〒520-2192 大津市瀬田月輪町
滋賀医科大学
生化学・分子生物学講座
分子病態生化学部門　
TEL: 077-548-2162（研究室）
FAX: 077-548-2164
E-mail: hqbioch2@
"@以下に belle.shiga-med.ac.jp
をつけて下さい"

過去の業績

欧文著書
2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001

邦文著書
2011 | 2009 | 2006 | 2005 | 2003 | 2002 | 2001

欧文著書

2013年

  1. Yamane T, Murao S, Kato I, Kashima L, Yuguchi M, Kozuka M, Takeuchi K, Ogita H, Ohkubo I, Ariga H. Transcriptional regulation of the legumain gene by p53 in HCT116 cells. Biochem Biophys Res Commun. 2013; 438: 613-618.
  2. Majima T, Takeuchi K, Sano K, Hirashima M, Zankov DP, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ogita H. An adaptor molecule afadin regulates lymphangiogenesis by modulating RhoA activity in the developing mouse embryo. PLoS One. 2013; 8: e68134.
  3. Yamane T, Hachisu R, Yuguchi M, Takeuchi K, Murao S, Yamamoto Y, Ogita H, Takasawa T, Ohkubo I, Ariga H. Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney. Biochem Biophys Res Commun. 2013; 430: 482-487.
  4. Zankov DP, Ogita H. ACTN4 (actinin, alpha 4). Atlas Genet Cytogenet Oncol Haematol. 2013; 17: 663-669.
  5. Wang Y, Zankov DP, Jiang M, Zhang M, Henderson SC, Tseng GN. [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. J Biol Chem. 2013; 288: 35358-35371.
  6. Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013; 288: 2210-2222.

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2012年

  1. Hatoh T, Maeda T, Takeuchi K, Ogikubo O, Uchiyama S, Otsuka T, Ohkubo I, Ogita H. Domain 5 of high molecular weight kininogen inhibits collagen-mediated cancer cell adhesion and invasion in association with α-actinin-4. Biochem Biophys Res Commun. 2012; 427: 497-502.
  2. Ueyama H, Muraki-Oda S, Yamade S, Tanabe S, Yamashita T, Shichida Y, Ogita H. Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect. Biochem Biophys Res Commun. 2012; 424: 152-157.
  3. An LP, Maeda T, Sakaue T, Takeuchi K, Yamane T, Du PG, Ohkubo I, Ogita H. Purification, molecular cloning and functional characterization of swine phosphatidylethanolamine-binding protein 4 from seminal plasma. Biochem Biophys Res Commun. 2012; 423: 690-696.
  4. Zhang M, Wang Y, Jiang M, Zankov DP, Chowdhury S, Kasirajan V, Tseng GN. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. Am J Physiol Heart Circ Physiol. 2012; 302: H910-H922.
  5. Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2. J Gen Physiol. 2012; 140: 653-669.
  6. Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK. Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphoring 3F dependent mechanism. Neoplasia. 2012; 14: 84-94.
  7. Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM. Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol. 2012; 181: 548-559.
  8. Sakane H, Yamamoto H, Matsumoto S, Sato A, Kikuchi A. Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling. J Cell Sci. 2012; 125: 449-460.
  9. Hanaki H, Yamamoto H, Sakane H, Matsumoto S, Ohdan H, Sato A, Kikuchi A. An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol Cancer Ther. 2012; 11: 298-307.
  10. Kikuchi A, Yamamoto H, Sato A, Matsumoto S. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol. 2012; 204: 17-33.

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2011年

  1. Ding WG, Toyoda F, Ueyama H, Matsuura H. Lysophosphatidylcholine enhances IKs currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. J Mol Cell Cardiol. 2011; 50: 58-65.
  2. Fukumoto Y, Kurita S, Takai Y, Ogita H. Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J Biol Chem. 2011; 286: 43537-43548.
  3. Kurita S, Ogita H, Takai Y. Cooperative role of the nectin-nectin and nectin-afadin interactions in the formation of the nectin-based cell-cell adhesion. J Biol Chem. 2011; 286: 36297-36303.
  4. Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M. KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm Electrophysiol. 2011; 4: 352-361.
  5. Coma S, Shimizu A, Klagsbrun M. Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF- dependent manner via transcriptional repression of their common receptor Neuropilin 2. Cell Adh Migr. 2011; 5: 268-275.
  6. Kikuchi A, Yamamoto H, Sato A, Matsumoto S. New insights into the mechanism of Wnt signaling pathway activation. Int Rev Cell Mol Biol. 2011; 291: 21-71.
  7. Liu W, Su LT, Khadka DK, Mezzacappa C, Komiya Y, Sato A, Habas R, Runnels LW. TRPM7 regulates gastrulation during vertebrate embryogenesis. Dev Biol. 2011; 350: 348-357.

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2010年

  1. Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Obayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci. 2010; 101: 1326-1330.
  2. Ogita H, Rikitake Y, Miyoshi J, Takai Y. Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology. Proc Jpn Acad Ser B Phys Biol Sci. 2010; 86: 621-629.
  3. Ooshio T, Kobayashi R, Ikeda W, Miyata M, Fukumoto Y, Matsuzawa N, Ogita H, Takai Y. Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells. J Biol Chem. 2010; 285: 5003-5012.
  4. Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata KI, Takai Y. Role of Afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. Circ Res. 2010; 106: 1731-1742.
  5. Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H. Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes. J Membr Biol. 2010; 235: 73-87.
  6. Coma S, Amin DN, Shimizu A, Lasorella A, Lavarone A, Klagsbrun M. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin3F. Cancer Res. 2010; 70: 3823-3832.
  7. Geretti E, van Meeteren LA, Shimizu A, Dudley AC, Claesson-Welsh L, Klagsbrun M. A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. Mol Cancer Res. 2010; 8: 1063-1073.
  8. Klagsbrun M, Shimizu A. Semaphorin 3E, an exception to the rule. J Clin Invest. 2010; 120: 2658-2660.
  9. Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A. Wnt5a regulates distinct signaing pathways by binding to Frizzled2. EMBO J. 2010; 29: 41-54.
  10. Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W, Kikuchi A. Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloprotainase. Oncogene. 2010; 29: 2036-2046.

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2009年

  1. Ando K, Imai S, Isoya E, Kubo M, Mimura T, Shioji S, Ueyama H, Matsusue Y. Effect of dynamic compressive loading and its combination with a growth factor on the chondrocytic phenotype of 3-dimensional scaffold-embedded chondrocytes. Acta Orthopaedica. 2009; 80: 724-733.
  2. Kawano S, Ikeda W, Kishimoto M, Ogita H, Takai Y. Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2. J Biol Chem. 2009; 284: 23793-23805.
  3. Majima T, Ogita H, Yamada T, Amano H, Togashi H, Sakisaka T, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Takai Y. Involvement of afadin in the formation and remodeling of synapses in the hippocampus. Biochem Biophys Res Commun. 2009; 385: 539-544.
  4. Miyata M, Ogita H, Komura H, Nakata S, Okamoto R, Ozaki M, Majima T, Matsuzawa N, Kawano S, Minami A, Waseda M, Fujita N, Mizutani K, Rikitake Y, Takai Y. Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor. J Cell Sci. 2009; 122: 4319-4329.
  5. Miyata M, Rikitake Y, Takahashi M, Nagamatsu Y, Yamauchi Y, Ogita H, Hirata KI, Takai Y. Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells. J Biol Chem. 2009; 284: 24595-24609.
  6. Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Human Mutation. 2009; 30: 557-563.
  7. Togashi H, Ogita H, Takai Y. Nectins and Nectin-like molecules in the nervous system. Chapter 8: Nectins/SynCams The Sticky Synapse (Hortsch M and Umemori H eds.) 2009; 185-206. Springer.
  8. Ueyama H, Tanabe S, Muraki-Oda S, Yamade S, Ohji M, Ohkubo I. Analysis of introns and promoters of L/M visual pigment genes in relation to deutan color-vision deficiency with an array of normal gene orders. J Hum Genet. 2009; 54: 525-530.
  9. Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura H, Horie M. Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of I (Ks) current in guinea pig atrium. Pflugers Arch. 2009; 458: 837-849.
  10. Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M. Adrenergic regulation of the rapid component of delayed rectifier K+ current: implications for arrhythmogenesis in LQT2 patients. Heart Rhythm. 2009; 6: 1038-1046.
  11. Terada M, Onishi C, Ueno N, Shimizu A, Kanai M, Kurokawa-Seo M. Enhanced expression of fibroblast growth factor receptor 3 in human skin cancer cells. Open Circ Vasc J. 2009; 2: 30-36.
  12. Kikuchi A, Yamamoto H, Sato A. Selective activation of mechanisms of Wnt signaling pathways. Trend Cell Biol. 2009; 19: 119-129.

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2008年

  1. Kanzaki N, Ogita H, Komura H, Ozaki M, Sakamoto Y, Majima T, Ijuin T, Takenawa T, Takai Y. Involvement of the nectin-afadin complex in PDGF-induced cell survival. J Cell Sci. 2008; 121: 2008-2017.
  2. Komura H, Ogita H, Ikeda W, Mizoguchi A, Miyoshi J, Takai Y. Establishment of cell polarity by afadin during the formation of embryoid bodies. Genes Cells. 2008; 13: 79-90.
  3. Ogita H, Ikeda W, Takai Y. Roles of cell adhesion molecules nectin and nectin-like molecule-5 in the regulation of cell movement and proliferation. J Microsc. 2008; 231: 455-465.
  4. Ogita H, Takai Y. Cross-talk among integrin, cadherin, and growth factor receptor: roles of nectin and nectin-like molecule. Int Rev Cytol. 2008; 265: 1-54.
  5. Sakamoto Y, Ogita H, Komura H, Takai Y. Involvement of nectin in inactivation of integrin αvβ3 after the establishment of cell-cell adhesion. J Biol Chem. 2008; 283: 496-505.
  6. Takai Y, Ikeda W, Ogita H, Rikitake Y. The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. Annu Rev Cell Dev Biol. 2008; 24: 309-342.
  7. Takai Y, Miyoshi J, Ikeda W, Ogita H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol. 2008; 9: 603-615.
  8. Geretti E, Shimizu A, Klagsbrun M. Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis. Angiogenesis. 2008; 11: 31-39.
  9. Shimizu A, Mammoto A, Italiano JE, Pravda E, Dudley AC, Ingber DE, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem. 2008; 283: 27230-27238.
  10. Kawamura H, Li X, Goishi K, van Meeteren LA, Jakobsson L, Cebe-Suarez S, Shimizu A, Edholm D, Ballmer-Hofer K, Kjellen L, Klagsbrun M, Claesson-Welsh L. Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood. 2008; 112: 3638-3649.
  11. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels LW, Habas R. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci USA. 2008; 105: 210-215.

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2007年

  1. Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M. S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts. J Mol Cell Cardiol. 2007; 42: 924-930.
  2. Muraki-Oda S, Toyoda F, Okada A, Tanabe S, Yamade S, Ueyama H, Matsuura H, Ohji M. Functional analysis of rod monochromacy-associated missense mutations in the CNGA3 subunit of the cone photoreceptor cGMP-gated channel. Biochem Biophys Res Commun. 2007; 362: 88-93.
  3. Nakata S, Fujita N, Kitagawa Y, Okamoto R, Ogita H, Takai Y. Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: Implications for cellular morphology. J Biol Chem. 2007; 282: 37815-37825.
  4. Ohno S, Zankov DP, Yoshida H, Tsuji K, Makiyama T, Itoh H, Akao M, Hancox JC, Kita T, Horie M. N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm. 2007; 4: 332-340.
  5. Ozaki M, Ogita H, Takai Y. Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions. Genes Cells. 2007; 12: 651-662.
  6. Sakisaka T, Ikeda W, Ogita H, Fujita N, Takai Y. The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors. Curr Opin Cell Biol. 2007; 19: 593-602.
  7. Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW, 2nd, Liao JK. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation. 2007; 115: 3197-3204.
  8. Wakamatsu K, Ogita H, Okabe N, Irie K, Tanaka-Okamoto M, Ishizaki H, Ishida-Yamamoto A, Iizuka H, Miyoshi J, Takai Y. Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes. J Biol Chem. 2007; 282: 18173-18181.
  9. Geretti E, Shimizu A, Kurschat P, Klagsbrun M. Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity for VEGF165 but not to SEMA3F. J Biol Chem. 2007; 282: 25698-25707.
  10. Yamashita K, Sato A, Asashima M, Wang PC, Nishinakamura R. Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells. 2007; 12: 171-182.

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2006年

  1. Fukuyama T, Ogita H, Kawakatsu T, Inagaki M, Takai Y. Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway. Oncogene. 2006; 25: 8-19.
  2. Ogita H, Takai Y. Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation. IUBMB Life. 2006; 58: 334-343.
  3. Ogita H, Takai Y. Activation of Rap1, Cdc42, and Rac by nectin adhesion system. Methods in Enzymology. (Balch WE, Der CJ and Hall A eds.) 2006; 406: 415-424. Academic Press.
  4. Sakamoto Y, Ogita H, Hirota T, Kawakatsu T, Fukuyama T, Yasumi M, Kanzaki N, Ozaki M, Takai Y. Interaction of integrin αvβ3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions. J Biol Chem. 2006; 281: 19631-19644.
  5. Satoh M, Ogita H, Takeshita K, Mukai Y, Kwiatkowski DJ, Liao JK. Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci USA. 2006; 103: 7432-7437.
  6. Ueyama H, Tanabe S, Muraki-Oda S, Yamade S, Ohkubo I. Protan color vision deficiency with a unique order of green-red as the first two genes of a visual pigment array. J Hum Genet. 2006; 51: 686-694.
  7. Usui T, Kuno T, Ueyama H, Ohkubo I, Mizutani T. Proximal HNF1 element is essential for the induction of human UDP-glucuronosyltransferase 1A1 by gludodorticoid receptor. Biochem Pharmacol. 2006; 71: 693-701.
  8. Toyoda F, Ueyama H, Ding WG, Matsuura H. Modulation of functional properties of KCNQ1 channel by association of KCNE1 and KCNE2. Biochem Biophys Res Commun. 2006; 344: 814-820.
  9. Zhang C, Yasuno S, Kuwahara K, Zankov DP, Kobori A, Makiyama T, Horie M. Blockade of angiotensin II type 1 receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy. Circ J. 2006; 70: 335-341.
  10. Zankov DP, Omatsu-Kanbe M, Isono T, Toyoda F, Ding WG, Matsuura H, Horie M. Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes. Circulation. 2006; 113: 1278-1286.
  11. Shimizu A, Goishi K, Najarro G, Watanabe S, Rogers R, Zon LI, Klagsbrun M. AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Development. 2006; 133: 2585-2593.
  12. Sato A, Khadka D, Liu W, Bharti R, Runnels LW, Dawid IB, Habas R. Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation. Development. 2006; 133: 4219-4231.
  13. Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N, Nishinakamura R. The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development. 2006; 133: 3005-3013.
  14. Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW. The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006; 133: 319-329.

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2005年

  1. Aiba T, Shimizu W, Inagaki M, Noda T, Miyoshi S, Ding WG, Zankov DP, Toyoda F, Matsuura H, Horie M, Sunagawa K. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil. J Am Coll Cardiol. 2005; 45: 300-307.
  2. Asanuma H, Minamino T, Sanada S, Ogita H, Kim J, Fujita M, Hirata A, Tsukamoto O, Ogai A, Node K, Hori M, Tomoike H, Kitakaze M. A calcium channel blocker amlodipine increases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts. J Mol Cell Cardiol. 2005; 39: 605-614.
  3. Fukuyama T, Ogita H, Kawakatsu T, Fukuhara T, Yamada T, Sato T, Shimizu K, Nakamura T, Matsuda M, Takai Y. Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J Biol Chem. 2005; 280: 815-825.
  4. Kawakatsu T, Ogita H, Fukuhara T, Fukuyama T, Minami Y, Shimizu K, Takai Y. Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac. J Biol Chem. 2005; 280: 4940-4947.
  5. Zankov DP, Ding WG, Matsuura H, Horie M. Open-state unblock characterizes acute inhibition of I potassium current by amiodarone in guinea pig ventricular myocytes. J Cardiovasc Electrophysiol. 2005; 16: 314-322.
  6. Park TJ, Gray RS, Sato A, Habas R, Wallingford JB. Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos. Curr Biol. 2005; 15: 1039-1044.

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2004年

  1. Asanuma H, Minamino T, Sanada S, Takashima S, Ogita H, Ogai A, Asakura M, Liao Y, Asano Y, Shintani Y, Kim J, Shinozaki Y, Mori H, Node K, Kitamura S, Tomoike H, Hori M, Kitakaze M. β-Adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine hearts. Circulation. 2004; 109: 2773-2779.
  2. Asanuma H, Sanada S, Ogai A, Minamino T, Takashima S, Asakura M, Ogita H, Shinozaki Y, Mori H, Node K, Tomoike H, Hori M, Kitakaze M. Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts. J Cardiovasc Pharmacol. 2004; 43: 574-579.
  3. Bielenberg DR, Hida Y, Shimizu A, Kaipainen A, Reuter M, Kim CC, Klagsbrun M. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. J Clin Invest. 2004; 114: 1260-1271.
  4. Fujita M, Minamino T, Sanada S, Asanuma H, Hirata A, Ogita H, Okada K, Tsukamoto O, Takashima S, Tomoike H, Node K, Hori M, Kitakaze M. Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts. J Mol Cell Cardiol. 2004; 37: 1219-1223.
  5. Fukuhara T, Shimizu K, Kawakatsu T, Fukuyama T, Minami Y, Honda T, Hoshino T, Yamada T, Ogita H, Okada M, Takai Y. Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol. 2004; 166: 393-405.
  6. Kanou M, Usui T, Ueyama H, Sato H, Ohkubo I, Mizutani T. Stimulation of transcriptional expression of human UDP-glucuronosyltransferase 1A1 by dexamethasone. Mol Biol Reports. 2004; 31: 151-158.
  7. Ogita H, Liao JK. Endothelial function and oxidative stress. Endothelium. 2004; 11: 123-132.
  8. Ogita H, Node K, Asanuma H, Sanada S, Kim J, Takashima S, Minamino T, Hori M, Kitakaze M. Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: Role of phosphatidylinositol 3-kinase/Akt pathway. J Cardiovasc Pharmacol. 2004; 43: 821-829.
  9. Ogita H, Node K, Liao Y, Ishikura F, Beppu S, Asanuma H, Sanada S, Takashima S, Minamino T, Hori M, Kitakaze M. Raloxifene prevents cardiac hypertrophy and dysfunction in pressure-overloaded mice. Hypertension. 2004; 43: 237-242.
  10. Okada A, Ueyama H, Toyoda F, Oda S, Ding WG, Tanabe S, Yamade S, Matsuura H, Ohkubo I, Kani K. Functional role of hCNGB3 in regulation of human cone CNG channel: Effect of rod-monochromacy-associated mutations in hCNGB3 on channel function. Inves Ophthalmol Vis Sci. 2004; 45: 2324-2332.
  11. Ueyama H, Kuwayama S, Imai H, Oda S, Nishida Y, Tanabe S, Shichida Y, Yamade S. Analysis of L-cone/M-cone visual pigment gene arrays in Japanese males with protan color-vision deficiency. Vision Res. 2004; 44: 2241-2252.
  12. Ueyama H, Torii R, Tanabe S, Oda S, Yamada S. An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays. J Hum Genet. 2004; 49: 548-557.
  13. Sato A, Kishida S, Tanaka T, Kikuchi A, Kodama T, Asashima M, Nishinakamura R. Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin. Biochem Biophys Res Commun. 2004; 319: 103-113.

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2003年

  1. Asakura M, Takashima S, Asano Y, Honma T, Asanuma H, Sanada S, Shintani Y, Liao Y, Kim J, Ogita H, Node K, Minamino T, Yorikane R, Ogai A, Kitamura S, Tomoike H, Hori M, Kitakaze M. Canine DNA array as a potential tool for combining physiology and molecular biology. Circ J. 2003; 67: 788-792.
  2. Asanuma H, Node K, Minamino T, Sanada S, Takashima S, Ueda Y, Sakata Y, Asakura M, Kim J, Ogita H, Tada M, Hori M, Kitakaze M. Celiprolol increases coronary blood flow and reduces severity of myocardial ischemia via nitric oxide release. J Cardiovasc Pharmacol. 2003; 41: 499-505.
  3. Liao Y, Takashima S, Asano Y, Asakura M, Ogai A, Shintani Y, Minamino T, Asanuma H, Sanada S, Kim J, Ogita H, Tomoike H, Hori M, Kitakaze M. Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model. Circ Res. 2003; 93: 759-766.
  4. Oda S, Ueyama H, Nishida Y, Tanabe S, Yamade S. Analysis of L-cone/M-cone visual pigment gene arrays in females by long-range PCR. Vision Res. 2003; 43: 489-495.
  5. Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Soma M, Kim J, Hori M, Kitakaze M. Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts. J Cardiovasc Pharmacol. 2003; 41: 964-969.
  6. Ogita H, Node K, Kitakaze M. The role of estrogen and estrogen-related drugs in cardiovascular diseases. Curr Drug Metab. 2003; 4: 497-504.
  7. Sanada S, Node K, Minamino T, Takashima S, Ogai A, Asanuma H, Ogita H, Liao Y, Asakura M, Kim J, Hori M, Kitakaze M. Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic no inhibition in rats. Hypertension. 2003; 41: 963-967.
  8. Ueyama H, Li YH, Fu GL, Lertrit P, Atchaneeyasakul L, Oda S, Tanabe S, Nishida Y, Yamade S, Ohkubo I. An A-71C substitution in a green gene at the second position in the red/green visual-pigment gene array is associated with deuta. Proc Natl Acad Sci USA. 2003; 100: 3357-3362.
  9. Yamada T, Shimonagata T, Fukunami M, Kumagai K, Ogita H, Hirata A, Asai M, Makino N, Kioka H, Kusuoka H, Hori M, Hoki N. Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure: A prospective study. J Am Coll Cardiol. 2003; 41: 231-238.
  10. Sato A, Matsumoto Y, Koide U, Kataoka Y, Yoshida N, Yokota T, Asashima M, Nishinakamura R. Zinc finger protein Sall2 is not essential for embryonic and kidney development. Mol Cell Biol. 2003; 23: 62-69.

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2002年

  1. Asakura M, Kitakaze M, Sakata Y, Asanuma H, Sanada S, Kim J, Ogita H, Liao Y, Node K, Takashima S, Tada M, Hori M. Adenosine-induced cardiac gene expression of ischemic murine hearts revealed by cDNA array hybridization. Circ J. 2002; 66: 93-96.
  2. Kitakaze M, Asanuma H, Funaya H, Node K, Takashima S, Sanada S, Asakura M, Ogita H, Kim J, Hori M. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers synergistically increase coronary blood flow in canine ischemic myocardium: Role of bradykinin. J Am Coll Cardiol. 2002; 40: 162-166.
  3. Liao Y, Ishikura F, Beppu S, Asakura M, Takashima S, Asanuma H, Sanada S, Kim J, Ogita H, Kuzuya T, Node K, Kitakaze M, Hori M. Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: Necropsy validation. Am J Physiol Heart Circ Physiol. 2002; 282: H1703-H1708.
  4. Ogita H, Node K, Asanuma H, Sanada S, Liao Y, Takashima S, Asakura M, Mori H, Shinozaki Y, Hori M, Kitakaze M. Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart. J Am Coll Cardiol. 2002; 40: 998-1005.
  5. Sanada S, Node K, Asanuma H, Ogita H, Takashima S, Minamino T, Asakura M, Liao Y, Ogai A, Kim J, Hori M, Kitakaze M. Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: Role of 70-kDa S6 kinase and extracellular signal-regulated kinase. J Am Coll Cardiol. 2002; 40: 991-997.
  6. Shimizu A, Takashima Y, Kurokawa-Seo M. FGFR3 isoforms have distinct functions in the regulation of growth and cell morphology. Biochem Biophys Res Commun. 2002; 290: 113-120.
  7. Ueyama H, Kuwayama S, Imai H, Tanabe S, Oda S, Nishida Y, Wada A, Shichida Y, Yamade S. Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. Biochem Biophys Res Commun. 2002; 294: 205-209.
  8. Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F. The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA. J Biochem. 2002; 131: 307-311.

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2001年

  1. Hayashi S, Ueyama H, Tanabe S, Yamade S, Kani K. Number and variations of the red and green visual pigment genes in Japanese men with normal color vision. Jpn J Ophthalmol. 2001; 45: 60-67.
  2. Hayashi T, Yamaguchi T, Kitahara K, Sharpe LT, Jagle H, Yamade S, Ueyama H, Motulsky AG, Deeb SS. The importance of gene order in expression of the red and green visual pigment genes in color vision. Color Res Appl. 2001; 26: S79-S83.
  3. Kamiyama F, Maeda T, Yamane T, Li YH, Ogikubo O, Otsuka T, Ueyama H, Takahashi S, Ohkubo I, Matsui N, Inhibition of vitronectin-mediated haptotaxis and haptoinvasion of MG-63 cells by domain 5 (D5H) of human high-molecular-weight kininogen adn identification of a minimum amino acid sequence. Biochem Biophys Res Commun. 2001; 288: 975-980.
  4. Ogita H, Shimonagata T, Fukunami M, Kumagai K, Yamada T, Asano Y, Hirata A, Asai M, Kusuoka H, Hori M, Hoki N. Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: A prospective study. Heart. 2001; 86: 656-660.
  5. Sanada S, Kitakaze M, Asanuma H, Harada K, Ogita H, Node K, Takashima S, Sakata Y, Asakura M, Shinozaki Y, Mori H, Kuzuya T, Hori M. Role of mitochondrial and sarcolemmal KATP channels in ischemic preconditioning of the canine heart. Am J Physiol Heart Circ Physiol. 2001; 280: H256-263.
  6. Sanada S, Kitakaze M, Node K, Takashima S, Ogai A, Asanuma H, Sakata Y, Asakura M, Ogita H, Liao Y, Fukushima T, Yamada J, Minamino T, Kuzuya T, Hori M. Differential subcellular actions of ACE inhibitors and AT1 receptor antagonists on cardiac remodeling induced by chronic inhibition of no synthesis in rats. Hypertension. 2001; 38: 404-411.
  7. Sanada S, Kitakaze M, Papst PJ, Asanuma H, Node K, Takashima S, Asakura M, Ogita H, Liao Y, Sakata Y, Ogai A, Fukushima T, Yamada J, Shinozaki Y, Kuzuya T, Mori H, Terada N, Hori M. Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: The role of protein kinase a and p38 mitogen-activated protein kinase. Circulation. 2001; 104: 705-710.
  8. Sanada S, Kitakaze M, Papst PJ, Hatanaka K, Asanuma H, Aki T, Shinozaki Y, Ogita H, Node K, Takashima S, Asakura M, Yamada J, Fukushima T, Ogai A, Kuzuya T, Mori H, Terada N, Yoshida K, Hori M. Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart. Circ Res. 2001; 88: 175-180.
  9. Shimizu A, Tada K, Shukunami C, Hiraki Y, Kurokawa T, Magane N, Kurokawa-Seo M. A novel alternatively spliced FGFR3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells. J Biol Chem. 2001; 276: 11031-11040.
  10. Terada M, Shimizu A, Sato N, Miyakaze SI, Katayama H, Kurokawa-Seo M. Fibroblast growth factor receptor 3 lacking the Ig IlIb and transmembrane domains secreted from human squamous cell carcinoma DJM- 1 binds to FGFs. Mol Cell Biol Res Commun. 2001; 4: 365-373.
  11. Ueyama H, Hayashi S, Tanabe S, Tanaka Y, Hayashi T, Deeb SS, Yamade S, Ohkubo I. Number and arrangement of the red and green visual pigment genes in color-normal Japanese males. Color Res Appl. 2001; 26: 84-88.
  12. Tsuzuki H, Tani T, Ueyama H, Kodama M. Lipopolysaccharide: Neutralization by polymyxin B shuts down the signaling pathway of nuclear factor κβ in peripheral blood mononuclear cells, even during activation. J Surg Res. 2001; 100: 127-134.
  13. Yamade S, Hayashi S, Ueyama H, Tanabe S, Hukami K, Ichikwa K, Tachibana M. Red-green pigment gene analysis as a clinical diagnostic tool. Color Res Appl. 2001; 26: 89-92.
  14. Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A, Copeland NG, Gilbert DJ, Jenkins NA, Scully S, Lacey DL, Katsuki M, Asashima M, Yokota T. Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development. 2001; 128: 3105-3115.

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邦文著書

2011年

  1. 上山久雄　新編 色彩科学ハンドブック 第３版（日本色彩学会） 2011; 354-358.　東京大学出版会
  2. 扇田久和　細胞間接着破綻　がんの浸潤・転移－臨床と基礎－　2011; 150-161.　南山堂
  3. 菊池章、佐藤朗、松本真司　Wntシグナルネットワークの異常と癌　実験医学増刊「秒進分歩する癌研究と分子標的治療」　2011; 29: 26-35.　羊土社

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2009年

  1. 菊池章、山本英樹、佐藤朗　Wntによるβ-カテニン非依存性経路の活性化とその異常による病態　蛋白質核酸酵素　2009; 54: 1-10.

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2006年

  1. 上山久雄　アシドーシスやアルカローシスってどういう状態？なぜ起こるの？　胚性幹細胞は他の細胞とどう違うの？どうして再生医療に利用されるの？　DNA・ゲノム・染色体・遺伝子---一体どう違うの？　遺伝情報からどうやってタンパク質がつくられるの？　クリニカルスタディ　2006; 27: 51-54.
  2. 扇田久和、高井義美　細胞接着と細胞骨格　実験医学　2006; 24: 122-128.
  3. 扇田久和、古瀬幹夫、月田承一郎、高井義美　細胞の接着と極性形成の分子機構　がん研究のいま（2. がん細胞の生物学） 2006; 111-140.　東京大学出版会

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2005年

  1. 福山泰平、扇田久和、高井義美　Small Gタンパク質−その細胞間接着における役割と作用機序−　日本老年医学会雑誌　2005; 42: 9-14.

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2003年

  1. 上山久雄　ビタミン関連約30項目　医学大辞典　2003.　医学書院
  2. 上山久雄　物質遺伝子の構成と色覚異常　ビタミン　2003; 77: 577-579.
  3. 扇田久和､北風政史　虚血心筋の病態生理　日本臨床 2003; 61: 735-750.
  4. 山出新一、上山久雄　色覚の展望－2002年度－　眼科　2003; 45: 1895-1915.

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2002年

  1. 扇田久和、野出孝一　Vascular vs. hepatic statins　 Cardiac Practice　2002; 13: 331-336.
  2. 扇田久和､野出孝一､堀正二　不整脈死をどう予防するか “β遮断薬”  Heart View 2002; 6: 132-136.
  3. 北風政史、扇田久和　心不全の大規模臨床研究　臨床医　2002; 28: 453-455.
  4. 山出新一、上山久雄　色覚の展望－2000年度－　眼科　2002; 44: 131-148.
  5. 山出新一、上山久雄　色覚の展望－2001年度－　眼科　2002; 44: 1853-1872.

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2001年

  1. 浅沼博司、北風政史、真田昌爾、高島成二、野出孝一、朝倉正紀、扇田久和、坂田泰彦、葛谷恒彦、多田道彦、堀正二　K+チャネル開口薬ニコランジルのNo-reflow現象抑制効果及び心筋梗塞縮小効果の検討　Therapeutic Research　2001; 22: 698-700.
  2. 扇田久和　心不全患者の予後　今日の循環器疾患治療指針（第2版） 2001; 301.　医学書院
  3. 扇田久和､野出孝一､北風政史　心筋虚血再灌流障害と酸化ストレスCardiac Practice　2001; 12: 397-401.
  4. 扇田久和､堀正二　神経体液性因子と心不全　別冊･医学のあゆみ-State of arts (Ver. 2)　2001; 19-21.　医歯薬出版
  5. 大久保岩男、上山久雄　Zn-α2-糖タンパク質　タンパク質化学（第５巻・血漿タンパク質） 2001; 119-125.　廣川書店
  6. 北風政史､扇田久和､堀正二　カルシウム拮抗薬　血管内科 2001; 339-344.　メディカルレビュー社
  7. 真田昌爾、北風政史、浅沼博司、南野哲男、野出孝一、高島成二、朝倉正紀、扇田久和、葛谷恒彦、堀正二　アデノシンと心筋保護−プレコンディショニングとの関わり　日本臨床生理学会雑誌　2001; 31: 73-78.
  8. 真田昌爾、北風政史、南野哲男、野出孝一、浅沼博司、坂田泰彦、朝倉正紀、扇田久和、葛谷恒彦、堀正二　ニコランジル長期投与によりNO欠乏による慢性心肥大が血圧非依存性に抑制される−KATPチャネル開口がp70S6KとERKに及ぼす影響　Therapeutic Research　2001; 22: 708-711.
  9. 山出新一、上山久雄　色覚の展望－1999年度－　眼科　2001; 43: 1-19.
  10. 山出新一、小田早苗、田中敬、上山久雄、田邊詔子、林孝彰、Deeb SS　正常遺伝子型を持つ色覚異常例の解析　臨床眼科　2001; 55: 265-269.

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