibodies against MMP1, CBX1, and CBX5
with transient ischemic attack and cerebral infarction
Oncotarget 2017; 9: 5600-5613.
doi: 10.18632/oncotarget.23789.
Hiwasa T, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kunimatsu M, Mine
S, Machida T, Sato E, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi
R, Yokote K, Kitamura K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Takizawa
H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Sunami K, Kobayashi E,
Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K,
Kuwabara S, Iwata Y, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi
K, Ito M, Shimada H, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira
A, Arita E, Goto K, Kudo T, Doi H.
Serum SH3BP5-specific antibody level is a biomarker of atherosclerosis.
Immunome Res 2017; 13 (2).
doi: 10.4172/1745-7580.1000132
Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H, Kudo T, Doi H, Mine S, Machida
T, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Yoshida Y, Matsutani
T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Takemoto
M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Iwata Y,
Harada J, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ohno
M, Chen PM, Nishi E, Ono K, Kimura T, Kitamura K, Takizawa H, Kashiwado
K, Shimada H, Ito M, Goto K, Zhang XM, Kimura R, Wang H, Taira A, Arita
E, Ashino H, Iwase K, Hiwasa T.
An Anti-Deoxyhypusine Synthase Antibody as a Marker of Atherosclerosis-Related
Cerebral Infarction, Myocardial Infarction, Diabetes Mellitus, and Chronic
Kidney Disease.
SM Atheroscler J. 2017; 1(1): 1001.
Morita Y, Ohno M, Nishi K, Hiraoka Y, Saijo S, Matsuda S, Kita T, Kimura
T and *Nishi E
Genome-wide profiling of nardilysin target genes reveals its role in epigenetic
regulation and cell cycle progression
Sci Rep. 7: 14801, 2017
doi: 10.1038/s41598-017-14942-4.
Fujii T, *Nishi E, *Ito H, Yoshitomi H, Furu M, Okabe N, Ohno M, Nishi
K, Morita Yus, Morita Yug, Azukizawa M, Okahata A, Tomizawa T, Kimura T,
and Matsuda S
Nardilysin is involved in autoimmune arthritis via the regulation of TNF-
secretion
RMD Open 3: e000436, 2017
doi: 10.1136/rmdopen-2017-000436
Chen PM, Ohno M, Hiwasa T, Nishi K, Saijo S, Sakamoto J, Morita Y, Matsuda
S, Watanabe S, Kuwabara Y, Ono K, Imai M, Inoue K, Murai T, Inada T, Tanaka
M, Kita T, Kimura T and *Nishi E
Nardilysin is a promising biomarker for the early diagnosis of Acute Coronary
Syndrome
Int J Cardiol. 243: 1-8, 2017
doi: 10.1016/j.ijcard.2017.04.047.
Kasai Y, Toriguchi K, *Hatano E, Nishi K, Ohno M, Yoh T, Fukuyaman K, Nishio
T, Okuno M, Iwaisako K, Seo S, Taura K, Kurokawa M, Kunichika M, Uemoto
S, *Nishi E
Nardilysin promotes hepatocellular carcinoma through activation of signal
transducer and activator of transcription 3
Cancer Sci. 108: 910-917, 2017
doi: 10.1111/cas.13204.
Kimura Y, Ikuta K, Kimura T, Chiba T, Oshima H, Oshima M, *Nishi E, *Seno
H
Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach
Sci Rep. 7: 43052, 2017
doi: 10.1038/srep43052.
Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman
NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham
BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda
VA, Nelson SF, Michael F. Wangler MF, Karaca E, Lupski JR, and Bellen HJ
Loss of Nardilysin, a mitochondrial co-chaperone for -Ketoglutarate Dehydrogenase,
promotes mTORC1 activation and neurodegeneration
Neuron 93: 115-131, 2017
Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita
Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H,
Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T and *Nishi
E
Nardilysin is Required for maintaining Pancreatic -Cell Function
Diabetes 65: 3015-27, 2016
DOI: 10.2337/db16-0178
Hiwasa T, Zhang XM, Kimura R, Ohno M, Chen PM, Nishi E, Ono K, Kimura T,
Kamitsukasa I, Wada T, Aotsuka A, Mine S, Takizawa H, Kashiwado K, Takemoto
M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Nakamura R, Tomiyoshi
G, Shinmen N, Kuroda H.
Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosisrelated
Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
J Circ Biomark, 5:8, 2016
doi: 10.5772/63218
Hiwasa T, Machida T, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira
A, Arita E, Mine S, Ohno M, Chen PM, Nishi E, Kitamura K, Yamazoe R, Takizawa
H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Matsutani
T, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S,
Iwata Y, Nakayama T, Harada JY, Kobayashi Y, Takemoto M, Kobayashi K, Kawamura
H, Ishibashi R, Sakurai KI, Fujimoto M, Yokote K, Goto K, Matsumura R,
Sugiyama T, Hayashi H, Hasegawa R, Shimada H, Ito M, Kudo T, Doi H, Nakamura
R, Tomiyoshi G, Shinmen N, Kuroda H.
Elevated Levels of Autoantibodies against ATP2B4 and BMP-1 in Sera of Patients
with Atherosclerosis-related Diseases.
Immunome Res 11: 097, 2015.
doi:10.4172/17457580.1000097
Hiwasa T, Zhang XM, Kimura R, Machida T, Kitamura K, Yamazoe R, Kunimatsu
M, Mine S, Kobayashi E, Iwadate Y, Saeki N, Takemoto M, Kobayashi K, Kawamura
H, Ishibashi R, Sakurai KI, Fujimoto M, Yokote K, Iwata Y, Nakayama T,
Harada JY, Kobayashi Y, Ohno M, Chen PM, Nishi E, Yokota M, Kamitsukasa
I, Wada T, Aotsuka A, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S,
Goto K, Matsumura R, Takizawa H, Shimada H, Ito M, Wang H, Taira A, Arita
E, Iwase K, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H
Association of Serum Antibody Levels against TUBB2C with Diabetes and Cerebral
Infarction
Gratis J Biomed Sci, 1(2): 49-63. 2015.
doi: 10.18314/gjbs.v1i2.27
Goto K, Sugiyama T, Matsumura R, Zhang XM, Kimura R, Taira A, Arita E,
Iwase K, Kobayashi E, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Kuwabara
S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto
M, Yokote K, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chin H, Nishi E,
Machida T, Iwata Y, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Katayama
K, Kikkawa Y, Sunami K, Takizawa H, Nakamura R, Tomiyoshi G, Shinmen N,
Kuroda H and Hiwasa T
Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies
Detected in Patients with Systemic Lupus Erythematosus.
J Mol Biomark Diagn 6: 219. 2015.
doi: 10.4172/2155-9929.1000219
Tien DN, Kishihata M, Yoshikawa A, Hashimoto A, Sabe H, Nishi E, Kamei
K, Arai H, Kita T, Kimura T, Yokode M, Ashida N.
AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory
conditions.
Sci Rep. 4:5094. 2014.
doi: 10.1038/srep05094.
Ishizu-Higashi S, *Seno H, *Nishi E, Matsumoto Y, Ikuta K, Tsuda M, Kimura
Y, Takada Y, Kimura Y, Nakanishi Y, Kanda K, Komekado H, Chiba T (*Co-corresponding
author)
Deletion of nardilysin prevents the development of steatohepatitis and
liver fibrotic changes
PLOS ONE 9(5): e98017, 2014
doi:10.1371/journal.pone.0098017
Hiraoka Y, Matsuoka T, Ohno M, Nakamura K, Saijo S, Matsumura S, Nishi
K, Sakamoto J, Chen Po-Min, Inoue K, Fushiki T, Kita T, Kimura T and *Nishi
E
Critical roles of nardilysin in the maintenance of body temperature homeostasis
Nat. Commun. 5: 3224, 2014.
doi: 10.1038/ncomms4224
Ohno M, Hiraoka Y, Lichtenthaler S, Nishi K, Saijo S, Matsuoka T, Tomimoto
H, Araki W, Takahashi R, Kita T, Kimura T and *Nishi E
Nardilysin prevents amyloid plaque formation by enhancing -secretase activity
in an Alzheimer’s disease mouse model
Neurobiol Aging 35: 213-22, 2014.
doi: 10.1016/j.neurobiolaging.2013.07.014.
Li J, Chu M, Wang S, Chan D, Qi S, Wu M, Zhou Z, Li Z, Nishi E, Qin J and
Wong J
Identification and Characterization of Nardilysin as a Novel Dimethyl H3K4
Binding Protein Involved in Transcriptional Regulation
J Biol Chem, 287:10089-98, 2012.
doi: 10.1074/jbc.M111.313965
Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi Y, Nakatsuji M, Akitake-Kawano
R, Ohno M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika
M, Kimura T, *Seno H, *Nishi E, and ChibaT (*Co-corresponding author)
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating
intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-a
EMBO Mol Med, 4:396-411, 2012.
doi: 10.1002/emmm.201200216
Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa,
S Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi
R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, and Uemoto S
Continuous cell supply from the Sox9-expressing progenitor zone in adult
liver, exocrine pancreas and intestine
Nat. Genet. 43: 34-41, 2011.
16.Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E,
and Furuse M.
Angulin/LSR defines cell corners for tricellular tight junction formation
in epithelial cells
J. Cell. Sci. 15: 548-55, 2011.
Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y,
Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition
of the neuregulin-ErbB pathway
Cardiovasc Res. 2010; 87: 656-64.
Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima
N, Kiyonari H, Kimura T, Kita T, and *Nishi E.
Nardilysin Regulates Axonal Maturation and Myelination in the Central and
Peripheral Nervous System
Nat. Neurosci. 2009; 12: 1506-1513
Hoshino K, Horiuchi H, Tada T, Tazaki J, Nishi E, Kawato M, Ikeda T, Yamamoto
H, Akao M, Furukawa Y, Shizuta S, Toma M, Tamura T, Saito N, Doi T, Ozasa
N, Jinnai T, Takahashi K, Watanabe H, Yoshikawa Y, Nishimoto N, Ouchi C,
Morimoto T, Kita T, Kimura T.
Clopidogrel Resistance in Japanese Patients Scheduled for Percutaneous
Coronary Intervention
Circ J. 2009; 73: 336-42
Mitsuoka H, Kume N, Hayashida K, Inui-Hayashiada A, Aramaki Y, Toyohara
M, Jinnai T, Nishi E, Kita T.
Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1
(sLOX-1).
Atherosclerosis. 2009; 202: 176-82
Hiraoka Y, Yoshida K, Ohno M, Matsuoka T, Kita T, Nishi E*.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation
of ADAM proteases.
Biochem. Biophs. Res. Commun. 2008; 370: 154-8
Matsuda M, Kobayashi Y, Masuda S, Adachi M, Watanabe T, Yamashita JK, Nishi
E, Tsukita S, Furuse M.
Identification of adherens junction-associated GTPase activating proteins
by the fluorescence localization-based expression cloning.
Exp Cell Res. 2008; 314: 939-49
Furukawa, K., Fujiwara, H., Sato, Y., Zeng, BX., Fujii, H., Yoshioka, S.,
Nishi, E. and Nishio, T. ; Platelets Are Novel Regulators of Neovascularization
and Luteinization during Human Corpus Luteum Formation.
Endocrinology 2007; 148: 3056-64
Hiraoka, Y., Ohno, M., Yoshida, K., Okawa, K., Tomimoto, H., Kita, T. and
Nishi E.
Enhancement of alpha-secretase cleavage of amyloid precursor protein by
a metalloendopeptidase nardilysin.
J Neurochem. 2007; 102: 1595-1605
Nishi, E., Hiraoka, Y., Yoshida, K., Okawa, K. and Kita, T.
Nardilysin enhances ectodomain shedding of heparin-binding EGF-like growth
factor through activation of TNF-alpha converting enzyme.
J. Biol. Chem. 281, 31164-72 (2006)
Ohtsuka, T., Imayoshi, I., Shimojo, H, Nishi, E., Kageyama, R. and McConnell,
SK.
Visualization of embryonic neural stem cells using Hes promoters in transgenic
mice.
Mol Cell Neurosci. 31, 109-22 (2006)
Nishi, E., and Klagsbrun, M.
Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) is
a Mediator of Multiple Physiological and Pathological Pathways.
Growth Factors. 22, 253-260 (2004)
Park, P.W, Foster, T.J., Nishi, E., Duncan,.S.J., Klagsbrun, M., and Chen,
Y.
Activation of syndecan-1 ectodomain shedding by Staphylococcus aureus and
toxins.
J. Biol. Chem. 279, 251-258 (2004)
Goishi K, Lee P, Davidson AJ, Nishi E, Zon LI and Klagsbrun M.
Inhibition of zebrafish epidermal growth factor receptor activity results
in cardiovascular defects.
Mech Dev. 2003; 120: 811-822.
Hospital V, Nishi E, Klagsbrun M, Cohen P, Seidah NG, Prat A.
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding
EGF-like growth factor (HB-EGF).
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【邦文】
藤井貴之、西英一郎：
重要な鍵分子の研究動向〜関節リウマチ
『創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術』第3章、第6節、
pp. 248〜256 出版社 (株)技術情報協会、発刊日 2021年8月31日 ISBN: 978-4-86104-856-2
岩﨑広高, 西 清人, 松田真太郎, 大野美紀子, 西英一郎:『肝細胞のナルディライジンは神経系を介して褐色脂肪組織の熱産生を制御する』
日本病態プロテアーゼ学会誌 42: 12-13 (2019)
