Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils

Biomaterials doi:10.1016/j.biomaterials.2021.120686

Daijiro Yanagisawa1, Tomoko Kato1, Hiroyasu Taguchi, Nobuaki Shirai, Koichi Hirao, Takayuki Sogabe, Takami Tomiyama, Keizo Gamo, Yukie Hirahara, Masaaki Kitada, IkuoTooyama*.
1Equally contribution, *Corresponding author

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.

Virology doi:10.1016/j.virol.2020.12.013

Hirohito Ishigaki, Misako Nakayama, Yoshinori Kitagawa, Cong Thanh Nguyen, Kaori Hayashi, Masanori Shiohara, Bin Gotoh, Yasushi Itoh.

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Bodyinduced mTORC1 Inhibition

Cell Metabolism  doi:10.1016/j.cmet.2020.06.020

Issei Tomita, Shinji Kume, Sho Sugahara, Norihisa Osawa, Kosuke Yamahara, Mako YasudaYamahara, Naoko Takeda, Masami Chin-Kanasaki, Tatsuroh Kaneko, Eric Mayoux, Michael Mark, Motoko Yanagita,   Hisakazu Ogita, Shin-ichi Araki, Hiroshi Maegawa.

Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor

The FASEB Journal, 2020 (in press)  doi:10.1096/fj.202000604R

Mikiko Ohno, Kiyoto Nishi, Yoshinori Hiraoka, Shinichiro Niizuma, Shintaro Matsuda,  Hirotaka Iwasaki, Takeshi Kimura, &* Eiichiro Nishi.

Open-channel blocking action of volatile anesthetics desflurane and sevoflurane on human voltage-gated Kv1.5 channel

British Journal of Pharmacology, 2020 (in press)  doi:10.1111/bph.15105

Yutaka Fukushima, Akiko Kojima, Xinya Mi, Wei-Guang Ding, Hirotoshi Kitagawa, Hiroshi Matsuura.

High Prevalence of Late-Appearing T-Wave in Patients with Long QT Syndrome Type 8

Circulation Journal 84(4): 559-568 (2020)  doi:10.1253/circj.CJ-19-1101

Fukuyama M, Ohno S, Ozawa J,  Kato K, Makiyama T,  Nakagawa Y,Horie M.

Generation of Transgenic Cynomolgus Monkeys overexpressing the Gene for Amyloid-β Precursor Protein

Journal of Alzheimer’s Disease 2020 Pre-press  doi:10.3233/JAD-191081

Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T,  Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.

Identification of transmembrane protein 168 mutation in familial Brugada syndrome

FASEB JOURNAL 2020 in press.  doi:10.1096/fj.201902991R

Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N,  Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H.

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Nature Communications  doi:10.1038/s41467-019-13398-6

Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi and  Masatsugu Ema

C. elegans collectively forms dynamical networks

Nature Communications  doi:10.1038/s41467-019-08537-y

Takuma Sugi, Hiroshi Ito,  Masaki Nishimura, and Ken H. Nagai