Failure of DNA Double-Strand Break Repair by Tau Mediates Alzheimer's Disease Pathology in vitro

Communications biology doi:10.1038/s42003-022-03312-0

Megumi Asada-Utsugi、Kengo Uemura、Takashi Ayaki、Maiko T Uemura、Sumio Minamiyama、Ryota Hikiami、Toshifumi Morimura、Akemi Shodai、 Takatoshi Ueki、Ryosuke Takahashi、Ayae Kinoshita、and Makoto Urushitani

Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis

Scientific Reports 2022; 12: 3449. doi:10.1038/s41598-022-07379-x

Sayaka Saijo、Mikiko Ohno、Hirotaka Iwasaki、Shintaro Matsuda、Kiyoto Nishi、Yoshinori Hiraoka、Natsuki Ide、Takeshi Kimura、Eiichiro Nishi

Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain

Human Molecular Genetics, 2022, Vol. 31, No. 1 doi:10.1093/hmg/ddab226

Naoki Watanabe、Masaki Nakano、Yachiyo Mitsuishi、Norikazu Hara、Tatsuo Mano、Atsushi Iwata、Shigeo Murayama、Toshiharu Suzuki、Takeshi Ikeuchi、Masaki Nishimura

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model

Molecular Therapy – Oncolytics doi:10.1016/j.omto.2021.12.003

Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata

Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice

Journal of Biological Chemistry. 2021; 296: 100761 doi:10.1016/j.jbc.2021.100761

Komeno M, Pang X, Shimizu A, Molla MR, Yasuda-Yamahara M, Kume S, Rahman NIA, Soh JEC, Nguyen LKC, Ahmat Amin MKB, Kokami N, Sato A, Asano Y, Maegawa H, Ogita H

Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth

Cancer Research. 2021; 81: 2318-2331. doi:10.1158/0008-5472.CAN-20-2331

Nor Idayu A. Rahman, Akira Sato, Khurelbaatar Tsevelnorov, Akio Shimizu, Masahiro Komeno, Mohammad Khusni Bin Ahmat Amin, Md Rasel Molla, Joanne Ern Chi Soh, Le Kim Chi Nguyen, Akinori Wada, Akihiro Kawauchi, Hisakazu Ogita

Similarities and differences in metabolites of tongue cancer cells among two- and three-dimensional cultures and xenografts

Cancer Science doi:10.1111/cas.14749.

Shoko Murakami, Hiroyuki Tanaka, Takahisa Nakayama, Naoko Taniura, Toru Miyake, Masaji Tani, Ryoji Kushima, Gaku Yamamoto, Hiroyuki Sugihara, Ken-ichi Mukaisho

Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils

Biomaterials doi:10.1016/j.biomaterials.2021.120686

Daijiro Yanagisawa1, Tomoko Kato1, Hiroyasu Taguchi, Nobuaki Shirai, Koichi Hirao, Takayuki Sogabe, Takami Tomiyama, Keizo Gamo, Yukie Hirahara, Masaaki Kitada, IkuoTooyama*.
1Equally contribution, *Corresponding author

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.

Virology doi:10.1016/j.virol.2020.12.013

Hirohito Ishigaki, Misako Nakayama, Yoshinori Kitagawa, Cong Thanh Nguyen, Kaori Hayashi, Masanori Shiohara, Bin Gotoh, Yasushi Itoh.

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Bodyinduced mTORC1 Inhibition

Cell Metabolism  doi:10.1016/j.cmet.2020.06.020

Issei Tomita, Shinji Kume, Sho Sugahara, Norihisa Osawa, Kosuke Yamahara, Mako YasudaYamahara, Naoko Takeda, Masami Chin-Kanasaki, Tatsuroh Kaneko, Eric Mayoux, Michael Mark, Motoko Yanagita,   Hisakazu Ogita, Shin-ichi Araki, Hiroshi Maegawa.

Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor

The FASEB Journal, 2020 (in press)  doi:10.1096/fj.202000604R

Mikiko Ohno, Kiyoto Nishi, Yoshinori Hiraoka, Shinichiro Niizuma, Shintaro Matsuda,  Hirotaka Iwasaki, Takeshi Kimura, &* Eiichiro Nishi.

Open-channel blocking action of volatile anesthetics desflurane and sevoflurane on human voltage-gated Kv1.5 channel

British Journal of Pharmacology, 2020 (in press)  doi:10.1111/bph.15105

Yutaka Fukushima, Akiko Kojima, Xinya Mi, Wei-Guang Ding, Hirotoshi Kitagawa, Hiroshi Matsuura.

High Prevalence of Late-Appearing T-Wave in Patients with Long QT Syndrome Type 8

Circulation Journal 84(4): 559-568 (2020)  doi:10.1253/circj.CJ-19-1101

Fukuyama M, Ohno S, Ozawa J,  Kato K, Makiyama T,  Nakagawa Y,Horie M.

Generation of Transgenic Cynomolgus Monkeys overexpressing the Gene for Amyloid-β Precursor Protein

Journal of Alzheimer’s Disease 2020 Pre-press  doi:10.3233/JAD-191081

Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T,  Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.

Identification of transmembrane protein 168 mutation in familial Brugada syndrome

FASEB JOURNAL 2020 in press.  doi:10.1096/fj.201902991R

Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N,  Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H.

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Nature Communications  doi:10.1038/s41467-019-13398-6

Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi and  Masatsugu Ema

C. elegans collectively forms dynamical networks

Nature Communications  doi:10.1038/s41467-019-08537-y

Takuma Sugi, Hiroshi Ito,  Masaki Nishimura, and Ken H. Nagai