〒520-2192 大津市瀬田月輪町
滋賀医科大学
生化学・分子生物学講座
分子病態生化学部門 
TEL: 077-548-2162(研究室)
FAX: 077-548-2164
E-mail: hqbioch2@
"@以下に belle.shiga-med.ac.jp
をつけて下さい"

業績集

欧文著書
2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

邦文著書
2017 | 2015 | 2011 | 2009

過去の業績はこちら

欧文著書

2017年

  1. Zankov DP, Sato A, Shimizu A, Ogita H. Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy. Circ J. 2017; in press.
  2. Sato A, Ogita H. Pathophysiological implications of dipeptidyl peptidases. Curr Protein Pept Sci. 2017; 18: 843-849.
  3. Zankov DP, Shimizu A, Tanaka-Okamoto M, Miyoshi J, Ogita H. Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage. Sci Rep. 2017; 7: 39335. 詳細はこちら

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2016年

  1. Pang X, Shimizu A, Kurita S, Zankov DP, Takeuchi K, Yasuda-Yamahara M, Kume S, Ishida T, Ogita H. Novel therapeutic role for dipeptidyl peptidase III in the treatment of hypertension. Hypertension. 2016; 68: 630-641. 詳細はこちら
  2. Muraki S, Ueyama H, Tanabe S, Yamade S, Ogita H, Ohji M. Novel mutations in the L visual pigment gene found in Japanese men with protan color-vision defect having a normal order L/M gene array. Ophthalmic Genet. 2016; 37: 471-472.
  3. Kuniyoshi K, Muraki S, Ueyama H, Toyoda F, Sakuramoto H, Ogita H, Irifune M, Nakao A, Yamamoto S, Iwata T, Ohji M, Shimomura Y. Novel mutations in the gene for α-subunit of retinal cone cyclic nucleotide-gated channels in a Japanese patient with congenital achromatopsia. Jpn J Ophthalmol. 2016; 60: 187-197.
  4. Ueno N, Shimizu A, Kanai M, Iwaya Y, Ueda S, Nakayama J, Kurokawa-Seo M. Enhanced expression of fibroblast growth factor receptor 3 IIIc promotes human esophageal carcinoma cell proliferation. J Histochem Cytochem. 2016; 64: 7-17.

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2015年

  1. Ueyama H, Muraki S, Tanabe S, Yamade S, Ogita H. A new subset of deutan color-vision defect associated with an L/M visual pigment gene array of normal order and -71C substitution in the Japanese population. J Biochem. 2015; 158: 197-204.
  2. Yoshida A, Shimizu A, Asano H, Kadonosono T, Kizaka-Kondoh S, Geretti E, Mammoto A,Klagsbrun M, Kurokawa-Seo M. VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Biol Open. 2015; 4: 1063-1076.
  3. Kurita S, Takeuchi K, Hayashi Y, Ueyama H, Zankov DP, Pang X, Otsuka T, Ohkubo I, Ogikubo O, Ogita H. Significance of serum Zn-α2-glycoprotein for the regulation of blood pressure. Hypertens Res. 2015; 38: 244-251.
  4. Zankov DP, Ogita H. Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. Biomed Res Int. 2015; Article ID 314178.
  5. Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-g in colitis. Sci Rep. 2015; 5: 10536.
  6. Shojima K, Sato A, Hanaki H, Tsujimoto I, Nakamura M, Hattori K, Sato Y, Dohi K, Hirata M, Yamamoto H, Kikuchi A. Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci Rep. 2015; 5: 8042.

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2014年

  1. Maeda T, Takeuchi K, Pang X, Zankov DP, Takashima N, Fujiyoshi A, Kadowaki T, Miura K, Ueshima H, Ogita H. Lipoprotein-associated phospholipase A2 regulates macrophage apoptosis through the Akt and caspase-7 pathways. J Atheroscler Thromb. 2014; 21: 839-853.
  2. Gardner JC1, Liew G, Quan YH, Ermetal B, Ueyama H, Davidson AE, Schwarz N, Kanuga N, Chana R, Maher ER, Webster AR, Holder GE, Robson AG, Cheetham ME, Liebelt J, Ruddle JB, Moore AT, Michaelides M, Hardcastle AJ. Three different cone opsin gene array mutational mechanisms with genotype-phenotype correlation and functional investigation of cone opsin variants. Hum Mutat. 2014; 35: 1354-1362.
  3. Procaccia V, Nakayama H, Shimizu A, Klagsbrun M. Gleevec/Imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun. 2014; 448: 134-138.
  4. Shahrabi-Farahani S, Wang L, Zwaans BM, Santana JM, Shimizu A, Takashima S, Kreuter M, Caultas L, D’Amore PA, Arbeit JM, Aksien LA, Bielenberg DR. Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Lab Invest. 2014; 94: 752-765.
  5. Komiya Y, Mandrekar N, Sato A, Dawid IB, Habas R. Custos controls β-catenin to regulate head development during vertebrate embryogenesis. Proc Natl Acad Sci USA. 2014; 111: 13099-13104.
  6. Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, Kikuchi A. A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J. 2014; 33: 702-718.

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2013年

  1. Yamane T, Murao S, Kato I, Kashima L, Yuguchi M, Kozuka M, Takeuchi K, Ogita H, Ohkubo I, Ariga H. Transcriptional regulation of the legumain gene by p53 in HCT116 cells. Biochem Biophys Res Commun. 2013; 438: 613-618.
  2. Majima T, Takeuchi K, Sano K, Hirashima M, Zankov DP, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ogita H. An adaptor molecule afadin regulates lymphangiogenesis by modulating RhoA activity in the developing mouse embryo. PLoS One. 2013; 8: e68134.
  3. Yamane T, Hachisu R, Yuguchi M, Takeuchi K, Murao S, Yamamoto Y, Ogita H, Takasawa T, Ohkubo I, Ariga H. Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney. Biochem Biophys Res Commun. 2013; 430: 482-487.
  4. Zankov DP, Ogita H. ACTN4 (actinin, alpha 4). Atlas Genet Cytogenet Oncol Haematol. 2013; 17: 663-669.
  5. Wang Y, Zankov DP, Jiang M, Zhang M, Henderson SC, Tseng GN. [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. J Biol Chem. 2013; 288: 35358-35371.
  6. Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013; 288: 2210-2222.

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2012年

  1. Hatoh T, Maeda T, Takeuchi K, Ogikubo O, Uchiyama S, Otsuka T, Ohkubo I, Ogita H. Domain 5 of high molecular weight kininogen inhibits collagen-mediated cancer cell adhesion and invasion in association with α-actinin-4. Biochem Biophys Res Commun. 2012; 427: 497-502.
  2. Ueyama H, Muraki-Oda S, Yamade S, Tanabe S, Yamashita T, Shichida Y, Ogita H. Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect. Biochem Biophys Res Commun. 2012; 424: 152-157.
  3. An LP, Maeda T, Sakaue T, Takeuchi K, Yamane T, Du PG, Ohkubo I, Ogita H. Purification, molecular cloning and functional characterization of swine phosphatidylethanolamine-binding protein 4 from seminal plasma. Biochem Biophys Res Commun. 2012; 423: 690-696.
  4. Zhang M, Wang Y, Jiang M, Zankov DP, Chowdhury S, Kasirajan V, Tseng GN. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. Am J Physiol Heart Circ Physiol. 2012; 302: H910-H922.
  5. Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2. J Gen Physiol. 2012; 140: 653-669.
  6. Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK. Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphoring 3F dependent mechanism. Neoplasia. 2012; 14: 84-94.
  7. Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM. Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol. 2012; 181: 548-559.
  8. Sakane H, Yamamoto H, Matsumoto S, Sato A, Kikuchi A. Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling. J Cell Sci. 2012; 125: 449-460.
  9. Hanaki H, Yamamoto H, Sakane H, Matsumoto S, Ohdan H, Sato A, Kikuchi A. An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol Cancer Ther. 2012; 11: 298-307.
  10. Kikuchi A, Yamamoto H, Sato A, Matsumoto S. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol. 2012; 204: 17-33.

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2011年

  1. Ding WG, Toyoda F, Ueyama H, Matsuura H. Lysophosphatidylcholine enhances IKs currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. J Mol Cell Cardiol. 2011; 50: 58-65.
  2. Fukumoto Y, Kurita S, Takai Y, Ogita H. Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J Biol Chem. 2011; 286: 43537-43548.
  3. Kurita S, Ogita H, Takai Y. Cooperative role of the nectin-nectin and nectin-afadin interactions in the formation of the nectin-based cell-cell adhesion. J Biol Chem. 2011; 286: 36297-36303.
  4. Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M. KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm Electrophysiol. 2011; 4: 352-361.
  5. Coma S, Shimizu A, Klagsbrun M. Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF- dependent manner via transcriptional repression of their common receptor Neuropilin 2. Cell Adh Migr. 2011; 5: 268-275.
  6. Kikuchi A, Yamamoto H, Sato A, Matsumoto S. New insights into the mechanism of Wnt signaling pathway activation. Int Rev Cell Mol Biol. 2011; 291: 21-71.
  7. Liu W, Su LT, Khadka DK, Mezzacappa C, Komiya Y, Sato A, Habas R, Runnels LW. TRPM7 regulates gastrulation during vertebrate embryogenesis. Dev Biol. 2011; 350: 348-357.

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2010年

  1. Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Obayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci. 2010; 101: 1326-1330.
  2. Ogita H, Rikitake Y, Miyoshi J, Takai Y. Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology. Proc Jpn Acad Ser B Phys Biol Sci. 2010; 86: 621-629.
  3. Ooshio T, Kobayashi R, Ikeda W, Miyata M, Fukumoto Y, Matsuzawa N, Ogita H, Takai Y. Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells. J Biol Chem. 2010; 285: 5003-5012.
  4. Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata KI, Takai Y. Role of Afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. Circ Res. 2010; 106: 1731-1742.
  5. Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H. Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes. J Membr Biol. 2010; 235: 73-87.
  6. Coma S, Amin DN, Shimizu A, Lasorella A, Lavarone A, Klagsbrun M. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin3F. Cancer Res. 2010; 70: 3823-3832.
  7. Geretti E, van Meeteren LA, Shimizu A, Dudley AC, Claesson-Welsh L, Klagsbrun M. A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. Mol Cancer Res. 2010; 8: 1063-1073.
  8. Klagsbrun M, Shimizu A. Semaphorin 3E, an exception to the rule. J Clin Invest. 2010; 120: 2658-2660.
  9. Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A. Wnt5a regulates distinct signaing pathways by binding to Frizzled2. EMBO J. 2010; 29: 41-54.
  10. Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W, Kikuchi A. Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloprotainase. Oncogene. 2010; 29: 2036-2046.

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2009年

  1. Ando K, Imai S, Isoya E, Kubo M, Mimura T, Shioji S, Ueyama H, Matsusue Y. Effect of dynamic compressive loading and its combination with a growth factor on the chondrocytic phenotype of 3-dimensional scaffold-embedded chondrocytes. Acta Orthopaedica. 2009; 80: 724-733.
  2. Kawano S, Ikeda W, Kishimoto M, Ogita H, Takai Y. Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2. J Biol Chem. 2009; 284: 23793-23805.
  3. Majima T, Ogita H, Yamada T, Amano H, Togashi H, Sakisaka T, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Takai Y. Involvement of afadin in the formation and remodeling of synapses in the hippocampus. Biochem Biophys Res Commun. 2009; 385: 539-544.
  4. Miyata M, Ogita H, Komura H, Nakata S, Okamoto R, Ozaki M, Majima T, Matsuzawa N, Kawano S, Minami A, Waseda M, Fujita N, Mizutani K, Rikitake Y, Takai Y. Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor. J Cell Sci. 2009; 122: 4319-4329.
  5. Miyata M, Rikitake Y, Takahashi M, Nagamatsu Y, Yamauchi Y, Ogita H, Hirata KI, Takai Y. Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells. J Biol Chem. 2009; 284: 24595-24609.
  6. Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Human Mutation. 2009; 30: 557-563.
  7. Togashi H, Ogita H, Takai Y. Nectins and Nectin-like molecules in the nervous system. Chapter 8: Nectins/SynCams The Sticky Synapse (Hortsch M and Umemori H eds.) 2009; 185-206. Springer.
  8. Ueyama H, Tanabe S, Muraki-Oda S, Yamade S, Ohji M, Ohkubo I. Analysis of introns and promoters of L/M visual pigment genes in relation to deutan color-vision deficiency with an array of normal gene orders. J Hum Genet. 2009; 54: 525-530.
  9. Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura H, Horie M. Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of I (Ks) current in guinea pig atrium. Pflugers Arch. 2009; 458: 837-849.
  10. Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M. Adrenergic regulation of the rapid component of delayed rectifier K+ current: implications for arrhythmogenesis in LQT2 patients. Heart Rhythm. 2009; 6: 1038-1046.
  11. Terada M, Onishi C, Ueno N, Shimizu A, Kanai M, Kurokawa-Seo M. Enhanced expression of fibroblast growth factor receptor 3 in human skin cancer cells. Open Circ Vasc J. 2009; 2: 30-36.
  12. Kikuchi A, Yamamoto H, Sato A. Selective activation of mechanisms of Wnt signaling pathways. Trend Cell Biol. 2009; 19: 119-129.

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2008年

  1. Kanzaki N, Ogita H, Komura H, Ozaki M, Sakamoto Y, Majima T, Ijuin T, Takenawa T, Takai Y. Involvement of the nectin-afadin complex in PDGF-induced cell survival. J Cell Sci. 2008; 121: 2008-2017.
  2. Komura H, Ogita H, Ikeda W, Mizoguchi A, Miyoshi J, Takai Y. Establishment of cell polarity by afadin during the formation of embryoid bodies. Genes Cells. 2008; 13: 79-90.
  3. Ogita H, Ikeda W, Takai Y. Roles of cell adhesion molecules nectin and nectin-like molecule-5 in the regulation of cell movement and proliferation. J Microsc. 2008; 231: 455-465.
  4. Ogita H, Takai Y. Cross-talk among integrin, cadherin, and growth factor receptor: roles of nectin and nectin-like molecule. Int Rev Cytol. 2008; 265: 1-54.
  5. Sakamoto Y, Ogita H, Komura H, Takai Y. Involvement of nectin in inactivation of integrin αvβ3 after the establishment of cell-cell adhesion. J Biol Chem. 2008; 283: 496-505.
  6. Takai Y, Ikeda W, Ogita H, Rikitake Y. The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. Annu Rev Cell Dev Biol. 2008; 24: 309-342.
  7. Takai Y, Miyoshi J, Ikeda W, Ogita H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol. 2008; 9: 603-615.
  8. Geretti E, Shimizu A, Klagsbrun M. Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis. Angiogenesis. 2008; 11: 31-39.
  9. Shimizu A, Mammoto A, Italiano JE, Pravda E, Dudley AC, Ingber DE, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem. 2008; 283: 27230-27238.
  10. Kawamura H, Li X, Goishi K, van Meeteren LA, Jakobsson L, Cebe-Suarez S, Shimizu A, Edholm D, Ballmer-Hofer K, Kjellen L, Klagsbrun M, Claesson-Welsh L. Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood. 2008; 112: 3638-3649.
  11. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels LW, Habas R. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci USA. 2008; 105: 210-215.

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邦文著書

2017年

  1. 清水昭男扇田久和 ジペプチジルペプチダーゼIIIのアンジオテンシンII分解活性と生体内での作用機序およびその治療応用への可能性 生化学 2017; 89: 449-452.

2015年

  1. 菊池章、佐藤朗 C1q サイトカイン・増殖因子キーワード辞典 2015; 373-374. 羊土社

2011年

  1. 上山久雄 新編 色彩科学ハンドブック 第3版(日本色彩学会) 2011; 354-358. 東京大学出版会
  2. 扇田久和 細胞間接着破綻 がんの浸潤・転移-臨床と基礎- 2011; 150-161. 南山堂
  3. 菊池章、佐藤朗、松本真司 Wntシグナルネットワークの異常と癌 実験医学増刊「秒進分歩する癌研究と分子標的治療」 2011; 29: 26-35. 羊土社

2009年

  1. 菊池章、山本英樹、佐藤朗 Wntによるβ-カテニン非依存性経路の活性化とその異常による病態 蛋白質核酸酵素 2009; 54: 1-10.

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