〒520-2192 大津市瀬田月輪町
滋賀医科大学
生化学・分子生物学講座
分子病態生化学部門　
TEL: 077-548-2162（研究室）
FAX: 077-548-2164
E-mail: hqbioch2@
"@以下に belle.shiga-med.ac.jp
をつけて下さい"

業績集

欧文著書
2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014

邦文著書
2023 | 2020 | 2018 | 2017 | 2015

過去の業績はこちら

欧文著書

2024年

  1. Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, Nishi E, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Mizutani KI, Ema M. Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Exp Anim. 2024; 73: 93-100.

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2023年

  1. Soh JEC, Shimizu A, Sato A, Ogita H. Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications. Biochem Pharmacol. 2023; 218: 115899.
  2. Sato A, Tsukiyama T, Komeno M, Iwatani C, Tsuchiya H, Kawamoto I, Murase M, Nakagawa T, Itagaki I, Seita Y, Matsumoto S, Nakaya M, Shimizu A, Yamada A, Ema M, Ogita H. Generation of a familial hypercholesterolemia model in non-human primate. Sci Rep. 2023; 13: 15649.
  3. Soh JEC, Shimizu A, Molla MR, Zankov DP, Nguyen LKC, Khan MR, Tesega WW, Chen S, Tojo M, Ito Y, Sato A, Hitosugi M, Miyagawa S, Ogita H. RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy. J Biol Chem. 2023; 299: 102993. （The year in JBC: 2023 に選出されました） 詳細はこちら　
  4. Nakai S, Tateoka Y, Miyaguchi Y, Takahashi M, Ogita H. Associations between habitual dietary behaviors and glutamic acid levels in human milk. J Hum Lact. 2023; 39: 315-324.
  5. Imamura-Uehara Y, Yasuda-Yamahara M, Kuwagata S, Yamahara K, Yoshibayashi M, Tanaka-Sasaki Y, Shimizu A, Ogita H, Chin-Kanasaki M, Kume S. Establishment of a novel mouse model of renal artery coiling-based chronic hypoperfusion-related kidney injury. Biochem Biophys Rep. 2023; 37: 101607.

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2022年

  1. Molla MR, Shimizu A, Komeno M, Rahman NIA, Soh JEC, Nguyen LKC, Khan MR, Tesega WW, Chen S, Pang X, Tanaka-Okamoto M, Takashima N, Sato A, Suzuki T, Ogita H. Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity. Commun Biol. 2022; 5: 1071. 詳細はこちら

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2021年

  1. Sato A, Rahman NIA, Shimizu A, Ogita H. Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment. Cancer Sci. 2021; 112: 4005-4012.
  2. Nguyen LKC*, Shimizu A*, Soh JEC, Komeno M, Sato A, Ogita H. Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics. J Biochem. 2021; 170: 577-585. (* contributed equally to this work)
  3. Komeno M*, Pang X*, Shimizu A*, Molla MR, Yasuda-Yamahara M, Kume S, Rahman NIA, Soh JEC, Nguyen LKC, Ahmat Amin MKB, Kokami N, Sato A, Asano Y, Maegawa H, Ogita H. Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice. J Biol Chem. 2021; 296: 100761. (* contributed equally to this work) 詳細はこちら
  4. Rahman NIA, Sato A*, Tsevelnorov K, Shimizu A, Komeno M, Ahmat Amin MKB, Molla MR, Soh JEC, Nguyen LKC, Wada A, Kawauchi A, Ogita H*. Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth. Cancer Res. 2021; 81: 2318-2331. (* co-corresponding author) 詳細はこちら
  5. Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K. Differences between atherosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery. Int Heart J. 2021; 62: 390-395.

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2020年

  1. Tomita I, Kume S, Sugahara S, Osawa N, Yamahara K, Yasuda-Yamahara M, Takeda N, Chin-Kanasaki M, Kaneko T, Mayoux E, Mark M, Yanagita M, Ogita H, Araki SI, Maegawa H. SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition. Cell Metab. 2020; 32: 404-419.
  2. Shimizu A*, Zankov DP*, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H. Identification of Transmembrane Protein 168 mutation in familial Brugada syndrome. FASEB J. 2020; 34: 6399-6417. (* contributed equally to this work) 詳細はこちら
  3. Matsushima S*, Shimizu A*, Kondo M, Asano H, Ueno N, Nakayama H, Sato N, Komeno M, Ogita H**, Kurokawa-Seo M**. Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis. Sci Rep. 2020; 10: 188. (* contributed equally to this work; ** co-corresponding author)

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2019年

  1. Ahmat Amin MKB, Shimizu A, Ogita H. The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis. Cancers. 2019; 11: 1620.
  2. Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S. Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation. Circulation. 2019; 139: 2157-2169.
  3. Zankov DP, Salloum FN, Jiang M, Tseng GN. Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes. Heart Rhythm. 2018; 16: 108-116.

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2018年

  1. Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H. Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1. Oncogene. 2018; 37: 5416-5434.　詳細はこちら
  2. Katagiri S*, Iwasa M*, Hayashi T, Hosono K, Yamashita T, Kuniyoshi K, Ueno S, Kondo M, Ueyama H, Ogita H, Shichida Y, Inagaki H, Kurahashi H, Kondo H, Ohji M, Hotta Y, Nakano T. Genotype determination of the OPN1LW/OPN1MW genes: novel disease-causing mechanisms in Japanese patients with blue cone monochromacy. Sci Rep. 2018; 8: 11507. (* contributed equally to this work)
  3. Ogura S, Yoshida Y, Kurahashi T, Egawa M, Furuta K, Kiso S, Kamada Y, Hikita H, Eguchi H, Ogita H, Doki Y, Mori M, Tatsumi T, Takehara T. Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma. Oncotarget. 2018; 9: 21022-21035.
  4. Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H. Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap. Int J Mol Sci. 2018; 19: E1203.

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2017年

  1. Zankov DP, Sato A, Shimizu A, Ogita H. Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy. Circ J. 2017; 81: 1862-1870.（Circulation Journal Award 2017を受賞）　詳細はこちら
  2. Yamamoto H, Sato A, Kikuchi A. Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking. J Biochem. 2017; 162: 317-326.
  3. Sato A, Ogita H. Pathophysiological implications of dipeptidyl peptidases. Curr Protein Pept Sci. 2017; 18: 843-849.
  4. Zankov DP, Shimizu A, Tanaka-Okamoto M, Miyoshi J, Ogita H. Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage. Sci Rep. 2017; 7: 39335.　詳細はこちら

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2016年

  1. Pang X, Shimizu A, Kurita S, Zankov DP, Takeuchi K, Yasuda-Yamahara M, Kume S, Ishida T, Ogita H. Novel therapeutic role for dipeptidyl peptidase III in the treatment of hypertension. Hypertension. 2016; 68: 630-641.（Editorialで紹介されています）　詳細はこちら
  2. Muraki S, Ueyama H, Tanabe S, Yamade S, Ogita H, Ohji M. Novel mutations in the L visual pigment gene found in Japanese men with protan color-vision defect having a normal order L/M gene array. Ophthalmic Genet. 2016; 37: 471-472.
  3. Kuniyoshi K, Muraki S, Ueyama H, Toyoda F, Sakuramoto H, Ogita H, Irifune M, Nakao A, Yamamoto S, Iwata T, Ohji M, Shimomura Y. Novel mutations in the gene for α-subunit of retinal cone cyclic nucleotide-gated channels in a Japanese patient with congenital achromatopsia. Jpn J Ophthalmol. 2016; 60: 187-197.
  4. Ueno N, Shimizu A, Kanai M, Iwaya Y, Ueda S, Nakayama J, Kurokawa-Seo M. Enhanced expression of fibroblast growth factor receptor 3 IIIc promotes human esophageal carcinoma cell proliferation. J Histochem Cytochem. 2016; 64: 7-17.

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2015年

  1. Ueyama H, Muraki S, Tanabe S, Yamade S, Ogita H. A new subset of deutan color-vision defect associated with an L/M visual pigment gene array of normal order and -71C substitution in the Japanese population. J Biochem. 2015; 158: 197-204.
  2. Yoshida A, Shimizu A, Asano H, Kadonosono T, Kizaka-Kondoh S, Geretti E, Mammoto A,Klagsbrun M, Kurokawa-Seo M. VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Biol Open. 2015; 4: 1063-1076.
  3. Kurita S, Takeuchi K, Hayashi Y, Ueyama H, Zankov DP, Pang X, Otsuka T, Ohkubo I, Ogikubo O, Ogita H. Significance of serum Zn-α2-glycoprotein for the regulation of blood pressure. Hypertens Res. 2015; 38: 244-251.
  4. Zankov DP, Ogita H. Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. Biomed Res Int. 2015; Article ID 314178.
  5. Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-g in colitis. Sci Rep. 2015; 5: 10536.
  6. Shojima K, Sato A, Hanaki H, Tsujimoto I, Nakamura M, Hattori K, Sato Y, Dohi K, Hirata M, Yamamoto H, Kikuchi A. Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci Rep. 2015; 5: 8042.

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2014年

  1. Maeda T, Takeuchi K, Pang X, Zankov DP, Takashima N, Fujiyoshi A, Kadowaki T, Miura K, Ueshima H, Ogita H. Lipoprotein-associated phospholipase A2 regulates macrophage apoptosis through the Akt and caspase-7 pathways. J Atheroscler Thromb. 2014; 21: 839-853.
  2. Gardner JC1, Liew G, Quan YH, Ermetal B, Ueyama H, Davidson AE, Schwarz N, Kanuga N, Chana R, Maher ER, Webster AR, Holder GE, Robson AG, Cheetham ME, Liebelt J, Ruddle JB, Moore AT, Michaelides M, Hardcastle AJ. Three different cone opsin gene array mutational mechanisms with genotype-phenotype correlation and functional investigation of cone opsin variants. Hum Mutat. 2014; 35: 1354-1362.
  3. Procaccia V, Nakayama H, Shimizu A, Klagsbrun M. Gleevec/Imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun. 2014; 448: 134-138.
  4. Shahrabi-Farahani S, Wang L, Zwaans BM, Santana JM, Shimizu A, Takashima S, Kreuter M, Caultas L, D’Amore PA, Arbeit JM, Aksien LA, Bielenberg DR. Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Lab Invest. 2014; 94: 752-765.
  5. Komiya Y, Mandrekar N, Sato A, Dawid IB, Habas R. Custos controls β-catenin to regulate head development during vertebrate embryogenesis. Proc Natl Acad Sci USA. 2014; 111: 13099-13104.
  6. Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, Kikuchi A. A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J. 2014; 33: 702-718.

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邦文著書

2023年

  1. 佐藤朗、扇田久和　間質細胞との異種細胞間接触によりがん細胞に高発現するストマチンの腫瘍抑制作用　生化学　2023; 95: 50-54.

2020年

  1. 清水昭男、扇田久和　がんの浸潤・転移を促進させるepithelial membrane protein 1の分子作用機構　生化学　2020; 92: 216-220.

2018年

  1. 佐藤朗、扇田久和　Lp-PLA2の新規アポトーシス制御機構－動脈硬化との関連－　臨床化学　2018; 47: 140-147.

2017年

  1. 清水昭男、扇田久和　ジペプチジルペプチダーゼIIIのアンジオテンシンII分解活性と生体内での作用機序およびその治療応用への可能性　生化学　2017; 89: 449-452.

2015年

  1. 菊池章、佐藤朗　C1q　サイトカイン・増殖因子キーワード辞典　2015; 373-374.　羊土社

 

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